Article
Behavioral Sciences
Jivago Ropke, Talita H. Ferreira-Vieira, Lia P. Iglesias, Laila Asth, Fabiola M. Ribeiro, Fabricio A. Moreira
Summary: The study demonstrated that increasing endocannabinoid levels can protect rats against haloperidol-induced TD through CB1 receptor mediation. High-VCM rats showed increased CB1 receptor expression, which was positively correlated with the number of VCMs.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2021)
Article
Cell Biology
Chao Hu, Cao Chen, Ying Xia, Jia Chen, Wei Yang, Lin Wang, Dong-Dong Chen, Yue-Zhang Wu, Qin Fan, Xiao-Xi Jia, Kang Xiao, Qi Shi, Zhi-Bao Chen, Xiao-Ping Dong
Summary: This study investigates the role of mGluR5 in prion diseases and its downstream signaling pathways. The results show abnormal alterations of mGluR5 and its downstream kinases during prion infection in both cell lines and animal models. Treatment with mGluR5 antagonist or removal of prion replication can partially restore the abnormal changes. Increased mGluR5 contributes to cell damage in prion-infected cells, while its levels are decreased in the brains of scrapie-infected rodents.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Banny Silva Barbosa Correia, Joao Victor Nani, Raniery Waladares Ricardo, Danijela Stanisic, Tassia Brena Barroso Carneiro Costa, Mirian A. F. Hayashi, Ljubica Tasic
Summary: This study evaluated the effects of antipsychotic drugs on blood serum lipids in an SCZ animal model and normal control rats, revealing similar lipid alterations to those seen in SCZ patients. The use of psychostimulants in normal rats resulted in decreased ω-3 fatty acids, similar to the first episode of psychosis in SCZ. CLZ was found to reverse lipid metabolism changes in SHR.
Article
Multidisciplinary Sciences
Junlin Wang, Richard D. Ye
Summary: The bacteria-derived formyl peptide fMet-Leu-Phe (fMLF) can activate different cellular functions at different concentrations, promoting migration at subnanomolar concentrations and bactericidal activities at higher concentrations. The mechanism of concentration-dependent signaling in FPR1 agonist has been discovered.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Pharmacology & Pharmacy
Sandra M. Martin-Guerrero, Paula Alonso, Alba Iglesias, Marta Cimadevila, Jose Brea, M. Isabel Loza, Pedro Casado, David Martin-Oliva, Pedro R. Cutillas, Javier Gonzalez-Maeso, Juan F. Lopez-Gimenez
Summary: Antipsychotic drugs induce phosphorylation of multiple pathways downstream of 5-HT2AR, and the single nucleotide polymorphism encoding 5-HT2AR-H452Y affects these drug-induced phosphorylation-dependent signaling networks.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Clinical Neurology
Matthew Harlin, Craig Chepke, Frank Larsen, Karimah S. Bell Lynum, Sanjeda R. Chumki, Heather Fitzgerald, Pedro Such, Jessica Madera-McDonough, Murat Yildirim, Moeen Panni, Stephen R. Saklad
Summary: Aripiprazole 2-month ready-to-use 960 mg and Aripiprazole lauroxil 1064 mg are both long-acting injectable formulations used for the treatment of schizophrenia. Comparing the drug concentrations, both formulations maintain therapeutic levels over the 2-month dosing interval.
NEUROPSYCHIATRIC DISEASE AND TREATMENT
(2023)
Article
Behavioral Sciences
Gary Remington, Margaret K. Hahn, Sri Mahavir Agarwal, Araba Chintoh, Ofer Agid
Summary: The introduction of chlorpromazine led to schizophrenia being repositioned as a biological illness. The evolution of antipsychotics, from 'typical' to 'atypical', and drug development that aligns with the illness' heterogeneity and complexity are explored. It may be time to reconsider the notion of developing drugs that specifically treat 'schizophrenia'.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Psychiatry
Yuta Kawakita, Masahiro Takeshima, Tomonari Komatsu, Aya Imanishi, Dai Fujiwara, Yu Itoh, Kazuo Mishima
Summary: This study retrospectively compared the incidence of appendicitis in patients with schizophrenia with and without a history of clozapine exposure, finding a relationship between clozapine exposure and appendicitis onset.
