TIME to face the reality about evening dosing of antihypertensive drugs in hypertension

Bedtime dosing of antihypertensive medications: systematic review and consensus statement: International Society of Hypertension position paper endorsed by World Hypertension League and European Society of Hypertension

(2022) George Stergiou et al.   JOURNAL OF HYPERTENSION

Cardiovascular outcomes in adults with hypertension with evening versus morning dosing of usual antihypertensives in the UK (TIME study): a prospective, randomised, open-label, blinded-endpoint clinical trial

(2022) Isla S Mackenzie et al.   LANCET

Missing Verification of Source Data in Hypertension Research: The HYGIA PROJECT in Perspective

(2021) Mattias Brunström et al.   HYPERTENSION

Blood pressure medication should not be routinely dosed at bedtime. We must disregard the data from the HYGIA project

(2020) Reinhold Kreutz et al.   BLOOD PRESSURE

Bedtime hypertension treatment improves cardiovascular risk reduction: the Hygia Chronotherapy Trial

(2019) Ramón C Hermida et al.   EUROPEAN HEART JOURNAL

Clinical Value of Ambulatory Blood Pressure: Evidence and Limits

(2015) G. Mancia et al.   CIRCULATION RESEARCH

Evaluating 24-h antihypertensive efficacy by the smoothness index: a meta-analysis of an ambulatory blood pressure monitoring database

(2010) Gianfranco Parati et al.   JOURNAL OF HYPERTENSION