Article
Neurosciences
Esra Al, Fivos Iliopoulos, Vadim V. Nikulin, Arno Villringer
Summary: Our perception of the external world is influenced by internal bodily signals, including the timing of stimulation along the cardiac cycle and fluctuations of heartbeat-evoked potential (HEP) amplitudes. These internal signals affect somatosensory perception and neural processing. Additionally, increased conscious perception seems to be associated with HEP fluctuations in certain brain regions, while engagement in somatosensory tasks leads to decreased HEP amplitudes.
Review
Biochemistry & Molecular Biology
Goran Simic, Mladenka Tkalcic, Vana Vukic, Damir Mulc, Ena Spanic, Marina Sagud, Francisco E. Olucha-Bordonau, Mario Vuksic, Patrick R. Hof
Summary: Emotions are generated by activations of specific neuronal populations in the cerebral cortex, while feelings are conscious emotional experiences of these activations that contribute to enhancing neuronal networks mediating thoughts, language, and behavior. Contemporary theories of emotion highlight the central role of the amygdala as a subcortical emotional brain structure.
Article
Psychology, Biological
Kelley Knapp-Kline, Christopher Ring, David Emmerich, Jasper Brener
Summary: The ability to detect heartbeat sensations plays a crucial role in evaluating individual differences in sensitivity to internal stimuli. The experiment confirmed the involvement of the somatosensory system in cardioception and highlighted the roles of both Pacinian and non-Pacinian somatosensory mechanoreceptors in heartbeat detection.
Article
Clinical Neurology
Yuanshu Chen, Congcong Liu, Fei Xin, Haochen Zou, Yulan Huang, Jinyu Wang, Jing Dai, Zhili Zou, Stefania Ferraro, Keith M. Kendrick, Bo Zhou, Xiaolei Xu, Benjamin Becker
Summary: Major depression (MDD) and generalized anxiety disorder (GAD) are leading causes of disability globally, with marked interpersonal and social impairments. This study used fMRI to investigate whether MDD and GAD share a neural basis during interpersonal processing. Results suggest that the dlPFC is involved in emotion-specific alteration during interpersonal processing, with depression symptom load positively associated with dlPFC reactivity to sad facial expressions. Dysregulated communication between the amygdala and salience network may be specific to depression.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2023)
Article
Psychology, Multidisciplinary
Katja Koelkebeck, Jochen Bauer, Thomas Suslow, Patricia Ohrmann
Summary: This case report describes a male patient with right amygdala damage and an ASD. He displayed a non-response of the amygdala to fearful faces and tended to misinterpret fearful expressions. Moreover, a non-reactivity of both amygdalae to emotional facial expressions at an implicit processing level was revealed.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Behavioral Sciences
Nathan A. Sollenberger, Adam Kimbler, Logan R. Cummings, Jeremy W. Pettit, Timothy Hayes, Guadalupe C. Patriarca, Alejandro L. Vazquez, Philip Shumway, Carlos E. Yeguez, Yasmin Rey, Aaron T. Mattfeld, Dana L. McMakin
Summary: Sleep-related problems can lead to escalating anxiety in early adolescence. Recent studies suggest that sleep depotentiates amygdala reactivity in adults, but this effect is blunted in youth with anxiety. Disruptions in sleep-related affective habituation may be a critical driver of anxiety.
COGNITIVE AFFECTIVE & BEHAVIORAL NEUROSCIENCE
(2023)
Article
Psychology, Biological
Alejandro Luis Callara, Lorenzo Fontanelli, Iacopo Belcari, Gianluca Rho, Alberto Greco, Zan Zelic, Laura Sebastiani, Enrica L. Santarcangelo
Summary: The aim of this study is to explore the difference in heartbeat evoked cortical potential (HEP) between individuals with low and high hypnotizability scores before and after hypnosis induction. The results showed that the HEP amplitude was lower in those with high hypnotizability scores at the right parietal site, possibly due to the functional connection differences between the right insula and parietal cortex. Moreover, the HEP increased in the high hypnotizability group and decreased in the low hypnotizability group throughout the session, which might be attributed to the predominantly internally directed attention in the high group and possible disengagement from the task in the low group. The individual differences in interoception related to hypnotizability could contribute to the variability of experience and behavior in daily life.
