Journal
JOURNAL OF NEUROSCIENCE
Volume 36, Issue 46, Pages 11646-11653Publisher
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.0654-16.2016
Keywords
glomerulus; mitral cells; olfaction; plasticity
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Funding
- National Institute on Deafness and Other Communication Disorders-National Institutes of Health [RO1DC011184, F30DC015161]
- Pennsylvania Department of Health Commonwealth Universal Research Enhancement Program
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The highly specific organization of the olfactory bulb (OB) is well known, but the impact of early odorant experience on its circuit structure is unclear. Olfactory sensory neurons (OSNs) project axons from the olfactory epithelium to the OB, where they form spherical neuropil structures called glomeruli. These glomeruli and the postsynaptic targets of OSNs, including mitral and tufted cells (M/TCs) and juxtaglomerular cells, form glomerular modules, which represent the basic odor-coding units of the OB. Here, we labeled M/TCs within a single glomerular module of the mouseOBand show that odorant exposure that starts prenatally and continues through postnatal day 25 has a major impact on the structure of the glomerular module. We confirm that exposure increases the volume of the activated glomeruli and show that exposure increases M/TC number by >40% in a glomerulus-specific fashion. Given the role of M/TCs in OB output and in lateral inhibition, increasing the number of M/TCs connected to a single glomerulus may also increase the influence of that glomerulus on the OB network and on OB output. Our results show that early odorant exposure has a profound effect on OB connectivity and thus may affect odorant processing significantly.
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