The noradrenergic locus coeruleus as a chronic pain generator

Neuropathic low back pain in clinical practice

(2016) R. Baron et al.   EUROPEAN JOURNAL OF PAIN

Noradrenergic Locus Coeruleus pathways in pain modulation

(2016) Meritxell Llorca-Torralba et al.   NEUROSCIENCE

GABA-A receptor activity in the noradrenergic locus coeruleus drives trigeminal neuropathic pain in the rat; contribution of NAα1 receptors in the medial prefrontal cortex

(2016) R. Kaushal et al.   NEUROSCIENCE

Gabapentin loses efficacy over time after nerve injury in rats

(2016) Masafumi Kimura et al.   PAIN

Increased Noradrenergic Neurotransmission to a Pain Facilitatory Area of the Brain Is Implicated in Facilitation of Chronic Pain

(2015) Isabel Martins et al.   ANESTHESIOLOGY

Impaired Pain-evoked Analgesia after Nerve Injury in Rats Reflects Altered Glutamate Regulation in the Locus Coeruleus

(2015) Masafumi Kimura et al.   ANESTHESIOLOGY

Pharmacotherapy for neuropathic pain in adults: a systematic review and meta-analysis

(2015) Nanna B Finnerup et al.   LANCET NEUROLOGY

Unilateral electrical stimulation of rat locus coeruleus elicits bilateral response of norepinephrine neurons and sustained activation of medial prefrontal cortex

(2014) Aude Marzo et al.   JOURNAL OF NEUROPHYSIOLOGY

Optoactivation of Locus Ceruleus Neurons Evokes Bidirectional Changes in Thermal Nociception in Rats

(2014) L. Hickey et al.   JOURNAL OF NEUROSCIENCE

Gabapentin increases extracellular glutamatergic level in the locus coeruleus via astroglial glutamate transporter-dependent mechanisms

(2014) Takashi Suto et al.   NEUROPHARMACOLOGY

Painful Traumatic Trigeminal Neuropathy: An Open Study on the Pharmacotherapeutic Response to Stepped Treatment

(2014) Yaron Haviv et al.   Journal of Oral & Facial Pain and Headache

The noradrenergic pain regulation system: A potential target for pain therapy

(2013) Antti Pertovaara   EUROPEAN JOURNAL OF PHARMACOLOGY

Noradrenaline increases pain facilitation from the brain during inflammatory pain

(2013) I. Martins et al.   NEUROPHARMACOLOGY

Endogenous analgesic action of the pontospinal noradrenergic system spatially restricts and temporally delays the progression of neuropathic pain following tibial nerve injury

(2013) S. W. Hughes et al.   PAIN

Neural mechanisms of pain and alcohol dependence

(2013) A. Vania Apkarian et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Gabapentin Inhibits γ-Amino Butyric Acid Release in the Locus Coeruleus but Not in the Spinal Dorsal Horn after Peripheral Nerve Injury in Rats

(2012) Masaru Yoshizumi et al.   ANESTHESIOLOGY

Spontaneous Behavioral Responses in the Orofacial Region: A Model of Trigeminal Pain in Mouse

(2012) Marcela Romero-Reyes et al.   HEADACHE

Evidence for a regional specificity in the density and distribution of noradrenergic varicosities in rat cortex

(2012) Kara L. Agster et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Corticostriatal functional connectivity predicts transition to chronic back pain

(2012) Marwan N Baliki et al.   NATURE NEUROSCIENCE

Spinal projections of the A5, A6 (locus coeruleus), and A7 noradrenergic cell groups in rats

(2011) Eveline Bruinstroop et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Depletion of Endogenous Noradrenaline Does Not Prevent Spinal Cord Plasticity Following Peripheral Nerve Injury

(2011) Ken-ichiro Hayashida et al.   JOURNAL OF PAIN

A Trigeminoreticular Pathway: Implications in Pain

(2011) W. Michael Panneton et al.   PLoS One

EFNS guidelines on the pharmacological treatment of neuropathic pain: 2010 revision

(2010) N. Attal et al.   EUROPEAN JOURNAL OF NEUROLOGY

Phasic and Tonic Patterns of Locus Coeruleus Output Differentially Modulate Sensory Network Function in the Awake Rat

(2010) David M. Devilbiss et al.   JOURNAL OF NEUROPHYSIOLOGY

Tuning arousal with optogenetic modulation of locus coeruleus neurons

(2010) Matthew E Carter et al.   NATURE NEUROSCIENCE

Reversal of neuropathic pain by HSV-1-mediated decrease of noradrenaline in a pain facilitatory area of the brain

(2010) I. Martins et al.   PAIN

The evidence for pharmacological treatment of neuropathic pain

(2010) Nanna Brix Finnerup et al.   PAIN

Spinal inhibitory neurotransmission in neuropathic pain

(2009) Bradley K. Taylor   Current Pain and Headache Reports

Retrograde Viral Vector-Mediated Inhibition of Pontospinal Noradrenergic Neurons Causes Hyperalgesia in Rats

(2009) P. W. Howorth et al.   JOURNAL OF NEUROSCIENCE

The locus coeruleus and noradrenergic modulation of cognition

(2009) Susan J. Sara   NATURE REVIEWS NEUROSCIENCE

Noradrenergic neurons in the locus coeruleus contribute to neuropathic pain

(2009) J.J. Brightwell et al.   NEUROSCIENCE

Gabapentin Acts within the Locus Coeruleus to Alleviate Neuropathic Pain

(2008) Ken-ichiro Hayashida et al.   ANESTHESIOLOGY

Descending control of nociception: Specificity, recruitment and plasticity

(2008) M.M. Heinricher et al.   BRAIN RESEARCH REVIEWS

Retrograde adenoviral vector targeting of nociresponsive pontospinal noradrenergic neurons in the rat in vivo

(2008) Patrick W. Howorth et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Peripheral Nerve Injury–Induced Changes in Spinal α2-Adrenoceptor–Mediated Modulation of Mechanically Evoked Dorsal Horn Neuronal Responses

(2008) Wahida Rahman et al.   JOURNAL OF PAIN

Brain derived nerve growth factor induces spinal noradrenergic fiber sprouting and enhances clonidine analgesia following nerve injury in rats

(2007) Ken-ichiro Hayashida et al.   PAIN