Article
Medicine, General & Internal
Piotr Gajewski, Marat Fudim, Veraprapas Kittipibul, Zoar J. Engelman, Jan Biegus, Robert Zymlinski, Piotr Ponikowski
Summary: In patients with heart failure, permanent ablation of the right greater splanchnic nerve leads to a significant reduction in intracardiac filling pressures during exercise within 24 hours following the procedure.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Filip Malek, Piotr Gajewski, Robert Zymlinski, Dariusz Janczak, Mariusz Chabowski, Marat Fudim, Tomas Martinca, Petr Neuzil, Jan Biegus, Martin Mates, Andreas Kruger, Ivo Skalsky, Anisha Bapna, Zoar J. Engelman, Piotr P. Ponikowski
Summary: This study showed that GSN ablation in patients with HFpEF is feasible and resulted in reduced cardiac filling pressure during exercise, improved quality of life, and exercise capacity.
EUROPEAN JOURNAL OF HEART FAILURE
(2021)
Article
Cardiac & Cardiovascular Systems
Marat Fudim, Manesh R. Patel, Richard Boortz-Marx, Barry A. Borlaug, Adam D. DeVore, Arun Ganesh, Cynthia L. Green, Renato D. Lopes, Robert J. Mentz, Chetan B. Patel, Joseph G. Rogers, G. Michael Felker, Adrian F. Hernandez, Kenji Sunagawa, Daniel Burkhoff
Summary: The study analyzed data from two prospective clinical studies on decompensated HFrEF and ambulatory heart failure patients. The results showed that splanchnic nerve block decreased the estimated stressed blood volume in decompensated HFrEF patients, while it increased in ambulatory HFrEF patients.
JACC-HEART FAILURE
(2021)
Review
Radiology, Nuclear Medicine & Medical Imaging
Harris Liou, Min J. Kong, Sadeer J. Alzubaidi, M-Grace Knuttinen, Indravadan J. Patel, J. Scott Kriegshauser
Summary: CT-guided CP/RSN blocks are effective in managing non-cancer related abdominal pain, with differences in efficacy between temporary and permanent blocks.
ACADEMIC RADIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Veraprapas Kittipibul, Arun Ganesh, Aubrie Coburn, Brian J. Coyne, James Matthew Gray, Jeroen Molinger, Neil Ray, Mihai Podgoreanu, Sharon L. McCartney, Negmeldeen Mamoun, Robert Curtis Fitzhugh, Philipp Lurz, Cynthia L. Green, Adrian F. Hernandez, Manesh R. Patel, Marat Fudim
Summary: Splanchnic nerve modulation is an emerging procedure to reduce cardiac filling pressures in heart failure. This study examines the changes in venous capacitance before and after SNM to evaluate its effectiveness.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Review
Biochemistry & Molecular Biology
Ioannis Paraskevaidis, Andrew Xanthopoulos, Elias Tsougos, Filippos Triposkiadis
Summary: There is a bidirectional relationship between the heart and gut. The gut microbiota plays a key role in maintaining gut homeostasis and metabolism. It has been implicated in the development of cardiovascular diseases, such as atherosclerosis and coronary artery disease. Heart failure can lead to gut barrier dysfunction, promoting leakage of microorganisms and triggering immune responses. The gut microbiota can also be influenced by drugs used for heart failure. Lifestyle interventions, including exercise and a Mediterranean diet, as well as the use of probiotics, may benefit the gut microbiota and potentially impact heart failure development and progression.
Review
Physiology
Mei Li, Hongmin Wang, Xiao-Jing Zhang, Jingjing Cai, Hongliang Li
Summary: This review summarizes the potential causal relationship between NAFLD and CVD, highlighting the evidence from prospective clinical and Mendelian randomization studies. The mechanisms of NAFLD contributing to the development of CVD and the necessity of addressing CVD risk while managing NAFLD in clinical practice are also discussed.
