Activation of σ1 and σ2 receptors by afobazole increases glial cell survival and prevents glial cell activation and nitrosative stress after ischemic stroke

Activation of Sigma-1 Receptor Alleviates Postpartum Estrogen Withdrawal-Induced “Depression” Through Restoring Hippocampal nNOS-NO-CREB Activities in Mice

(2016) Suyun Zhang et al.   MOLECULAR NEUROBIOLOGY

Sigma-2 receptor binding is decreased in female, but not male, APP/PS1 mice

(2015) Kristoffer Sahlholm et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Pharmacological stimulation of sigma-1 receptors has neurorestorative effects in experimental parkinsonism

(2014) Veronica Francardo et al.   BRAIN

The sigma-1 receptor agonist 4-phenyl-1-(4-phenylbutyl) piperidine (PPBP) protects against newborn excitotoxic brain injury by stabilizing the mitochondrial membrane potential in vitro and inhibiting microglial activation in vivo

(2014) Karina Wegleiter et al.   EXPERIMENTAL NEUROLOGY

Treatment with afobazole at delayed time points following ischemic stroke improves long-term functional and histological outcomes

(2013) C. Katnik et al.   NEUROBIOLOGY OF DISEASE

Neuroprotective effects of the Sigma-1 receptor (S1R) agonist PRE-084, in a mouse model of motor neuron disease not linked to SOD1 mutation

(2013) Marco Peviani et al.   NEUROBIOLOGY OF DISEASE

Inhibitory Effects of Sigma-2 Receptor Agonists on T Lymphocyte Activation

(2013) Miguel A. Iñiguez et al.   Frontiers in Pharmacology

Effects of the Sigma-1 Receptor Agonist 1-(3,4-Dimethoxyphenethyl)-4-(3-Phenylpropyl)-Piperazine Dihydro-Chloride on Inflammation after Stroke

(2012) Karsten Ruscher et al.   PLoS One

The sigma-1 receptor enhances brain plasticity and functional recovery after experimental stroke

(2011) Karsten Ruscher et al.   BRAIN

Sigma-1 receptor ligand PRE-084 reduced infarct volume, neurological deficits, pro-inflammatory cytokines and enhanced anti-inflammatory cytokines after embolic stroke in rats

(2011) Mohammad Allahtavakoli et al.   BRAIN RESEARCH BULLETIN

Expression of IL-10 and TNF-α in Rats with Cerebral Infarction after Transplantation with Mesenchymal Stem Cells

(2010) Nan Liu et al.   Cellular & Molecular Immunology

Human Microglia Transplanted in Rat Focal Ischemia Brain Induce Neuroprotection and Behavioral Improvement

(2010) Dashdemberel Narantuya et al.   PLoS One

Administration of a Sigma Receptor Agonist Delays MCAO-Induced Neurodegeneration and White Matter Injury

(2010) Christopher C. Leonardo et al.   Translational Stroke Research

Sigma receptor ligand 4-phenyl-1-(4-phenylbutyl)-piperidine modulates neuronal nitric oxide synthase/postsynaptic density-95 coupling mechanisms and protects against neonatal ischemic degeneration of striatal neurons

(2009) Zeng-Jin Yang et al.   EXPERIMENTAL NEUROLOGY

Stroke Therapy Academic Industry Roundtable (STAIR) Recommendations for Extended Window Acute Stroke Therapy Trials

(2009) Jeffrey L. Saver et al.   STROKE

Astrocytes are More Resistant to Focal Cerebral Ischemia Than Neurons and Die by a Delayed Necrosis

(2008) Günfer Gürer et al.   BRAIN PATHOLOGY

Sigma receptors suppress multiple aspects of microglial activation

(2008) Aaron A. Hall et al.   GLIA

DHEA-Neuroprotection and -Neurotoxicity after Transient Cerebral Ischemia in Rats

(2008) Zhen Li et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Rat focal cerebral ischemia induced astrocyte proliferation and delayed neuronal death are attenuated by cyclin-dependent kinase inhibition

(2008) Wei Wang et al.   JOURNAL OF CLINICAL NEUROSCIENCE

 -1 Receptor Modulation of Acid-Sensing Ion Channel a (ASIC1a) and ASIC1a-Induced Ca2+ Influx in Rat Cortical Neurons

(2008) Y. Herrera et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS