Review
Neurosciences
Soshi Samejima, Richard Henderson, Jared Pradarelli, Sarah E. Mondello, Chet T. Moritz
Summary: Spinal cord injuries often result in permanent physical impairments despite being incomplete disruptions. However, remaining connections between the brain and spinal cord can induce neural plasticity to improve sensorimotor function, even years post-injury. This review provides an overview of evidence for motor recovery, plasticity, and interventions in spinal cord stimulation for motor control restoration. It discusses both open-loop and closed-loop stimulation approaches, as well as mechanisms of spinal cord neuromodulation for sensorimotor recovery, aiming to advance rehabilitation for spinal cord injuries.
EXPERIMENTAL NEUROLOGY
(2022)
Review
Cell Biology
Katherine Locke, Margo Randelman, Daniel Hoh, Lyandysha Zholudeva, Michael Lane
Summary: This review focuses on the study of respiratory plasticity in animal models, aiming to shed light on preclinical work that can influence future clinical investigations and treatments for spinal cord injury. Despite extensive research in animal models, relatively few treatments have made it through to clinical application.
NEURAL REGENERATION RESEARCH
(2022)
Article
Clinical Neurology
Ajay Pal, HongGeun Park, Aditya Ramamurthy, Ahmet S. Asan, Thelma Bethea, Meenu Johnkutty, Jason B. Carmel
Summary: In this study, the researchers developed a plasticity protocol in rats that aims to activate both sensory and motor connections in the spinal cord. They found that repeated application of this protocol in rats with spinal cord injury improved their forelimb dexterity and reduced hyperreflexia. This study shows the importance of targeting the sensory and motor systems in the spinal cord for promoting recovery after spinal cord injury.
Article
Neurosciences
Lauren F. Borkowski, Amy N. Keilholz, Catherine L. Smith, Kaylie A. Canda, Nicole L. Nichols
Summary: This study utilized a CTB-SAP rodent model to investigate the effects of motor neuron death on the output of surviving phrenic motor neurons, revealing different outcomes at different time points. Factors contributing to enhancing or constraining phrenic long-term facilitation were explored.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Neurosciences
Latoya L. Allen, Nicole L. Nichols, Zachary A. Asa, Anna T. Emery, Marissa C. Ciesla, Juliet V. Santiago, Ashley E. Holland, Gordon S. Mitchell, Elisa J. Gonzalez-Rothi
Summary: The study tested the hypothesis that C2 spinal hemisection (C2Hx) minimally impacts phrenic motor neuron (PMN) survival and found no evidence of PMN loss at 2- or 8-weeks post-C2Hx. This insight is crucial for studying strategies for inducing plasticity and/or regeneration within the phrenic motor system after high cervical injury.
EXPERIMENTAL NEUROLOGY
(2021)
Article
Immunology
Jia-Lin Liu, Shuai Wang, Zheng-Hong Chen, Rong-Jie Wu, Hai-Yang Yu, Shang-Bin Yang, Jing Xu, Yi-Nan Guo, Ying Ding, Ge Li, Xiang Zeng, Yuan-Huan Ma, Yu-Lai Gong, Chuang-Ran Wu, Li-Xin Zhang, Yuan-Shan Zeng, Bi-Qin Lai
Summary: Transcranial intermittent theta-burst stimulation (iTBS) can reduce inflammation and neuronal apoptosis, promote axonal regeneration and synaptic plasticity, and improve motor function recovery and corticospinal tract regeneration after spinal cord transection injury.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Neurosciences
Marissa C. Ciesla, Yasin B. Seven, Latoya L. Allen, Kristin N. Smith, Zachary A. Asa, Alec K. Simon, Ashley E. Holland, Juliet Santiago, Kelsey Stefan, Ashley Ross, Elisa J. Gonzalez-Rothi, Gordon S. Mitchell
Summary: The study found that there is substantial serotonergic reinnervation following cervical spinal cord injury, but intermittent hypoxia does not affect the extent of reinnervation.
EXPERIMENTAL NEUROLOGY
(2021)
Article
Neurosciences
Timothy D. Faw, Bimal Lakhani, Petra Schmalbrock, Michael V. Knopp, Keith R. Lohse, John L. K. Kramer, Hanwen Liu, Huyen T. Nguyen, Eileen G. Phillips, Anna Bratasz, Lesley C. Fisher, Rochelle J. Deibert, Lara A. Boyd, Dana M. McTigue, D. Michele Basso
Summary: Experience-dependent white matter plasticity offers new potential for rehabilitation-induced recovery after neurotrauma. Downhill training increases myelin water fraction in brain motor learning regions and mixed motor and sensory tracts of the ventral cervical spinal cord in humans, and induces oligodendrogenesis and improves sensorimotor recovery in mice with thoracic SCI.
