Article
Gastroenterology & Hepatology
Florian A. Lempp, Tassilo Volz, Elisabetta Cameroni, Fabio Benigni, Jiayi Zhou, Laura E. Rosen, Julia Noack, Fabrizia Zatta, Hannah Kaiser, Siro Bianchi, Gloria Lombardo, Stefano Jaconi, Lucia Vincenzetti, Hasan Imam, Leah B. Soriaga, Nadia Passini, David M. Belnap, Andreas Schulze, Marc Luetgehetmann, Amalio Telenti, Andrea L. Cathcart, Gyorgy Snell, Lisa A. Purcell, Christy M. Hebner, Stephan Urban, Maura Dandri, Davide Corti, Michael A. Schmid
Summary: This study describes a monoclonal antibody that targets the surface antigen of hepatitis B virus (HBV) and shows potential for treating chronic hepatitis B and chronic hepatitis D. The antibody effectively neutralizes HBV and HDV infections in vitro and reduces viral levels in human liver-chimeric mice.
JOURNAL OF HEPATOLOGY
(2023)
Article
Pharmacology & Pharmacy
Yu Bagger, William R. Ravis, Geoff Harris, Stan Bukofzer
Summary: OCE-205 is a novel selective vasopressin V1a receptor mixed agonist/antagonist that may have improved therapeutic effects in treating complications related to portal hypertension in end-stage liver disease as compared to currently used nonselective full-agonist vasopressin analogs.
CLINICAL DRUG INVESTIGATION
(2023)
Article
Pharmacology & Pharmacy
Glenn Croston, Edward E. Cable, Jeannine Toy, Hiroe Tariga, Regent Laporte, Geoff Harris, Stan Bukofzer
Summary: The selectivity and degree of functional agonism of Ocelot Bio's molecule, OCE-205, at the vasopressin 1a receptor (V1aR) were tested. Results showed that OCE-205 had an average efficacy of 39% of the maximal possible effect (MPE) at hV1aR, with an EC50 of 0.71 nM. OCE-205 demonstrated selectivity for hV1aR, as indicated by higher EC50 values at hV1bR, hV2R, and OTR. OCE-205 also exhibited functional partial agonism by producing 40.0% of maximal depolarization-induced contraction.
JOURNAL OF PHARMACOLOGY & PHARMACOTHERAPEUTICS
(2023)
Article
Chemistry, Multidisciplinary
Antonio Scarano, Francesco Inchingolo, Biagio Rapone, Alberta Greco Lucchina, Erda Qorri, Felice Lorusso
Summary: The study demonstrated that autologous platelet gel promotes new bone formation and accelerates healing in rabbit bone defects, with higher percentages of lamellar and woven bone in the treated group compared to untreated controls.
APPLIED SCIENCES-BASEL
(2021)
Article
Chemistry, Analytical
Ana Batista, Pedro Serranho, Mario J. Santos, Carlos Correia, Jose P. Domingues, Custodio Loureiro, Joao Cardoso, Silvia Barbeiro, Miguel Morgado, Rui Bernardes
Summary: Robust methods for computing tissue displacements in optical coherence elastography (OCE) data are crucial for accurate estimation of tissue elastic properties. This study evaluated the accuracy of different phase estimators on simulated and real OCE data, and found that combining three phase-difference estimates minimized errors in estimation. The median root-mean-square error in displacement prediction was significantly reduced using this combined approach, demonstrating its feasibility for tissue elasticity estimation.
Review
Biochemistry & Molecular Biology
Ilaria Plantamura, Alessandra Cataldo, Giulia Cosentino, Marilena V. Iorio
Summary: Despite controversial roles in different cancer types, miR-205 is mainly described as an oncosuppressive miRNA in breast cancer. Its expression decreases from less aggressive to more aggressive subtypes and influences metastasis capability, therapy response, and patient survival. MiR-205 plays a role in breast cancer initiation and progression, stemness maintenance, tumor microenvironment, and may serve as a biomarker with relevance in normal breast physiology. Additionally, some lncRNAs are implicated in breast cancer progression by acting as sponges of miR-205.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Physics, Multidisciplinary
Juvenal Ormachea, Fernando Zvietcovich
Summary: Various approaches are used for elastography imaging, with the reverberant shear wave elastography (RSWE) showing promise as an alternative method. RSWE has been implemented in ultrasound and optical coherence tomography, demonstrating potential for characterizing the elastic and viscoelastic properties of tissues in various organs.
FRONTIERS IN PHYSICS
(2021)
Article
Astronomy & Astrophysics
Huseyin Er, Aykut Ozdonmez, Ilham Nasiroglu
Summary: Several post-common envelope eclipsing binaries have been found to have variations in their orbital periods, potentially due to the presence of additional bodies in the system or other physical effects. The sdB+M eclipsing system NY Vir has shown such variations in the past decade, with recent observations indicating a new trend in the O - C diagram. Further research is needed to understand the mechanism behind these changes.
