Review
Materials Science, Multidisciplinary
Na Xu, Wenxin Xu, Manyue Zhang, Jia Yu, Guixia Ling, Peng Zhang
Summary: The traditional way of disease diagnosis faces issues such as wound infection and pain. Minimally invasive detection of biomarkers, using microneedles (MNs) to collect interstitial fluid (ISF) from the skin, has gained attention as a new method for patient monitoring and disease diagnosis. The advantages of MNs, including painless collection and patient compliance, open up new possibilities for individualized and long-term treatments.
ADVANCED MATERIALS TECHNOLOGIES
(2022)
Review
Chemistry, Analytical
Bao Li Zhang, Xiao Peng Zhang, Bo Zhi Chen, Wen Min Fei, Yong Cui, Xin Dong Guo
Summary: The article discusses the applications of microneedle (MN) technology in medical health sensing devices and platforms, including the use of electrochemical biosensors and interstitial fluid (ISF) direct extraction technologies in medical sensing.
MICROCHEMICAL JOURNAL
(2021)
Article
Chemistry, Analytical
Jinze Li, Huiting Lu, Yeyu Wang, Shuangshuang Yang, Yufan Zhang, Wei Wei, YuChun Qiao, Wenhao Dai, Rujiao Ge, Haifeng Dong
Summary: The study introduces an attractive Microneedle (MN) sensor array for minimally invasive monitoring of ISF microRNA and Cu2+, cross-linked through blue-light irradiation. The array displays good mechanical properties and a high swelling ratio for efficient and quantitative detection of miRNA and Cu2+.
ANALYTICAL CHEMISTRY
(2022)
Article
Engineering, Environmental
Hui Huang, Moyuan Qu, Yan Zhou, Wei Cao, Xiaohui Huang, Jian Sun, Wujin Sun, Xingwu Zhou, Meimei Xu, Xing Jiang
Summary: This study designed a microneedle patch for rapid and minimally invasive extraction of interstitial fluid (ISF) for breast cancer patients. By measuring tumor markers, the patch could detect cancer earlier than other common screening methods, leading to timely treatment and prolonged survival.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Nanoscience & Nanotechnology
Zengjie Fan, Yuan Wei, Zhengrong Yin, Haofei Huang, Xiaozhu Liao, Luyi Sun, Bin Liu, Fengzhen Liu
Summary: A microneedle patch loaded with VEGF and NIR-triggered graphene oxide was designed for minimally invasive treatment of myocardial infarction (MI), showing promising application prospects in promoting neovascularization, reducing myocardial fibrosis, and restoring cardiac function.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Review
Medicine, General & Internal
Antonia C. Rowson, Daniel T. Hogarty, Dominic Maher, Lei Liu
Summary: Significant advances have been made in the field of minimally invasive glaucoma surgery (MIGS) devices, which aim to defer or prevent traditional high-risk surgical procedures for certain types of glaucoma. The quality of current studies is generally poor, with a lack of randomized or prospective data.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Girdhari Roy, Prashant Garg, Venkata Vamsi Krishna Venuganti
Summary: The microneedle scleral patch (MSP) demonstrates effective drug delivery to the posterior segment of the eye, showing higher safety scores and efficacy compared to traditional intravitreal injections and other methods.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Chemistry, Analytical
Md Sharifuzzaman, Young Do Shin, Junghyun Yoo, Md Selim Reza, Yang-Rae Kim, Jae Y. Park
Summary: Despite advances in diabetes management, continuous glucose monitoring devices (CGMDs) still have disadvantages due to accuracy, low interference effect, precision, and stability. A new oxygen-insensitive polymeric glucose microneedle (MN) was developed, functionalized with an electron-transfer mediator and graphene oxide to enhance conductivity and sensor performance. The MN showed a wide linear range, low detection limit, high sensitivity, stability, selectivity, and fast response time. In vivo testing on rabbits demonstrated strong correlation between MN-measured interstitial fluid (ISF) glucose concentrations and blood glucose concentrations measured with a commercial glucometer.
