Article
Biochemistry & Molecular Biology
Hao Liu, Nana Li, Ge Kuang, Xia Gong, Ting Wang, Jun Hu, Hui Du, Minxuan Zhong, Jiashi Guo, Yao Xie, Yang Xiang, Shengwang Wu, Yiling Yuan, Xinru Yin, Jingyuan Wan, Ke Li
Summary: Protectin D1 (PTD1) improves hepatic steatosis, inflammation and fibrosis in a NASH mouse model by inhibiting the activation of TLR4 downstream signaling pathway, possibly through upregulation of IRAK-M expression, suggesting a potential new treatment for NASH.
FREE RADICAL BIOLOGY AND MEDICINE
(2024)
Review
Immunology
Kari Ann Shirey, Jorge C. G. Blanco, Stefanie N. Vogel
Summary: Respiratory viral infections, such as influenza, can lead to severe consequences due to misalignments between circulating strains and predicted vaccine strains. In addition to traditional antiviral treatments, blocking the host's immune response may offer a more effective approach to combat these infections.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Qiang Wang, Hairong Zhao, Yuan Gao, Jiaming Lu, De Xie, Wei Yu, Furong He, Weidong Liu, Ichiro Hisatome, Tetsuya Yamamoto, Wei Wang, Jidong Cheng
Summary: Uric acid can alleviate brain damage caused by acute ischemic stroke by inhibiting microglia's inflammatory response, thereby protecting cell viability and reducing the release of inflammatory factors.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Chao Han, Xue Zhang, Kaixin Dou, Weichao Yao, Minyi Yao, Qi Wan, Anmu Xie
Summary: This study found that repetitive transcranial magnetic stimulation (rTMS) may be a promising method for alleviating neuroinflammation in a rat model of Parkinson's disease (PD), and the effects might be mediated through the downregulation of the HMGB1/TLR4 pathway.
MOLECULAR BIOLOGY REPORTS
(2023)
Article
Immunology
Jinfeng Xie, Bingtian Bi, Yunyun Qin, Wenli Dong, Jiahong Zhong, Mengfan Li, Yufang Cheng, Jiangping Xu, Haitao Wang
Summary: Inhibition of phosphodiesterase-4 (PDE4) can reduce depressive symptoms and inflammation in mice, showing potential as antidepressant drugs. The down-regulation of HMGB1/RAGE signaling pathway and suppression of inflammasome may contribute to the antidepressant-like effects of PDE4 inhibitors.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Medicine, Research & Experimental
Xiaoyu Duan, Jing Wen, Min Zhang, Chao Wang, Yalan Xiang, Lu Wang, Changwei Yu, Gongying Deng, Miao Yan, Bikui Zhang, Pingfei Fang
Summary: The acute toxicity of Semen Strychni and the detoxification effect of liquorice were investigated in this study. The results showed that treatment with Semen Strychni extracts caused oxidative stress and inflammation in the hippocampus of rats. Liquorice and its active components mitigated Semen Strychni-induced neurotoxicity partly through the HMGB1-related pathway.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Environmental Sciences
Ge Shi, Chunhui Zhang, Guoliang Li, Qian Cai, Min Huang
Summary: Atrazine affects the phagocytic function of microglia by acetylating HMGB1 and inducing its translocation from the nucleus to the cytoplasm.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Biochemistry & Molecular Biology
Ya Gao, Jian Zhang, Shuyue Li, Yidan Zhang, Yuan Zhao, Cui Chang, Ya Qiu, Guofeng Yang
Summary: The study showed that CEGI could alleviate cognitive deficits in APP/PS1 mice by increasing BDNF expression and inhibiting the TLR4/NF-kappa B pathway.
NEUROCHEMICAL RESEARCH
(2021)
Article
Immunology
Kisha Pradhan, Shuo Geng, Yao Zhang, Rui-Ci Lin, Liwu Li
Summary: The study reveals a competing intracellular circuitry involving TRAM and IRAK-M that modulate the polarization of low-grade inflammatory monocytes with an immune-enhancing function. They found that subclinical superlow-dose LPS can trigger the expression of CD40 and CD11a on these monocytes, leading to an exacerbation of the inflammatory environment conducive for chronic diseases. Additionally, mice with IRAK-M deficiency have increased inflammatory monocytes population and reduced CD8 T regulatory cells, while mice with TRAM deficiency exhibit the opposite effect.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Cell Biology
Seung-Woo Kim, Sang-A Oh, Song- Seol, Dashdulam Davaanyam, Ja-Kyeong Lee
Summary: The study found that HMGB1 plays a critical role in mediating NOD2-induced autophagy in microglia. Cytoplasmic accumulation of HMGB1 activates a cell-autonomous pro-autophagic pathway, while extracellular secretion of HMGB1 activates a cell-autonomous pro-inflammatory pathway.
