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Title
ATR Inhibition in Advanced Urothelial Carcinoma
Authors
Keywords
-
Journal
Clinical Genitourinary Cancer
Volume -, Issue -, Pages -
Publisher
Elsevier BV
Online
2022-11-04
DOI
10.1016/j.clgc.2022.10.016
References
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Related references
Note: Only part of the references are listed.- Cancer Statistics, 2021
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- Effect of Cisplatin and Gemcitabine With or Without Berzosertib in Patients With Advanced Urothelial Carcinoma
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- Prognostic Value of DNA Damage Response Genomic Alterations in Relapsed/Advanced Urothelial Cancer
- (2020) Ming Yin et al. ONCOLOGIST
- Phase I Trial of First-in-Class ATR Inhibitor M6620 (VX-970) as Monotherapy or in Combination With Carboplatin in Patients With Advanced Solid Tumors
- (2020) Timothy A. Yap et al. JOURNAL OF CLINICAL ONCOLOGY
- First-in-Human Trial of the Oral Ataxia Telangiectasia and Rad3-Related Inhibitor BAY 1895344 in Patients with Advanced Solid Tumors
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- Alterations in DNA Damage Response and Repair Genes as Potential Marker of Clinical Benefit From PD-1/PD-L1 Blockade in Advanced Urothelial Cancers
- (2018) Min Yuen Teo et al. JOURNAL OF CLINICAL ONCOLOGY
- The ATR Inhibitor AZD6738 Synergizes with GemcitabineIn VitroandIn Vivoto Induce Pancreatic Ductal Adenocarcinoma Regression
- (2018) Yann Wallez et al. MOLECULAR CANCER THERAPEUTICS
- ATM/RB1 mutations predict shorter overall survival in urothelial cancer
- (2018) Ming Yin et al. Oncotarget
- Abstract 838: Synergisticin vivoactivity of the ATR inhibitor BAY 1895344 in combination with the targeted alpha therapy radium-223 dichloride in a preclinical tumor model mimicking bone metastatic castration-resistant prostate cancer (mCRPC)
- (2018) Antje Margret Wengner et al. CANCER RESEARCH
- Inhibition of ATR potentiates the cytotoxic effect of gemcitabine on pancreatic cancer cells through enhancement of DNA damage and abrogation of ribonucleotide reductase induction by gemcitabine
- (2017) Shuang Liu et al. ONCOLOGY REPORTS
- Phase I modular study of AZD6738, a novel oral, potent and selective ataxia telangiectasia Rad3-related (ATR) inhibitor in combination (combo) with carboplatin, olaparib or durvalumab in patients (pts) with advanced cancers
- (2016) T.A. Yap et al. EUROPEAN JOURNAL OF CANCER
- ATR inhibition rewires cellular signaling networks induced by replication stress
- (2016) Sebastian A. Wagner et al. PROTEOMICS
- Mutational signatures associated with tobacco smoking in human cancer
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- ATM and ATR as therapeutic targets in cancer
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- The orally active and bioavailable ATR kinase inhibitor AZD6738 potentiates the anti-tumor effects of cisplatin to resolve ATM-deficient non-small cell lung cancer in vivo
- (2015) Frank P. Vendetti et al. Oncotarget
- Potentiation of tumor responses to DNA damaging therapy by the selective ATR inhibitor VX-970
- (2015) Amy B. Hall et al. Oncotarget
- Functional interplay between ATM/ATR-mediated DNA damage response and DNA repair pathways in oxidative stress
- (2014) Shan Yan et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- A Synthetic Lethal Screen Reveals Enhanced Sensitivity to ATR Inhibitor Treatment in Mantle Cell Lymphoma with ATM Loss-of-Function
- (2014) Daniel L. Menezes et al. MOLECULAR CANCER RESEARCH
- CHK2 kinase in the DNA damage response and beyond
- (2014) L. Zannini et al. Journal of Molecular Cell Biology
- Targeting ATR in DNA damage response and cancer therapeutics
- (2013) Emmanouil Fokas et al. CANCER TREATMENT REVIEWS
- Causes and consequences of replication stress
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- Targeting nuclear kinases in cancer: Development of cell cycle kinase inhibitors
- (2013) Todd M. Pitts et al. PHARMACOLOGY & THERAPEUTICS
- Association Between Smoking and Risk of Bladder Cancer Among Men and Women
- (2011) Neal D. Freedman JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Selective killing of ATM- or p53-deficient cancer cells through inhibition of ATR
- (2011) Philip M Reaper et al. Nature Chemical Biology
- A role for neoadjuvant gemcitabine plus cisplatin in muscle-invasive urothelial carcinoma of the bladder
- (2008) Atreya Dash et al. CANCER
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