Article
Veterinary Sciences
Kaori Takahashi, Hiroshi Nango, Mitsuyasu Ushijima, Miyuki Takashima, Masato Nakamoto, Toshiaki Matsutomo, Hiroshi Jikihara, Nanami Arakawa, Shinichiro Maki, Akira Yabuki, Yasuyuki Endo, Osamu Yamato
Summary: Aged garlic extract (AGE) has potential therapeutic effects on canine periodontal disease, improving gingival index, volatile sulfur compounds, and enzyme activity of periodontal pathogens without adverse effects.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Review
Biochemistry & Molecular Biology
Paola Tedeschi, Manuela Nigro, Alessia Travagli, Martina Catani, Alberto Cavazzini, Stefania Merighi, Stefania Gessi
Summary: Garlic contains bioactive compounds with anti-inflammatory, antioxidant, and neuroprotective properties. Research has shown that garlic and its components may have potential therapeutic effects on dementia, including Alzheimer's disease. This paper reviews the chemical composition, metabolism, and bioavailability of garlic bioactive compounds, as well as the signaling mechanisms triggered by garlic derivatives for improving learning and memory.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Nutrition & Dietetics
Lloyd Noriega, Cheng-Ying Yang, Chih-Hao Wang
Summary: Brown and beige adipocytes have the ability to generate heat and can be activated by various methods. Understanding the molecular mechanisms of their differentiation and function is crucial for developing clinical therapies. Drugs and nutritional interventions can activate these adipocytes while minimizing potential side effects.
Article
Food Science & Technology
Yang-Ju Son, Da Seul Jung, Ji Min Shin, Saruul Erdenebileg, Chu Won Nho
Summary: HD extract showed significant effects on weight reduction and improvement of serum lipid status in a high-fat diet-induced metabolic syndrome mouse model. Additionally, HD extract can alleviate oxidation, inflammation, and insulin resistance through various mechanisms, while also increasing energy expenditure.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Gastroenterology & Hepatology
Amalia Gastaldelli, Silvia Sabatini, Fabrizia Carli, Melania Gaggini, Fernando Bril, Renata Belfort-DeAguiar, Vincenzo Positano, Diana Barb, Sushma Kadiyala, Stephen Harrison, Kenneth Cusi
Summary: The study found that PPAR-gamma agonists, along with an increase in ADPN levels, a decrease in VF, and an improvement in VF/SC fat distribution, are closely related to improving the pathological condition of patients with NASH.
LIVER INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Xingxing Zhang, Xin Wu, Gengsheng Xiao, Gongliang Liu, Hao Dong, Rui Liu, Qun Lu
Summary: This study found that phenolamide extract (PAE) from apricot bee pollen has a significant weight loss effect on obese mice fed a high-fat diet. PAE can reduce weight gain and lipid accumulation, improve glucose tolerance, reduce insulin resistance, and improve lipid metabolism. In addition, PAE can regulate the gut microbiota and metabolites. This study suggests that PAE can be used as a functional dietary supplement to alleviate HFD-induced obesity.
Article
Cell Biology
Tiffany M. Newman, Adam S. Wilson, Kenysha Y. J. Clear, E. Ann Tallant, Patricia E. Gallagher, Katherine L. Cook
Summary: The study demonstrates that dietary intervention with muscadine grape extract (MGE) and probiotics modulates gut microbiome dysbiosis, metabolic dysfunction, and systemic inflammation, reducing poor health outcomes associated with Western diet intake.
Article
Public, Environmental & Occupational Health
Xiaoyan Feng, Junyi Wang, Shupei Wang, Zhihao Wang, Shan Wu, Yuan Wei, Lvrong Li, Tianran Shen, Qingsong Chen
Summary: In recent years, the incidence of obesity among people aged 60 and above has significantly increased, and abdominal obesity has been identified as an independent risk factor for diabetes. However, the relationship between abdominal obesity indicators and diabetes in this age group remains unclear. Therefore, it is necessary to study the correlation between anthropometric indices and diabetes and explore potential predictors.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Endocrinology & Metabolism
Bixi Li, Yun Li, Yaxin Zhang, Pan Liu, Yu Song, Yaru Zhou, Lina Ma
Summary: This study investigated the association between visceral fat obesity (VFO) and frailty in middle-aged and older adults. The results showed that individuals with VFO had a higher risk of frailty, which was associated with increased estimated visceral fat area (eVFA) but not with waist circumference, body mass index (BMI), or waist-to-hip ratio (WHR). Furthermore, the frailty score was positively correlated with eVFA and BMI in women, but not in men. A higher eVFA was also associated with worse physical function.