Article
Psychology, Biological
Charles Verdonk, Marion Trousselard, Caroline Di Bernardi Luft, Takfarinas Medani, Jean-Baptiste Billaud, Celine Ramdani, Frederic Canini, Damien Claverie, Aurore Jaumard-Hakoun, Francois Vialatte
Summary: This study investigated the relationship between trait mindfulness and body awareness by combining self-report measures and physiological data analysis. The results showed that there was no correlation between HEP amplitude and trait mindfulness, but a potentially unstable association between HEP amplitude and self-reported body awareness. However, a reliable positive correlation was found between self-reported trait mindfulness and body awareness.
Article
Computer Science, Software Engineering
Abdallah El Ali, Rayna Ney, Zeph M. C. van Berlo, Pablo Cesar
Summary: This study investigated the influence of different environments and modes on cardiac interoceptive accuracy. The findings showed that participants tended to underestimate their heart rate, and including audio in the mode increased interoceptive awareness.
IEEE TRANSACTIONS ON VISUALIZATION AND COMPUTER GRAPHICS
(2023)
Review
Psychology, Biological
Anne Buot, Damiano Azzalini, Maximilien Chaumon, Catherine Tallon-Baudry
Summary: This study examined the relationship between cardiac parameters, blood volume, and heartbeat-evoked responses. The findings suggest that HERs fluctuate in sync with stroke volume on a beat-to-beat basis, but ICA correction tailored to the cardiac artifact is necessary. Additionally, easily measurable cardiac parameters can serve as proxies for stroke volume fluctuations when direct measurements are unavailable.
BIOLOGICAL PSYCHOLOGY
(2021)
Article
Psychology, Experimental
Dominika Radziun, Maksymilian Korczyk, Laura Crucianelli, Marcin Szwed, H. Henrik Ehrsson
Summary: Blind individuals have enhanced abilities in perceiving their own heartbeats, which is attributed to heightened cross-modal plasticity after visual loss. This finding has implications for understanding the extent of neuroplasticity, emotional processing, and bodily self-awareness in blind individuals.
JOURNAL OF EXPERIMENTAL PSYCHOLOGY-GENERAL
(2023)
Article
Psychology, Developmental
Eleanor R. Palser, Alejandro Galvez-Pol, Clare E. Palmer, Ricci Hannah, Aikaterini Fotopoulou, Elizabeth Pellicano, James M. Kilner
Summary: Research has found that autistic children show less differentiation in bodily maps of emotion, but this does not impact their objective or subjective interoceptive processing.
Article
Neurosciences
Jungwon Min, Kaoru Nashiro, Hyun Joo Yoo, Christine Cho, Padideh Nasseri, Shelby L. Bachman, Shai Porat, Julian F. Thayer, Catie Chang, Tae-Ho Lee, Mara Mather
Summary: Research indicates that different brain regions are involved in regulating and assessing emotions during upregulation and downregulation. Upregulation of emotions increases activity in regions associated with emotional experience and sympathetic vascular activity, while downregulation decreases activity in regions receiving interoceptive input. However, subjective sense of emotional intensity is associated with activity in overlapping brain regions across upregulation and downregulation.
JOURNAL OF NEUROSCIENCE
(2022)
Review
Psychology, Biological
Noemie Parrinello, Jessica Napieralski, Alexander L. Gerlach, Anna Pohl
Summary: Emotion theories highlight the importance of bodily changes in the formation of individual emotions. This meta-analysis examines the relationship between interoceptive accuracy and emotion intensity perception. The results indicate a significant association between interoceptive accuracy and emotion intensity perception when emotions are experimentally induced, but not in studies without emotion induction. The findings also suggest biases and differences in study protocols that need to be addressed in future research.
PHYSIOLOGY & BEHAVIOR
(2022)
Article
Psychology, Biological
Niia Nikolova, Olivia Harrison, Sophie Toohey, Malthe Braendholt, Nicolas Legrand, Camile Correa, Melina Vejlo, Martin Snejbjerg Jensen, Francesca Fardo, Micah Allen
Summary: Respiratory interoception is a core homeostatic ability that is closely related to mental and physical health. Existing methods for measuring respiratory interoception are limited and challenging. To facilitate research in this area, a new fully automated and computer-controlled apparatus and method have been developed for flexible measurement of respiratory-related sensitivity, bias, and metacognition.
