Article
Endocrinology & Metabolism
Michael P. Greenwood, Mingkwan Greenwood, Soledad Barez-Lopez, Joe W. Hawkins, Katherine Short, Danijela Tatovic, David Murphy
Summary: This study identifies the role of CREB3L1 in coordinating vasopressin synthesis and release, and demonstrates that GLP-1R signaling inhibits the vasopressin system. These findings reveal the mechanisms underlying vasopressin release and provide insight into current therapeutic strategies.
MOLECULAR METABOLISM
(2023)
Review
Biochemistry & Molecular Biology
Yuki Takayanagi, Tatsushi Onaka
Summary: Oxytocin plays a role in anxiety suppression, anti-stress, psychosocial behavior, and reproductive functions; responds to various stressful stimuli; maintains stability, adjusts adaptive set points, and promotes adaptive responses to stressors; involved in treating stress-related disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Neurosciences
Angel Baudon, Etienne Clauss Creusot, Ferdinand Althammer, Christian P. Schaaf, Alexandre Charlet
Summary: The neuropeptide oxytocin has been studied for its effects on physiology, neuronal circuits, and behaviors, particularly sociality. Recent studies have shown the existence and importance of astroglial oxytocin receptors in various brain regions. The role of astrocytic oxytocin receptors in neuromodulation and integrated brain functions still needs further investigation.
PROGRESS IN NEUROBIOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Yi Zhang, Yangyang Zhu, Jinghui Wang, Li Jin, Mingwei Guo, Liwei Chen, Lina Zhang, Yangyang Li, Baocheng Wan, Rong Zhang, Weiping Jia, Cheng Hu
Summary: Nrg4 is an adipose tissue-enriched factor that regulates glucose and lipid metabolism and is closely associated with obesity. It acts on ErbB4 in the hypothalamus, excites PVN neurons, and influences energy balance. Its effects on reducing obesity are mediated through ErbB4-mediated excitation of Oxt release from Oxt neurons.
Article
Neurosciences
Mehwish Abbasi, Michael R. Perkinson, Alexander J. Seymour, Richard Piet, Rebecca E. Campbell, Karl J. Iremonger, Colin H. Brown
Summary: The research found that kisspeptin can directly activate oxytocin neurons during late pregnancy by increasing post-spike excitability. This study is important for understanding the mechanism of kisspeptin's role in pregnancy.
JOURNAL OF PHYSIOLOGY-LONDON
(2022)
Article
Behavioral Sciences
Takako Tokui, Takako Kawakita, Rie Yanagihara, Shuhei Kamada, Saki Minato, Asuka Takeda, Junki Imaizumi, Yuri Yamamoto, Kanako Yoshida, Takeshi Kato, Minoru Irahara, Takeshi Iwasa
Summary: The study found that estradiol can regulate the expression of the oxytocin system in rats, reducing appetite and weight gain by increasing oxytocin levels. Therefore, oxytocin may be a potential target for interventions in metabolic disorders induced by menopause.
HORMONES AND BEHAVIOR
(2021)
Article
Neurosciences
Marie Barbier, Pierre-Yves Risold
Summary: Recent data shows that the STN is actually part of the hypothalamus, along with the premammillary and mammillary nuclei, forming a larger brain region. This region is characterized by receiving convergent projections from the cortex and pallidum, interacting with distinct functional networks that adjust behavior based on external and internal contexts in coordination with the ventral mesencephalon.
Article
Cardiac & Cardiovascular Systems
Peter Hanna, Michael J. Dacey, Jaclyn Brennan, Alison Moss, Shaina Robbins, Sirisha Achanta, Natalia P. Biscola, Mohammed A. Swid, Pradeep S. Rajendran, Shumpei Mori, Joseph E. Hadaya, Elizabeth H. Smith, Stanley G. Peirce, Jin Chen, Leif A. Havton, Zixi (Jack) Cheng, Rajanikanth Vadigepalli, James Schwaber, Robert L. Lux, Igor Efimov, John D. Tompkins, Donald B. Hoover, Jeffrey L. Ardell, Kalyanam Shivkumar
Summary: This study provides an in-depth examination of the innervation of the sinoatrial node by the right atrial ganglionated plexus in porcine and human hearts. It demonstrates the significant phenotypic diversity of neurons in the ganglionated plexus and their role in modulating cardiac function. The findings suggest that intrinsic cardiac neurons play a crucial role in controlling specific regions of the heart and could pave the way for targeted therapies in the future.
