Article
Radiology, Nuclear Medicine & Medical Imaging
Ieun Yoon, Jae Seok Bae, Jeongin Yoo, Dong Ho Lee, Se Hyung Kim
Summary: Studies suggest that compared to MDCT alone, MDCT combined with [F-18]FDG PET/MRI can improve the diagnostic accuracy for preoperative M staging and resectability in patients with recurrent gastric cancer, with a significant advantage in evaluating M staging.
EUROPEAN RADIOLOGY
(2021)
Article
Biology
Hyein Ahn, Geum Jong Song, Moon-Soo Lee, Ji-Hye Lee, Si-Hyong Jang, Mee-Hye Oh, Jong Hyuk Yun, Sang Mi Lee, Jeong Won Lee
Summary: This study aimed to investigate the relationship of FDG uptake in the bone marrow (BM) and spleen with histopathological findings and recurrence-free survival (RFS) in patients with gastric cancer. The results showed significant correlations between FDG uptake and immune cell infiltration in tumor tissue, as well as predictive value for RFS. FDG uptake in the BM and spleen might be potential imaging biomarkers for evaluating tumor immune microenvironment conditions and predicting RFS in patients with gastric cancer.
Article
Medicine, Research & Experimental
Liqiao Chen, Zizhen Wu, Jiamei Guo, Xinyu Wang, Zhenzhen Zhao, Han Liang, Rupeng Zhang, Jingyu Deng
Summary: The expression of ALDOA in gastric cancer is associated with the progression and prognosis of the disease. High ALDOA expression is correlated with poor prognosis and lymph node metastasis. ALDOA may impact the progression of gastric cancer by affecting the expression of immune molecules. Therefore, ALDOA could serve as a promising biomarker and therapeutic target for evaluating the prognosis of gastric cancer.
CLINICAL AND EXPERIMENTAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Hyein Ahn, Geum Jong Song, Si-Hyong Jang, Myoung Won Son, Hyun Ju Lee, Moon-Soo Lee, Ji-Hye Lee, Mee-Hye Oh, Geum Cheol Jeong, Jong Hyuk Yun, Sang Mi Lee, Jeong Won Lee
Summary: This study assessed the relationship between histopathological and textural features of perigastric adipose tissue on PET/CT and found that these features were significant prognostic factors for predicting recurrence-free survival in gastric cancer patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Editorial Material
Hematology
Andrew Wirth, N. George Mikhaeel
Summary: This study demonstrates that in patients with DLBCL, those who are EOT PET-negative may be spared from radiotherapy, while selected patients with EOT PET-positive sites can achieve outcomes comparable to PET-negative patients when receiving selective treatment.
Article
Chemistry, Analytical
Siyang Liu, Ye Liu, Zhe Zhang, Xiaodong Wang, Yicheng Yang, Kai Sun, Jiangbo Yu, Daniel T. Chiu, Changfeng Wu
Summary: This study developed a near-infrared optical transducer to monitor glucose variations in cerebrospinal fluid, and observed abnormal glucose uptake in transgenic mice with brain tumors.
ANALYTICAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Jun Su Park, Jeong Il Yu, Do Hoon Lim, Heerim Nam, Young Il Kim, Jeeyun Lee, Won Ki Kang, Se Hoon Park, Seung Tae Kim, Jung Yong Hong, Tae Sung Sohn, Jun Ho Lee, Ji Yeong An, Min Gew Choi, Jae Moon Bae
Summary: In this study, the clinical significance of preoperative hematological parameters in patients with advanced stomach cancer was investigated. The results showed that absolute monocyte count (AMC) was the most relevant prognostic factor for overall survival and recurrence-free survival. Furthermore, adjuvant concurrent chemoradiotherapy (CCRT) improved recurrence-free survival in patients with a high absolute lymphocyte count (ALC).