Review
Medicine, General & Internal
Bartosz Dawidowski, Adrianna Gorniak, Piotr Podwalski, Zofia Lebiecka, Blazej Misiak, Jerzy Samochowiec
Summary: Schizophrenia may be associated with immune dysfunction, with alterations in cytokine levels, childhood trauma, and disturbances in the gut microbiome potentially influencing its pathomechanism and clinical presentation. Different subtypes of schizophrenia, such as deficit schizophrenia, show variations in peripheral cytokine levels. The narrative review provides a comprehensive presentation of the evidence, utilizing a holistic approach to understand the complex relationships involved.
JOURNAL OF CLINICAL MEDICINE
(2021)
Biographical-Item
Psychology, Clinical
Mary V. Seeman
Summary: Philip Seeman's discovery of the dopamine D2 receptor's isolation is an example of how a small step can lead to a major shift in our understanding of the etiology of schizophrenia.
PSYCHOLOGICAL MEDICINE
(2022)
Review
Health Care Sciences & Services
Alexandre Gonzalez-Rodriguez, Armand Guardia, Jose Antonio Monreal
Summary: Premenopausal women show better response to antipsychotic drugs, caution is needed in using hormone replacement therapy for postmenopausal women with schizophrenia, and raloxifene combined with antipsychotics can effectively improve psychotic and cognitive symptoms in postmenopausal women with schizophrenia and related disorders.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Clinical Neurology
Mengqing Xia, Yingchan Wang, Wenjun Su, Yingying Tang, Tianhong Zhang, Huiru Cui, Yanyan Wei, Xiaochen Tang, Lihua Xu, Hao Hu, Qian Guo, Zhenying Qian, Xuming Wu, Chunbo Li, Jijun Wang
Summary: This study explores the interaction between age and antipsychotic-induced volumetric changes in the hippocampus and amygdala of first-episode schizophrenia patients undergoing medication treatment. It was found that older patients had smaller baseline hippocampal volumes compared to healthy controls. Additionally, younger patients exhibited greater hippocampal volumetric decreases following treatment.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2023)
Article
Biochemistry & Molecular Biology
Keqiang Wang, Meihong Xiu, Xiuru Su, Fengchun Wu, Xiangyang Zhang
Summary: This study examined the effect of risperidone monotherapy on total antioxidant status (TAS) in antipsychotic-naive first-episode schizophrenia (ANFE) patients, and found that antioxidant protection may be associated with clinical improvement.
Review
Biochemistry & Molecular Biology
Jeremy C. Burton, William Antoniades, Jennifer Okalova, Morgan M. Roos, Neil J. Grimsey
Summary: The MAPK p38 plays a crucial role in regulating responses to environmental stress and inflammation. A newly identified atypical p38 signaling pathway driven by direct interaction between TAB1 and p38α has been linked to various diseases including dermal and vascular inflammation, myocardial ischemia, and cancer metastasis. Further studies are needed to fully understand the implications and mechanisms of atypical p38 signaling.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Plant Sciences
Noah A. Omeiza, Adewale Bakre, Benneth Ben-Azu, Abimbola A. Sowunmi, Halimat A. Abdulrahim, Joseph Chimezie, Sodiq O. Lawal, Olusegun G. Adebayo, Abdullateef I. Alagbonsi, Olugbenga Akinola, Amos O. Abolaji, Adegbuyi O. Aderibigbe
Summary: Neurotherapeutic role of Carpolobia lutea ethanol extract (C. lutea) in ketamine-induced schizophrenia-like symptoms in mice was explored. Results showed that C. lutea reversed the cardinal symptoms of ketamine-induced schizophrenia in a dose-dependent fashion by modulating the oxido-inflammatory and neurotransmitter-related mechanisms.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Adam Kazimierz Gorka, Andrzej Gorecki, Marta Dziedzicka-Wasylewska
