Article
Biochemistry & Molecular Biology
Carsten Carlberg
Summary: Nutrigenomics explores the connection between nutrients and our genome. Over the past 50,000 years, our genome has undergone evolutionary changes due to migration, change in lifestyle, and dietary shifts. These adaptations have affected not only physical traits but also our susceptibility to complex diseases. Studying the variation in our (epi)genome in response to environmental changes provides insights into the mechanisms of disease development and prevention.
Article
Microbiology
Ulrika Boulund, Diogo M. Bastos, Bart Ferwerda, Bert-Jan van den Born, Sara-Joan Pinto-Sietsma, Henrike Galenkamp, Evgeni Levin, Albert K. Groen, Aeilko H. Zwinderman, Max Nieuwdorp
Summary: This study conducted a large-scale fecal microbiome genome-wide association study on a multiethnic cohort, revealing ethnic-specific associations between host genomes and gut microbiota. The study also sheds light on the potential effects of gut microbes on cardiometabolic health factors.
CELL HOST & MICROBE
(2022)
Article
Multidisciplinary Sciences
Alexander Klassmann, Mathieu Gautier
Summary: Analysis of population genetic data often involves the search for genomic regions with signs of recent positive selection. In this study, we propose and test modifications to the concept of extended haplotype homozygosity (EHH) and its associated statistics to relax data requirements. Our findings show the indispensability of phased haplotypes for accurate estimation of within-population statistics and cross-population statistics for small samples. Ancestry information, however, is found to be less important for both types of statistics. Our modified statistics are implemented in the publicly available R package rehh.
Article
Multidisciplinary Sciences
Carol A. Wang, John R. Attia, Stephen J. Lye, Wendy H. Oddy, Lawrence Beilin, Trevor A. Mori, Claire Meyerkort, Craig E. Pennell
Summary: The study highlights the importance of genetics, early life nutrition, and their interaction in adult health. Longer duration of breastfeeding is beneficial for all individuals, and particularly associated with lower BMI and lower Systolic Blood Pressure in those with higher birthweight polygenic scores.
SCIENTIFIC REPORTS
(2021)
Article
Biology
Megha Srigyan, Hector Bolivar, Irene Urena, Jonathan Santana, Andrew Petersen, Eneko Iriarte, Emrah Kirdok, Nora Bergfeldt, Alice Mora, Mattias Jakobsson, Khaled Abdo, Frank Braemer, Colin Smith, Juan Jose Ibanez, Anders Gotherstrom, Torsten Gunther, Cristina Valdiosera
Summary: This study utilizes multidisciplinary bioarchaeological analysis to reveal the genetic characteristics of early Islamic burials in the Middle East region, and finds genomic similarity between the individuals from 7th-8th century Syria and modern Bedouins and Saudis.
COMMUNICATIONS BIOLOGY
(2022)
Article
Cell Biology
Janine Giovanella, Luana Maria Wollinger, Luisa Capra, Fabiane Dresch, Julia Pasqualini Genro, Veronica Contini
Summary: The study revealed significant interactions between genetic polymorphisms (rs699-AGT and rs1799722-BDKRB2) and the consumption of micronutrients (sodium, magnesium, and calcium) on blood pressure variation.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Article
Immunology
Alexandre R. Marra, Joao Luiz Miraglia, Daniel Tavares Malheiros, Yang Guozhang, Vanessa Damazio Teich, Elivane da Silva Victor, Joao Renato Rebello Pinho, Adriana Cypriano, Laura Wanderly Vieira, Miria Polonio, Rafael Herrera Ornelas, Solange Miranda de Oliveira, Flavio Araujo Borges Junior, Silvia Cristina Cassiano Oler, Guilherme de Paula Pinto Schettino, Ketti Gleyzer de Oliveira, Rubia Anita Ferraz Santana, Fernanda de Mello Malta, Deyvid Amgarten, Ana Laura Boechat, Noelly Maria Zimpel Trecenti, Takaaki Kobayashi, Jorge L. Salinas, Michael B. Edmond, Luiz Vicente Rizzo
Summary: This study investigated the effectiveness of two doses of Oxford-AstraZeneca and CoronaVac vaccines, as well as a third dose of mRNA vaccine, among healthcare workers in a private healthcare system in Brazil. The results showed that receiving an mRNA booster after two doses of viral vector or inactivated viral vaccines provided higher protection. The viral vector and inactivated virus COVID-19 vaccines remained effective when boosted with a third dose of Pfizer/BioNTech vaccine.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Public, Environmental & Occupational Health
Alexandre R. Marra, Joao Luiz Miraglia, Daniel Tavares Malheiros, Yang Guozhang, Vanessa Damazio Teich, Elivane da Silva Victor, Joao Renato Rebello Pinho, Adriana Cypriano, Laura Wanderly Vieira, Miria Polonio, Rafael Herrera Ornelas, Solange Miranda de Oliveira, Flavio Araujo Borges Junior, Audrey Rie Ogawa Shibata, Guilherme de Paula Pinto Schettino, Ketti Gleyzer de Oliveira, Rubia Anita Ferraz Santana, Fernanda de Mello Malta, Deyvid Amgarten, Ana Laura Boechat, Noelly Maria Zimpel Trecenti, Takaaki Kobayashi, Jorge L. Salinas, Michael B. Edmond, Luiz Vicente Rizzo
Summary: This study investigated the real-world effectiveness of the Oxford-AstraZeneca (ChAdOx1) and CoronaVac vaccines against SARS-CoV-2 infection among healthcare workers in Brazil. The results showed that both vaccines significantly prevented COVID-19, but CoronaVac was much less effective. Additionally, both vaccines reduced hospitalizations and the need for mechanical ventilation, and were effective against the dominant gamma variant.