Article
Hematology
Enora Le Goff, Paul Blanc-Durand, Louise Roulin, Charlotte Lafont, Romain Loyaux, Diana-Laure MBoumbae, Ichrafe Benmaad, Alexis Claudel, Elsa Poullot, Cyrielle Robe, Guillaume Gricourt, Abdelrazak Aissat, Christiane Copie-Bergman, Francois Lemonnier, Philippe Gaulard, Emmanuel Itti, Corinne Haioun, Marie-Helene Delfau-Larue
Summary: This study aimed to evaluate the prognostic value of circulating tumour DNA (ctDNA) and total metabolic tumour volume (TMTV) in large B-cell lymphoma (LBCL). High ctDNA load or high TMTV were associated with shorter 1-year progression-free survival (PFS). Combining ctDNA load with TMTV improved risk stratification in aggressive LBCL patients. Therefore, high-risk patients may benefit from CAR T-cell therapy or bispecific antibodies as first-line treatments in the future.
BRITISH JOURNAL OF HAEMATOLOGY
(2023)
Article
Medicine, Research & Experimental
Matteo Bauckneht, Cecilia Marini, Vanessa Cossu, Cristina Campi, Mattia Riondato, Silvia Bruno, Anna Maria Orengo, Francesca Vitale, Sonia Carta, Silvia Chiola, Sabrina Chiesa, Alberto Miceli, Francesca D'Amico, Giuseppe Fornarini, Carlo Terrone, Michele Piana, Silvia Morbelli, Alessio Signori, Paola Barboro, Gianmario Sambuceti
Summary: This study investigated the independent and additive prognostic value of PSMA and FDG gene expression in risk-stratification of prostate cancer (PCa). Machine learning analysis identified a predictive functional network involving glucose metabolism-related genes. Cellular experiments showed that increased proliferation and migration of PCa cells were associated with enhanced FDG uptake and decreased PSMA retention, indicating the prognostic value of FDG PET imaging.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Cecilia Marini, Matteo Bauckneht, Anna Borra, Rita Lai, Maria Isabella Donegani, Alberto Miceli, Cristina Campi, Vanessa Cossu, Daniela Schenone, Silvia Morbelli, Stephane Chauvie, Michele Piana, Andrea Gallamini, Gianmario Sambuceti
Summary: The study found that the curative potential of ABVD chemotherapy in Hodgkin lymphoma patients may be related to the metabolic response of normal tissues. Predicting efficacy through 18F-fluorodeoxyglucose PET/CT imaging, cardiac FDG uptake and complete switch-off of HL lesions predicted favorable outcomes in Kaplan-Mayer analysis.
Article
Hematology
J. J. Eertink, C. N. Burggraaff, M. W. Heymans, U. Duehrsen, A. Huettmann, C. Schmitz, S. Mueller, P. J. Lugtenburg, S. F. Barrington, N. G. Mikhaeel, R. Carr, S. Czibor, T. Gyoerke, L. Ceriani, E. Zucca, M. Hutchings, L. Kostakoglu, A. Loft, S. Fanti, S. E. Wiegers, S. Pieplenbosch, R. Boellaard, O. S. Hoekstra, J. M. Zijlstra, H. C. W. de Vet
Summary: The study investigated the optimal timing and response criteria for using I-PET in evaluating prognosis in DLBCL patients. Results showed that I-PET2 and I-PET4 could effectively discriminate good responders from poor responders during R-CHOP therapy.
Article
Gastroenterology & Hepatology
William McGahan, Venkata Chikatamarla, Paul Thomas, David Cavallucci, Nicholas O'Rourke, Matthew Burge
Summary: SUVmax-p on routine FDG-PET/CT can serve as a useful indicator for predicting early post-operative recurrence and guiding additional pre-operative staging or neoadjuvant therapy.