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2022)
Article
Endocrinology & Metabolism
Haishan Huang, Xiaobin Zheng, Xiaoming Wen, Jingyi Zhong, Yanting Zhou, Lingling Xu
Summary: This study found that visceral fat affects insulin secretion and sensitivity in Chinese patients with T2DM, and the impact is more significant in overweight/obese individuals. This suggests that visceral fat plays a crucial role in diabetes.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Agriculture, Multidisciplinary
Kazuki Abe, Takao Myoda, Satoshi Nojima
Summary: The aroma of aged garlic extract (AGE) has been characterized as having seasoning-like, metallic, fatty, and acidic notes. A study identified previously known aromatic compounds and isolated new acidic odor compounds, including rare dithiolane and dithiane compounds. The AGE contains all stereoisomers of each of these components and a recombinant aroma with these compounds showed good agreement with the aroma of AGE.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Medicine, General & Internal
Juan Shi, Guoqing Bao, Jie Hong, Simin Wang, Yufei Chen, Shaoqian Zhao, Aibo Gao, Ru Zhang, Jingfen Hu, Wenjie Yang, Fuhua Yan, Ankang Lyu, Ruixin Liu, Bin Cui, Yuhong Chen, Jiabin Jin, Baiyong Shen, Yifei Zhang, Weiqiong Gu, Dagan Feng, Weiqing Wang, Jiqiu Wang, Xiuying Wang, Guang Ning
Summary: Texture features of VAT, extracted from CT scans and analyzed with machine learning, can predict metabolic disorders and estimate surgery-induced weight loss effects. These findings have important implications for understanding the role of visceral adipose tissue in metabolic disorders and surgical interventions.
Review
Nutrition & Dietetics
Xiujuan Wang, Meihong Xu, Yong Li
Summary: Adipose tissue, as the largest endocrine organ, plays a crucial role in regulating energy balance and immune function. Nutritional interventions have been proven effective in managing adipose tissue aging's adverse effects.
Article
Biochemistry & Molecular Biology
Jialin Tang, Qiufang Liang, Xiaofeng Ren, Husnain Raza, Haile Ma
Summary: Novel lotus root starch-myristic acid complexes prepared using ultrasound-assisted hydrothermal method exhibited excellent nutritional intervention effects in type 2 diabetes mellitus, reducing body weight, fasting blood glucose, and improving blood lipid levels and liver damage.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Food Science & Technology
Seiichiro Aoe, Takanori Kawano, Junko Naito, Norihisa Nishida, Madoka Takahashi
Summary: This study aimed to investigate the effect of supplementation with paramylon-rich Euglena gracilis EOD-1 powder on reducing visceral fat obesity in moderately obese Japanese individuals. The results showed that EOD-1 intake led to a significant reduction in VFA in male subjects and increased serum adiponectin levels. Additionally, it also resulted in a significant decrease in serum HbA1c levels, indicating potential benefits in preventing visceral fat obesity and improving glucose homeostasis.
FOOD SCIENCE & NUTRITION
(2023)
Article
Cardiac & Cardiovascular Systems
Philip G. Joseph, Jeffrey S. Healey, Parminder Raina, Stuart J. Connolly, Quazi Ibrahim, Rajeev Gupta, Alvaro Avezum, Antonio L. Dans, Patricio Lopez-Jaramillo, Karen Yeates, Koon Teo, Reuben Douma, Ahmad Bahonar, Jephat Chifamba, Fernando Lanas, Gilles R. Dagenais, Scott A. Lear, Rajesh Kumar, Andre P. Kengne, Mirac Keskinler, Viswanathan Mohan, Prem Mony, Khalid F. Alhabib, Hugo Huisman, Thomas Iype, Katarzyna Zatonska, Rosnah Ismail, Khawar Kazmi, Annika Rosengren, Omar Rahman, Afzalhussein Yusufali, Li Wei, Andres Orlandini, Shofiqul Islam, Sumathy Rangarajan, Salim Yusuf
Summary: This study compares the prevalence of atrial fibrillation (AF) across eight regions and shows significant variations in different income level countries and regions. Despite traditional risk factors, antithrombotic therapy is infrequently used in poorer countries, highlighting the disproportionate risk associated with AF.
