Article
Agriculture, Multidisciplinary
Lei Dai, Liyang Zhou, Hualu Zhou, Bingjing Zheng, Na Ji, Xingfeng Xu, Xiaoyang He, Liu Xiong, David Julian McClements, Qingjie Sun
Summary: The bioaccessibility of lutein is significantly increased when consumed with excipient nanoemulsions, compared to when consumed alone in capsules or soft gels. Lutein-loaded nanoemulsions exhibit the highest bioaccessibility, attributed to the rapid release and solubilization of lutein within the small intestine. These findings provide important insights for designing more effective lutein supplements.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Qi Han, Huiling Chen, Likai Wang, Yang An, Xiaoxiang Hu, Yaofeng Zhao, Hao Zhang, Ran Zhang
Summary: Research on the relationship between GHR mutation and lipid metabolism in GHR KO pigs and siGHR-treated human liver cells showed that GHR loss disrupts the ERK-AHR-ACOX1/CPT1A pathway, leading to hepatic steatosis. AHR has been identified as a key modulator of lipid metabolism disorder and a potential therapeutic target for hepatic steatosis. The study sheds light on the molecular mechanisms underlying lipid metabolism abnormalities in LS and provides new insights for developing treatments.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Beatriz Agame-Lagunes, Peter Grube-Pagola, Rebeca Garcia-Varela, Alfonso Alexander-Aguilera, Hugo S. Garcia
Summary: The study indicated that the use of curcumin nanoemulsions in treating hepatic steatosis rat model can improve body and liver weight, decrease serum cholesterol and liver enzyme levels, and reduce the extent of steatosis and inflammation.
Article
Gastroenterology & Hepatology
Willemien van Zwol, Antoine Rimbert, Justina C. Wolters, Marieke Smit, Vincent W. Bloks, Niels J. Kloosterhuis, Nicolette C. A. Huijkman, Mirjam H. Koster, Umesh Tharehalli, Simon M. de Neck, Colin Bournez, Marceline M. Fuh, Jeroen Kuipers, Sujith Rajan, Alain de Bruin, Henry N. Ginsberg, Gerard J. P. van Westen, M. Mahmood Hussain, Ludger Scheja, Joerg Heeren, Philip Zimmerman, Bart van de Sluis, Jan Albert Kuivenhoven
Summary: By analyzing the co-expression of genes, we identified the small leucine-rich protein 1 (SMLR1) as a player in the VLDL biogenesis pathway. The loss of hepatic SMLR1 in mice leads to hepatic steatosis, reduced VLDL secretion, providing protection against hyperlipidemia and atherosclerosis.
Article
Biotechnology & Applied Microbiology
Yujiao Wang, Mingyang Geng, Xiangxiang Zhang, Manlin Yan, Liming Sun, Quanyu Zhao
Summary: This study prepared lutein nanoemulsions through ultrasonic homogenization method, optimized the composition and preparation conditions, and evaluated their anti-inflammatory activity and long-term stability. The results showed that lutein affected the secretion levels of interleukin-6 (IL-6), interleukin-10 (IL-10) and monocyte chemotactic and activating factor (MCAF). The addition of propyl gallate (PG) greatly improved the retention rate of lutein and the particle size stability of the lutein nanoemulsion.
ALGAL RESEARCH-BIOMASS BIOFUELS AND BIOPRODUCTS
(2023)
Article
Pediatrics
Ousseynou Sarr, Katherine E. Mathers, Christina Vanderboor, Kristina Wiggers, Aditya Devgan, Daniel B. Hardy, Lin Zhao, Timothy R. H. Regnault
Summary: The study found that male guinea pigs with intrauterine growth restriction and low birth weight had hepatic cholesterol accumulation in later life, while females did not show the same effect. The increased hepatic cholesterol in LBW male guinea pigs, along with the decreased expression of cholesterol metabolism-related proteins, may contribute to hepatic lipotoxicity.