Review
Cardiac & Cardiovascular Systems
Christelle Lteif, Ali Ataya, Julio D. Duarte
Summary: PH caused by LHD is believed to be the most common form, with challenges in treatment. Specific therapies for PH-LHD have not been identified yet, and pulmonary artery hypertension-targeted therapies are not recommended.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Oncology
Ryota Yanaizumi, Yusuke Nagamine, Shinsuke Harada, Tomoko Kuramochi, Shuhei Ota, Takahisa Goto
Summary: This study aimed to investigate the incidence of and risk factors for opioid withdrawal (OW) among cancer patients who underwent neurolytic splanchnic nerve block (NSNB) and had reduced opioid doses. The study found that OW occurred in 20.8% of the patients within 14 days after NSNB. Longer pain and opioid use duration, as well as a larger opioid tapering dose, may increase the risk of OW.
SUPPORTIVE CARE IN CANCER
(2023)
Article
Cardiac & Cardiovascular Systems
Marat Fudim, Muhammad Shahzeb Khan, Anousheh Awais Paracha, Kenji Sunagawa, Daniel Burkhoff
Summary: Preload augmentation is important for increasing cardiac output, but in heart failure, excessive preload recruitment may worsen congestion and limit exercise capacity. Recent studies focus on regulating splanchnic vascular redistribution to improve cardiac filling pressures and patient-centered outcomes.
CIRCULATION-HEART FAILURE
(2022)
Review
Medicine, General & Internal
Ki Wan Park, Peter Kullar, Charvi Malhotra, Konstantina M. Stankovic
Summary: Chronic subjective tinnitus is a condition where individuals perceive sound without an external source for longer than six months. Current treatments are not very effective, and there is a high demand for new therapies for tinnitus.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, Research & Experimental
Jaewoong Jung, Misoon Lee, Yang-Hoon Chung, Sung-Hwan Cho
Summary: The number of patients with heart failure with reduced ejection fraction (HFrEF) is increasing, and proper preoperative evaluation is essential for determining the best type of anesthesia. In this case, a sciatic nerve and fascia iliaca compartment block was successfully performed in a patient with HFrEF undergoing lower limb surgery, demonstrating that peripheral nerve block can be a viable alternative option for these patients.
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Danish Saleh, Rebecca T. L. Jones, Samantha L. Schroth, Edward B. Thorp, Matthew J. Feinstein
Summary: The field of cardio-immunology has emerged from discoveries that define roles for immune responses associated with inflammation and heart failure. Dendritic cells (DCs) play an important role in regulating acute and chronic inflammatory responses. However, the specific involvement of DCs in cardiac injury remains poorly understood.
Review
Cardiac & Cardiovascular Systems
Azka Latif, Muhammad Junaid Ahsan, Noman Lateef, Vikas Kapoor, Scott Lundgren, Muhammad Zoraiz Ahsan, Soban Ahmad, Mohsin Mirza
Summary: The use of methamphetamines is increasing globally, causing cardiovascular disease to become the leading cause of death and morbidity. Long-term use of methamphetamines is associated with various cardiovascular problems, which are dose-dependent and potentially reversible if methamphetamines are discontinued early. This review aims to summarize epidemiological data, describe the pathophysiology and clinical presentation, manage methamphetamines-induced cardiomyopathy and its potential complications, and propose strategies to reduce methamphetamines abuse and hospitalization.
CURRENT PROBLEMS IN CARDIOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Shuqing Shi, Bingxuan Zhang, Yumeng Li, Xia Xu, Jiayu Lv, Qiulei Jia, Ruoning Chai, Wenjing Xue, Yuan Li, Yajiao Wang, Huaqin Wu, Qingqiao Song, Yuanhui Hu
Summary: The communication between the heart and kidney is bidirectional and regulated by complex hemodynamic factors, biochemical and hormonal pathways. Mitochondrial dysfunction plays a crucial role in heart failure and chronic kidney disease, and may also be central in the development and progression of cardiorenal syndrome.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