MONTHLY NOTICES OF THE ROYAL ASTRONOMICAL SOCIETY
(2021)
Article
Chemistry, Physical
Ekaterina V. Gubarkova, Aleksander A. Sovetsky, Lev A. Matveev, Aleksander L. Matveyev, Dmitry A. Vorontsov, Anton A. Plekhanov, Sergey S. Kuznetsov, Sergey V. Gamayunov, Alexey Y. Vorontsov, Marina A. Sirotkina, Natalia D. Gladkova, Vladimir Y. Zaitsev
Summary: Compression optical coherence elastography (C-OCE) is a promising tool for evaluating the nonlinear properties of breast cancer tissues and improving the accuracy of elastographic examination. The study found significant differences in Young's modulus and the nonlinearity parameter among different subtypes of tumorous and nontumorous breast tissues. The nonlinearity parameter can effectively differentiate certain malignant breast tissue subtypes from benign ones.
Article
Engineering, Electrical & Electronic
Luis A. Aleman-Castaneda, Fernando Zvietcovich, Kevin J. Parker
Summary: The study investigates reverberant elastography in anisotropic elastic media, deriving closed-form solutions validated with finite element numerical simulations. OCE experiments characterize chicken muscle samples, obtaining results on shear modulus and unifying previous research findings on reverberant elastography.
IEEE JOURNAL OF SELECTED TOPICS IN QUANTUM ELECTRONICS
(2021)
Article
Computer Science, Artificial Intelligence
Yanjun Cao, Giovanni Beltrame
Summary: In this paper, a system is proposed that utilizes Ultra-WideBand (UWB) ranging along with a static anchor to correct drift in long trajectories. This system is also used for collaborative SLAM, with experimental results showing that it can outperform pure visual-inertial odometry by more than 20%. The method is effective in visually challenging environments, and inter-robot transformation matrices can be computed at almost no extra computation cost.
Article
Astronomy & Astrophysics
A. S. Baran, R. H. Ostensen, U. Heber, A. Irrgang, S. Sanjayan, J. H. Telting, M. D. Reed, J. Ostrowski
Summary: This study provides an overview of HW-Vir type eclipsing systems based on space observations from the TESS mission. The analysis focuses on AA Doradus, with detailed examination of its properties and confirmation of stable orbital period through eclipse timing measurements. The study also suggests possible pulsations in the system, which will be confirmed or rejected with further cadence data in the future.
MONTHLY NOTICES OF THE ROYAL ASTRONOMICAL SOCIETY
(2021)
Article
Oncology
Jing Deng, Aneel Paulus, Douglas D. Fang, Alak Manna, Guangfeng Wang, Hengbang Wang, Saijie Zhu, Jianyong Chen, Ping Min, Yan Yin, Navnita Dutta, Nabanita Halder, Gina Ciccio, John A. Copland III, James Miller, Bing Han, Longchuan Bai, Liu Liu, Mi Wang, Donna McEachern, Sally Przybranowski, Chao-Yie Yang, Jeanne A. Stuckey, Depei Wu, Caixia Li, Jeremy Ryan, Anthony Letai, Sikander Ailawadhi, Dajun Yang, Shaomeng Wang, Asher Chanan-Khan, Yifan Zhai
Summary: This study investigated a novel BCL-2-selective inhibitor lisaftoclax and its preclinical potential. The findings demonstrated that lisaftoclax selectively binds BCL-2, disrupts complexes, and induces apoptosis in hematologic malignancies. It showed strong antitumor activity in various types of cancer cells and enhanced the activity when combined with other drugs.
CLINICAL CANCER RESEARCH
(2022)
Article
Cell Biology
Yu-Jie Dong, Wei Feng, Yan Li
Summary: The study identified the HOTTIP-miR-205-ZEB2 axis as a key player in cisplatin resistance in ovarian cancer cells. Inhibiting HOTTIP and increasing miR-205 levels can reverse resistance to cisplatin, indicating that modulation of this axis may improve drug efficacy.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Ophthalmology
Xiao Lin, Taye Mekonnen, Sudhir Verma, Christian Zevallos-Delgado, Manmohan Singh, Salavat R. Aglyamov, Tarsis F. Gesteira, Kirill V. Larin, Vivien J. Coulson-Thomas
Summary: This study investigated the effect of changes in hyaluronan (HA) distribution on the biomechanical properties of the cornea after a corneal alkali burn. It was found that mice lacking HA synthase 1 and 3 showed an increase in corneal stiffness, while mice lacking HA synthase 2 showed a decrease in corneal stiffness.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)