Article
Behavioral Sciences
Krystyna Pierzchala-Koziec, Marta Dziedzicka-Wasylewska, Colin G. Scanes
STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS
(2019)
Article
Biochemistry & Molecular Biology
Matgorzata Figiel, Julia Lakomska, Piotr Milek, Marta Dziedzicka-Wasylewska, Andrzej Gorecki
Article
Neurosciences
Dariusz Zurawek, Piotr Gruca, Lucyna Antkiewicz-Michaluk, Marta Dziedzicka-Wasylewska
MOLECULAR NEUROBIOLOGY
(2019)
Article
Chemistry, Multidisciplinary
Sylwia Lukasiewicz, Antoni Mikolajczyk, Marta Szczgech, Krzysztof Szczepanowicz, Piotr Warszynski, Marta Dziedzicka-Wasylewska
JOURNAL OF NANOPARTICLE RESEARCH
(2019)
Article
Neurosciences
Marta Szlachta, Maciej Kusmider, Joanna Solich, Magdalena Kolasa, Paulina Pabian, Marta Dziedzicka-Wasylewska, Agata Faron-Gorecka
NEUROSCIENCE LETTERS
(2019)
Article
Cell Biology
Pawel Mystek, Beata Rysiewicz, Jan Gregrowicz, Marta Dziedzicka-Wasylewska, Agnieszka Polit
Meeting Abstract
Pharmacology & Pharmacy
Agata Faron-Gorecka, Marta Szlachta, Marta Dziedzicka-Wasylewska
PHARMACOLOGICAL REPORTS
(2019)
Meeting Abstract
Pharmacology & Pharmacy
Joanna Solich, Maciej Kusmider, Magdalena Kolasa, Agata Faron-Gorecka, Paulina Pabian, Marta Szlachta, Marta Dziedzicka-Wasylewska
PHARMACOLOGICAL REPORTS
(2019)
Meeting Abstract
Pharmacology & Pharmacy
Maciej Kusmider, Agata Faron-Gorecka, Marta Dziedzicka-Wasylewska, Mariusz Papp
PHARMACOLOGICAL REPORTS
(2019)
Article
Neurosciences
Alan Kania, Agata Szlaga, Patryk Sambak, Anna Gugula, Ewa Blasiak, Maria Vittoria Micioni Di Bonaventura, Mohammad Akhter Hossain, Carlo Cifani, Grzegorz Hess, Andrew L. Gundlach, Anna Blasiak
JOURNAL OF NEUROSCIENCE
(2020)
Article
Biochemistry & Molecular Biology
M. Kusmider, A. Faron-Gorecka, J. Solich, P. Pabian, M. Dziedzicka-Wasylewska
NEUROCHEMISTRY INTERNATIONAL
(2020)
Review
Biochemistry & Molecular Biology
Agnieszka Polit, Pawel Mystek, Ewa Blasiak
Summary: This passage discusses how individual cell functions in multicellular organisms rely on signal transduction through GPCRs and G proteins, with a focus on the protein-lipid interactions and G proteins' attachment to cell membranes. While the interaction mode between the cell membrane and G proteins is well known, the molecular-level recognition mechanisms and the interrelation of individual G protein-membrane attachment signals in controlling membrane targeting remain unclear.
Article
Biochemistry & Molecular Biology
Urszula Jankowska, Bozena Skupien-Rabian, Bianka Swiderska, Gabriela Prus, Marta Dziedzicka-Wasylewska, Sylwia Kedracka-Krok
Summary: This study investigated the impact of clozapine, risperidone, and haloperidol on the proteome of PC12 cells, revealing significant alterations in protein pathways, including inhibition of ciliary trophic factor signaling and acute phase response signaling. Interestingly, all tested drugs showed changes in PC12 proteome corresponding to the inhibition of cytokines such as TNF and TGF-beta 1. Additionally, the study highlighted the central role of mTORC1 and mTORC2 in the signal transduction of clozapine.
NEUROCHEMICAL RESEARCH
(2021)
Meeting Abstract
Biochemistry & Molecular Biology
M. Figiel, P. Milek, M. Dziedzicka-Wasylewska, A. Gorecki
Article
Biochemistry & Molecular Biology
Pei-Yang Gao, Ya-Nan Ou, Yi-Ming Huang, Zhi-Bo Wang, Yan Fu, Ya-Hui Ma, Qiong-Yao Li, Li-Yun Ma, Rui-Ping Cui, Yin-Chu Mi, Lan Tan, Jin-Tai Yu
Summary: Liver function may play a role in the progression of Alzheimer's disease. The study found that as AD progressed, certain liver function markers increased while others decreased. The relationship between liver function and CSF AD biomarkers indicates a potential mediation effect on cognition.
JOURNAL OF NEUROCHEMISTRY
(2024)