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
(2023)
Article
Substance Abuse
Melissa Rivera-Mateos, Omar Ramos-Lopez
Summary: The prevalence of food addiction among undergraduate students from Northwest Mexico is 12.9%. Insomnia may increase the risk of food addiction, while habitual consumption of fruits appears to have a protective role.
JOURNAL OF ADDICTIVE DISEASES
(2023)
Article
Microbiology
Leticia Mello Bezinelli, Luciana Correa, Stephany Beyerstedt, Erika Bevilaqua Rangel, Carlos Benitez, Nelson Hamerschlak, Joao Renato Rebello Pinho, Debora Heller, Fernanda de Paula Eduardo
Summary: This study investigated the effectiveness of an oral hygiene protocol in reducing the SARS-CoV-2 viral load in the oral cavity. The results showed that using chlorhexidine (CHX) and hydrogen peroxide (HP) in the oral rinse immediately after the procedure significantly reduced the viral load.
JOURNAL OF ORAL MICROBIOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Alexandre R. Marra, Vanderson Souza Sampaio, Mina Cintho Ozahata, Rafael Lopes, Anderson F. Brito, Marcelo Bragatte, Jorge Kalil, Joao Luiz Miraglia, Daniel Tavares Malheiro, Guozhang Yang, Vanessa Damazio Teich, Elivane da Silva Victor, Joao Renato Rebello Pinho, Adriana Cypriano, Laura Wanderly Vieira, Miria Polonio, Solange Miranda de Oliveira, Victoria Catharina Volpe Ricardo, Aline Miho Maezato, Gustavo Yano Callado, Guilherme de Paula Pinto Schettino, Ketti Gleyzer de Oliveira, Rubia Anita Ferraz Santana, Fernanda de Mello Malta, Deyvid Amgarten, Ana Laura Boechat, Takaaki Kobayashi, Eli Perencevich, Michael B. Edmond, Luiz Vicente Rizzo
Summary: The objective of this study was to determine risk factors for the development of long COVID-19 in healthcare personnel. A case-control study was conducted among healthcare personnel in a Brazilian healthcare system, and factors associated with the development of long COVID-19 were found to be female sex, age, and multiple SARS-CoV-2 infections. Additionally, infection with the SARS-CoV-2 Delta or Omicron variant, and receiving 4 COVID-19 vaccine doses prior to infection, were significantly associated with a lower likelihood of developing long COVID-19.
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
(2023)
Article
Multidisciplinary Sciences
Lisie Souza Castro, Grazielli Rocha de Rezende, Marco Antonio Moreira Puga, Larissa Melo Bandeira, Tayana Serpa Ortiz Tanaka, Sabrina Weis-Torres, Deborah Ledesma Taira, Luiz Henrique Ferraz Demarchi, Julio Rosa Henrique Croda, Joao Renato Rebello Pinho, Michele Soares Gomes-Gouvea, Ana Rita Coimbra Motta-Castro
Summary: A study conducted in Central Brazil analyzed the seroprevalence of anti-HAV and its associated risk factors among inmates from twelve prisons. The results showed that the prevalence rate of HAV exposure was 88.1%, with no positive reaction to IgM anti-HAV. Increasing age, low level of education, and being imprisoned in Corumba city were found to be independently associated with HAV exposure among prisoners. Vaccination strategies should be considered to prevent the burden of the disease.
Article
Multidisciplinary Sciences
Santiago Justo Arevalo, Carmen Sofia Uribe Calampa, Cinthy Jimenez Silva, Mauro Quinones Aguilar, Remco Bouckaert, Joao Renato Rebello Pinho
Summary: Peru has a high mortality rate due to COVID-19, and the second wave in Peru was dominated by Lambda and Gamma variants. The center of Peru played a significant role in transmitting the virus to other regions within the country.
