Review
Plant Sciences
Qiu-Ping Liu, Yu-Ying Chen, Pei An, Khalid Rahman, Xin Luan, Hong Zhang
Summary: Macrophages in the tumor microenvironment (TME) can polarize into M2 type, which promotes tumor development. This review summarizes the effects of TME on macrophage polarization and the reversal of M2 polarization by natural products, providing directions for tumor therapy.
Review
Biochemistry & Molecular Biology
Lu Shi, Hongchen Gu
Summary: Despite the great progress in immunotherapy, the efficacy in treating solid tumors has not met expectations, largely due to the immune-suppressive tumor microenvironment. Tumor-associated macrophages (TAMs) play crucial roles in this environment, and research focuses on repolarizing them from pro-tumor to anti-tumor phenotypes. Nanotechnology offers significant opportunities for targeting and modulating TAM polarization to improve cancer immunotherapy outcomes.
Article
Engineering, Biomedical
Cuidi Li, Changwei Li, Zhenjiang Ma, Hongfang Chen, Huitong Ruan, Lianfu Deng, Jinwu Wang, Wenguo Cui
Summary: This study proposes a novel approach for postoperative treatment of bone tumors by constructing a dual-stage regenerative scaffold that regulates the immune microenvironment, thereby improving the survival rate of patients.
BIOACTIVE MATERIALS
(2023)
Article
Engineering, Biomedical
Xin Huang, Lutong Wang, Haoyu Guo, Weiyue Zhang
Summary: In this study, a novel drug delivery system was developed to target both tumors and macrophages, inhibiting tumor growth and inducing macrophage polarization. The results showed that METTL14 inhibited tumor growth by regulating the TLR4 pathway in macrophages.
BIOACTIVE MATERIALS
(2023)
Article
Chemistry, Physical
Bingbing Bai, Chaoyu Gu, Xiaohui Lu, Xingyu Ge, Junling Yang, Chenfei Wang, Yongchun Gu, Aidong Deng, Yuehua Guo, Xingmei Feng, Zhifeng Gu
Summary: The study developed a novel ROS-responsive drug delivery system using PDA functionalized nanoparticles to deliver MH for treating periodontitis. This system successfully polarized macrophages from pro-inflammatory M1 to anti-inflammatory M2 phenotype, preventing tooth loss and reducing inflammatory response.
Review
Medicine, Research & Experimental
Xintong Zhou, Xiaomin Wang, Qi Sun, Wenfeng Zhang, Cun Liu, Wenzhe Ma, Changgang Sun
Summary: This paper discusses the infiltration and polarization effects of natural compounds on lung cancer tumor-associated macrophages (TAMs), provides a detailed classification and systematic review of natural compounds, and summarizes the bias of different kinds of natural compounds by affecting their antitumor mechanism of TAMs, with the aim of providing new perspectives and potential therapeutic drugs for targeted macrophages in the treatment of lung cancer.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Nanoscience & Nanotechnology
Ao Chen, Fan Yang, Jing Kuang, Yuan Xiong, Bo-Bin Mi, Ying Zhou, Jing-Jing Hu, Shu-Jun Song, Tao Wan, Zhong-Zhong Wan, Hong-Yang Huang, Xin-Run Li, Wen Song, Wen-Xiu Qiu
Summary: A nanoplatform was constructed to reverse tumor acidosis and hypoxia through alkali and oxygen generation triggered by tumor acidosis, polarizing tumor-associated macrophages to anti-tumor M1 phenotype macrophages and enhancing tumor immune response. Furthermore, under regional light irradiation, reactive oxygen species produced by photosensitizers in the nanoplatform could increase the immunogenicity of tumors, transitioning tumors from immunosuppressive cold tumors to immunogenic hot tumors and amplifying the effect of immunotherapy.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Review
Medicine, Research & Experimental
Alireza Najafi, Maryam Keykhaee, Hossein Khorramdelazad, Mohammad Yahya Karimi, Leila Nejatbakhsh Samimi, Nazanin Aghamohamadi, Milad Karimi, Reza Falak, Mehdi Khoobi
Summary: The tumor microenvironment (TME) plays a critical role in tumor progression and resistance to treatment. Tumor-associated macrophages (TAMs) and hypoxia are important factors in the TME. Catalase and catalase-mimicking compounds can reduce hypoxia and promote TAM polarization, showing potential in cancer therapy.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Engineering, Biomedical
Yongjiang Li, Junyong Wu, Xiaohan Qiu, Suhe Dong, Jun He, Jihua Liu, Wenjie Xu, Si Huang, Xiongbin Hu, Da-Xiong Xiang
Summary: This study demonstrates the potential of using OMVs as antitumor therapeutics. By co-loading photosensitizer and chemotherapeutic drugs into OMVs and enhancing tumor-targeting ability through macrophage-mediated delivery, a combination of photodynamic therapy, chemotherapy, and immunotherapy can be achieved, effectively eradicating breast tumors and preventing tumor metastasis.
