Review
Immunology
Yu Gan, Xiaoying Li, Shuangze Han, Qi Liang, Xiaoqian Ma, Pengfei Rong, Wei Wang, Wei Li
Summary: The cGAS/STING pathway plays a crucial role in the immune system by recognizing abnormal DNA and activating the STING signaling pathway, leading to immune responses. However, chronic activation of STING may promote tumorigenesis in anticancer therapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Liang Ou, Ao Zhang, Yuxing Cheng, Ying Chen
Summary: The cGAS-STING signal pathway is an important innate immune signal pathway that plays a role in regulating cancer, autoimmune and inflammatory diseases, microbial and parasitic infectious diseases, as well as bridging innate immunity and adaptive immunity.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Zhuoying Tian, Yue Zeng, Yurong Peng, Junqi Liu, Fang Wu
Summary: Activation of the cGAS-STING pathway by cytoplasmic DNA leads to the production of Type-1 interferons, which play a critical role in cancer-immunity cycle. Research has shown that combination therapy of STING agonists has made progress in preclinical and clinical trials, but selecting appropriate combination therapy regimens remains a challenge.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Ghazal Mohseni, Juan Li, Abakundana Nsenga Ariston Gabriel, Lutao Du, Yun-shan Wang, Chuanxin Wang
Summary: Activation of the STING signaling pathway has been shown to enhance immune responses against malignancy, especially in highly immunosuppressive tumor microenvironments like pancreatic cancer. Utilizing STING in various strategies has shown promise in the treatment of pancreatic cancer, and ongoing research is focusing on new advances in STING-based immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Engineering, Biomedical
Lei Cao, Huixiang Tian, Man Fang, Zhe Xu, Dongsheng Tang, Juan Chen, Jiye Yin, Haihua Xiao, Kun Shang, Hongbin Han, Xiangping Li
Summary: This study developed a new nano delivery system to activate the cGAS-STING pathway and enhance the effect of chemotherapy and immunotherapy by releasing chemotherapeutic drugs cisplatin and camptothecin. It provides a new strategy for clinical antitumor therapy.
Article
Engineering, Biomedical
Yi Zheng, Jing Chen, Xin-Ran Song, Mei-Qi Chang, Wei Feng, Hui Huang, Cai-Xia Jia, Li Ding, Yu Chen, Rong Wu
Summary: This study presents a combined tumor-therapeutic strategy of Prussian blue (PB)-mediated photothermal therapy and Mn2+-augmented immunotherapy by activating the cGAS-STING pathway. The treatment successfully activates local and systemic immune responses, inhibiting the growth of primary and distant metastatic tumors in mice.
Article
Chemistry, Multidisciplinary
Minhui Cui, Dongsheng Tang, Bin Wang, Hanchen Zhang, Ganghao Liang, Haihua Xiao
Summary: This study presents novel nanoparticles based on aggregation-induced emission (AIE) photosensitizer for targeted tumor therapy and near-infrared II fluorescence imaging (NIR-II FLI). These nanoparticles exhibit multifaceted effects including photodynamic therapy (PDT), photothermal therapy (PTT), and NIR-II FLI upon 808 nm laser irradiation, resulting in enhanced immune response and significant tumor inhibition.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Shiyu Du, Chao Chen, Suchen Qu, Hongxiu Song, Jingjing Yang, Yayao Li, Kunguo Liu, Qianglan Lu, Wen Luo, Runtian Wang, Xiaoxiang Guan, Yujun Song, Xin Han
Summary: Immunotherapy is a promising therapeutic strategy against cancer, but it faces challenges. This study develops a strategy of multiple activation of immune pathways to treat tumors through the combination of gene therapy and immunotherapy. The study finds that a pH/glutathione responsive drug-loading nanosystem can effectively enhance drug delivery and generate immune activation effects to destroy tumor cells.
Article
Engineering, Biomedical
Qianglan Lu, Ruiyue Chen, Shiyu Du, Chao Chen, Yongchun Pan, Xiaowei Luan, Jingjing Yang, Fei Zeng, Bangshun He, Xin Han, Yujun Song
Summary: This study reports a nanoplatform that utilizes CRISPR-Cas9 gene editing and cGAS-STING pathway activation to trigger long-term immunotherapy by silencing PD-L1 immune checkpoint. In the tumor microenvironment, the nanoplatform can persistently activate the cGAS-STING pathway and release large amounts of interferon and pro-inflammatory factors. Additionally, the platform can use CRISPR-Cas9 technology to silence the PD-L1 gene, reactivating immune cells to fight against tumors.
