Article
Pharmacology & Pharmacy
Gi Suk Nam, Soyoung Kim, Yun-Suk Kwon, Min-Kyung Kim, Kyung-Soo Nam
Summary: MAP4K4 inhibitors reduce thrombus formation by regulating platelet activation, showing potential for the treatment of thrombosis.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Hematology
Yana Roka-Moiia, Samuel Miller-Gutierrez, Daniel E. Palomares, Joseph E. Italiano, Jawaad Sheriff, Danny Bluestein, Marvin J. Slepian
Summary: Our study shows that exposure of platelets to elevated shear stress leads to downregulation of GPIb and alpha(IIb)beta(3) receptors on platelets, while increasing the generation of platelet-derived microparticles expressing elevated levels of these receptors. This mechanism limits platelet activation and aggregatory response induced by physiological stimuli.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Review
Hematology
James I. Hearn, Elizabeth E. Gardiner
Summary: This article discusses the role of platelets in the formation of a hemostatic response and vascular injury repair, as well as their function in flowing blood. The article highlights the importance of platelet adhesion and activation in forming and strengthening adhesive ties, and discusses the challenges faced in research.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Article
Hematology
Rui-Gang Xu, Julia S. Gauer, Stephen R. Baker, Alexandre Slater, Eleyna M. Martin, Helen R. McPherson, Cedric Duval, Iain W. Manfield, Arkadiusz M. Bonna, Steve P. Watson, Robert A. S. Ariens
Summary: The study demonstrates that dimeric GPVI binds to fibrinogen with higher affinity compared to the monomer, primarily through avidity effects. The interaction of GPVI with the α C-region of fibrinogen is crucial for its binding. These findings suggest that clustering of GPVI through the α C-region during fibrin polymerization may lead to downstream signaling, platelet activation, and clot growth.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Hla Nu Swe, Boonchoo Sritularak, Ponlapat Rojnuckarin, Rataya Luechapudiporn
Summary: Lusianthridin inhibited platelet aggregation induced by various stimuli and showed inhibitory effects on both COX-1 and COX-2 enzymatic activities. Its mechanisms of action may involve the arachidonic acid-thromboxane and adenylate cyclase pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Xiaoying Ma, Jady Liang, Guangheng Zhu, Preeti Bhoria, Aron A. Shoara, Daniel T. MacKeigan, Christopher J. Khoury, Sladjana Slavkovic, Lisha Lin, Danielle Karakas, Ziyan Chen, Viktor Prifti, Zhenze Chen, Chuanbin Shen, Yuchong Li, Cheng Zhang, Jiayu Dou, Zack Rousseau, Jiamin Zhang, Tiffany Ni, Xi Lei, Pingguo Chen, Xiaoyu Wu, Hamed Shaykhalishahi, Samira Mubareka, Kim A. Connelly, Haibo Zhang, Ori Rotstein, Heyu Ni
Summary: The ongoing COVID-19 pandemic caused by SARS-CoV-2 virus has become a global health burden. This study found that both severe cases of COVID-19 and rare cases of vaccine-induced thrombosis are associated with thrombosis and thrombocytopenia. The spike protein receptor-binding domain (RBD) of SARS-CoV-2 plays a role in platelet activation and aggregation, potentially contributing to the observed thrombosis and thrombocytopenia in COVID-19 and vaccine-induced thrombosis.