BIOLOGICAL PSYCHOLOGY
(2022)
Article
Neurosciences
Jamie D. Feusner, Florian Kurth, Eileen Luders, Ronald Ly, Wan-Wa Wong
Summary: This study found that individuals with BDD have larger gray matter volumes in the early extrastriate visual cortex, consistent with previous neuroimaging studies. This may be related to the specific functional abnormalities in these regions that are characteristic of BDD.
BIOLOGICAL PSYCHIATRY-COGNITIVE NEUROSCIENCE AND NEUROIMAGING
(2023)
Editorial Material
Neurosciences
Negar Fani, Sahib S. Khalsa
NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Psychiatry
Stuart B. Murray, Ryan P. Cabeen, Kay Jann, Reza Tadayonnejad, Michael Strober, Jamie D. Feusner
Summary: The study found that adolescents with anorexia nervosa exhibit reduced neurite and myelin density, as well as reduced orientation dispersion in white matter tracts connecting prominent reward system nodes. There were no significant relationships between tract microstructure and reward responsiveness, compulsive behaviors, illness duration, or BMI.
ACTA PSYCHIATRICA SCANDINAVICA
(2023)
Article
Psychiatry
David Castle, Jamie Feusner, Judith M. Laposa, Peggy M. A. Richter, Rahat Hossain, Ana Lusicic, Lynne M. Drummond
Summary: In order to improve treatment options for OCD, it is important to consider the role of iterative or alternate psychotherapies as well as the potential of digital technologies. Personalized treatment choices that take into account clinical, genetic, and neuroimaging predictors of treatment response should also be embraced.
COMPREHENSIVE PSYCHIATRY
(2023)
Article
Neurosciences
Feliberto De la Cruz, Adam R. Teed, Rachel C. Lapidus, Valerie Upshaw, Andy Schumann, Martin P. Paulus, Karl-Jurgen Bar, Sahib S. Khalsa
Summary: This study found that individuals with anorexia nervosa (AN) exhibit dysregulated neural coupling between central autonomic network brain regions and other brain regions involved in motor, premotor, frontal, parietal, and visual processes. These functional connectivity changes were associated with trait anxiety, depression, and negative body image perception, but not with changes in resting heart rate.
BIOLOGICAL PSYCHIATRY-COGNITIVE NEUROSCIENCE AND NEUROIMAGING
(2023)
Article
Psychiatry
Franklin R. Schneier, Jamie Feusner, Michael G. Wheaton, Gloria J. Gomez, Giselle Cornejo, Akansha Mahesh Naraindas, David J. Hellerstein
Summary: This study aimed to test the feasibility, tolerability, safety, and efficacy of psilocybin treatment for body dysmorphic disorder (BDD). The results showed that psilocybin had a significant therapeutic effect on BDD, supporting the need for further controlled studies.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Willem B. Bruin, Yoshinari Abe, Pino Alonso, Alan Anticevic, Lea L. Backhausen, Srinivas Balachander, Nuria Bargallo, Marcelo C. Batistuzzo, Francesco Benedetti, Sara Bertolin Triquell, Silvia Brem, Federico Calesella, Beatriz Couto, Damiaan A. J. P. Denys, Marco A. N. Echevarria, Goi Khia Eng, Sonia Ferreira, Jamie D. Feusner, Rachael G. Grazioplene, Patricia Gruner, Joyce Y. Guo, Kristen Hagen, Bjarne Hansen, Yoshiyuki Hirano, Marcelo Q. Hoexter, Neda Jahanshad, Fern Jaspers-Fayer, Selina Kasprzak, Minah Kim, Kathrin Koch, Yoo Bin Kwak, Jun Soo Kwon, Luisa Lazaro, Chiang-Shan R. Li, Christine Lochner, Rachel Marsh, Ignacio Martinez-Zalacain, Jose M. Menchon, Pedro S. Moreira, Pedro Morgado, Akiko Nakagawa, Tomohiro