Article
Hematology
Sara Beygi, George E. Duran, Sebastian Fernandez-Pol, Alain H. Rook, Youn H. Kim, Michael S. Khodadoust
Summary: Resistance to mogamulizumab in mycosis fungoides and Sezary syndrome is often associated with loss of CCR4 expression and emergence of CCR4 genomic alterations. This finding has significant implications for the management and monitoring of patients receiving mogamulizumab and the development of future CCR4-directed therapies.
Review
Cell Biology
Amy Xiao, Oleg E. Akilov
Summary: The loss of CD47 on aging cells signals macrophages to eliminate the target. CD47 acts as a "do-not-eat-me" sign that prevents macrophagal phagocytosis by interacting with its ligand SIRP alpha. Malignant lymphocytes highly express CD47, making them ideal candidates for targeted anti-CD47 therapies. There are various types of anti-CD47-SIRP alpha therapeutic molecules, including monoclonal antibodies, bioengineered proteins, miRNAs, and bispecific antibodies. Blocking the CD47-SIRP alpha axis in combination with targeting secondary tumor microenvironment (TME) may enhance the effectiveness of current immunotherapeutic approaches.
Article
Multidisciplinary Sciences
Xiangjun Liu, Shanzhao Jin, Simeng Hu, Ruoyan Li, Haihao Pan, Yi Liu, Pan Lai, Deshu Xu, Jingru Sun, Ziyang Liu, Yumei Gao, Yifan Zhao, Fengjie Liu, Yu Xiao, Yingyi Li, Yujie Wen, Zhuojing Chen, Bufang Xu, Yuchieh Lin, Menglong Ran, Qianxi Li, Shuxia Yang, Hang Li, Ping Tu, Muzlifah Haniffa, Sarah A. Teichmann, Fan Bai, Yang Wang
Summary: Cutaneous T cell lymphoma (CTCL) is a heterogeneous group of non-Hodgkin lymphoma characterized by clonal malignant T cells. This study analyzed CTCL patient samples using single-cell RNA-seq, TCR and whole-exome sequencing, revealing the molecular profiles of malignant T cells and their association with the microenvironment and clinical outcomes.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Minami Sakamoto, Tomomitsu Miyagaki, Hiroaki Kamijo, Tomonori Oka, Hikari Boki, Naomi Takahashi-Shishido, Hiraku Suga, Makoto Sugaya, Shinichi Sato
Summary: CD147 and CypA are overexpressed in tumor cells of mycosis fungoides and Sezary syndrome patients, and CypA is also expressed by epidermal keratinocytes in lesional skin. Serum CypA levels are elevated and correlated with disease severity markers. Anti-CD147 and/or anti-CypA antibodies can suppress the proliferation of CTCL cell lines by downregulating signaling pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Delice Kayishunge, Sophia Ly, Joseph Su, Henry K. Wong
Summary: This article presents a demographic and epidemiological analysis of CTCL patients in Arkansas and nationwide. The study found that CTCL primarily affects males, especially young black males. Additionally, the study identified certain geographic and environmental factors associated with CTCL.
Article
Dermatology
Janika Gosmann, Rudolf Stadler, Koen D. Quint, Ralf Gutzmer, Maarten H. Vermeer
Summary: This study aimed to report on the efficacy, adverse events, and therapy regimens of PEG-IFN alpha in cutaneous T-cell lymphoma. Results showed that PEG-IFN alpha, especially in combination with skin-directed therapies, is an effective treatment option for cutaneous T-cell lymphoma in clinical practice.
ACTA DERMATO-VENEREOLOGICA
(2023)
Review
Dermatology
Kazuyasu Fujii
Summary: Mycosis fungoides (MF) and Sezary syndrome (SS) are representative cutaneous lymphomas, with a shift from Th1 to Th2 environment as the disease progresses. Staphylococcus aureus is highly sensitive in advanced stages, and susceptibility to infection is related to the main symptoms of MF.
JOURNAL OF DERMATOLOGY
(2022)
Review
Medicine, Research & Experimental
Man Hu, Joerg Scheffel, Daniel Elieh-Ali-Komi, Marcus Maurer, Tomasz Hawro, Martin Metz
Summary: Primary cutaneous T-cell lymphomas (CTCL) are characterized by the accumulation of malignant T-lymphocytes in the skin, leading to severe pruritus that significantly impacts patients' quality of life. Understanding the underlying mechanisms of CTCL pruritus is challenging, but studies suggest that proteases (such as tryptase) and neuropeptides (particularly Substance P) may play a significant role, alongside cytokine receptors, MRGPRs, and TRP channels. Targeting these mediators and receptors could lead to effective treatment options for CTCL pruritus.