Review
Engineering, Biomedical
Yongjuan Li, Xinyan Li, Jinmeng Yi, Yongjian Cao, Zhihai Qin, Zhiyuan Zhong, Weijing Yang
Summary: As the first line of host defense against pathogenic infections, innate immunity plays a key role in anti-tumor immunotherapy. The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) (cGAS-STING) pathway and its activation of proinflammatory cytokines and chemokines have attracted attention for cancer immunotherapy. However, the limitations of small molecule STING agonists, such as fast excretion, low bioavailability, nonspecificity, and adverse effects, hinder their therapeutic efficacy. Nanodelivery systems with appropriate characteristics can address these challenges.
ADVANCED HEALTHCARE MATERIALS
(2023)
Review
Immunology
Lishuang Deng, Zhiwen Xu, Fengqin Li, Jun Zhao, Zhijie Jian, Huidan Deng, Siyuan Lai, Xiangang Sun, Yi Geng, Ling Zhu
Summary: Herpesviruses are large DNA viruses that can establish lifelong infection in hosts, posing a burden on human and animal health. The cGAS-STING signaling pathway plays an important role in the innate immunity against herpesvirus infections.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Engineering, Environmental
Wencheng Xu, Luying Qiao, Zhifang Wang, Yanrong Qian, Lei Li, Qianqian Sun, Chunxia Li
Summary: HER2 can inhibit the immune activity of the cGAS-STING pathway, reducing its anti-tumor efficacy. Therefore, by designing a nanosystem and introducing the HER2-specific inhibitor Lapatinib, the immune therapeutic effect of the cGAS-STING pathway can be enhanced.
CHEMICAL ENGINEERING JOURNAL
(2023)
Review
Oncology
Qinfu Dan, Yang Yang, Hong Ge
Summary: Immunotherapy has revolutionized lung cancer treatment and improved overall survival for advanced patients, but many are still resistant. The cGAS-STING pathway has shown potential in overcoming resistance and enhancing antitumor immunity, making it a promising target for new therapies.
CURRENT CANCER DRUG TARGETS
(2023)
Article
Chemistry, Multidisciplinary
Feixiang Ding, Junyan Liu, Kelong Ai, Chun Xu, Xiaoyuan Mao, Zhaoqian Liu, Haihua Xiao
Summary: This study presents a tumor-specific nanotheranostic platform that combines photodynamic therapy (PDT) with epigenetic therapy to simultaneously activate pyroptosis and the cGAS-STING pathway in a light-controlled manner. The approach involves the use of oxidation-sensitive nanoparticles loaded with a photosensitizer and decitabine nanomicelles to restore the expression of gasdermin and STING. The study demonstrates the potential of this strategy for targeted photoimmunotherapy in immunotolerant tumors.
ADVANCED MATERIALS
(2023)
Article
Multidisciplinary Sciences
Manuel Adrian Suter, Nikki Y. Tan, Chung Hwee Thiam, Muznah Khatoo, Paul A. MacAry, Veronique Angeli, Stephan Gasser, Y. L. Zhang
Summary: Deficiencies in DNA repair and nucleases lead to cytosolic DNA accumulation. The cGAS-STING pathway is important for detecting cytosolic DNA, but its function can be modulated by IL-6 and JAK2/STAT3 signaling pathways in cancer cells, affecting interferon expression and tumor rejection.
SCIENTIFIC REPORTS
(2021)
Review
Pharmacology & Pharmacy
Lingyun Yi, Yanan Zhang, Xiaoqun Shi, Xiyou Du, Xinyi Wang, Aihua Yu, Guangxi Zhai
JOURNAL OF DRUG TARGETING
(2019)
Review
Pharmacology & Pharmacy
Huiling Cheng, Mengrui Liu, Xiyou Du, Jiangkang Xu, Yujia Zhai, Jianbo Ji, Shuwang He, Guangxi Zhai
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2019)
Review
Pharmacology & Pharmacy
Yuanxiu Liu, Abdur Rauf Khan, Xiyou Du, Yujia Zhai, Haining Tan, Guangxi Zhai
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2019)
Article
Chemistry, Applied
Abdur Rauf Khan, Xiaoye Yang, Xiyou Du, Haotong Yang, Yuanxiu Liu, Abdul Qayyum Khan, Guangxi Zhai
CARBOHYDRATE POLYMERS
(2020)
Article
Pharmacology & Pharmacy
Siyu Sun, Xiyou Du, Manfei Fu, Abdur Rauf Khan, Jianbo Ji, Weidong Liu, Guangxi Zhai
Summary: Galactosamine-modified poly(ethylene glycol)-poly(lactide) polymers were synthesized in this study to design Gal-PEG-PLA/D-alpha-tocopherol polyethylene glycol 1000 succinate (TPGS) micelles for improving the oral absorption of curcumin. The high Gal density GPP3 micelles showed superior uptake in epithelial cells, improved intestinal permeation, and reduced damage to liver and intestinal tissues. These Gal-modified micelles have promising prospects for oral delivery of hydrophobic drugs and targeted delivery to the liver.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Biophysics
Huixian Yan, Xiyou Du, Rujuan Wang, Guangxi Zhai
Summary: TPGS serves as a P-gp inhibitor and drug carrier with unique advantages in reversing multidrug resistance, making it a promising approach for cancer chemotherapy. The latest research on TPGS-based nanodelivery systems demonstrates its potential in preventing MDR and reducing toxic side effects in clinical applications.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Review
Chemistry, Medicinal
Na Qiu, Xiyou Du, Jianbo Ji, Guangxi Zhai
Summary: Polymeric micelles have gained attention as intelligent carriers for curcumin, improving solubility, targeting delivery, prolonging circulation time, and enhancing bioavailability. Research on tumor microenvironment enables the design of stimuli-responsive smart micelles for precise drug release.