Article
Radiology, Nuclear Medicine & Medical Imaging
Yoshiharu Ohno, Masao Yui, Daisuke Takenaka, Takeshi Yoshikawa, Hisanobu Koyama, Yoshimori Kassai, Kaori Yamamoto, Yuka Oshima, Nayu Hamabuchi, Satomu Hanamatsu, Yuki Obama, Takahiro Ueda, Hirotaka Ikeda, Hidekazu Hattori, Kazuhiro Murayama, Hiroshi Toyama
Summary: cDWI with a b-value of 600 sec/mm² may improve the accuracy of lymph node staging in NSCLC patients compared to aDWI, STIR, and PET/CT.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Oncology
Sangwon Han, Sae Byul Lee, Gyungyub Gong, Jungbok Lee, Sun Young Chae, Jungsu S. S. Oh, Dae Hyuk Moon
Summary: This study aimed to determine whether tumor uptake of F-18-fluorodeoxyglucose (F-18-FDG) is associated with invasive disease-free survival (IDFS) in patients with hormone receptor (HR)-positive ERBB2-negative early-stage breast cancer treated with adjuvant chemotherapy. It was found that the maximum standardized uptake value (SUVmax) on preoperative F-18-FDG positron emission tomography/computed tomography (PET/CT) was independently associated with reduced long-term IDFS. Rating: 9/10
BREAST CANCER RESEARCH AND TREATMENT
(2023)
Article
Medicine, General & Internal
Shengbing Zang, Lei Liu, Junjie Bao, Min Xiong, Yumo Zhao, Suxia Lin, Xiaoping Lin
Summary: This study investigated the clinicopathologic features, F-18-FDG PET/CT findings, and outcomes for patients with primary thymic MALT lymphoma. The results showed no correlation between SUVmax and Ki-67 index.
FRONTIERS IN MEDICINE
(2022)
Article
Endocrinology & Metabolism
Jonghwa Ahn, Meihua Jin, Won Gu Kim, Tae Yong Kim, Won Bae Kim, Young Kee Shong, Jung Hwan Baek, Dong Eun Song, Min Ji Jeon
Summary: This study aims to evaluate the role of FNA and CNB in the preoperative diagnosis of TCV-PTC. The findings suggest that both FNA and CNB have limitations in predicting TCV-PTC.
CLINICAL ENDOCRINOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Boeun Lee, Sae Rom Chung, Young Jun Choi, Tae-Yon Sung, Dong Eun Song, Tae Yong Kim, Jeong Hyun Lee, Jung Hwan Baek
Summary: The purpose of this study was to assess the diagnostic role of fine-needle aspiration cytology (FNAC) and analyze factors associated with false-negative FNAC results in patients with parathyroid incidentaloma. The results showed that FNAC had low sensitivity for diagnosing parathyroid incidentaloma, and measuring washout parathyroid hormone (PTH) can improve diagnostic accuracy. Obtaining two or more FNA samples can reduce the false-negative rate.
Editorial Material
Oncology
Hyunju Park, Jung Heo, Chang-Seok Ki, Jung Hee Shin, Young Lyun Oh, Young Ik Son, Jee Soo Kim, Sun Wook Kim, Jae Hoon Chung, Tae Yong Kim, Tae Hyuk Kim, Jung-Han Kim
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Hyunju Park, Jung Heo, Chang-Seok Ki, Jung Hee Shin, Young Lyun Oh, Young Ik Son, Jee Soo Kim, Sun Wook Kim, Jae Hoon Chung, Tae Yong Kim, Tae Hyuk Kim, Jung-Han Kim
Summary: This study aimed to clarify the selection criteria for completion thyroidectomy using telomerase reverse transcriptase (TERT) promoter mutation. The results showed that 2 cm was a critical threshold diameter for initial distant metastasis, disease recurrence, and cancer-specific death in minimally invasive and encapsulated angioinvasive follicular thyroid carcinoma with mutant TERT. For follicular thyroid carcinoma with wild-type TERT, the critical diameter was 4 cm.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Hye Jung Jang, Myung Geun Song, Cho Rong Park, Hyewon Youn, Yun-Sang Lee, Gi Jeong Cheon, Keon Wook Kang