EXPERIMENTAL NEUROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jian Zhao, Ailang Pang, Saige Yin, Meifeng Yang, Xuemei Zhang, Rong Zhang, Jingfei Liu, Yuanqi Gu, Shanshan Li, Yan Hu, Yue Zhang, Yingchun Ba, Buliang Meng, Xinwang Yang
Summary: OM-LV20 promotes structural and functional recovery of spinal cord injury by increasing neuronal survival, enhancing BDNF and TrkB expression, and regulating oxidative stress balance.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Review
Neurosciences
Tommy Sutor, Kathryn Cavka, Alicia K. Vose, Joseph F. Welch, Paul Davenport, David D. Fuller, Gordon S. Mitchell, Emily J. Fox
Summary: The study found that a single session of acute intermittent hypoxia (AIH) can increase maximal inspiratory pressure generation in adults with chronic spinal cord injury (SCI), but does not affect other breathing functions. Further investigation into the potential therapeutic effects is warranted.
EXPERIMENTAL NEUROLOGY
(2021)
Article
Biology
Afaf Bajjig, Pauline Michel-Flutot, Tiffany Migevent, Florence Cayetanot, Laurence Bodineau, Stephane Vinit, Isabelle Vivodtzev
Summary: This study used spinal cord contusion in mice to mimic human tetraplegia and found that the C3 model was an appropriate model for interventions aimed at restoring breathing following tetraplegia.
Article
Neurosciences
Masahiro Sawada, Yukio Nishimura
Summary: Post-brain damage depression can hinder functional recovery, while higher motivation can facilitate recovery after damage to the central nervous system. The nucleus accumbens (NAcc), traditionally not considered directly linked to motor function, has been shown to contribute to motor performance after spinal cord injury by enhancing motor cortex activity. However, the exact neural mechanisms behind the psychological effects on functional recovery remain unclear.
NEUROSCIENCE RESEARCH
(2021)
Article
Neurosciences
Kristi A. Streeter, Michael D. Sunshine, Paul W. Davenport, David D. Fuller
Summary: The activation of phrenic afferents enhances contralateral phrenic motor amplitude when large-diameter fibers are activated, while recruitment of small-diameter fibers is associated with changes in burst frequency and cardiovascular parameters. Episodic activation of large-diameter phrenic afferents may also induce short-term plasticity.
JOURNAL OF NEUROPHYSIOLOGY
(2021)
Article
Neurosciences
Lauren F. Borkowski, Catherine L. Smith, Amy N. Keilholz, Nicole L. Nichols
Summary: This study found that A2A receptors are required for enhanced pLTF in 7-day CTB-SAP rats, whereas 5-HT receptors are required for moderate pLTF in 28-day CTB-SAP rats. Targeting these time-dependent mechanisms have implications for breathing maintenance over the course of many neuromuscular diseases.
JOURNAL OF NEUROPHYSIOLOGY
(2021)
Review
Neurosciences
Margo Randelman, Lyandysha V. Zholudeva, Stephane Vinit, Michael A. Lane
Summary: This article reviews the anatomical incompleteness and neuroplasticity resulting from spinal cord injuries, as well as how non-invasive respiratory treatments can enhance recovery. It focuses on current clinically used respiratory training strategies and those in development, while also considering the impact of training on non-respiratory networks. Insights are given on advances in pre-clinical and translational research in this area, with a look into future directions for enhancing plasticity and improving functional outcomes after SCI.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Nanoscience & Nanotechnology
Lingxiao Xie, Xiong Ding, Rachel Budry, Guangzhao Mao
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2018)
Article
Oncology
Nadia Saadat, Fangchao Liu, Brittany Haynes, Pratima Nangia-Makker, Xun Bao, Jing Li, Lisa A. Polin, Smiti Gupta, Guangzhao Mao, Malathy P. Shekhar
MOLECULAR CANCER THERAPEUTICS
(2018)
Article
Chemistry, Multidisciplinary
Myunggi An, Chunsong Yu, Jingchao Xi, Joyce Reyes, Guangzhao Mao, Wei-Zen Wei, Haipeng Liu
Article
Clinical Neurology
Fangchao Liu, Yanhua Zhang, Janelle Schafer, Guangzhao Mao, Harry G. Goshgarian
JOURNAL OF SPINAL CORD MEDICINE
(2019)
Correction
Nanoscience & Nanotechnology
Brittany Haynes, Yanhua Zhang, Fangchao Liu, Jing Li, Sarah Petit, Hend Kothayer, Xun Bao, Andrew D. Westwell, Guangzhao Mao, Malathy P. V. Shekhar
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2019)
Article
Physiology
Abdulghani Sankari, Zeljka Minic, Pershang Farshi, Medea Shanidze, Wafaa Mansour, Fangchao Liu, Guangzhao Mao, Harry G. Goshgarian
JOURNAL OF APPLIED PHYSIOLOGY
(2019)
Article
Materials Science, Multidisciplinary
Xuecheng Yu, Mohamed Kilani, Abdurrafay Siddiqui, Guangzhao Mao
ADVANCED MATERIALS TECHNOLOGIES
(2020)
Article
Oncology
Branislava Janic, Stephen L. Brown, Ryan Neff, Fangchao Liu, Guangzhao Mao, Yalei Chen, Latoya Jackson, Indrin J. Chetty, Benjamin Movsas, Ning Wen
Summary: Gold nanoparticles have shown to enhance the efficacy of cancer radiotherapy by localizing radiation energy in tumors, leading to improved cell death. The size of nanoparticles plays a role in this enhancement, with different sizes affecting intracellular targeting and immunological responses.