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
(2021)
Review
Pharmacology & Pharmacy
Yingying Li, Shan Gao, Xiyou Du, Jianbo Ji, Yanwei Xi, Guangxi Zhai
Summary: Autophagy is a crucial cellular degradation process that impacts health and disease, especially playing a dual role in tumor treatment. Regulating autophagy pathways and utilizing nano drug delivery systems can enhance the efficacy of tumor therapy.
JOURNAL OF DRUG TARGETING
(2022)
Article
Engineering, Biomedical
Yu Zhang, Xiyou Du, Shangui Liu, Huixian Yan, Jianbo Ji, Yanwei Xi, Xiaoye Yang, Guangxi Zhai
Summary: The CPIM nanoplatform combines size-transforming and transcytosis strategies to enhance tumor penetration and drug delivery, resulting in significant effects on tumor penetration, drug transport, and anti-tumor immunity.
Article
Engineering, Biomedical
Zhijing He, He Zhou, Yu Zhang, Xiyou Du, Shangui Liu, Jianbo Ji, Xiaoye Yang, Guangxi Zhai
Summary: This study introduces a novel biomimetic nanoplatform for enhanced cancer treatment through photodynamic therapy (PDT). The platform addresses common challenges faced in PDT treatment, such as hypoxia and resistance mechanisms, by boosting oxygen supply, activating ferroptosis, and blocking CD47-SIRP alpha pathway. The results show that this nanoplatform effectively inhibits tumor growth and metastasis.
Article
Chemistry, Multidisciplinary
Xiyou Du, Xiaoye Yang, Yu Zhang, Shan Gao, Shangui Liu, Jianbo Ji, Guangxi Zhai
Summary: In this study, a new nanosheet D-1/GH was developed to overcome the challenges of skin penetration and tumor infiltration in melanoma treatment. D-1/GH can penetrate the skin through heparin-mediated hydration of the stratum corneum and be transported to the tumor site through blood and lymphatic vessels. D-1/GH can induce immunogenic cell death, recruit immune cells, and boost immune response. Furthermore, D-1/GH can reverse the immunosuppressive tumor microenvironment and suppress tumor metastasis.
Article
Materials Science, Multidisciplinary
Xiyou Du, Yu Zhang, Yanan Zhang, Shan Gao, Xiaoye Yang, Lei Ye, Guangxi Zhai
Summary: This study presents a novel biomimetic nano-carrier for targeted delivery of chemotherapy drugs to melanoma cells. The strategy integrates photothermal therapy, chemotherapy, starvation therapy, and immunotherapy, showing significant efficacy against melanoma.
APPLIED MATERIALS TODAY
(2022)
Article
Nanoscience & Nanotechnology
J. Li, Q. Tian, H. Sun, Y. Zhang, X. Yang, P. Kaur, R. Wang, Y. Fang, H. Yan, X. Du, L. Ye, G. Zhai
Summary: Choroidal neovascularization (CNV) is a common cause of severe vision loss in the elderly. The current treatment method of intravitreal injection of anti-VEGF drug has limitations. In this study, a novel liposome-loaded injectable hydrogel was developed for the treatment of CNV using a minimally invasive sub-tenon's injection. The results showed strong anti-angiogenesis effect and enhanced anti-CNV effect of the drug delivery system, providing a new minimally invasive alternative for neovascular ocular diseases.
MATERIALS TODAY NANO
(2022)