Article
Critical Care Medicine
Amber L. Nolan, Cathrine Petersen, Diego Iacono, Christine L. Mac Donald, Pratik Mukherjee, Andre van der Kouwe, Sonia Jain, Allison Stevens, Bram R. Diamond, Ruopeng Wang, Amy J. Markowitz, Bruce Fischl, Daniel P. Perl, Geoffrey T. Manley, C. Dirk Keene, Ramon Diaz-Arrastia, Brian L. Edlow
Summary: Utilizing ex vivo diffusion MRI technology and histopathological validation, this study found varying degrees of tract disruptions in the cerebral white matter regions of patients with TBI, with pathological features including white matter injury and a strong correlation between tract disruption and density of APP-positive axonal swellings and neurofilament loss.
JOURNAL OF NEUROTRAUMA
(2021)
Article
Biochemistry & Molecular Biology
Anna Tyrtyshnaia, Olga Manzhulo, Igor Manzhulo
Summary: Traumatic brain injury (TBI) is a global public health concern, affecting 55 million people and being the leading cause of death and disability. Our study investigated the potential therapeutic use of synaptamide in a mouse model of TBI and found that it could prevent working memory decline, neurodegenerative changes, and decreased neurogenesis in the hippocampus. Synaptamide also regulated the production of astro- and microglial markers, promoting an anti-inflammatory microglial phenotype. Additionally, synaptamide stimulated antioxidant and antiapoptotic defense, leading to the downregulation of the pro-apoptotic marker Bad. These findings suggest that synaptamide has promising potential as a therapeutic agent for preventing long-term neurodegenerative consequences of TBI and improving quality of life.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neuroimaging
Chiara Maffei, Natalie Gilmore, Samuel B. Snider, Andrea S. Foulkes, Yelena G. Bodien, Anastasia Yendiki, Brian L. Edlow
Summary: New techniques are needed to assess white matter integrity in individual patients with traumatic brain injury (TBI). Diffusion MRI tractography has been used to quantify white matter microstructure, but it is not commonly used in clinical settings due to the presence of focal lesions. In this study, we propose an automated tractography pipeline that successfully detected and quantified TAI in patients with acute severe TBI.
NEUROIMAGE-CLINICAL
(2023)
Article
Neurosciences
Louise Pham, David K. Wright, William T. O'Brien, Jesse Bain, Cheng Huang, Mujun Sun, Pablo M. Casillas-Espinosa, Anup D. Shah, Ralf B. Schittenhelm, Christopher G. Sobey, Rhys D. Brady, Terence J. O'Brien, Richelle Mychasiuk, Sandy R. Shultz, Stuart J. McDonald
Summary: This study using a rat model found that repeated mTBI can cause acute cognitive deficits and prolonged sensorimotor impairments, with elevated serum NfL levels correlating with sensorimotor deficits at 7 days post injury. Furthermore, several hippocampal proteins were altered by repeated mTBI and diffusion MRI analysis at 3.5 months revealed widespread reductions in white matter integrity.
NEUROBIOLOGY OF DISEASE
(2021)
Article
Neurosciences
Habiba Rashid, Touqeer Ahmed
Summary: Traumatic brain injury (TBI) is a significant global risk factor for cognitive impairment and neurodegenerative diseases. Cognitive and memory impairment following a TBI is associated with dysregulation of cholinergic neurotransmission. The severity of memory impairment varies by sex. This study investigated the role of muscarinic cholinergic modulation in neurological functioning and episodic memory retrieval in a TBI mouse model, revealing sex differences in the response to treatments.
Article
Neurosciences
Carmen Munoz-Ballester, Dzenis Mahmutovic, Yusuf Rafiqzad, Alia Korot, Stefanie Robel
Summary: This study using a mouse model of mTBI found that exposure of neurons to blood-borne factors causes a rapid and sustained loss of neuronal proteins and changes in spine morphology, without neurodegeneration, which may be relevant to many neuropathologies.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Clinical Neurology
Zachary A. Haynes, Ian J. Stewart, Eduard A. Poltavskiy, Aaron B. Holley, Jud C. Janak, Jeffrey T. Howard, Jessica Watrous, Lauren E. Walker, Emerson M. Wickwire, Kent Werner, Lee Ann Zarzabal, Alan Sim, Adi Gundlapalli, Jacob F. Collen
Summary: This study investigates the incidence and predictors of obstructive sleep apnea among survivors of combat-related traumatic injury and a matched control group. The results show that traumatic brain injury, posttraumatic stress disorder, depression, anxiety, insomnia, and obesity were associated with the development of obstructive sleep apnea. The higher incidence in injured service members compared to uninjured ones appears to be driven by traumatic brain injury and the long-term mental health sequelae of injury.
JOURNAL OF CLINICAL SLEEP MEDICINE
(2022)
Article
Neurosciences
Jean Michaud, Isabelle Plu, Jacqueline Parai, Andre Bourgault, Caroline Tanguay, Danielle Seilhean, John Woulfe
Summary: Traumatic brain injury is a major insult that can lead to the development of chronic traumatic encephalopathy. In this study, severe TBI patients who remained comatose until death were found to have ballooned neurons, similar to those seen in neurodegenerative disorders. The presence of these neurons in TBI patients has not been previously reported. Further research is needed to understand the frequency of this neuronal finding and its relationship with proximal axonal defects.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2023)
Article
Neurosciences
William T. O'Brien, Louise Pham, Rhys D. Brady, Jesse Bain, Glenn R. Yamakawa, Mujun Sun, Richelle Mychasiuk, Terence J. O'Brien, Mastura Monif, Sandy R. Shultz, Stuart J. McDonald
Summary: The study demonstrates that serum NfL levels significantly increase following mTBI in rats, with a peak at 1 day post-injury and sustained elevation at 14 days. Repeat mTBI further elevates NfL levels, which are correlated with the severity of sensorimotor impairment. These findings highlight the potential utility of NfL as a blood biomarker for assessing the severity of mTBI.
EXPERIMENTAL NEUROLOGY
(2021)
Review
Neurosciences
Ariel Walker, Ben Chapin, Jose Abisambra, Steven T. DeKosky
Summary: This literature review investigated whether a single moderate to severe head injury leads to long-term development of tauopathy. The results of most human and animal studies suggest that a single moderate to severe head injury is associated with greater chronic development of tauopathy, but caution is needed due to limitations in the studies.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2022)
Review
Medicine, General & Internal
Zara Raza, Syeda F. Hussain, Suzanne Ftouni, Gershon Spitz, Nick Caplin, Russell G. Foster, Renata S. M. Gomes
Summary: Military personnel and veterans are exposed to unique risk factors such as TBI, PTSD, combat, blast exposure, and chemical exposure, which may increase the risk of dementia. Sleep problems have also been associated with dementia risk in this population.
MILITARY MEDICAL RESEARCH
(2021)
Article
Oncology
Chung-Che Lu, Tee-Tau Eric Nyam, Chung-Han Ho, Jinn-Rung Kuo, Chung-Ching Chio, Jhi-Joung Wang, Che-Chuan Wang
Summary: This study found that moderate/severe TBI patients had a higher mortality rate and shorter time interval from TBI to death compared to mild TBI patients. There were no significant differences in cancer incidence and risk factors for mortality between mild and moderate/severe TBI patients. However, patients aged between 46 and 55 years, female patients, and patients with pre-existing renal disease had a significantly higher cancer incidence risk in moderate/severe TBI compared with mild TBI patients.
Review
Chemistry, Analytical
Maria Roldan, Panayiotis A. Kyriacou
Summary: Traumatic brain injury (TBI) occurs when sudden trauma causes damage to the brain, with secondary injuries potentially affecting cerebral oxygenation and autoregulation. Near-infrared spectroscopy (NIRS) is a potential noninvasive monitoring technique for assessing TBI early, based on chromophore absorption of infrared light.
Article
Clinical Neurology
Amy E. Jolly, Maria Balaet, Adriana Azor, Daniel Friedland, Stefano Sandrone, Neil S. N. Graham, Karl Zimmerman, David J. Sharp
Summary: This study introduces a pipeline for assessing the presence of axonal injury in traumatic brain injury patients, revealing that the majority of patients have axonal injury in the chronic and subacute phases. Patients with axonal injury exhibit significantly poorer cognitive and functional outcomes.