Nakao, Janardhanan C. Narayanaswamy, Erika Nurmi, Jose C. Pariente Zorrilla, John Piacentini, Maria Pico-Perez, Fabrizio Piras, Federica Piras, Christopher Pittenger, Janardhan Y. C. Reddy, Daniela Rodriguez-Manrique, Yuki Sakai, Eiji Shimizu, Venkataram Shivakumar, Blair H. Simpson, Carles Soriano-Mas, Nuno M. Sousa, Gianfranco Spalletta, Emily R. Stern, S. Evelyn Stewart, Philip Szeszko, Jinsong Tang, Sophia Thomopoulos, Anders L. Thorsen, Yoshida Tokiko, Hirofumi Tomiyama, Benedetta Vai, Ilya M. Veer, Ganesan Venkatasubramanian, Nora C. Vetter, Chris Vriend, Susanne Walitza, Lea Waller, Zhen Wang, Anri Watanabe, Nicole Wolff, Je-Yeon Yun, Qing Zhao, Wieke A. van Leeuwen, Hein J. F. van Marle, Laurens A. van de Mortel, Anouk van der Straten, Ysbrand D. van der Werf, Paul M. Thompson, Dan J. Stein, Odile A. van den Heuvel, Guido A. van Wingen
Summary: Current knowledge about functional connectivity in obsessive-compulsive disorder (OCD) is based on small-scale studies, limiting the generalizability of results. A mega-analysis of data from 1024 OCD patients and 1028 healthy controls revealed widespread abnormalities in functional connectivity in OCD, including global hypo-connectivity and few hyper-connections mainly with the thalamus. Classification performances based on resting-state connectivity were poor, indicating that it is not an accurate biomarker for identifying individual patients.
MOLECULAR PSYCHIATRY
(2023)
Article
Psychology, Clinical
Clemens Mielacher, Dirk Scheele, Maximilian Kiebs, Laura Schmitt, Torge Dellert, Alexandra Philipsen, Claus Lamm, Rene Hurlemann
Summary: This study found that there are altered neural responses to social touch in patients with major depressive disorder (MDD). Despite clinical improvements after antidepressant treatment, MDD patients still showed aversion to interpersonal touch and reduced brain responses in areas such as the nucleus accumbens compared to healthy controls. These findings reveal the abnormal processing of social touch in MDD, which may contribute to social withdrawal and isolation.
PSYCHOLOGICAL MEDICINE
(2023)
Correction
Psychiatry
Eric Ettore, Philipp Mueller, Jonas Hinze, Matthias Riemenschneider, Michel Benoit, Bruno Giordana, Danilo Postin, Rene Hurlemann, Amandine Lecomte, Michel Musiol, Hali Lindsay, Philippe Robert, Alexandra Koenig
JMIR MENTAL HEALTH
(2023)
Article
Behavioral Sciences
Nilab Nasrullah, Wesley T. Kerr, John M. Stern, Yanlu Wang, Hiroyuki Tatekawa, John K. Lee, Amir H. Karimi, Siddhika S. Sreenivasan, Jerome Engel Jr, Dawn E. Eliashiv, Jamie D. Feusner, Noriko Salamon, Ivanka Savic
Summary: Functional seizures (FS) are associated with neuroanatomic changes in subregions of the amygdala and hippocampus, which align with cerebral changes in chronic stress conditions and depression. These findings may serve as potential biomarkers for diagnosis and treatment.
EPILEPSY & BEHAVIOR
(2023)
Article
Neurosciences
Christopher E. Murphy, Andreas Rhode, Jeremy Kreyling, Scott Appel, Jonathan Heintz, Kerry Osborn, Kyle Lucas, Reza Mohideen, Larry Trusky, Stephen Smith, Jamie D. Feusner
Summary: Exposure and response prevention (ERP) therapy, a form of cognitive-behavioral therapy, is an effective treatment for OCD. To improve treatment adherence, NOCD combines data science, digital interventions, and peer support to identify and support at-risk patients, resulting in increased therapy hours completed and reductions in OCD severity.