PEDIATRIC RESEARCH
(2022)
Article
Gastroenterology & Hepatology
Samuel D. Gerrard, Joseph A. Yonke, Kacie A. Seymour, Nishanth E. Sunny, Samer W. El-Kadi
Summary: This study aimed to compare the effects of medium-chain fatty acids (MCFA) and long-chain fatty acids (LCFA) on neonatal pig growth. The results showed that MCFA promoted growth and caused hepatic steatosis, while LCFA had a lesser effect on growth.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2023)
Article
Immunology
Hong-Ying Qiu, Na-Na Zhang, Qing-Qing Ma, Rui-Ting Li, Meng-Yue Guan, Li-Li Zhang, Jia Zhou, Rong-Rong Zhang, Xing-Yao Huang, Wen-Hui Yang, Yong-Qiang Deng, Cheng-Feng Qin, Dong-Sheng Zhou
Summary: This study demonstrates that Zika virus can be transmitted via aerosol routes, resulting in systemic infection and inducing immune responses.
EMERGING MICROBES & INFECTIONS
(2022)
Article
Chemistry, Multidisciplinary
Shirong Wang, Lin Zha, Xin Cui, Yu-Te Yeh, Ruochuan Liu, Jia Jing, Huidong Shi, Weiping Chen, John Hanover, Jun Yin, Liqing Yu, Bingzhong Xue, Hang Shi
Summary: DNA methylation plays an important role in regulating hepatic lipid metabolism. High-fat diet induces increased DNA methylation at the Klb promoter, leading to decreased Klb expression and hepatic steatosis. Targeted demethylation at the Klb promoter can increase Klb expression and fatty acid oxidation, resulting in reduced lipid accumulation.
Article
Plant Sciences
Yajuan Bi, Xue Wang, Lifeng Han, Yiqing Tian, Tongwei Bo, Caiyu Li, Bowen Shi, Chunshan Gui, Youcai Zhang
Summary: This study systematically investigated the inhibitory effect of 200 natural products on OCT1 and identified benzoylpaeoniflorin as the most potent and selective OCT1 inhibitor. Benzoylpaeoniflorin prevented lipid accumulation in hepatocytes and down-regulated lipogenic genes. These findings provide valuable insights into natural product-drug interactions involving OCT1 and offer potential for treating fatty liver diseases.
JOURNAL OF NATURAL PRODUCTS
(2022)
Article
Materials Science, Multidisciplinary
Vereesh Toragall, Priyanka Srirangam, Naveen Jayapala, Baskaran Vallikanan
Summary: The study designed lutein-enriched nanoemulsions with small particle size and spherical shape, significantly increased water solubility, higher in vitro bioaccessibility, and higher in vivo bioavailability compared to other forms of lutein, with higher lutein accumulation in the liver and eye regions.
MATERIALS TODAY COMMUNICATIONS
(2021)
Article
Agriculture, Dairy & Animal Science
Petr Tejml, Vojtech Navratil, Lubos Zabransky, Miloslav Soch
Summary: Cases of newborn conjoined twins in guinea pigs are extremely rare, with this report detailing the fourth described case in which two male twins were connected in the upper body. The twins had separate hearts and livers, but shared lungs. The anomaly of this type of conjoined twins in guinea pigs has not yet been fully explained.
Review
Cell Biology
Vitor de Miranda Ramos, Alicia J. Kowaltowski, Pamela A. Kakimoto
Summary: This study examines the relationship between autophagy and the development of fatty liver disease, but the exact role of autophagy in fatty liver disease development remains unclear. Research suggests that autophagy is necessary for the regulation of basic metabolism in hepatocytes and is closely linked to hepatic lipid metabolism.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Maura Mobilia, Callie Whitus, Alexander Karakashian, Hong S. Lu, Alan Daugherty, Scott M. Gordon
Summary: This study highlighted the significant impact of Dennd5b on plasma and hepatic lipid concentrations, as well as its role in resistance to PCSK9-induced hypercholesterolemia in mice lacking Dennd5b. The findings also revealed smaller atherosclerotic lesions and reduced hepatic lipid content in Dennd5b(-/-) mice, associated with differential expression of genes involved in hepatic lipid metabolism.