CARDIOVASCULAR RESEARCH
(2021)
Article
Multidisciplinary Sciences
Manuel E. Baldeon, Camilo Felix, Marco Fornasini, Federico Zertuche, Carolina Largo, Maria Jose Paucar, Liz Ponce, Sumathy Rangarajan, Salim Yusuf, Patricio Lopez-Jaramillo
Summary: This study described the prevalence of MetS and T2D in the Ecuadorian cohort of the PURE study and their potential association with the consumption of protein rich foods. The research found a significant protective effect of higher consumption of dairy and legumes in the prevalence of MetS and T2D compared with low consumption. It is important to develop policies for ample production and consumption of protein rich foods, such as legumes and dairy, to reduce the burden of cardio-metabolic diseases.
Article
Cardiac & Cardiovascular Systems
Andrew Smyth, Martin O'Donnell, Graeme J. Hankey, Sumathy Rangarajan, Patricio Lopez-Jaramillo, Denis Xavier, Hongye Zhang, Michelle Canavan, Albertino Damasceno, Peter Langhorne, Alvaro Avezum, Nana Pogosova, Aytekin Oguz, Salim Yusuf
Summary: The INTERSTROKE study found that acute stroke is associated with anger or emotional upset and heavy physical exertion. Anger or emotional upset is associated with all stroke, ischemic stroke, and intracerebral hemorrhage, while heavy physical exertion is only associated with intracerebral hemorrhage.
EUROPEAN HEART JOURNAL
(2022)
Article
Peripheral Vascular Disease
Jorge Andres Delgado-Ron, Patricio Lopez-Jaramillo, M. Ehsan Karim
Summary: Small studies have shown reduced sodium-sensitivity of blood pressure in obese adolescents on a caloric deficit, but there is no significant association between mean daily sodium intake and prevalent hypertension among a nationally representative sample of U.S. adults. Sensitivity analyses support the main findings.
JOURNAL OF HUMAN HYPERTENSION
(2021)
Article
Cardiac & Cardiovascular Systems
Andre Lamy, Wesley Tong, Philip Joseph, Peggy Gao, Prem Pais, Patricio Lopez-Jaramillo, Marjan Walli-Attaei, Tony Dans, Denis Xavier, Shamim Talukder, Anwar Santoso, Habib Gamra, Salim Yusuf
Summary: The International Polycap Study 3 (TIPS-3) trial showed that a polypill containing multiple drugs can effectively reduce the occurrence of cardiovascular events in people without cardiovascular disease. There are regional variations in the costs and affordability of this polypill. Based on the economic classification by the World Bank, the polypill is affordable in countries at different economic levels.
EUROPEAN HEART JOURNAL-QUALITY OF CARE AND CLINICAL OUTCOMES
(2022)
Review
Peripheral Vascular Disease
Patricio Lopez-Jaramillo, Jose Lopez-Lopez, Daniel Cohen, Natalia Alarcon-Ariza, Margarita Mogollon-Zehr
Summary: Hypertension and type 2 diabetes mellitus are prevalent in Latin America, contributing significantly to cardiovascular diseases. Low awareness, treatment and control of these conditions, along with factors such as obesity and unhealthy diet, are major contributors to the high prevalence.
CURRENT HYPERTENSION REVIEWS
(2021)
Article
Cardiac & Cardiovascular Systems
Patricio Lopez-Jaramillo, Philip Joseph, Jose P. Lopez-Lopez, Fernando Lanas, Alvaro Avezum, Rafael Diaz, Paul A. Camacho, Pamela Seron, Gustavo Oliveira, Andres Orlandini, Sumathy Rangarajan, Shofiqul Islam, Salim Yusuf
Summary: In a multinational South American cohort, variations in CVD incidence and mortality rates were examined between sub-populations stratified by country, sex, and urban or rural location. The study found that men had higher rates of CVD and death compared to women, and death rates were higher in rural areas. Hypertension, obesity, diabetes, and tobacco use were identified as leading risk factors for both CVD and death.
EUROPEAN HEART JOURNAL
(2022)
Article
Gastroenterology & Hepatology
Maritza Perez-Mayorga, Jose P. Lopez-Lopez, Maria A. Chacon-Manosalva, Maria G. Castillo, Johanna Otero, Daniel Martinez-Bello, Diego Gomez-Arbelaez, Daniel D. Cohen, Patricio Lopez-Jaramillo
Summary: This study found that the triglycerides/glucose index and triglycerides/HDL cholesterol ratio are effective markers for detecting nonalcoholic fatty liver disease (NAFLD), with comparable performance to the insulin resistance index.
CANADIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Peripheral Vascular Disease
Daniel D. Cohen, Gustavo Aroca-Martinez, Javier Carreno-Robayo, Alvaro Castaneda-Hernandez, Yaneth Herazo-Beltran, Paul A. Camacho, Johanna Otero, Daniel Martinez-Bello, Jose P. Lopez-Lopez, Patricio Lopez-Jaramillo
Summary: Isometric handgrip or (wall) squat exercise performed three times per week reduces systolic blood pressure in adults with hypertension. Comparing the two interventions, the wall squat appears to be more effective in maintaining benefits with a minimal training dose. This low-cost, time-efficient intervention has promising potential for public health settings.
JOURNAL OF CLINICAL HYPERTENSION
(2023)
Article
Cardiac & Cardiovascular Systems
Andrew Mente, Mahshid Dehghan, Sumathy Rangarajan, Martin O'Donnell, Weihong Hu, Gilles Dagenais, Andreas Wielgosz, Scott A. Lear, Li Wei, Rafael Diaz, Alvaro Avezum, Patricio Lopez-Jaramillo, Fernando Lanas, Sumathi Swaminathan, Manmeet Kaur, K. Vijayakumar, Viswanathan Mohan, Rajeev Gupta, Andrzej Szuba, Romaina Iqbal, Rita Yusuf, Noushin Mohammadifard, Rasha Khatib, Nafiza Mat Nasir, Kubilay Karsidag, Annika Rosengren, Afzalhussein Yusufali, Edelweiss Wentzel-Viljoen, Jephat Chifamba, Antonio Dans, Khalid F. Alhabib, Karen Yeates, Koon Teo, Hertzel C. Gerstein, Salim Yusuf
Summary: A healthy diet score based on fruits, vegetables, nuts, legumes, fish, and whole-fat dairy is associated with lower risk of all-cause mortality, cardiovascular disease, myocardial infarction, and stroke in a global population. This score exhibits stronger associations with death or CVD compared to other common diet scores.
EUROPEAN HEART JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Juan Carlos Sanchez-Delgado, Daniel D. Cohen, Paul A. Camacho-Lopez, Javier Carreno-Robayo, Alvaro Castaneda-Hernandez, Daniel Garcia-Gonzalez, Daniel Martinez-Bello, Gustavo Aroca-Martinez, Gianfranco Parati, Patricio Lopez-Jaramillo
Summary: The association between handgrip strength (HGS) and arterial stiffness parameters in individuals with Metabolic Syndrome (MetS) is not well defined. This study found that lower HGS is associated with an increased risk of cardiometabolic diseases, and higher HGS asymmetry may be associated with greater vascular resistance.
Letter
Peripheral Vascular Disease
Jorge Andres Delgado-Ron, Patricio Lopez-Jaramillo, Mohammad Ehsanul Karim
JOURNAL OF HUMAN HYPERTENSION
(2023)
Letter
Peripheral Vascular Disease
Patricio Lopez-Jaramillo, Jose P. Lopez-Lopez
VASCULAR HEALTH AND RISK MANAGEMENT
(2023)
Review
Peripheral Vascular Disease
Jose P. Lopez-Lopez, Ana Maria Gonzalez, Paola Lanza, Patricio Lopez-Jaramillo
Summary: The polypill is an effective, safe, and practical strategy to improve medication adherence in people at risk of cardiovascular disease. Although there is a demonstrated benefit in reducing major adverse cardiovascular events (MACE), there are still gaps in its efficacy in primary prevention and reducing total mortality.
VASCULAR HEALTH AND RISK MANAGEMENT
(2023)
Article
Cardiac & Cardiovascular Systems
Patricio Lopez-Jaramillo, Jose P. Lopez-Lopez, Johanna Otero, Natalia Alarcon-Ariza, Margarita Mogollon-Zehr, Paul Anthony Camacho, Gregorio Sanchez, Claudia Narvaez, Maria Casanova, Edgar Arcos, Gustavo Aroca, Adalberto Quintero, Thomas Beaney, Giles Partington, Neil R. Poulter
Summary: The study reveals low levels of awareness, treatment, and control of hypertension in Colombia, highlighting the urgent need for implementation of programs to improve the diagnosis and management of hypertension in the country.
EUROPEAN HEART JOURNAL SUPPLEMENTS
(2021)