Article
Engineering, Multidisciplinary
Naser Almansouri, Ahmed Samir Bakry, Mona Aly Abbassy, Amal Ibrahim Linjawi, Ali Habib Hassan
Summary: This study examined the effect of different agents on the protection of enamel proximal surfaces against acidic attack after interproximal reduction (IPR) using trans-micro-radiography. The MI varnish demonstrated the highest resistance to acidic attack.
Article
Dentistry, Oral Surgery & Medicine
John Yun Niu, Iris Xiaoxue Yin, William Ka Kei Wu, Quan-Li Li, May Lei Mei, Chun Hung Chu
Summary: The dual-action peptide GA-KR12 showed antibiofilm effects by inhibiting the growth of Streptococcus mutans biofilm, and also demonstrated remineralising effects by promoting the remineralisation of enamel caries. The mineral losses and calcium-to-phosphorus ratios were significantly lower in the GA-KR12-treated group compared to the control group, indicating the potential of GA-KR12 in preventing enamel caries and promoting enamel remineralisation.
CLINICAL ORAL INVESTIGATIONS
(2022)
Article
Multidisciplinary Sciences
Enrico Salvati, Cyril Besnard, Robert A. Harper, Thomas Moxham, Richard M. Shelton, Gabriel Landini, Alexander M. Korsunsky
Summary: This study presents a simplified calculation framework for numerical simulation of the demineralisation process at the length scale of enamel rods, validated by experimental data. It explores the impact of etchant solution pH levels and etching angles on the demineralisation process. The study aims to pave the way for simulations of enamel demineralisation in different scenarios and length scales.
JOURNAL OF ADVANCED RESEARCH
(2021)
Article
Engineering, Biomedical
Robert A. Harper, Richard M. Shelton, Jonathan D. James, Enrico Salvati, Cyril Besnard, Alexander M. Korsunsky, Gabriel Landini
Summary: This study utilized in situ microradiography and polarised light microscopy to investigate the progression of enamel demineralisation under different acidic conditions and the impact of intrinsic enamel structure and pH on demineralisation kinetics. The findings provide insights into the relationship between enamel structure, pH, and mineral loss dynamics, which can contribute to the development of improved anti-demineralisation/remineralisation treatments.
ACTA BIOMATERIALIA
(2021)
Article
Materials Science, Multidisciplinary
Cyril Besnard, Robert A. Harper, Thomas E. J. Moxham, Jonathan D. James, Malte Storm, Enrico Salvati, Gabriel Landini, Richard M. Shelton, Alexander M. Korsunsky
Summary: This study reports significant advances in analyzing synchrotron 3D datasets of human dental enamel, highlighting the differences in structural features between healthy and carious enamel. The study demonstrates a new method for studying dental lesions and their potential applications.
MATERIALS TODAY COMMUNICATIONS
(2021)
Article
Dentistry, Oral Surgery & Medicine
Mauro A. Tudares, George J. Eckert, Frank Lippert
Summary: This study investigates the effects of 5% sodium fluoride varnish and 38% silver diamine fluoride on preventing demineralization of human enamel lesions of different severities. The results suggest that silver diamine fluoride may have comparable benefits to fluoride varnish in preventing mineral loss.
JOURNAL OF APPLIED ORAL SCIENCE
(2023)
Article
Multidisciplinary Sciences
Hanaa M. M. Elgamily, Samah M. M. El-Sayed, Hoda S. S. El-Sayed, Ahmed M. M. Youssef
Summary: We evaluated the anti-cariogenic effect of an experimental synbiotic compound on biofilm formation and colonization. We also analyzed the remineralizing effect of synbiotic jelly candy on enamel surface lesions. The results showed a significant decrease in colony formation of Streptococcus mutans and alterations in the morphological structure of these bacteria. The synbiotic jelly candy also demonstrated potential remineralizing activity.