BIOACTIVE MATERIALS
(2023)
Review
Pharmacology & Pharmacy
Jipeng Jiang, Jie Mei, Shaoqiong Yi, Changjiang Feng, Yongfu Ma, Yang Liu, Ying Liu, Chunying Chen
Summary: The occurrence and development of tumors depend on the tumor microenvironment (TME), in which tumor associated macrophages (TAMs) and microbes play important roles. By targeting TAMs and microbes, tumor vaccine delivery can remodel TME, enhance antigen specificity and immunogenicity, and contribute to the regulation of TME.
ADVANCED DRUG DELIVERY REVIEWS
(2022)
Review
Immunology
Zicong He, Shuixing Zhang
Summary: TAMs are crucial immune cells in tumors, and their functional transformation from M1 to M2 as tumors progress plays a key role in immunosuppression and tumor promotion processes. Understanding the mechanism of TAM functional transformation in the hypoxic environment is essential for developing novel tumor immunotherapeutic strategies.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Pharmacology & Pharmacy
Srijan Dubey, Sayak Ghosh, Debosmita Goswami, Debapriya Ghatak, Rudranil De
Summary: Macrophages are immune cells that can engulf and destroy target cells, including tumor cells. Some macrophages undergo a change to become polarized M2 macrophages while devouring cancer cells. M2 macrophages play important roles in metastasis, tumor suppression, and angiogenesis.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Nanoscience & Nanotechnology
Jiabao Ling, Yanzhou Chang, Zhongwen Yuan, Qi Chen, Lizhen He, Tianfeng Chen
Summary: This study proposes a feasible therapeutic strategy for depleting lactate and reconstructing an immunosuppressive tumor microenvironment using Se-containing nanosheets, which can restore the potent tumor-killing activity of macrophages, thereby amplifying the effects of TAM-based antitumor immunotherapy.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Pharmacology & Pharmacy
Oishani Chaterjee, Debjeet Sur
Summary: Macrophages are mature form of monocytes that can shift from one phenotype to another through the process of macrophage polarization. Different phenotypes of macrophages have different functions with M1 macrophages being responsible for immune responses and M2 macrophages having healing properties. Maintaining macrophage homeostasis is important to avoid tissue damage and ensure proper wound healing and angiogenesis.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Ziwan Xu, Wenyao Zhen, Caroline McCleary, Taokun Luo, Xiaomin Jiang, Cheng Peng, Ralph R. Weichselbaum, Wenbin Lin
Summary: In this study, a novel nanoscale metal-organic framework (nMOF) Hf-TP-SN, containing an X-ray-triggerable 7-ethyl-10-hydroxycamptothecin (SN38) prodrug, was designed for synergistic radiotherapy and chemotherapy. Upon X-ray irradiation, Hf-12 secondary building units served as radiosensitizers to enhance the generation of hydroxyl radicals, leading to the on-demand release of SN38. The Hf-TP-SN showed 5-fold higher release of SN38 compared to its molecular counterpart, resulting in significant cytotoxicity to cancer cells and efficient tumor growth inhibition in colon and breast cancer mouse models.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Review
Pharmacology & Pharmacy
Ye Li, Xiaomin Wang, Xiaoran Ma, Cun Liu, Jibiao Wu, Changgang Sun
Summary: Polysaccharides, as adjuvant drugs in cancer immunotherapy, can activate immune cells, regulate adaptive immune pathways, and improve immune suppression, suggesting a promising future in cancer therapy.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Cell Biology
Xiaomin Wang, Ye Li, Li Han, Jie Li, Cun Liu, Changgang Sun
Summary: Iron overload is a high risk factor for many diseases, while flavonoids have been found to affect iron status and may act as potential complementary therapies.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Oncology
Yiwei Xu, Xiaomin Wang, Lijuan Liu, Jia Wang, Jibiao Wu, Changgang Sun
Summary: The number and phenotype of macrophages play a crucial role in tumor growth, progression, and prognosis. Targeting tumor-associated macrophages can improve the efficacy of cancer treatment by modifying the tumor microenvironment and reducing immunosuppression.