Article
Agriculture, Multidisciplinary
Yue Shang, Min Jiang, Nan Chen, Xue-Li Jiang, Zi-Ying Zhan, Zhi-Hong Zhang, Rong-Mei Zuo, Hui Wang, Xiao-Qi Lan, Jie Ren, Yan-Ling Wu, Zhen-Yu Cui, Ji-Xing Nan, Li-Hua Lian
Summary: This study investigated the inhibitory effects of Digitoflavone (DG) on inflammation and lipid accumulation in alcoholic liver disease (ALD). The results showed that DG reduced lipid and inflammatory levels in ALD mice by inhibiting the HMGB1-TLR4 axis.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Immunology
Laifa Wang, Xueqin Wang, Ling Deng, Hui Zhang, Binsheng He, Wenyu Cao, Yanhui Cui
Summary: Social behavior is crucial for individual well-being and survival. However, social isolation, particularly during the COVID-19 pandemic, has become a serious public health issue, affecting numerous individuals worldwide and potentially leading to significant psychological crises. This study investigated the role of microglia in modulating social isolation and found that inhibiting microglia in the hippocampus could mitigate depressive-like behavior in mice, offering a new perspective for the treatment of psychiatric disorders such as depression.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Environmental Sciences
Chunhua Wan, Tianye Gu, Junyi Ling, Yi Qin, Jiashan Luo, Lingli Sun, Lu Hua, Jianya Zhao, Shengyang Jiang
Summary: This study revealed that subchronic exposure to PFOS may worsen liver fibrosis induced by carbon tetrachloride. The exposure to PFOS led to the activation of the HMGB1/TLR4 signaling pathway, which in turn promoted liver injury and activation of hepatic stellate cells. The study also showed that PFOS exposure induced the translocation of HMGB1 from the nucleus to the cytoplasm, accompanied by calcium flux, suggesting a potential link between calcium signaling and HMGB1 release. Additionally, the study demonstrated that PFOS-exposed conditional medium of hepatocytes induced the translocation of Smad2/3 in hepatic stellate cells in a TLR4-dependent manner.
ENVIRONMENTAL TOXICOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Urszula Hohmann, Chalid Ghadban, Tim Hohmann, Joshua Kleine, Miriam Schmidt, Christian Scheller, Christian Strauss, Faramarz Dehghani
Summary: During injuries in the central nervous system, nimodipine, a lipophilic L-type calcium channel blocking agent, has neuroprotective effects on neurons and affects the survival of glia cells. The protective actions of nimodipine are time-dependent.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Amany A. Alzokaky, Ahmed A. Al-Karmalawy, Mohamed A. Saleh, Walied Abdo, Amira E. Farage, Amany Belal, Mohammed A. S. Abourehab, Samar A. Antar
Summary: The study aims to investigate the preventive role of Metformin in DOX-induced cardiotoxicity. The results showed that Metformin reduced cardiac toxicity caused by DOX, possibly by inhibiting the HMGB1/NF-Kappa B inflammatory pathway and preserving heart function.
Article
Clinical Neurology
Chen Wang, Verena Boerger, Ayan Mohamud Yusuf, Tobias Tertel, Oumaima Stambouli, Florian Murke, Nico Freund, Christoph Kleinschnitz, Josephine Herz, Matthias Gunzer, Aurel Popa-Wagner, Thorsten R. Doeppner, Bernd Giebel, Dirk M. Hermann
Summary: This study demonstrates the neuroprotective and anti-inflammatory effects of MSC-sEVs in aged mice after ischemia, which can reduce neurological deficits, infarct volume, brain edema, neuronal injury, and the infiltration of leukocytes in the brain, as well as decrease the number of monocytes and activated T cells in peripheral blood.
Article
Cell & Tissue Engineering
Fabiola Nardi Bauer, Tobias Tertel, Oumaima Stambouli, Chen Wang, Robin Dittrich, Simon Staubach, Verena Borger, Dirk M. Hermann, Sven Brandau, Bernd Giebel
Summary: Extracellular vesicles (EVs) derived from human mesenchymal stromal cells (MSCs) have shown immunomodulatory activity in various assays. However, it has been observed that only a proportion of the MSC-EV preparations possess immunomodulatory capabilities, and these preparations are able to suppress acute graft-versus-host disease (aGVHD) symptoms. Thus, the development of a standardized potency assay for MSC-EV products is crucial.