Article
Engineering, Electrical & Electronic
Avra Kundu, Spencer Langevin, Adam Rozman, Julia Patrone, Leslie Hamilton, Swaminathan Rajaraman
Summary: A micromilled microneedle flexible patch array fabricated using stainless steel has been demonstrated, showing potential as a bioelectronic interface. Microfabrication of the array with various microneedle geometries has been optimized for minimally invasive applications. The micromilled array was further acid pickled to sharpen the tips for easier penetration through porcine skin, demonstrating potential applications for monitoring skin dehydration.
JOURNAL OF MICROMECHANICS AND MICROENGINEERING
(2021)
Article
Automation & Control Systems
Wen Qi, Hang Su, Ke Fan, Ziyang Chen, Jiehao Li, Xuanyi Zhou, Yingbai Hu, Longbin Zhang, Giancarlo Ferrigno, Elena De Momi
Summary: This study focuses on promoting human-machine interaction through robot-assisted minimally invasive surgery (RAMIS), proposing a multimodal data fusion framework to enhance accuracy, and designing a multi-sensors hardware structure to capture various data. Experimental results demonstrate the effectiveness of this framework in a surgical robot environment, indicating potential collaboration with medical staff in the future.
TRANSACTIONS OF THE INSTITUTE OF MEASUREMENT AND CONTROL
(2022)
Article
Materials Science, Biomaterials
Changyuan Zhan, Fanmao Liu, Zhiran Shen, Xinshuo Huang, Shuang Huang, Xiangling Li, Jing Liu, Jiang Yang, Jiefeng Xu, Xi Xie, Hui-Jiuan Chen
Summary: This study reported the development of a microneedle (MN) extraction system based on patterned electrodes for convenient and minimally invasive detection of bio-analytes. The system could detect corresponding bio-analytes in a minimally invasive manner without causing significant tissue damage. This work provides promising technology to expand the application of POCT for minimal tests on interstitial fluids.
BIOMATERIALS SCIENCE
(2023)
Article
Engineering, Electrical & Electronic
Guillermo M. Besne Villanueva, Peio Lopez-Iturri, Manuel Alegre Esteban, Julio Artieda Gonzalez Granda, Jesus D. Trigo, Luis Serrano-Arriezu, Francisco Falcone, Miguel Valencia Ustarroz
Summary: This study investigates the feasibility of a multimodal system targeting the periauricular area and presents a prototype device. The results show the reliability and practicality of certain parameters, as well as the integration of a wireless body area transceiver.
IEEE SENSORS JOURNAL
(2023)
Editorial Material
Surgery
Rod J. Rohrich, Edward S. Chamata, Justin L. Bellamy, Brendan Alleyne
Summary: This article discusses the indications and technique for the treatment of facial and neck skin laxity using bipolar radiofrequency devices.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2022)
Article
Pharmacology & Pharmacy
Mengfang Wu, Tian Xia, Yaran Li, Tianfa Wang, Shijia Yang, Jinchao Yu, Qiaoyan Liang, Teng Shen, Min Yu, Bing Zhao
Summary: Cardiovascular disease is the leading cause of global mortality. Anticoagulant therapy, specifically using a micro-needle array produced through 3D printing technology, shows potential in preventing thromboembolic disease via transdermal drug delivery without the risk of bleeding.
ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Medicine, General & Internal
Shintaro Oyama, Nobuo Niimi, Masato Mori, Hitoshi Hirata
Summary: In this study, a small intra-articular ultrasound (AUS) probe for upper extremity joint surgery was developed, and its safety and visualization capability were evaluated. The experiments confirmed the biological safety of the AUS probe and demonstrated its sufficient output power level. The reconstructed images of blood vessels and nerves using A-mode imaging of an agar phantom provided proof-of-concept for the AUS probe in upper extremity surgery.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cell & Tissue Engineering
Shun Ouyang, Yan Li, Xing Wu, Yan Wang, Fanmao Liu, Jianning Zhang, Yumin Qiu, Zhe Zhou, Zhichao Wang, Wenhao Xia, Xiufang Lin
Summary: This study found that the angiogenic capacity of EPCs from CAD patients declined in different pH environments, while EPCs from non-CAD individuals showed enhanced angiogenic capacity in acidic conditions. GPR4 expression in EPCs was significantly lower in CAD patients than in non-CAD individuals, and upregulation of GPR4 promoted neovessel formation in EPCs from CAD patients by activating the STAT3/VEGF signaling pathway.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Chemistry, Multidisciplinary
Xiangling Li, Xinshuo Huang, Jingshan Mo, Hao Wang, Qiqi Huang, Cheng Yang, Tao Zhang, Hui-Jiuan Chen, Tian Hang, Fanmao Liu, Lelun Jiang, Qianni Wu, Hongbo Li, Ning Hu, Xi Xie
Summary: This study developed a fully integrated wearable closed-loop system based on a mini-invasive microneedle platform for in situ diabetic sensing and treatment, with features such as painless skin penetration, electrical insulin delivery control, and glucose monitoring. It shows great potential in improving the treatment of diabetic patients.
Review
Nanoscience & Nanotechnology
Xingxing Liu, Jiaru Fang, Shuang Huang, Xiaoxue Wu, Xi Xie, Ji Wang, Fanmao Liu, Meng Zhang, Zhenwei Peng, Ning Hu
Summary: Tumor-on-a-chip devices provide a promising platform for mimicking the complex tumor microenvironment and have the potential to bridge the gap between basic research and clinical applications in cancer biology and therapy. These emerging platforms, integrating 3D cell culture, microfluidic technology, and tissue engineering, offer new insights into the mechanisms of tumor evolution, drug screening, and cancer treatment development.
MICROSYSTEMS & NANOENGINEERING
(2021)
Article
Cardiac & Cardiovascular Systems
Xing Liu, Zhuoshan Huang, Yuanyuan Zhang, Xing Shui, Fanmao Liu, Zhen Wu, Shiyue Xu
Summary: Lacidipine treatment lowers blood pressure in SHR by increasing CXCR7 expression and suppressing P38 and C/EBP-beta. It enhances EC cell viability and function under oxidative stress, cell senescence, and inflammatory activation via the CXCR7/P38 signaling pathway.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Chemistry, Multidisciplinary
Shuang Huang, Tao Zhang, Hongbo Li, Mingyue Zhang, Xingxing Liu, Dongxin Xu, Hao Wang, Zhiran Shen, Qianni Wu, Jun Tao, Wenhao Xia, Xi Xie, Fanmao Liu
Summary: Electric stimulation on the tongue can evoke taste sensations, and a portable flexible tongue electrode array system has been developed to provide electrical stimulation and signal mapping. Tests on rats' tongues show that appropriate electrical stimulation can induce multiple sensations simultaneously, with no significant distinction in the distribution of each sensation on the tongue.
Article
Chemistry, Analytical
Jingshan Mo, Junqing Liu, Shuang Huang, Baoming Liang, Xinshuo Huang, Cheng Yang, Meiwan Chen, Jing Liu, Tong Zhang, Xi Xie, Jun Guo, Fanmao Liu, Hui-Jiuan Chen
Summary: This study demonstrates a method based on impedance measurements and numerical check screening algorithm to determine the transdermal rate of metallic microneedle arrays. Different sizes of metallic sheet microneedle array sensors were fabricated to evaluate different transdermal rates, and in vitro sensing experiments confirmed the effect of transdermal rate on sensing outcomes. Two methods for calculating the transdermal rate were derived, providing foundations for real-time transdermal rate estimation.
Article
Materials Science, Multidisciplinary
Xiaoyi Mo, Zhenxing Wen, Shengli Zhao, Jingshan Mo, Fanmao Liu, Meiwan Chen, Changyuan Zhan, Meng Zhang, Ji Wang, Shifeng Wen, Xi Xie, Hui-Jiuan Chen, Bailing Chen
Summary: This study introduces an integrated micro-extracting system for efficient extraction of interstitial fluid (ISF) and enrichment of biomacromolecular markers. The system utilizes microfabrication technology to create microchannels around dermal capillaries, enabling the enrichment of biomarkers in ISF. With negative pressure, ISF can be extracted efficiently. The system is minimally invasive and stable, making it suitable for disease diagnosis and prognosis.
