Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 299, Issue -, Pages 158-163Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2016.09.004
Keywords
Multiple sclerosis; B cell; Precursor; NKT cell; Bone marrow; FACS
Categories
Funding
- Research Foundation of Neuro Sweden, Stockholm
- Research Foundation of the Gothenburg MS Society
- Bjornsson's Research Foundation, Goteborg, Sweden
- Vastra Gotaland region, Sweden [VGFOUREG-570441]
Ask authors/readers for more resources
Contemporary evidence supports that MS immunopathology starts in the peripheral lymphatic system. However, the site and character of crucial initiating events are unknown. We examined subsets of the first stages of blood cells in the bone marrow of 9 MS patients and 11 neurologically healthy controls using FACS analysis. The proportion of natural killer T cells was lower (P = 0.045) in the bone marrow of MS patients, but proportions of hematogenous stem cells, myeloblasts, and B cell precursor subsets in the bone marrow did not differ between MS patients and controls. In this pilot study with a limited number of samples we found no deviation of the early B cell lineage in bone marrow from MS patients. (C) 2016 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available