FRONTIERS IN HUMAN NEUROSCIENCE
(2023)
Article
Psychiatry
M. Derissen, D. -S. A. Majid, R. Tadayonnejad, R. Seiger, M. Strober, J. D. Feusner
Summary: This study found that anxiety symptoms in patients with anorexia nervosa predicted reductions in body mass index (BMI) over time. Early intervention targeting anxiety may help prevent further clinical worsening in individuals with anorexia nervosa.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Correction
Biochemistry & Molecular Biology
Willem Bruin, Yoshinari Abe, Pino Alonso, Alan Anticevic, Lea Backhausen, Srinivas Balachander, Nuria Bargallo, Marcelo Batistuzzo, Francesco D. Benedetti, Sara G. Bertolin Triquell, Silvia Brem, Federico Y. Calesella, Beatriz Couto, Damiaan A. J. P. Denys, Marco A. N. Echevarria, Goi Khia Q. Eng, Sonia Ferreira, Jamie Feusner, Rachael Grazioplene, Patricia Gruner, Joyce Guo, Kristen Hagen, Bjarne Hansen, Yoshiyuki Hirano, Marcelo Hoexter, Neda Jahanshad, Fern Jaspers-Fayer, Selina Kasprzak, Minah M. Kim, Kathrin S. Koch, Yoo Bin Kwak, Jun Soo Kwon, Luisa Lazaro, Chiang-Shan R. C. Li, Christine L. Lochner, Rachel Marsh, Ignacio Martinez-Zalacain, Jose Menchon, Pedro Moreira, Pedro Morgado, Akiko Nakagawa, Tomohiro Nakao, Janardhanan Narayanaswamy, Erika Nurmi, Jose C. Pariente Zorrilla, John Piacentini, Maria H. Pico-Perez, Fabrizio Piras, Federica Piras, Christopher Pittenger, Janardhan Y. C. R. Reddy, Daniela Rodriguez-Manrique, Yuki R. Sakai, Eiji Shimizu, Venkataram I. Shivakumar, Blair L. Simpson, Carles Soriano-Mas, Nuno Sousa, Gianfranco Spalletta, Emily M. Stern, S. Evelyn Stewart, Philip C. Szeszko, Jinsong Tang, Sophia Thomopoulos, Anders Thorsen, Tokiko Yoshida, Hirofumi Tomiyama, Benedetta Vai, Ilya Veer, Ganesan Venkatasubramanian, Nora A. Vetter, Chris Vriend, Susanne A. Walitza, Lea Waller, Zhen D. Wang, Anri Watanabe, Nicole Wolff, Je-Yeon Yun, Qing Zhao, Wieke van Leeuwen, Hein J. F. van Marle, Laurens van de Mortel, Anouk van der Straten, Ysbrand van der Werf, Honami C. Arai, Irene Bollettini, Rosa Calvo Escalona, Ana Coelho, Federica Colombo, Leila Darwich, Martine Fontaine, Toshikazu Ikuta, Jonathan Ipser, Asier Juaneda-Segui, Hitomi Kitagawa, Gerd Kvale, Mafalda R. Machado-Sousa, Astrid Morer, Takashi G. Nakamae, Jin J. Narumoto, Joseph O'Neill, Sho A. Okawa, Eva Real, Veit A. Roessner, Joao Sato, Cinto D. Segalas, Roseli A. Shavitt, Dick A. Veltman, Kei M. Yamada, Paul J. Thompson, Dan A. Stein, Odile A. van den Heuvel, Guido van Wingen
MOLECULAR PSYCHIATRY
(2023)
Article
Neurosciences
Brigitte Zrenner, Christoph Zrenner, Nicholas Balderston, Daniel M. Blumberger, Stefan Kloiber, Judith M. Laposa, Reza Tadayonnejad, Alisson Paulino Trevizol, Gwyneth Zai, Jamie D. Feusner
Summary: Symptom provocation is an important component in psychiatric research and therapy. By activating specific brain circuits involved in the expression of symptoms, it can provide targets for therapeutic interventions. This article discusses the potential of symptom provocation to identify neurophysiological biomarkers that reflect the activity of relevant brain networks, with the aim of using these markers as targets for therapy.
FRONTIERS IN NEURAL CIRCUITS
(2023)
Article
Medicine, General & Internal
Emily M. Choquette, Michael C. Flux, Scott E. Moseman, Sheridan Chappelle, Jessyca Naegele, Valerie Upshaw, Alexa Morton, Martin P. Paulus, Justin S. Feinstein, Sahib S. Khalsa
Summary: This study found that compared to usual care, Floatation-REST can acutely reduce body dissatisfaction after each float session and at a six-month follow-up for inpatients with anorexia nervosa. Additionally, there were long-term benefits in terms of lower body dissatisfaction for the Floatation-REST group at the six-month follow-up.