Review
Oncology
Jessica Thornton, Gagan Chhabra, Chandra K. Singh, Glorimar Guzman-Perez, Carl A. Shirley, Nihal Ahmad
Summary: Melanoma is one of the most common cancers in the US and its incidence is increasing. Immunotherapies have significantly improved survival rates for metastatic melanoma, but half of the patients do not respond to current therapies. Tumor immune evasion is a major factor contributing to this resistance, and new strategies are needed to overcome it.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Ryan C. Augustin, Sarah Newman, Aofei Li, Marion Joy, Maureen Lyons, Mary P. Pham, Peter Lucas, Katelyn Smith, Cindy Sander, Brian Isett, Diwakar Davar, Yana G. Najjar, Hassane M. Zarour, John M. Kirkwood, Jason John Luke, Riyue Bao
Summary: In this study, we characterized acral melanoma (AM) and investigated its response to immune checkpoint inhibitors (ICIs). We found differential gene expression and pathway activation in a non-T cell-inflamed tumor microenvironment (TME) of AM, which may contribute to its poor response to ICIs.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Oncology
Anne Zaremba, Peter Mohr, Ralf Gutzmer, Friedegund Meier, Claudia Pfoehler, Michael Weichenthal, Patrick Terheyden, Andrea Forschner, Ulrike Leiter, Jens Ulrich, Jochen Utikal, Julia Welzel, Martin Kaatz, Christoffer Gebhardt, Rudolf Herbst, Anca Sindrilaru, Edgar Dippel, Michael Sachse, Frank Meiss, Lucie Heinzerling, Sebastian Haferkamp, Carsten Weishaupt, Harald Loeffler, Sophia Kreft, Klaus Griewank, Elisabeth Livingstone, Dirk Schadendorf, Selma Ugurel, Lisa Zimmer
Summary: This study analyzed the impact of NRAS gene mutations on melanoma patients treated with immune checkpoint inhibitors. The results showed that NRAS mutations were not significantly correlated with patients' survival and treatment response, and had no correlation with the expression of the T-cell immune checkpoint molecule PD-L1.
EUROPEAN JOURNAL OF CANCER
(2023)
Review
Oncology
Yefang Lao, Daoming Shen, Weili Zhang, Rui He, Min Jiang
Summary: Immune checkpoint inhibitors are an important strategy in cancer therapy, but some patients develop resistance to these inhibitors. Understanding the mechanisms of antitumor action and drug resistance is crucial to narrow down the population of resistant patients. This review discusses the antitumor action sites and mechanisms of different types of immune checkpoint inhibitors, as well as proposes current and future solutions for resistance.
Article
Oncology
Olivier J. van Not, Melissa M. de Meza, Alfons J. M. van den Eertwegh, John B. Haanen, Christian U. Blank, Maureen J. B. Aarts, Franchette W. P. J. van den Berkmortel, Jesper van Breeschoten, Jan-Willem B. de Groot, Geke A. P. Hospers, Rawa K. Ismail, Ellen Kapiteijn, Djura Piersma, Roos S. van Rijn, Marion A. M. Stevense-den Boer, Astrid A. M. van der Veldt, Gerard Vreugdenhil, Han J. Bonenkamp, Marye J. Boers-Sonderen, Willeke A. M. Blokx, Michel W. J. M. Wouters, Karijn P. M. Suijkerbuijk
Summary: This study reveals the lower effectiveness of immune checkpoint inhibitors in patients with acral melanoma compared to cutaneous melanoma, with lower response rates, progression-free survival, and overall survival.
EUROPEAN JOURNAL OF CANCER
(2022)
Article
Oncology
Simona Manacorda, Maria De Toro Carmena, Ciara Malone, Ha Mo Linh Le, Andrew J. S. Furness, James Larkin, Andreas M. Schmitt
Summary: This study investigated the efficacy of PD-1-directed antibody-based therapy in patients with symptomatic melanoma brain metastases (MBM) and concurrent treatment with corticosteroids. The findings showed that patients only derived modest benefit from the treatment, but those with disease response had the potential to derive long-term benefit, justifying the use of this therapy in this group in the absence of other more effective treatment options.