MATERIALS & DESIGN
(2022)
Article
Chemistry, Multidisciplinary
Dong Liu, Qianni Wu, Wan Chen, Kexin Chen, Haotian Lin, Fanmao Liu, Xi Xie, Hui-jiuan Chen, Weirong Chen
Summary: This study presents a functionalized intraocular lens (R-IOL) with a region-confined photothermal effect for the prevention of posterior capsular opacification (PCO) after cataract surgery. The R-IOL, decorated with a nanoporous gold (NPG) ring, eliminates lens epithelial cells (LECs) and inhibits their migration, thus preventing PCO. The region-confined photothermal effect based on NPG provides a promising strategy to prevent PCO.
Article
Biophysics
Zhiran Shen, Fanmao Liu, Shuang Huang, Hao Wang, Cheng Yang, Tian Hang, Jun Tao, Wenhao Xia, Xi Xie
Summary: Flexible strain sensors play a crucial role in wearable and implantable electronics for human health monitoring and diagnosis. This paper selectively reviews the recent progresses and correlations between the device microstructure and their corresponding applications in flexible strain sensors, highlighting the advancements and potential future challenges in this field.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Chemistry, Multidisciplinary
Qianni Wu, Cheng Yang, Wan Chen, Kexin Chen, Hui-jiuan Chen, Fanmao Liu, Dong Liu, Haotian Lin, Xi Xie, Weirong Chen
Summary: A wireless-powered electrical bandage contact lens (EBCL) is developed to accelerate corneal wound healing and vision recovery through generating a localized external electric field. The electrical stimulation promotes cell migration and alignment, and controls cell division, proliferation, and migration.
Article
Chemistry, Multidisciplinary
Zhiran Shen, Chengduan Yang, Chuanjie Yao, Ziqi Liu, Xinshuo Huang, Zhengjie Liu, Jingshan Mo, Huihua Xu, Gen He, Jun Tao, Xi Xie, Tian Hang, Hui-Jiuan Chen, Fanmao Liu
Summary: In this work, a capacitive-piezoresistive hybrid flexible pressure sensor based on conductive micropillar arrays was developed to detect various physiological mechanical signals. The improved fabrication process and sensing strategy enabled all-round sensing performance and flexible design.
MATERIALS HORIZONS
(2023)
Article
Materials Science, Biomaterials
Changyuan Zhan, Fanmao Liu, Zhiran Shen, Xinshuo Huang, Shuang Huang, Xiangling Li, Jing Liu, Jiang Yang, Jiefeng Xu, Xi Xie, Hui-Jiuan Chen
Summary: This study reported the development of a microneedle (MN) extraction system based on patterned electrodes for convenient and minimally invasive detection of bio-analytes. The system could detect corresponding bio-analytes in a minimally invasive manner without causing significant tissue damage. This work provides promising technology to expand the application of POCT for minimal tests on interstitial fluids.
BIOMATERIALS SCIENCE
(2023)
Article
Engineering, Electrical & Electronic
Cheng Yang, Zhiran Shen, Chuanjie Yao, Shuang Huang, Xinshuo Huang, Jingshan Mo, Chengduan Yang, Meiwan Chen, Hui-Jivan Chen, Tian Hang, Xi Xie, Fanmao Liu
Summary: This study focuses on the fabrication of flexible strain sensors using vertical graphene nanowalls (VG) and their applications in physiological assessment. The sensors were used to collect radial and carotid pulses as well as respiratory rate for risk assessment of cardiac bradycardia, arrhythmias, arrest, and artery stiffening. A wearable circuit was also designed and fabricated for portable physiological monitoring.
ACS APPLIED ELECTRONIC MATERIALS
(2022)
Review
Materials Science, Biomaterials
Xiangling Li, Jingshan Mo, Jiaru Fang, Dongxin Xu, Cheng Yang, Meng Zhang, Hongbo Li, Xi Xie, Ning Hu, Fanmao Liu
JOURNAL OF MATERIALS CHEMISTRY B
(2020)