Journal
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
Volume 75, Issue 5, Pages 408-414Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/jnen/nlw015
Keywords
G34R; Glioblastoma; H3; Histology; IDH1; K27M; Molecular subgroups
Categories
Funding
- Friedrich-Baur-Stiftung
- K.L. Weigand'sche Stiftung
- Verein zur Forderung von Wissenschaft und Forschung an der Medizinischen Fakultat der LMU Munchen e.V.
- Deutsche Krebshilfe
- Wilhelm Sander Foundation
- Else-Kroner-Fresenius Foundation
Ask authors/readers for more resources
Glioblastomas (GBMs) are malignant brain tumors that can be divided into different molecular subtypes based on genetics, global gene expression, and methylation patterns. Among these subgroups, IDH GBMs carry mutations within IDH1 or IDH2. The K27 and G34 subgroups are characterized by distinct mutations within Histone 3 (H3). These subtypes can be identified by sequencing methods and are particularly found in younger patients. To determine whether the molecular subtypes correlate with distinct histological features among the diverse histologic patterns of GBM, we performed a blinded assessment of the histology of GBMs of 77 patients a parts per thousand currency sign30 years old at the time of biopsy. The tumors were of the following molecular subtypes: IDH (n = 12), H3 K27M (n = 25), H3 G34R (n = 12), or no IDH/H3 mutations (n = 28). Of IDH-mutated cases, 75% had microcystic features or gemistocytic tumor cells. K27 GBMs had higher cell densities and pronounced nuclear pleomorphism, with 28% harboring tumor giant cells. All G34 GBMs had variable extents of a poorly differentiated/primitive neuroectodermal tumor-like morphology. GBMs without IDH/H3 mutations had foci of epitheliod-appearing cells. Thus, molecular GBM subgroups are associated with distinct histological patterns, suggesting that morphological features reflect the specific underlying molecular genetic abnormalities.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available