EUROPEAN JOURNAL OF CANCER
(2023)
Review
Immunology
Lili Mao, Zhonghui Qi, Li Zhang, Jun Guo, Lu Si
Summary: Acral and mucosal melanomas are rare in Caucasians but predominant in Asians, displaying aggressive phenotypes and similar genetic landscapes. Current therapies show limited benefit for these subtypes, and mechanisms contributing to disparities remain unclear. Early diagnosis and effective interventions for these melanoma subtypes are crucial.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Manyi Xu, Yue Hao, Zheng Shi, Zhengbo Song
Summary: Immunotherapy rechallenge may be a viable option for patients with resistance, particularly after acquired resistance.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Review
Oncology
Nicolas Huyghe, Elena Benidovskaya, Philippe Stevens, Marc Van den Eynde
Summary: ICIs are effective in Microsatellite Instability High Colorectal Cancer (MSI-H CRC), but have limited clinical benefit in Microsatellite Stable (MSS) CRC. Efforts are being made to understand the heterogeneous CRC microenvironment and find predictive biomarkers for selecting CRC patients who may respond to ICIs-based therapies. Trials are also being conducted to study new biomarkers and treatments targeting immune checkpoint molecules to improve response in MSS CRC.
Review
Oncology
Dimitrios C. Ziogas, Charalampos Theocharopoulos, Panagiotis-Petros Lialios, Dimitra Foteinou, Ioannis-Alexios Koumprentziotis, Georgios Xynos, Helen Gogas
Summary: Although immune checkpoint inhibitors have significantly improved prognosis for melanoma patients, some patients do not benefit from them. Other immune checkpoint molecules beyond PD-1 and CTLA-4 play a major role in immune evasion. This comprehensive overview provides information on the functional characteristics and therapeutic modalities of various immune checkpoint molecules for melanoma treatment.
Letter
Medicine, General & Internal
Anusha S. Thomas, Weijie Ma, Yinghong Wang
Summary: Two patients developed severe refractory autoimmune colitis after cancer treatment with immune checkpoint inhibitors, but responded well to a course of subcutaneously administered ustekinumab, an antibody that blocks interleukin-12/23 signaling.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Oncology
Rom Leidner, Kevin Conlon, Douglas G. Mcneel, Andrea Wang-Gillam, Sumati Gupta, Robert Wesolowski, Monica Chaudhari, Nadia Hassounah, Jong Bong Lee, Lang Ho Lee, Jessica A. O'Keeffe, Nancy Lewis, George N. Pavlakis, John A. Thompson
Summary: This study investigated the efficacy and safety of NIZ985 as monotherapy and in combination with spartalizumab in the treatment of advanced solid tumors. The results showed that NIZ985 demonstrated antitumor activity and was well tolerated in patients with advanced solid tumors.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Narjess Ayati, Zahra Jamshidi-Araghi, Magdalena Hoellwerth, Gregor Schweighofer-Zwink, Wolfgang Hitzl, Peter Koelblinger, Christian Pirich, Mohsen Beheshti
Summary: This study assessed tumor response in patients with metastatic melanoma treated with ICIs using three modified response criteria. Results showed that PERCIMT provided a more reliable assessment of disease control rate and overall patient survival.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Oncology
Simone M. Goldinger, Kristina Buder-Bakhaya, Serigne N. Lo, Andrea Forschner, Meredith McKean, Lisa Zimmer, Chloe Khoo, Reinhard Dummer, Zeynep Eroglu, Elizabeth I. Buchbinder, Paolo A. Ascierto, Ralf Gutzmer, Elisa A. Rozeman, Christoph Hoeller, Douglas B. Johnson, Anja Gesierich, Peter Koelblinger, Naima Bennannoune, Justine Cohen, Katharina C. Kaehler, Melissa A. Wilson, Jonathan Cebon, Victoria Atkinson, Jessica L. Smith, Olivier Michielin, Georgina Long, Jessica C. Hassel, Benjamin Weide, Lauren E. Haydu, Dirk Schadendorf, Grant McArthur, Patrick A. Ott, Christian Blank, Caroline Robert, Ryan Sullivan, Axel Hauschild, Matteo S. Carlino, Claus Garbe, Michael A. Davies, Alexander M. Menzies
Summary: Chemotherapy has limited activity in patients with metastatic melanoma who have failed checkpoint inhibitor therapy, although the activity varies among different chemotherapy regimens.