Summary: Glioblastoma is a common and fatal primary glioma, but complete removal of brain tumor tissues is challenging for neurosurgeons. Fluorescence-guided surgery (FGS) and indocyanine green (ICG) are used to enhance visualization of tumor edges. The binding properties of ICG to human serum albumin (HSA) and the extracellular glycoprotein SPARC were studied. In vitro and in vivo studies showed that the uptake of ICG-HSA complex was higher in SPARC-expressing glioblastoma cells and tumors compared to free ICG. This suggests that ICG-HSA complex could be an efficient imaging agent for SPARC-expressing tumors, especially glioblastoma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Tae-Han Kim, In-Ho Kim, Seung Joo Kang, Miyoung Choi, Baek-Hui Kim, Bang Wool Eom, Bum Jun Kim, Byung-Hoon Min, Chang In Choi, Cheol Min Shin, Chung Hyun Tae, Chung Sik Gong, Dong Jin Kim, Arthur Eung-Hyuck Cho, Eun Jeong Gong, Geum Jong Song, Hyeon-Su Im, Hye Seong Ahn, Hyun Lim, Hyung-Don Kim, Jae-Joon Kim, Jeong Il Yu, Jeong Won Lee, Ji Yeon Park, Jwa Hoon Kim, Kyoung Doo Song, Minkyu Jung, Mi Ran Jung, Sang-Yong Son, Shin-Hoo Park, Soo Jin Kim, Sung Hak Lee, Tae-Yong Kim, Woo Kyun Bae, Woong Sub Koom, Yeseob Jee, Yoo Min Kim, Yoonjin Kwak, Young Suk Park, Hye Sook Han, Su Youn Nam, Seong-Ho Kong
Summary: This is the fourth gastric cancer guideline published in Korea, revised in 2018 based on evidence-based approach. It is a collaborative work of an interdisciplinary working group and includes 33 updated or proposed key questions, with 40 statements developed based on systematic review. The evidence level and recommendations were categorized according to the Grading of Recommendations, Assessment, Development and Evaluation proposition. The guideline covers screening, diagnosis, staging and follow-up.
JOURNAL OF GASTRIC CANCER
(2023)
Article
Oncology
Lyn Ley Lam, Nick Pavlakis, Kohei Shitara, Katrin M. Sjoquist, Andrew J. Martin, Sonia Yip, Yoon-Koo Kang, Yung-Jue Bang, Li-Tzong Chen, Markus Moehler, Tanios Bekaii-Saab, Thierry Alcindor, Christopher J. O'Callaghan, Niall C. Tebbutt, Wendy Hague, Howard Chan, Sun Young Rha, Keun-Wook Lee, Val Gebski, Anthony Jaworski, John Zalcberg, Timothy Price, John Simes, David Goldstein
Summary: This study aims to evaluate the efficacy and safety of regorafenib alone and in combination with nivolumab in advanced gastro-oesophageal cancer patients. The study consists of two international randomized controlled trials, comparing the efficacy of regorafenib versus placebo, and the efficacy of regorafenib plus nivolumab versus chemotherapy. The primary endpoint of the study is overall survival.
Article
Medicine, General & Internal
Kohei Shitara, Florian Lordick, Yung-Jue Bang, Peter Enzinger, David Ilson, Manish A. Shah, Eric Van Cutsem, Rui-Hua Xu, Giuseppe Aprile, Jianming Xu, Joseph Chao, Roberto Pazo-Cid, Yoon-Koo Kang, Jianning Yang, Diarmuid Moran, Pranob Bhattacharya, Ahsan Arozullah, Jung Wook Park, Mok Oh, Jaffer A. Ajani
Summary: Zolbetuximab in combination with mFOLFOX6 significantly prolongs progression-free survival and overall survival in patients with CLDN18.2-positive, HER2-negative, locally advanced unresectable or metastatic gastric or gastro-oesophageal junction adenocarcinoma, with good safety profile.