NATURE COMMUNICATIONS
(2023)
Article
Nutrition & Dietetics
Francisca Salas-Perez, Tais Silveira Assmann, Omar Ramos-Lopez, J. Alfredo Martinez, Jose Ignacio Riezu-Boj, Fermin I. Milagro
Summary: This study found a link between gut microbiota and DNA methylation patterns in individuals with obesity. Through DNA methylation and bacterial DNA sequencing analysis, they identified BMI-related differentially methylated DNA regions (DMRs) and bacterial genera. The abundance of Ruminococcus was found to be negatively correlated with BMI, and it was associated with a hypermethylated DMR located between the MACROD2/SEL1L2 genes. The mediation test showed that 19% of the effect of Ruminococcus abundance on BMI is mediated by the methylation of the MACROD2/SEL1L2 DMR. These findings suggest that crosstalk between gut microbiota and epigenetic markers may contribute to obesity development.
Article
Nutrition & Dietetics
Yolanda E. Perez-Beltran, Karina Gonzalez-Becerra, Ingrid Rivera-Iniguez, Erika Martinez-Lopez, Omar Ramos-Lopez, Mildreth Alcaraz-Mejia, Roberto Rodriguez-Echevarria, Sonia G. Sayago-Ayerdi, Edgar J. Mendivil
Summary: This study evaluated the effect of a nutrigenetic intervention on adults with obesity and overweight. The results showed significant improvements in blood lipid levels, body composition, and inflammation markers in the nutrigenetic diet group, suggesting that nutrigenetic strategies can enhance the standard dietary treatment for cardiometabolic diseases.
Review
Nutrition & Dietetics
Omar Ramos-Lopez
Summary: This article reviews the evidence on the use of epigenetic signatures as potential biomarkers for predicting metabolic outcomes and discusses their potential application in the field of precision nutrition.
Meeting Abstract
Allergy
Beatriz Todt, Cristina Kokron, Myrthes Toledo-Barros, Joao Renato Pinho, Cecilia Charbel, Priscila Saihg, Octavio Grecco, Ana Karolina BB. Marinho, Carlos Felipe Silva, Jorge Kalil, Fabiana Lima
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Infectious Diseases
Daniel Joelsons, Cecilia Salete Alencar, Joao Renato Rebello Pinho, Yeh-Li Ho
Summary: This study aimed to identify the main microorganisms causing CAP in Brazil by using a multiplex Polymerase Chain Reaction (mPCR) at a leading public hospital. The mPCR panel detected an etiological agent in 61.5% of patients, with viruses being the most common, followed by bacteria. The study found that the prescription for a majority of patients could be modified, leading to de-escalation of antibiotics and antiviral therapy.
BRAZILIAN JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Health Care Sciences & Services
Yesenia Martinez-Aceviz, Ana Alondra Sobrevilla-Navarro, Omar Ramos-Lopez
Summary: This study found a positive association between dietary capsaicin consumption and markers of body adiposity and fatty liver in a Mexican adult population.
Article
Infectious Diseases
Fernando Franco-Miraglia, Beatriz Martins-Freitas, Andre Mario Doi, Rubia Anita Ferraz Santana, Joao Renato Rebello Pinho, Vivian I. Avelino-Silva
Summary: The cycle threshold (Ct) values in COVID-19 RT-PCR tests are associated with viral load and transmissibility. This study found significant associations between Ct values and patient's age, sample collection setting, and pandemic period. Older age, samples collected in emergency units during the Gamma and Delta periods, were associated with lower Ct values, while children under 10 years old, home-based tests, and the Omicron period were associated with higher Ct values. There was a linear trend between age and Ct values, with Ct values decreasing as age increases. No clear temporal associations were found between Ct values and local indicators of COVID-19 incidence, mortality, or vaccination coverage.
REVISTA DO INSTITUTO DE MEDICINA TROPICAL DE SAO PAULO
(2023)
Article
Infectious Diseases
Rogerio Soares Castro, Barbara Silva Cordeiro, Marco Aurelio Ferreira Rolim, Alessandra Porto de Macedo Costa, Max Diego Cruz Santos, Marcos Antonio Custodio Neto da Silva, Ingrid de Campos Albuquerque, Lena Maria Barros Fonseca, Joao Renato Rebello Pinho, Michelle Soares Gomes Gouvea, Antonio Augusto Moura da Silva, Adalgisa de Souza Paiva Ferreira
Summary: Children in Maranhao State, Brazil have an increased likelihood of being carriers of chronic hepatitis B virus. A study found a high prevalence of current and past HBV infection among 1,381 children and adolescents in five municipalities. Factors associated with infection included residing in Morros or Humberto de Campos municipality, living in rural areas, being between the ages of 13 and 15, and illicit drug use. The study also revealed low vaccination coverage and serological responses, highlighting concerns about prevention measures and vaccine quality.
REVISTA DO INSTITUTO DE MEDICINA TROPICAL DE SAO PAULO
(2023)