EUROPEAN JOURNAL OF CANCER
(2022)
Article
Oncology
Tuba N. Gide, Elizabeth C. Paver, Zarwa Yaseen, Nigel Maher, Nurudeen Adegoke, Alexander M. Menzies, Ines Pires da Silva, James S. Wilmott, Georgina V. Long, Richard A. Scolyer
Summary: This study evaluated the association between LAG-3 expression and clinical outcomes in metastatic melanoma patients treated with anti-LAG-3 and anti-PD-1 immunotherapy. The results showed that LAG-3 expression was related to treatment response and tumor-infiltrating lymphocytes, and patients with ≥ 1% LAG-3+ cells had longer progression-free survival.
Review
Oncology
Dimitrios C. Ziogas, Dimitrios Mandellos, Charalampos Theocharopoulos, Panagiotis-Petros Lialios, Spyros Bouros, Paolo A. Ascierto, Helen Gogas
Summary: This study presents the first case of anti-MUSK-positive myasthenia gravis in a female patient with metastatic BRAF-mutant melanoma after long-term treatment with dabrafenib and trametinib. A systematic literature review identified 12 cancer cases with TKI-related myasthenia gravis, highlighting the challenges in diagnosis and treatment.
FRONTIERS IN ONCOLOGY
(2021)
Review
Immunology
Charalampos Theocharopoulos, Panagiotis-Petros Lialios, Michael Samarkos, Helen Gogas, Dimitrios C. Ziogas
Summary: ADCs combine the high selectivity and specificity of monoclonal antibodies with the cytotoxic potency of attached payloads. Ten ADCs have been approved by FDA for oncological indications, with many others currently being tested in clinical and preclinical level. Explore bioengineering breakthroughs such as bispecific mAbs, dual-drug platforms, novel linkers, and conjugation chemistries to enhance the effectiveness and safety of immunoconjugates.
Review
Oncology
Dimitrios C. Ziogas, Charalampos Theocharopoulos, Panagiotis-Petros Lialios, Dimitra Foteinou, Ioannis-Alexios Koumprentziotis, Georgios Xynos, Helen Gogas
Summary: Although immune checkpoint inhibitors have significantly improved prognosis for melanoma patients, some patients do not benefit from them. Other immune checkpoint molecules beyond PD-1 and CTLA-4 play a major role in immune evasion. This comprehensive overview provides information on the functional characteristics and therapeutic modalities of various immune checkpoint molecules for melanoma treatment.
Review
Oncology
Charalampos Theocharopoulos, Panagiotis-Petros Lialios, Helen Gogas, Dimitrios C. Ziogas
THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY
(2020)
Review
Oncology
Albrecht Stenzinger, Arndt Vogel, Ulrich Lehmann, Angela Lamarca, Paul Hofman, Luigi Terracciano, Nicola Normanno
Summary: Cholangiocarcinomas are a heterogeneous group of tumors with distinct genomic alterations. Next-generation sequencing is a powerful tool for identifying gene variants and guiding personalized treatment for patients with cholangiocarcinomas. Understanding the use of NGS in molecular profiling is crucial for healthcare professionals to optimize treatment outcomes.
CANCER TREATMENT REVIEWS
(2024)