Article
Biochemistry & Molecular Biology
Vivek Subbiah, Robert J. Kreitman, Zev A. Wainberg, Anas Gazzah, Ulrik Lassen, Alexander Stein, Patrick Y. Wen, Sascha Dietrich, Maja J. A. de Jonge, Jean-Yves Blay, Antoine Italiano, Kan Yonemori, Daniel C. Cho, Filip Y. F. L. de Vos, Philippe Moreau, Elena Elez Fernandez, Jan H. M. Schellens, Christoph C. Zielinski, Suman Redhu, Aislyn Boran, Vanessa Q. Passos, Palanichamy Ilankumaran, Yung-Jue Bang
Summary: This study is a phase 2 basket trial evaluating the efficacy and safety of dabrafenib plus trametinib in patients with BRAFV600E-mutated advanced rare cancers. The overall response rates in different tumor types ranged from 56% to 89%. Secondary endpoints included duration of response, progression-free survival, overall survival, and safety.
Correction
Endocrinology & Metabolism
Won Gu Kim, Won Bae Kim, Gyeongji Woo, Hyejin Kim, Yumi Cho, Tae Yong Kim, Sun Wook Kim, Myung-Hee Shin, Jin Woo Park, Hai-Lin Park, Kyungwon Oh, Jae Hoon Chung
ENDOCRINOLOGY AND METABOLISM
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
So Yeong Jeong, Jung Hwan Baek, Sae Rom Chung, Young Jun Choi, Ki-Wook Chung, Tae Yong Kim, Jeong Hyun Lee
Summary: The study aimed to evaluate the technical feasibility, efficacy, and safety of anterolateral hydrodissection (ALHD) in radiofrequency ablation (RFA) for benign thyroid nodules. ALHD technique was technically feasible and effective in all patients, achieving a mean initial ablation ratio (IAR) of 90.7%. The ALHD technique also had a pain-relieving effect, resulting in only low amounts of lidocaine administration being required during the procedure.
Letter
Oncology
Hyunju Park, Tae Yong Kim, Tae Hyuk Kim, Jung-Han Kim
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Manish A. Shah, Kohei Shitara, Jaffer A. Ajani, Yung-Jue Bang, Peter Enzinger, David Ilson, Florian Lordick, Eric Van Cutsem, Javier Gallego Plazas, Jing Huang, Lin Shen, Sang Cheul Oh, Patrapim Sunpaweravong, Hwoei Fen Soo Hoo, Haci Mehmet Turk, Mok Oh, Jung Wook Park, Diarmuid Moran, Pranob Bhattacharya, Ahsan Arozullah, Rui-Hua Xu
Summary: The GLOW trial demonstrated that zolbetuximab, a monoclonal antibody targeting CLDN18.2, combined with CAPOX, significantly improved progression-free survival and overall survival in patients with CLDN18.2-positive, HER2-negative, locally advanced unresectable or metastatic gastric or gastroesophageal junction adenocarcinoma.
Article
Multidisciplinary Sciences
Meihua Jin, Chae A. Kim, Dong Jun Bae, Sang-Yeob Kim, Tae Yong Kim, Won Bae Kim, Young Kee Shong, Won Gu Kim, Min Ji Jeon
Summary: This study evaluated changes in the peripheral blood immune cell population in patients with advanced thyroid cancer receiving lenvatinib treatment to confirm the immune-modulatory effect of lenvatinib. After obtaining informed consent from patients, we prospectively collected 20 ml of whole blood at 2-3 months intervals 2-4 times from each patient; peripheral blood mononuclear cells (PBMCs) were separated, and the Maxpar Direct Immune Profiling Assay was performed. A total of 10 patients were enrolled, and 31 blood samples were obtained. The proportion of peripheral natural killer (NK) cells significantly increased during lenvatinib treatment in advanced thyroid cancer patients, confirming the immune-modulatory effect of lenvatinib.
SCIENTIFIC REPORTS
(2023)
Meeting Abstract
Oncology
Ah Rong Nam, Jeesun Yoon, Kyoung-Seok Oh, Jae-Min Kim, Ju-Hee Bang, Yoojin Jeong, Sea Young Choo, Hyo Jung Kim, Su In Lee, Tae-Yong Kim, Do-Youn Oh