CIRCULATION RESEARCH
(2021)
Article
Neurosciences
Luis Henrique Angenendt da Costa, Nilton Nascimento Santos-Junior, Carlos Henrique Rocha Catalao, Maria Jose Alves Rocha
Summary: The study findings demonstrate that microglial activation modulates the secretion of several hormones to varying degrees during sepsis, and this process is associated with inflammatory mediators produced both centrally and peripherally.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Damien Hunter, Kee Heng, Navdeep Mann, Ravinder Anand-Ivell, Richard Ivell
Summary: This study found that maternal exposure to xenobiotics DBP or DES may cause long-term changes in hypothalamic gene expression and reproductive behavior in offspring, particularly leading to significant impact on gene expression and sexual behavior with DES treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Alexandra Marsillo, Lovena David, Bishoy Gerges, Daniel Kerr, Rodina Sadek, Vitaliy Lasiychuk, David Salame, Youstina Soliman, Silvia Menkes, Aheli Chatterjee, Andrew Mancuso, Probal Banerjee
Summary: FXS, caused by the non-expression of the Fmr1 gene, leads to developmental disorders and abnormal behaviors mainly in males. Activation of PKCε has shown to correct abnormal behaviors in FXS mice during brain development and adulthood.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2021)
Article
Pharmacology & Pharmacy
Fiona O'Brien, Claire H. Feetham, Caroline A. Staunton, Kathryn Hext, Richard Barrett-Jolley
Summary: The transient receptor potential cation channel subfamily V Member 4 (Trpv4) in the paraventricular nucleus (PVN) of the hypothalamus plays an important role in temperature sensitivity of PVN neurons, affecting their activity frequency. At physiological temperatures, the activity frequency of PVN neurons is primarily regulated by Trpm2 channels, while at room temperature, it is mainly regulated by reduced Trpv4 activity.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Konstantina Vraka, Dimitrios Mytilinaios, Andreas P. Katsenos, Anastasios Serbis, Stavros Baloyiannis, Stefanos Bellos, Yannis V. Simos, Nikolaos P. Tzavellas, Spyridon Konitsiotis, Patra Vezyraki, Dimitrios Peschos, Konstantinos I. Tsamis
Summary: This study provides information about the distribution of OX1R in the human hypothalamus. OX1R is mainly found in the lateral hypothalamic area, the lateral preoptic nucleus, the supraoptic nucleus, the dorsomedial nucleus, the ventromedial nucleus, and the paraventricular nucleus. The majority of neurons in these areas (over 80%) express OX1R, with particularly high expression in the lateral tuberal nucleus (over 95% of neurons). These results reveal the distribution of OX1R at the cellular level and discuss its regulatory role in the hypothalamus.
Article
Biology
Susu Pan, Kaili Yin, Zhiwei Tang, Shuren Wang, Zhuo Chen, Yirong Wang, Hongxia Zhu, Yunyun Han, Mei Liu, Man Jiang, Ningzhi Xu, Guo Zhang
Summary: Colorectal cancer is the second leading cause of cancer death globally, with lifestyle factors and inflammatory bowel conditions being risk factors. Research has also linked the development of colorectal tumors to stress, anxiety, and depression. The hypothalamus and its Oxt-producing neurons may influence the progression of colorectal cancer in mice by regulating the activity of an abdominal 'hub' of the nervous system.
Article
Multidisciplinary Sciences
Yoko Kato, Harumi Katsumata, Ayumu Inutsuka, Akihiro Yamanaka, Tatsushi Onaka, Shiro Minami, Chitose Orikasa
Summary: The study demonstrates that neurons expressing melanin concentrating hormone (MCH) in the lateral hypothalamic area (LHA) play a crucial role in parental nursing behavior in mammals. Genetic ablation of these neurons leads to impaired maternal nursing and reduced post-birth survival rates. Additionally, chemogenetic and optogenetic stimulation of LHA-MCH neurons induces parental nursing in virgin female and male mice, highlighting the importance of hypothalamic MCH neural relays in reproductive behavior.
