Fingolimod promotes peripheral nerve regeneration via modulation of lysophospholipid signaling

Activation of Lysophosphatidic Acid Receptor Type 1 Contributes to Pathophysiology of Spinal Cord Injury

(2015) E. Santos-Nogueira et al.   JOURNAL OF NEUROSCIENCE

Improved regeneration after femoral nerve injury in mice lacking functional T- and B-lymphocytes

(2014) Ali Mehanna et al.   EXPERIMENTAL NEUROLOGY

Anti-lysophosphatidic acid antibodies improve traumatic brain injury outcomes

(2014) Peter J Crack et al.   Journal of Neuroinflammation

Fingolimod: Direct CNS effects of sphingosine 1-phosphate (S1P) receptor modulation and implications in multiple sclerosis therapy

(2013) Aran Groves et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Blockage of Lysophosphatidic Acid Signaling Improves Spinal Cord Injury Outcomes

(2012) Yona Goldshmit et al.   AMERICAN JOURNAL OF PATHOLOGY

FTY720 Improves Functional Recovery after Spinal Cord Injury by Primarily Nonimmunomodulatory Mechanisms

(2012) Yusuke Norimatsu et al.   AMERICAN JOURNAL OF PATHOLOGY

Autotaxin and Lysophosphatidic Acid1 receptor-Mediated Demyelination of Dorsal Root Fibers by Sciatic Nerve Injury and Intrathecal Lysophosphatidylcholine

(2010) Jun Nagai et al.   Molecular Pain

Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis

(2010) Volker Brinkmann et al.   NATURE REVIEWS DRUG DISCOVERY

Endogenous antibodies promote rapid myelin clearance and effective axon regeneration after nerve injury

(2010) M. E. Vargas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

G protein-coupled receptors: the inside story

(2009) Kees Jalink et al.   BIOESSAYS

Differential expression of sphingosine-1-phosphate receptors 1-5 in the developing nervous system

(2009) H. Meng et al.   DEVELOPMENTAL DYNAMICS

Functional recovery and facial motoneuron survival are influenced by immunodeficiency in crush-axotomized mice

(2009) Taylor Beahrs et al.   EXPERIMENTAL NEUROLOGY

Immediate anti-tumor necrosis factor-α (etanercept) therapy enhances axonal regeneration after sciatic nerve crush

(2009) Kinshi Kato et al.   JOURNAL OF NEUROSCIENCE RESEARCH

FTY720 Reduces Inflammation and Promotes Functional Recovery after Spinal Cord Injury

(2009) Kangmin D. Lee et al.   JOURNAL OF NEUROTRAUMA

Persistent signaling induced by FTY720-phosphate is mediated by internalized S1P1 receptors

(2009) Florian Mullershausen et al.   Nature Chemical Biology

Anticancer activity of FTY720: Phosphorylated FTY720 inhibits autotaxin, a metastasis-enhancing and angiogenic lysophospholipase D

(2008) Laurens A. van Meeteren et al.   CANCER LETTERS