Article
Neurosciences
Jessica M. Sharkey, Ryan D. Quarrington, Justin L. Krieg, Lola Kaukas, Renee J. Turner, Anna Leonard, Claire F. Jones, Frances Corrigan
Summary: Damage to axonal white matter tracts within the brain is a major contributor to neurological impairment and long-term disability after traumatic brain injury (TBI). This study aimed to investigate the effect of post-traumatic hypoxia on axonal injury and inflammation in a sheep model of TBI. The results showed that early axonal injury was characterized by calpain activation and increased SNTF immunoreactivity, while axonal transport was not impaired. These findings indicate that axonal injury post-TBI is driven by different pathophysiological mechanisms.
Article
Clinical Neurology
Raul Martinez-Fernandez, Sujitha Mahendran, Jose Angel Pineda-Pardo, Lukas L. Imbach, Jorge U. Manez-Miro, Fabian Buechele, Marta del Alamo, Rafael Rodriguez-Rojas, Frida Hernandez-Fernandez, Beat Werner, Michele Matarazzo, Ignacio Obeso, Lain H. Gonzalez-Quarante, Gunther Deuschl, Lennart Stieglitz, Christian R. Baumann, Jose A. Obeso
Summary: Unilateral magnetic resonance-guided focused ultrasound (FUS) thalamotomy is effective for treating medically refractory essential tremor (ET). The feasibility, safety, and efficacy of bilateral staged FUS thalamotomy for ET were explored in this study, showing promising results in improving voice and head tremor.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2021)
Article
Clinical Neurology
Anelia Dietmann, Elena Wenz, Julia van Der Meer, Maya Ringli, Jan D. Warncke, Ellen Edwards, Markus H. Schmidt, Corrado A. Bernasconi, Arto Nirkko, Mathias Strub, Silvia Miano, Mauro Manconi, Jens Acker, Sigrid von Manitius, Christian R. Baumann, Philip O. Valko, Bahtiyar Yilmaz, Andreas-David Brunner, Athina Tzovara, Zhongxing Zhang, Carlo R. Largiader, Mehdi Tafti, Daniela Latorre, Federica Sallusto, Ramin Khatami, Claudio L. A. Bassetti
Summary: The SPHYNCS study aims to investigate the clinical presentation, pathophysiology, and long-term course of Narcolepsy type 1 (NT1) and the narcoleptic borderland (NBL) disorders, in order to validate new and reevaluate established markers for the characterization of NBL and facilitate the diagnostic process. The study involves multiple Swiss sleep centers and will prospectively enroll over 500 patients with excessive daytime sleepiness, hypersomnia, or suspected disorders of hypersomnolence, with the goal of improving understanding, diagnosis, and management of these conditions.
JOURNAL OF SLEEP RESEARCH
(2021)
Article
Multidisciplinary Sciences
Oliver Bichsel, Lennart H. Stieglitz, Markus F. Oertel, Christian R. Baumann, Roger Gassert, Lukas L. Imbach
Summary: Patients with Parkinson's disease can volitionally control ongoing beta-oscillatory activity through deep brain electrical neurofeedback, leading to a gradual reduction in beta-oscillatory activity and improved motor performance. The strategies acquired through neurofeedback training are retained in the short-term and can result in motor improvement even without neurofeedback, suggesting the therapeutic potential of deep brain neurofeedback for Parkinson patients.
SCIENTIFIC REPORTS
(2021)
Review
Clinical Neurology
Fabian Buechele, Christian R. Baumann, Andrew Lees, Gunther Deuschl
MOVEMENT DISORDERS CLINICAL PRACTICE
(2022)
Article
Behavioral Sciences
Yannick Rothacher, Anh Nguyen, Evdokia Efthymiou, Esther Werth, Christian R. R. Baumann, Bigna Lenggenhager, Peter Brugger, Andreas Kunz, Lukas L. Imbach
Summary: Recent VR research has shown evidence of dissociation between motor control and motor awareness in awake sleepwalkers. By measuring EEG modulation during redirected walking in VR, researchers discovered distinct EEG patterns in sleepwalkers compared to controls, supporting the hypothesis of brain-body dissociation in awake sleepwalkers. The study also demonstrates the potential of using EEG biomarkers in VR to better understand altered motor awareness in sleepwalkers and potentially diagnose neurological diseases.