SCIENTIFIC REPORTS
(2021)
Review
Endocrinology & Metabolism
Gareth Leng, John A. Russell
JOURNAL OF NEUROENDOCRINOLOGY
(2019)
Review
Multidisciplinary Sciences
Gareth Leng, Rhodri Ivor Leng, Stewart Maclean
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2019)
Review
Biochemistry & Molecular Biology
Luis Boto, Manuel Pineda, Rafael Pineda
Article
Endocrinology & Metabolism
Catherine Hume, Andrew Allchorne, Valery Grinevich, Gareth Leng, Mike Ludwig
JOURNAL OF NEUROENDOCRINOLOGY
(2019)
Article
Endocrinology & Metabolism
Luis Paiva, Gareth Leng
JOURNAL OF NEUROENDOCRINOLOGY
(2020)
Article
Neurosciences
Yan Tang, Diego Benusiglio, Arthur Lefevre, Louis Hilfiger, Ferdinand Althammer, Anna Bludau, Daisuke Hagiwara, Angel Baudon, Pascal Darbon, Jonas Schimmer, Matthew K. Kirchner, Ranjan K. Roy, Shiyi Wang, Marina Eliava, Shlomo Wagner, Martina Oberhuber, Karl K. Conzelmann, Martin Schwarz, Javier E. Stern, Gareth Leng, Inga D. Neumann, Alexandre Charlet, Valery Grinevich
NATURE NEUROSCIENCE
(2020)
Article
Cell Biology
Violeta Heras, Juan Manuel Castellano, Daniela Fernandois, Inmaculada Velasco, Elvira Rodriguez-Vazquez, Juan Roa, Maria Jesus Vazquez, Francisco Ruiz-Pino, Matias Rubio, Rafael Pineda, Encarnacion Torres, Maria Soledad Avendano, Alfonso Paredes, Leonor Pinilla, Denise Belsham, Carlos Dieguez, Francisco Gaytan, Nuria Casals, Miguel Lopez, Manuel Tena-Sempere
Article
Endocrinology & Metabolism
Encarnacion Torres, Inmaculada Velasco, Delphine Franssen, Violeta Heras, Francisco Gaytan, Silvia Leon, Victor M. Navarro, Rafael Pineda, M. Luz Candenas, Antonio Romero-Ruiz, Manuel Tena-Sempere
Summary: The study explored the role of NK2R in the neuroendocrine control of the reproductive axis using a novel Tacr2 knockout mouse model. Results showed that NK2R stimulation elicited LH responses in mice, with partial suppression of basal and stimulated LH secretion in Tacr2 knockout mice, impacting LH pulsatility and breeding intervals. NK2R plays a modest role in the gonadotropic axis, overlapping with other tachykinin receptors.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2021)
Article
Endocrinology & Metabolism
Antonio Romero-Ruiz, Beatriz Pineda, David Ovelleiro, Cecilia Perdices-Lopez, Encarnacion Torres, Maria J. Vazquez, Ipek Guler, Alvaro Jimenez, Rafael Pineda, Mariasara Persano, Cristina Romero-Baldonado, Jose E. Arjona, Juan Lorente, Concepcion Munoz, Elier Paz, Fe-Isabel Garcia-Maceira, Alvaro Arjona-Sanchez, Manuel Tena-Sempere
Summary: This study developed a tool for accurate diagnosis of PCOS through targeted miRNA profiling, which can also distinguish between PCOS and obesity. The method is reliable for diagnosing non-obese women with PCOS and distinguishing between these two conditions.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Rafael Pineda, Encarnacion Torres, Manuel Tena-Sempere
Summary: Body energy and metabolic homeostasis are tightly controlled by multiple regulatory mechanisms, connected with reproductive signals and amygdala pathways for the integral control of energy balance and gonadal function. This article aims to summarize the role of the amygdala as a key brain region in emotional learning, behavior, and reward processing, in the physiological control of feeding and energy balance.
Article
Immunology
Carmen Navarrete, Adela Garcia-Martin, Alejandro Correa-Saez, Maria E. Prados, Francisco Fernandez, Rafael Pineda, Massimiliano Mazzone, Marina Alvarez-Benito, Marco A. Calzado, Eduardo Munoz
Summary: This study reveals that VCE-004.8 regulates the PP2A/B55 alpha/PHD2/HIF pathway and shows potential efficacy in the treatment of traumatic brain injury (TBI) by preventing blood-brain barrier disruption, enhancing angiogenesis, and ameliorating neuroinflammation and neurodegeneration after brain injury.
JOURNAL OF NEUROINFLAMMATION
(2022)
Letter
Oncology
Mari C. Vazquez-Borrego, Melissa Granados-Rodriguez, Florina I. Bura, Ana Martinez-Lopez, Blanca Rufian-Andujar, Francisca Valenzuela-Molina, Lidia Rodriguez-Ortiz, Sergio Haro-Yuste, Ana Moreno-Serrano, Rosa Ortega-Salas, Rafael Pineda-Reyes, Carmen Michan, Jose Alhama, Antonio Romero-Ruiz, Alvaro Arjona-Sanchez
Summary: In this study, the efficacy of a small-molecule KRAS(G12D) inhibitor, MRTX1133, was tested in a high-grade PMP xenograft mouse model carrying a KRAS(G12D) mutation. The results showed a profound inhibition of tumor growth, associated with a reduction in cell proliferation, an increase in apoptosis, and a reduction in the MAPK and PI3K/AKT/mTOR signaling pathways.
EXPERIMENTAL HEMATOLOGY & ONCOLOGY
(2023)
Article
Physiology
Takahiro Tsuji, Chiharu Tsuji, Maja Lozic, Mike Ludwig, Gareth Leng
PHYSIOLOGICAL REPORTS
(2019)
Review
Physiology
Catherine Hume, Gareth Leng
CURRENT OPINION IN PHYSIOLOGY
(2019)
Meeting Abstract
Clinical Neurology
G. Leng
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2019)