CANCER BIOLOGY & THERAPY
(2021)
Article
Pathology
Ashapurna Sarma, Ambikai Gajan, Seongho Kim, Katherine Gurdziel, Guangzhao Mao, Pratima Nangia-Makker, Malathy P. V. Shekhar
Summary: Canonical Wnt signaling plays a critical role in melanocyte lineage commitment and melanoma development. RAD6B, a ubiquitin-conjugating enzyme involved in translesion DNA synthesis, enhances beta-catenin stability/activity through a proteasome-insensitive polyubiquitination process. Targeting RAD6B through genetic knockout or selective small-molecule inhibition has been shown to inhibit melanoma cell proliferation and reduce metastasis, suggesting a potential novel strategy for treating melanomas with dysregulated canonical Wnt signaling.
AMERICAN JOURNAL OF PATHOLOGY
(2021)
Article
Multidisciplinary Sciences
Xin Geng, Shuwei Li, Lalani Mawella-Vithanage, Tao Ma, Mohamed Kilani, Bingwen Wang, Lu Ma, Chathuranga C. Hewa-Rahinduwage, Alina Shafikova, Eranda Nikolla, Guangzhao Mao, Stephanie L. Brock, Liang Zhang, Long Luo
Summary: The study introduces a novel bimetallic PbCdSe quantum dot gel sensor with high sensitivity and fast response for detecting NO2 gas. By employing the strategy of atomically dispersed metal ions, the sensor achieves an optimal combination of response and recovery, leading to high performance in NO2 detection.
NATURE COMMUNICATIONS
(2021)
Article
Nanoscience & Nanotechnology
Yifang Wang, Mohannad Mayyas, Jiong Yang, Mohammad B. Ghasemian, Jianbo Tang, Maedehsadat Mousavi, Jialuo Han, Mostak Ahmed, Mahroo Baharfar, Guangzhao Mao, Yin Yao, Dorna Esrafilzadeh, David Cortie, Kourosh Kalantar-Zadeh
Summary: The method presented in the study utilizes liquid metal-based technology to achieve room temperature deposition and patterning of MoO2, providing a new way of fabrication. Through laser writing technique, electrically conductive MoO2 patterns can be obtained on desired substrates. The electrical conductivity and plasmonic properties of MoO2 are analyzed and demonstrated.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Biochemistry & Molecular Biology
Md Musfizur Hassan, Malsha Hettiarachchi, Mohamed Kilani, Xiaohua Gao, Abdulghani Sankari, Cyrille Boyer, Guangzhao Mao
Summary: Respiratory dysfunction is a major cause of death in SCI patients. By utilizing neural tracing proteins to bypass the blood-brain barrier and target respiratory motoneurons in the spinal cord and brainstem, this study introduces a novel approach to deliver drugs with reduced side effects and improved efficacy for treating SCI-related respiratory issues.
ACS CHEMICAL NEUROSCIENCE
(2021)
Meeting Abstract
Oncology
Branislava Janic, Stephen Brown, Ryan Neff, Fangchao Liu, Kevin Bobbitt, Guangzhao Mao, Indrin Chetty, Benjamin Movsas, Ning Wen
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2020)
Meeting Abstract
Oncology
B. Janic, R. Neff, S. L. Brown, F. Liu, G. Mao, I. J. Chetty, B. Movsas, N. Wen
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2020)
Article
Electrochemistry
Disni Gunasekera, Mohamed Kilani, Xuecheng Yu, Qianjin Chen, Guangzhao Mao, Long Luo
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
(2019)