CLINICAL AND EXPERIMENTAL MEDICINE
(2023)
Article
Cell Biology
Loka Reddy Velatooru, Cheng Hui Hu, Pedram Bijani, Xiaohong Wang, Pierr Bojaxhi, Hao Chen, Madeleine Duvic, Xiao Ni
Summary: In this study, a novel JAK3-INSL3 fusion transcript was identified in cutaneous T-cell lymphomas (CTCL). Higher expression of JAK3-INSL3 was associated with poorer survival in CTCL patients. Knockdown of JAK3-INSL3 decreased cell proliferation and tumor growth.
Article
Cell Biology
Xiaotong Xue, Zhenzhen Wang, Zihao Mi, Tingting Liu, Chuan Wang, Peidian Shi, Lele Sun, Yongliang Yang, Wenchao Li, Zhe Wang, Hong Liu, Furen Zhang
Summary: Sezary syndrome, a rare and aggressive type of cutaneous T cell lymphoma, poses challenges in diagnosis and treatment due to its intra-tumoral heterogeneity and poor understanding of its pathogenesis. Single-cell transcriptomic and chromatin accessibility data analysis revealed developmental differences and specific marker genes in Sezary cells from different sources, providing insights into the diagnosis and prognosis of MF/SS. Functional experiments demonstrated that targeting inhibition of KLHL42 could be a promising therapeutic approach in CTCL.
CELL DEATH & DISEASE
(2022)
Article
Dermatology
Janika Gosmann, Annette Bielefeld, Franz-Josef Schmitz, Katrin Schaper-Gerhardt, Ralf Gutzmer, Rudolf Stadler
Summary: This study investigated the effect of Mogamulizumab on TC cells and aberrant T cell population in CTCL patients. The results showed a reduction in abnormal T cell population and normal TC cells after the administration of Mogamulizumab. However, further studies are needed to determine the correlation between TCP and the efficacy of Mogamulizumab.
JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT
(2023)
Article
Dermatology
Yuka Mizuno, Sayaka Shibata, Tomomitsu Miyagaki, Yukiko Ito, Haruka Taira, Issei Omori, Teruyoshi Hisamoto, Kenta Oka, Kazuki M. Matsuda, Hikari Boki, Naomi Takahashi-Shishido, Makoto Sugaya, Shinichi Sato
Summary: In recent years, circulating cell-free DNA (cfDNA) has gained attention as a biomarker for cancer. This study found that serum cfDNA levels in patients with cutaneous T-cell lymphoma (CTCL) were significantly higher than healthy controls and increased with disease progression. There were positive correlations between cfDNA levels and certain blood markers and clinical findings, and higher cfDNA levels were associated with a worse prognosis in CTCL patients.
JOURNAL OF DERMATOLOGY
(2022)
Article
Hematology
Alberto Herrera, Anthony Cheng, Eleni P. Mimitou, Angelina Seffens, Dean George, Michal Bar-Natan, Adriana Heguy, Kelly V. Ruggles, Jose U. Scher, Kenneth Hymes, Jo-Ann Latkowski, Niels Odum, Marshall E. Kadin, Zhengqing Ouyang, Larisa J. Geskin, Peter Smibert, Terkild B. Buus, Sergei B. Koralov
Summary: CTCL is a group of mature T-cell tumors that accumulate in the skin, with potential spread to the blood and lymph nodes. Analysis reveals transcriptional and genetic evolution in malignant T-cell populations, with environmental signals and genetic aberrations influencing their profiles. The skin microenvironment promotes a transcriptional response supporting rapid malignant expansion, shedding light on the need for personalized therapy to target all subclones.
Article
Cell Biology
Philipp Licht, Volker Mailaender
Summary: Cutaneous T-Cell Lymphomas (CTCL) exhibit clinical variability and transcriptional heterogeneity, with different T-cell subtypes suggested as sources of the disease. The microbiome may play a role in disease progression and transcriptional heterogeneity, and microbial approaches have the potential to aid in diagnosis and treatment of CTCL.
Article
Dermatology
Sara Peru, Martina Prochazkova-Carlotti, Floriane Cherrier, Joanne Velazquez, Elodie Richard, Yamina Idrissi, David Cappellen, Lamia Azzi-Martin, Anne Pham-Ledard, Marie Beylot-Barry, Jean-Philippe Merlio, Sandrine Poglio
Summary: Cutaneous T-cell lymphoma (CTCL) is characterized by abnormal infiltration of T lymphocytes in the skin. In this study, the researchers found that the expression of cutaneous lymphocyte antigen (CLA) in CTCL cells is crucial for their migration and survival. The use of a CLA antibody significantly reduced the migration and survival of CTCL cells both in vitro and in vivo. These findings suggest that inhibiting CLA could be a potential therapeutic strategy for CTCL patients.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