INTERNATIONAL JOURNAL OF ONCOLOGY
(2022)
Review
Medicine, Research & Experimental
Xintong Zhou, Xiaomin Wang, Qi Sun, Wenfeng Zhang, Cun Liu, Wenzhe Ma, Changgang Sun
Summary: This paper discusses the infiltration and polarization effects of natural compounds on lung cancer tumor-associated macrophages (TAMs), provides a detailed classification and systematic review of natural compounds, and summarizes the bias of different kinds of natural compounds by affecting their antitumor mechanism of TAMs, with the aim of providing new perspectives and potential therapeutic drugs for targeted macrophages in the treatment of lung cancer.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Medicine, Research & Experimental
Xiaomin Wang, Yiwei Xu, Qi Sun, Xintong Zhou, Wenzhe Ma, JiBiao Wu, Jing Zhuang, Changgang Sun
Summary: Tumor-associated macrophages (TAMs) play a crucial role in tumor microenvironment and their invasion in tumors is closely related to poor prognosis. However, studying TAMs' heterogeneity and developing drugs targeting them is challenging. Single-cell RNA sequencing (scRNA-seq) provides an efficient detection method to reveal TAMs' heterogeneity and offers more accurate information for TAM-related studies.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Pharmacology & Pharmacy
Qi Sun, Qi Liu, Xintong Zhou, Xiaomin Wang, Huayao Li, Wenfeng Zhang, Hailian Yuan, Changgang Sun
Summary: In recent years, the focus of tumor therapy has shifted to multi-mode interventions in the tumor microenvironment. Flavonoids have diverse immunomodulatory and anti-cancer activities in the tumor microenvironment. This study provides a comprehensive understanding of how flavonoids regulate tumor-associated macrophages and discusses their potential implications in cancer immunotherapy.
PHARMACOLOGICAL RESEARCH
(2022)
Review
Immunology
Liguang Fang, Kunjing Liu, Cun Liu, Xiaomin Wang, Wenzhe Ma, Wenhua Xu, Jibiao Wu, Changgang Sun
Summary: This article summarizes the dynamic evolution of inflammation from acute to chronic in tumor development and its impact on T cells. Understanding the state of inflammation and T cells at different stages is crucial for clinical decision-making and improving the efficacy of tumor immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Oncology
Xinru Zhou, Yin Jia, Chuanbin Mao, Shanrong Liu
Summary: Small extracellular vesicles (sEVs), such as exosomes, have emerged as crucial targets for liquid biopsy and promising drug delivery vehicles in tumor progression. They can serve as biomarkers for tumor diagnosis and as drug carriers for cancer treatment.
Article
Oncology
Ruochan Chen, Ju Zhu, Xiao Zhong, Jie Li, Rui Kang, Daolin Tang
Summary: The interplay between autophagy and apoptosis plays a crucial role in tumorigenesis and cancer therapy, with HMGB1 serving as a key regulator in these processes.
Article
Oncology
Zongfu Pan, Xixuan Lu, Tong Xu, Jinming Chen, Lisha Bao, Ying Li, Yingying Gong, Yulu Che, Xiaozhou Zou, Zhuo Tan, Ping Huang, Minghua Ge
Summary: This study uncovered the emerging role of HN1 in promoting dedifferentiation of anaplastic thyroid cancer (ATC) cells. HN1 negatively regulated the thyroid differentiation markers and had an inhibitory effect on the transcriptional activation of CTCF, thereby influencing the chromatin accessibility of thyroid differentiation genes.
Article
Oncology
Yi Qin, Shengjun Xiong, Jun Ren, Gautam Sethi
Summary: Autophagy plays an important regulatory role in glioblastoma, and its dysregulation can lead to drug resistance and radioresistance. It also affects stem cell characteristics, overall growth, and metastasis. Therefore, autophagy is a promising target for glioblastoma therapy.
Article
Oncology
Katsuya Nagaoka, Xuewei Bai, Dan Liu, Kevin Cao, Joud Mulla, Chengcheng Ji, Hongze Chen, Muhammad Azhar Nisar, Amalia Bay, William Mueller, Grace Hildebrand, Jin-Song Gao, Shaolei Lu, Hiroko Setoyama, Yasuhito Tanaka, Jack R. Wands, Chiung-Kuei Huang
Summary: This study found that serum 2-OG levels in cholangiocarcinoma patients are associated with the effectiveness of chemotherapy. Patients with progressive disease showed significantly higher levels of serum 2-OG compared to stable disease and partial response patients. The study also revealed that overexpression of ASPH mimics the effects of 2-OG, and knockdown of ASPH improves chemotherapy. Targeting ASPH enhances the effects of chemotherapy by modulating ATM and ATR, two key regulators of DDRs.