JOURNAL OF LIPID RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Li Yu, Kojun Tsuji, Izumi Ujihara, Qi Liu, Nikoleta Pavelkova, Takanori Tsujimura, Makoto Inoue, Sonya Meeker, Eric Nisenbaum, Jeff S. McDermott, Jeff Krajewski, Bradley J. Undem, Marian Kollarik, Brendan J. Canning
Summary: The study suggests that the NaV 1.7 channel plays a role in regulating cough and is a potential therapeutic target, but systemic administration of NaV 1.7 inhibitors may lead to side effects such as hypotension and respiratory depression. Topical application of NaV 1.7 inhibitors showed promising antitussive effects, indicating a possible alternative therapeutic strategy to minimize systemic side effects.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Chemistry, Applied
Yang Chen, Xiangzhou Yi, Zhenyu Zhang, Baomiao Ding, Zhenshun Li, Yangchao Luo
Summary: This study used tannic acid to increase the interfacial stability of ovalbumin-stabilized high internal phase Pickering emulsions (HIPEs). It was found that tannic acid significantly improved the wettability of ovalbumin, resulting in better interfacial stability. HIPEs formed at pH 4.0 exhibited stronger gel network and higher viscosity, and showed good storage and freeze-thaw stability.
FOOD HYDROCOLLOIDS
(2022)
Article
Biochemistry & Molecular Biology
Courtney L. Millar, Liya Anto, Chelsea Garcia, Mi -Bo Kim, Anisha Jain, Anthony A. Provatas, Robert B. Clark, Ji -Young Lee, Frank C. Nichols, Christopher N. Blesso
Summary: Oral and gut bacteria produce glycine lipids that protect against atherosclerosis by reducing inflammation and macrophage activation. However, high-fat diets lead to a decrease in bacterial glycine lipids, which can worsen the development of atherosclerosis and liver injury.
JOURNAL OF LIPID RESEARCH
(2022)
Article
Food Science & Technology
Yali Zhang, Yang Chen, Yating Xiong, Baomiao Ding, Zhenshun Li, Yangchao Luo
Summary: This study successfully obtained soluble HDL by dissolving egg yolk granules and removing phosvitin, and used it as a stabilizer to prepare HIPPEs. The pH conditions and HDL concentrations showed a strong correlation with the emulsifying ability. HIPPEs prepared at pH 5 exhibited small droplet size, high viscosity, and gel stability.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Nutrition & Dietetics
Minu S. Thomas, Marissa DiBella, Christopher N. Blesso, Olga Malysheva, Marie Caudill, Maria Sholola, Jessica L. Cooperstone, Maria Luz Fernandez
Summary: This study found that intake of eggs significantly increased the plasma levels of lutein and zeaxanthin in subjects with metabolic syndrome. This increase may provide additional protection against oxidative stress, which is a common condition in metabolic syndrome.
Review
Biochemistry & Molecular Biology
Liya Anto, Christopher N. Blesso
Summary: Atherosclerosis is the leading cause of death worldwide, and lifestyle modifications such as diet and exercise are recommended for its prevention. Dietary patterns are strongly associated with the risk of atherosclerosis, and dysbiosis of the gut microbiota and changes in microbial metabolites can influence its progression.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Article
Veterinary Sciences
Emma A. Borkowski, Justine Shotton, Joan A. Smyth
Summary: This article reports a rare case of leiomyosarcoma in a capybara, with extensive metastasis and no previous similar reports. An incidental dermal histiocytoma, also not reported before in this species, was found in the same case.
JOURNAL OF VETERINARY DIAGNOSTIC INVESTIGATION
(2022)
Article
Medicine, Research & Experimental
Minu S. Thomas, Christopher N. Blesso, Mariana C. Calle, Ock K. Chun, Michael Puglisi, Maria Luz Fernandez
Summary: There is a clear correlation between gut microbiota, diet, and metabolic outcomes. A diet high in fiber can decrease inflammation and increase insulin sensitivity, while a diet high in fat and sugar can lead to dyslipidemia, insulin resistance, and low-grade inflammation. Unhealthy diets can alter the gut microbiota, disrupt the intestinal barrier, and contribute to the development of metabolic syndrome (MetS), while healthy diets can improve gut barrier function and reduce low-grade inflammation.
METABOLIC SYNDROME AND RELATED DISORDERS
(2022)
Article
Nutrition & Dietetics
Minu S. Thomas, Lindsey Huang, Chelsea Garcia, Junichi R. Sakaki, Christopher N. Blesso, Ock K. Chun, Maria Luz Fernandez
Summary: This study found that adding whole eggs to a plant-based diet does not have adverse effects on inflammation and oxidative stress. On the contrary, eggs seem to provide additional protection against the biomarkers that define metabolic syndrome.
