Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 301, Issue -, Pages 61-64Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2016.10.006
Keywords
Ganglioside; Galactocerebroside; Guillain-Barre syndrome; Electrophysiological study; Demyelinating neuropathy
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Funding
- Ministry of Education, Culture, Sports, Science, and Technology of Japan [26110721, 15H04845]
- Practical Research Project for Rare/Intractable Diseases from the Agency for Medical Research and Development, AMED of Japan [16ek0109056h0003]
- Grants-in-Aid for Scientific Research [26110721, 15H04845] Funding Source: KAKEN
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Whether patients who have GBS with antibodies to galactocerebroside (Gal-C) and gangliosides (Gal-C-GS-GBS) more often have demyelinating or axonal neuropathy remains controversial. We assessed the electrophysiological data from 16 patients with Gal-C-GS-GBS based on the two established criteria to clarify this issue. In this largest cohort of Gal-C-GS-GBS, eight patients had demyelinating neuropathy and none exhibited axonal neuropathy on either criterion. These data indicated that antibodies to Gal-C, a myelin antigen, might predominantly be associated with demyelinating neuropathy, even in the presence of concomitant antibodies to gangliosides. (C) 2016 Elsevier B.V. All rights reserved.
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