Article
Cell Biology
Xianghui Zhou, Xin Zhou, Ruirui Zhu, Zhangyin Ming, Zhipeng Cheng, Yu Hu
Summary: Our study found that oleic acid can inhibit platelet activation and reduce thrombogenesis by inhibiting the phosphorylation of multiple signaling molecules, providing new insights into the research and development of antiplatelet drugs.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Pharmacology & Pharmacy
Yulong Li, Guang Xin, Shiyi Li, Yuman Dong, Yuda Zhu, Xiuxian Yu, Chengyu Wan, Fan Li, Zeliang Wei, Yilan Wang, Kun Zhang, Qingqiu Chen, Hai Niu, Wen Huang
Summary: This study reveals the regulatory role of PD-L1 in platelet activation and thrombosis. PD-L1 knockout inhibits platelet activation and thrombus formation, and improves the severity of ischemic stroke and survival rate.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Plant Sciences
Nayeon Kim, CheLynn Jeon, Chaeyeong Kim, Soo Ho Ryu, Wonhwa Lee, Jong-Sup Bae
Summary: This study found that SsnB has anti-inflammatory and antithrombotic activities. It prolongs clotting time, inhibits platelet aggregation and phosphorylation of phospholipase C, increases nitric oxide production, suppresses endothelin-1 secretion, and reduces factor Xa activity and platelet aggregation. SsnB injection also reduces thrombus formation and related mortality.
Review
Chemistry, Medicinal
Mehdi Mollahosseini, Elham Hosseini-Marnani, Asieh Panjeshahin, Monireh Panbehkar-Jouybari, Alireza Gheflati, Hassan Mozaffari-Khosravi
Summary: This article summarized the effect of garlic on platelet aggregation and found that garlic has a beneficial effect on reducing platelet aggregation. However, due to the limited number of studies and heterogeneity between studies, further accurate trials are needed to validate the impact of garlic on platelet aggregation.
PHYTOTHERAPY RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Paresh P. Kulkarni, Mohammad Ekhlak, Vipin Singh, Vikas Kailashiya, Nitesh Singh, Debabrata Dash
Summary: A comprehensive analysis showed that beta-oxidation of fatty acids is crucial for maintaining ATP levels and plays a critical role in activated platelet responses. Therefore, targeting fatty acid oxidation may be a promising strategy for developing novel antiplatelet agents.
Article
Plant Sciences
Ching-Chieh Kao, Po-Hsiung Kung, Chi-Jung Tai, Meng-Chun Tsai, Yuan-Bin Cheng, Chin-Chung Wu
Summary: Juglone demonstrates potent in vitro antiplatelet and antithrombotic effects, associated with the inhibition of Akt activation and platelet surface PDI activity.
Article
Multidisciplinary Sciences
Amin Polzin, Lisa Dannenberg, Rene M'Pembele, Philipp Mourikis, David Naguib, Saif Zako, Carolin Helten, Tobias Petzold, Bodo Levkau, Thomas Hohlfeld, Mareike Barth, Tobias Zeus, Stephan Sixt, Ragnar Huhn, Payam Akhyari, Artur Lichtenberg, Malte Kelm, Till Hoffmann
Summary: In patients with infective endocarditis, platelet reactivity is increased in those with Staphylococcus aureus (SA) infection. However, the use of aspirin can reduce this increased reactivity without increasing bleeding risk. More research is needed to confirm the potential benefits of aspirin in SA-positive infective endocarditis.
SCIENTIFIC REPORTS
(2022)
Article
Pharmacology & Pharmacy
Georges Jourdi, Imane Boukhatem, Pablo F. Barcelona, Samuel Fleury, Melanie Welman, H. Uri Saragovi, Samuela Pasquali, Marie Lordkipanidze
Summary: Recent research has shown that brain-derived neurotrophic factor (BDNF) has activating effects on isolated platelets. However, since BDNF circulates in plasma, it is necessary to find a mechanism to prevent constant activation of platelets. In this study, α2M was identified as a physiological regulator of BDNF bioavailability and an inhibitor of BDNF-induced platelet activation.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Hematology
Hem Kumar Tamang, Ruey-Bing Yang, Zong-Han Song, Shao-Chun Hsu, Chien-Chung Peng, Yi-Chung Tung, Bing-Hsiean Tzeng, Chien-Chang Chen
Summary: This study explores the expression and role of Ca(v)3.2 in platelet function, revealing its importance for optimal platelet activation.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)