Article
Radiology, Nuclear Medicine & Medical Imaging
Patrick Vagenknecht, Artur Luzgin, Maiko Ono, Bin Ji, Makoto Higuchi, Daniela Noain, Cinzia A. Maschio, Jens Sobek, Zhenyue Chen, Uwe Konietzko, Juan A. Gerez, Roland Riek, Daniel Razansky, Jan Klohs, Roger M. Nitsch, Xose Luis Dean-Ben, Ruiqing Ni
Summary: This study demonstrated high-resolution imaging of tau protein in the whole brain of mice using non-invasive imaging technique. The results showed that the tau-targeted probe PBB5 specifically bound to tau protein and exhibited similar binding ability in diseased brain tissue.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Editorial Material
Clinical Neurology
Sebastian R. Schreglmann, Kailash P. Bhatia
MOVEMENT DISORDERS CLINICAL PRACTICE
(2022)
Article
Clinical Neurology
Carlos G. Moreira, Pascal Hofmann, Adrian Muellner, Christian R. Baumann, Varun R. Ginde, Sedef Kollarik, Marta M. Morawska, Daniela Noain
Summary: A rodent auditory stimulation method was developed to modulate slow-wave activity, and its modulatory strength was compared to classical slow-wave activity modulators in a rat model of traumatic brain injury. The results showed that this auditory stimulation method was not as effective as the classical modulators in reducing slow-wave activity or altering posttraumatic outcomes.
JOURNAL OF SLEEP RESEARCH
(2022)
Article
Clinical Neurology
Lennart H. Stieglitz, Sujitha Mahendran, Markus F. Oertel, Christian R. Baumann
Summary: This study reports a successful case of bilateral MRgHiFUS pallidotomy for peak-dose dyskinesia in a patient with Parkinson's disease (PD). The treatment decision was based on the patient's reluctance toward brain implants and pump therapies as well as limited access to a deep brain stimulation center in his home country.
MOVEMENT DISORDERS CLINICAL PRACTICE
(2022)
Article
Engineering, Biomedical
Maria Laura Ferster, Giulia Da Poian, Kiran Menachery, Simon J. Schreiner, Caroline Lustenberger, Angelina Maric, Reto Huber, Christian R. Baumann, Walter Karlen
Summary: This study introduces two novel algorithms for real-time EEG phase estimation and compares them with a traditional method. The results show that both new algorithms can accurately estimate the phase of EEG signals, even at low amplitudes and non-constant frequencies. These algorithms perform better in targeting low-amplitude and higher frequency SW. Hardware testing demonstrates that these algorithms have little impact on microcontroller load.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2022)
Article
Clinical Neurology
Sedef Kollarik, Ines Dias, Carlos G. Moreira, Dorita Bimbiryte, Djordje Miladinovic, Joachim M. Buhmann, Christian R. Baumann, Daniela Noain
Summary: This study investigated the sleep-wake phenotype of a widely used mouse model of AD, Tg2576, and found that at the plaque-free stage of the disease, Tg2576 mice exhibited decreased sleep quality similar to aged healthy controls, indicating an early-onset sleep-wake deterioration in murine AD. This result further explores the impact of sleep on disease progression.
NEURODEGENERATIVE DISEASES
(2023)
Article
Neurosciences
Sophie Masneuf, Lukas L. Imbach, Fabian Buchele, Giovanni Colacicco, Marco Penner, Carlos G. Moreira, Christian Ineichen, Ali Jahanshahi, Yasin Temel, Christian R. Baumann, Daniela Noain
Summary: This study explores the effects of deep brain stimulation on sleep-wake characteristics in rats, finding that high-frequency stimulation of specific hypothalamic regions can modulate the intensity of slow-wave sleep without major impacts on overall sleep-wake architecture.
TRANSLATIONAL NEUROSCIENCE
(2021)
Article
Medicine, General & Internal
Lennart H. Stieglitz, Anna-Sophie Hofer, Marc Bolliger, Markus F. Oertel, Linard Filli, Romina Willi, Adrian Cathomen, Christian Meyer, Martin Schubert, Michele Hubli, Thomas M. Kessler, Christian R. Baumann, Lukas Imbach, Iris Krusi, Andrea Prusse, Martin E. Schwab, Luca Regli, Armin Curt
Summary: MLR-DBS has shown potential in enhancing functional recovery in SCI patients through a prospective study, with promising results suggesting safety and feasibility.