Article
Chemistry, Applied
Zhenshun Li, Yating Xiong, Yi Wang, Yali Zhang, Yangchao Luo
Summary: This study explored the feasibility of using egg yolk low density lipoproteins (LDL) and pectin (PE) as naturally occurring nanoparticles to prepare high internal phase Pickering emulsions (HIPEs), and examined the role of PE in improving emulsifying stability. The results showed that the particle sizes and surface activities of LDL-PE complexes depended on electrostatic interactions, with smaller particles and higher surface activity formed under neutral pH conditions or higher concentrations of PE. The stability of HIPEs was enhanced when using LDL-PE complexes as stabilizers compared to using free LDL as stabilizers.
FOOD HYDROCOLLOIDS
(2023)
Article
Nutrition & Dietetics
Chelsea Garcia, Liya Anto, Christopher N. Blesso
Summary: This study aimed to explore the effects of milk polar lipids (MPLs) and anhydrous milk fat on colitis disease activity. The results showed that mice fed added MPLs were protected against colitis when on a high-fat diet, while added MPLs during a low-fat diet attenuated disease activity during the induction period but promoted colitis and inflammation in male mice during the recovery period.
Article
Food Science & Technology
Sunni Chen, Honglin Zhu, Yangchao Luo
Summary: Polyphenols have been proven to effectively improve the symptoms of nonalcoholic fatty liver disease (NAFLD). The role of intestinal bacterial translocation (BT) in the pathogenesis of NAFLD suggests that the gut may connect polyphenols and NAFLD. Recent scientific evidence from animal and human studies has reviewed the polyphenol-mediated targets of intestinal integrity and colonic microbiota in this opinion article. Microencapsulated polyphenols are preferred over isolated polyphenols for functional food applications due to their different characteristics. Considering dysbacteriosis as an initiator in BT, the encapsulation technology for colon-targeted mucoadhesive delivery of polyphenols is envisioned as a future trend in functional food development.
CURRENT OPINION IN FOOD SCIENCE
(2023)
Article
Agriculture, Dairy & Animal Science
J. Allen, B. Balasubramanian, A. M. Donoghue, I. Upadhyaya, Y. Luo, A. Upadhyay
Summary: The effect of TCNE wash treatments on embryonic development in fertilized eggs was investigated. Results showed that washing with TCNE-Tw.80 or TCNE-GAL did not significantly affect egg weight, fertility rate, and mortality rate. Additionally, TCNE wash treatments did not alter yolk sac and embryo weight, as well as tibia weight and length.
Article
Chemistry, Applied
Bai Qu, Zhenlei Xiao, Yaguang Luo, Yangchao Luo
Summary: This study demonstrates the use of choline acetate (ChAc) to improve the dispersibility and antimicrobial activity of zinc oxide nanoparticles (ZnO NPs). The ChAc/ZnO-CMC nanoparticles exhibited strong antimicrobial effects against L. monocytogenes and E. coli K-12, and may have potential applications in food packaging films and coatings.
CARBOHYDRATE POLYMER TECHNOLOGIES AND APPLICATIONS
(2023)
Article
Engineering, Chemical
Fang Xie, Yuan Fang, Xin Liu, Xin Cong, Yangchao Luo, Jiaojiao Zhou, Zia-ud Din, Shuiyuan Cheng, Jie Cai
Summary: This study successfully prepared O/W/O and W/O/W emulsions using a simple method. These emulsions have important applications in healthy food development, as they can efficiently load selenium-enriched peptides and vitamin E, and exhibit good antioxidant properties. Additionally, they effectively mask the odor of selenium-enriched peptides.
JOURNAL OF FOOD ENGINEERING
(2024)
Review
Materials Science, Biomaterials
Sunni Chen, Honglin Zhu, Yangchao Luo
Summary: Oral colon-targeted delivery systems (OCDSs), which offer enhanced efficacy and reduced side effects, have gained significant attention in the treatment of colon and non-colon diseases. Chitosan, a biopolymer with great biocompatibility and sensitivity to colonic flora, serves as an ideal biomaterial for OCDS construction. This review provides a detailed overview of the preparation of chitosan-based delivery systems and summarizes recent research findings on its application in nutritional and biomedical fields, shedding light on the future development of OCDSs.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)