Article
Immunology
Jiancong Chen, Yuan Chang, Juan Zhu, Yuqin Peng, Zheqi Li, Kunxue Zhang, Yuzhen Zhang, Chuman Lin, Zhenzhou Lin, Suyue Pan, Kaibin Huang
Summary: The study found that flufenamic acid (FFA) could reduce brain injury after cardiac arrest and CPR by blocking the TRPM4 channel in the neurovascular unit, leading to improved survival and neurological deficits.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Materials Science, Composites
Yunong Zhao, Xiaohui Guo, Weiqiang Hong, Tong Zhu, Tianxu Zhang, Zihao Yan, Kangli Zhu, Jingyi Wang, Guoqing Zheng, Shanan Mao, Kaikai Wang, Yuqing Wang, Chengchao Jin, Guopeng Tang, Shuang Shao, Yun Xia, Guoliang Xing, Qi Hong, Yaohua Xu, Jun Wu
Summary: This paper presents a flexible capacitive pressure sensor that utilizes a biomimetic frog-leg structure as the dielectric layer. A low-cost 3D printing technique is used to fabricate the dielectric layer with 3D features. The dimensional parameters of the dielectric layer structure are optimized through experimental studies, and the feasibility of using the bionic frog-leg structure is evaluated. The sensor exhibits improved sensing performance, rapid response and recovery, and reliable long-term stability.
COMPOSITES SCIENCE AND TECHNOLOGY
(2023)
Article
Physics, Multidisciplinary
Akihiko Sumiyama, Takumi Nagaeki, Akira Yamaguchi, Ke Jia, Jie Yang, Youguo Shi, Guo-qing Zheng
Summary: We measured the DC magnetic susceptibility of single crystals of the quasi-one-dimensional superconductor Cs2Cr3As3. Diamagnetism appears below 1.2 and 2 K for magnetic fields parallel and perpendicular to the c-axis, respectively, whereas the Meissner effect emerges at 1.2 K in both directions, suggesting that, between 1.2 and 2 K, superconductivity is filamentary along the c-axis.
JOURNAL OF THE PHYSICAL SOCIETY OF JAPAN
(2023)
Article
Pharmacology & Pharmacy
Xiao-Jie Zhang, Yi-Jing Wang, Xiao Lu, Peng-Jie Ying, Shi-Yan Qian, Jie Liang, Guo-Qing Zheng
Summary: This study evaluates the reporting quality of randomized controlled trials (RCTs) on HuatuoZaizao pill (HZP) for stroke. The results show that the overall report quality of RCTs related to HZP is low, indicating a need for higher quality RCTs to prove its effectiveness and safety.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Neurosciences
Mina Borbor, Dongpei Yin, Ulf Brockmeier, Chen Wang, Marius Doeckel, Matthias Pillath-Eilers, Britta Kaltwasser, Dirk M. Hermann, Egor Dzyubenko
Summary: This study reveals that astrocytes play a crucial role in the maintenance of neuronal networks and their dysfunction can contribute to neurodegeneration. The researchers found that ischemia-reperfusion induces metabolic reprogramming in astrocytes, resulting in mitochondrial dysfunction and synaptic degeneration. Inhibiting STAT3 signaling pathway and increasing glycogen content in astrocytes can prevent synaptic degeneration.
Article
Engineering, Electrical & Electronic
Decheng Xu, Bing Hu, Guoqing Zheng, Jingyi Wang, Cuicui Li, Yunong Zhao, Zihao Yan, Ziyang Jiao, Yongci Wu, Ming Wang, Huarui Li, Xiaohui Guo
Summary: A sandwich-like flexible tactile sensor with high sensitivity, wide detection range and rapid response time was developed for electronic skin applications. The sensor demonstrated excellent performance in detecting both normal and tangential forces, with low hysteresis. Simulation modeling confirmed the working principle and characteristics of the sensor. Its application in soft manipulator grasping and gamepad rotation highlighted its potential in robotic sensing. This research opens up possibilities for tactile/pressure perception strategies in various fields such as e-skin, soft robotics, dexterous manipulation, and intelligent prosthetics.