SCIENTIFIC REPORTS
(2023)
Article
Dentistry, Oral Surgery & Medicine
Maria Jacinta Rosario H. Romero, Frank Lippert
Summary: The study found that in the chemical model, 38% silver diamine fluoride completely inhibited demineralization of adjacent untreated sound enamel, had some prevention effect on pre-demineralized enamel, and was ineffective on dentine.
EUROPEAN JOURNAL OF ORAL SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Hani M. Nassar, Frank Lippert
Summary: This study investigated artificial caries lesion characteristics after secondary demineralization with different levels of fluoride and theobromine. The results showed that fluoride-containing groups had significantly deeper lesions, while theobromine did not have an additional effect on mineral uptake.
Article
Dentistry, Oral Surgery & Medicine
Bader A. Aldhaian, Abdulrahman A. Balhaddad, Areej A. Alfaifi, John A. Levon, George J. Eckert, Anderson T. Hara, Frank Lippert
Summary: The study revealed that fluoride and silver nanoparticles have a significant effect on preventing in vitro demineralization of sound enamel and enamel caries-like lesions of varying severities. The effectiveness of fluoride and silver nanoparticles is influenced by lesion severity, with no significant interaction between them.
JOURNAL OF DENTISTRY
(2021)
Article
Materials Science, Multidisciplinary
Cyril Besnard, Robert A. Harper, Enrico Salvati, Thomas E. J. Moxham, Leon Romano Brandt, Gabriel Landini, Richard M. Shelton, Alexander M. Korsunsky
Summary: In this study, a multi-scale correlative approach was used to compare artificially demineralised human enamel with healthy enamel, revealing structural differences at the micron to sub-micron scale. The decrease in Ca/P atomic % ratio in etched samples compared to healthy enamel, as shown by energy-dispersive X-ray spectroscopy, suggests greater loss of calcium. Synchrotron wide-angle X-ray scattering was employed to analyze differences in lattice structure and texture before and after etching, providing insights into the demineralisation-induced enamel structure alteration.
MATERIALS & DESIGN
(2021)
Article
Multidisciplinary Sciences
Marcella Esteves-Oliveira, Vanara F. Passos, Tereza M. A. Z. C. Russi, Argus R. R. Fernandes, Caroline N. N. Terto, Juliano S. Mendonca, Guglielmo Campus, Richard J. Wierichs, Hendrik Meyer-Lueckel, Juliana P. M. Lima
Summary: This study evaluated the effect of different surface polishing protocols on enamel roughness, bacterial adhesion, and caries-protective effect of a resin infiltrant. The results showed that certain polishing protocols can decrease the roughness of enamel, but did not have a significant impact on bacterial counts or demineralization.
SCIENTIFIC REPORTS
(2022)
Article
Chemistry, Physical
Miyu Iwasaki, Ryouichi Satou, Naoki Sugihara
Summary: This study aimed to develop a new approach for root caries prevention using a combination of bioapatite (BioHap) and fluoride. The experimental results showed that the dentin in the BioHap group had higher acid resistance, less lesion depth, and minimal mineral loss.
Article
Dentistry, Oral Surgery & Medicine
Haixia Xing, George J. Eckert, Masatoshi Ando
Summary: The study aimed to evaluate the impact of scanning angles on the detection and quantification of non-cavitated caries using photothermalradiometry and modulated-luminescence (PTR/LUM, Canary System), as well as to assess the association between PTR/LUM value and lesion depth (LD) and sound tissue thickness under the lesion (ST). The results showed that scanning angles within a 20-degree deviation may have a statistical impact on PTR/LUM values but did not affect the detection performance. PTR/LUM values were positively correlated with non-cavitated lesion depth and were not affected by the thickness of sound tissue under the lesion.
JOURNAL OF DENTISTRY
(2023)
Article
Oncology
Jonathan M. Roberts, David J. Bradshaw, Richard J. M. Lynch, Susan M. Higham, Sabeel P. Valappil
Summary: Hyperspectral fluorescence imaging (HI) shows promising potential as a non-destructive method for quantifying mineral loss from bovine enamel, with strong correlation found between TMR and HI. However, the correlation between QLF and HI is weaker in comparison.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2021)