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
(2023)
Article
Materials Science, Multidisciplinary
X. Y. Feng, Z. Zhao, J. Luo, J. Yang, A. F. Fang, H. T. Yang, H. J. Gao, R. Zhou, Guo-qing Zheng
Summary: Clarifying the interplay between charge-density waves (CDWs) and superconductivity is important in CsV3Sb5. Under hydrostatic pressures, CDW gradually changes from a commensurate to an incommensurate modulation. The appearance of short-range CDW order and the existence of a CDW quantum critical point (QCP) at a specific pressure suggest their role in determining the maximum superconducting temperature (Tc) in CsV3Sb5.
NPJ QUANTUM MATERIALS
(2023)
Article
Immunology
Dongpei Yin, Chen Wang, Yachao Qi, Ya-Chao Wang, Nina Hagemann, Ayan Mohamud Yusuf, Egor Dzyubenko, Britta Kaltwasser, Tobias Tertel, Bernd Giebel, Matthias Gunzer, Aurel Popa-Wagner, Thorsten R. Doeppner, Dirk M. Hermann
Summary: Intravenous administration of adult neural precursor cells can induce brain tissue remodeling and recovery in mice, but the effects are not persistent in hyperlipidemic mice, and other parameters are not influenced.
JOURNAL OF NEUROINFLAMMATION
(2023)
Article
Biochemistry & Molecular Biology
Yang Zheng, Cenglin Xu, Jinyi Sun, Wenjie Ming, Sijie Dai, Yuying Shao, Xiaoyun Qiu, Menghan Li, Chunhong Shen, Jinghong Xu, Fan Fei, Jiajia Fang, Xuhong Jiang, Guoqing Zheng, Weiwei Hu, Yi Wang, Shuang Wang, Meiping Ding, Zhong Chen
Summary: This study demonstrates the epileptogenic role of the hippocampus in patients with late-stage cortical dysplasia and identifies the involvement of somatostatin-positive interneurons in seizure generalization. This findings provide new insights into the cellular basis of cortical dysplasia-related seizures.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)
Article
Materials Science, Multidisciplinary
M. Yokoyama, H. Nishigaki, S. Ogawa, S. Nita, H. Shiokawa, K. Matano, Guo-qing Zheng
Summary: Electronic nematicity is observed in various new materials as a result of rotational symmetry breaking. In this study, we successfully manipulate the nematic director, the d vector, in the spin-triplet superconducting state of CuxBi2Se3 by magnetic fields. The ac susceptibility related to the upper critical field exhibits a twofold symmetry at H = 0.5 T and a sixfold symmetry at H = 1.5 T, which is unprecedented in any superconductor. The d vector is initially locked in a certain direction but becomes unlocked by a threshold field, respecting the trigonal crystal symmetry.
Article
Chemistry, Applied
Hecang Zang, Yanjing Wang, Xiuzhong Yang, Jia He, Meng Zhou, Guoqing Zheng, Guoqiang Li
Summary: To quickly and accurately obtain density and height information of winter wheat varieties, the use of unmanned aerial vehicles (UAV) images and digital models can provide efficient and precise monitoring methods. The extracted coverage and estimation models based on the images and models showed good applicability in predicting the plant density and height of new wheat varieties.
JOURNAL OF BIOBASED MATERIALS AND BIOENERGY
(2022)
Proceedings Paper
Computer Science, Artificial Intelligence
Guoqing Zheng, Giannis Karamanolakis, Kai Shu, Ahmed Hassan Awadallah
Summary: This paper introduces a benchmark called WALNUT for weak supervision in natural language understanding (NLU) to promote and facilitate further research. WALNUT consists of NLU tasks with weak labels generated by real-world weak sources and a small set of clean labels. Evaluations on WALNUT demonstrate the effectiveness of weak supervision for low-resource NLU tasks and reveal interesting patterns across tasks.
NAACL 2022: THE 2022 CONFERENCE OF THE NORTH AMERICAN CHAPTER OF THE ASSOCIATION FOR COMPUTATIONAL LINGUISTICS: HUMAN LANGUAGE TECHNOLOGIES
(2022)
Article
Remote Sensing
Yan Guo, Jia He, Jingyi Huang, Yuhang Jing, Shaobo Xu, Laigang Wang, Shimin Li, Guoqing Zheng
Summary: This study evaluated the predictability of models established using UAV multispectral images with different spatial resolutions for nitrogen content of winter wheat. The results showed that model performance increased with decreasing image spatial resolution. Additionally, the transferability of models differed when applied to images with coarser or finer resolutions.