Article
Multidisciplinary Sciences
Daniel J. Christoffel, Jessica J. Walsh, Paul Hoerbelt, Boris D. Heifets, Pierre Llorach, Ricardo C. Lopez, Charu Ramakrishnan, Karl Deisseroth, Robert C. Malenka
Summary: The study reveals that dopamine and serotonin modulate excitatory synaptic transmission in the nucleus accumbens in input-specific ways, influencing motivated behaviors differently. Endogenous release of DA and 5-HT, as well as optogenetic inhibition, alter the behavioral effects of drugs in distinct manners.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Pharmacology & Pharmacy
Lucia Caffino, Francesca Mottarlini, Giorgia Targa, Michel M. M. Verheij, Judith Homberg, Fabio Fumagalli
Summary: The study found that the deletion of serotonin transporter (SERT) may sensitize the glutamatergic synapses of the nucleus accumbens core to long-term but not short-term intake of cocaine.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Neurosciences
Valeska Cid-Jofre, Macarena Garate-Perez, Philip J. Clark, Viviana Valero-Jara, Rodrigo A. Espana, Ramon Sotomayor-Zarate, Gonzalo Cruz, Georgina M. Renard
Summary: Chronic Mod treatment during preadolescence impairs dopaminergic neurotransmission in NAc and decreases the capacity of rats to perceive rewarding effects of social play. It is important to consider potential effects on social behavior when evaluating Mod to treat ADHD in children and adolescents. Social interactions play a crucial role in neurodevelopment during this particular stage.
Article
Neurosciences
Tong-Yu Liang, Hua Zhou, Yan-Gang Sun
Summary: Ventral tegmental area (VTA) dopaminergic neurons participate in itch processing through their projection to the nucleus accumbens (NAc). The roles of dopamine receptor subtypes in different subregions of the NAc during itch processing were investigated. It was found that dopamine D1 receptors (D1R) blockade in the lateral shell (LaSh) impaired pruritogen-induced scratching behavior, while D2R activation in both LaSh and medial shell (MeSh) attenuated scratching behavior. Dopamine release in LaSh was elevated during scratching behavior, suggesting a motivational component of itch processing. This study highlights the importance of D1R in the LaSh of the NAc in itch signal processing.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Dan P. Covey, Edith Hernandez, Miguel A. Lujan, Joseph F. Cheer
Summary: The study found that dopamine release in the nucleus accumbens responds differently to cues signaling increasing cost of reward. Endocannabinoid signaling facilitates goal-seeking and nucleus accumbens dopamine release, while chronic MAGL treatment stably facilitates goal-seeking and dopamine encoding without the development of tolerance.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Multidisciplinary Sciences
Yang Li, Liang Qu, Nan Li, Xin Wang, Ping Wang, Shun-nan Ge, Xue-lian Wang
Summary: The study aimed to improve the success rate of rat jugular vein catheterization and the self-administration (SA) model through an optimized scheme. The results showed that the success rate in the optimized operation group was significantly higher than the traditional operation group. The optimized scheme made various improvements in materials and techniques, providing a more stable and efficient tool for basic research on drug addiction.
SCIENTIFIC REPORTS
(2022)
Article
Neurosciences
Allison E. Carney, Caitlin Clarke, Wayne E. Pratt
Summary: Previous research has shown that both dopamine and Neuropeptide Y (NPY) play a role in motivated behavior, potentially through interaction within the neural circuitry related to motivation. This study aimed to further understand the relationship between NAc NPY and dopamine and their effects on motivated behavior. The findings suggest that NPY in the NAc shell can improve motivational impairments caused by dopamine antagonism, and these effects are specific to the site of injection. These results imply that increasing NPY expression in neurodegenerative diseases may help alleviate early motivational deficits caused by dopamine depletion.
NEUROSCIENCE LETTERS
(2023)
Article
Pharmacology & Pharmacy
Ana Paula S. Dornellas, Giovana C. Macedo, Minna H. McFarland, Alexander Gomez-A, Todd K. O'Buckley, Claudio Da Cunha, A. Leslie Morrow, Donita L. Robinson
Summary: Research has shown that allopregnanolone can reduce dopamine release in both male and female rats, with its effects modulated by sex and estrous cycle stages.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Xiaonan Li, Lehua Lu, Ying He, Hui Zhang, Yihui Zhang, Huaquan Sheng, Ming Chen, Jiexiong Ru, Yihan Gao
Summary: This study examined the effects of different nicotine salts on dopamine (DA) release in the nucleus accumbens (NAc) using a fluorescent probe and optical fiber photometric recording equipment. The results showed that different nicotine salts increased DA release in the NAc, but each salt had different efficiency in increasing DA release with concentration changes.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Endocrinology & Metabolism
Sharmili Edwin Thanarajah, Ruth Hanssen, Corina Melzer, Marc Tittgemeyer
Summary: The study explored the effect of FTO genetic variations on impulsivity and neuroplastic alterations. It found that FTO risk allele carriers exhibited higher impulsivity and increased structural connectivity between VTA/SN and NAc. These findings suggest that FTO variants may influence obesity-promoting behavioral traits through neuroplastic alterations.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Pharmacology & Pharmacy
Lucia Caffino, Francesca Mottarlini, Giorgia Targa, Michel M. M. Verheij, Fabio Fumagalli, Judith R. Homberg
Summary: This study investigates the influence of SERT deletion on glutamate homeostasis in the NAc, and finds that SERT deletion leads to a reduction in glutamate signaling and further dysregulation in the glutamatergic synapse after cocaine self-administration.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Neurosciences
Erin W. Noye Tuplin, Faye Chleilat, Erna Alukic, Raylene A. Reimer
Summary: This study investigated the effects of diets fortified with HMO during the critical period of reward system development on the structure of the reward system. Sex differences in the expression of dopamine markers suggest the importance of investigating sex-specific responses to HMO supplementation for preventing or treating obesity. Further research is needed to understand the functional significance of nutritional interventions during dopamine system development.
Review
Biochemistry & Molecular Biology
Xinjian Zhang, Daisuke Tsuboi, Yasuhiro Funahashi, Yukie Yamahashi, Kozo Kaibuchi, Taku Nagai
Summary: Dopamine regulates emotional behaviors, including rewarding and aversive behaviors, through the mesolimbic dopaminergic pathway. Protein phosphorylation plays a critical role in intracellular signaling pathways and physiological functions, and dopamine regulates neuronal excitability and synaptic plasticity through phosphorylation of intracellular substrates. Understanding the mechanisms by which dopamine controls emotional behaviors is crucial.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Behavioral Sciences
Anil Joshi, Marion Schott, Susanne Eva la Fleur, Michel Barrot
Summary: Food intake is a necessary behavior for all animals, but excessive consumption of fat and sugar can lead to obesity. This review provides insights into the impact of food intake on the striatal complex and the modulation of palatable food intake by different neurochemical systems.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Article
Psychiatry
Rapheal G. Williams, Kevin H. Li, Paul E. M. Phillips
Summary: This study found that stress affects the interaction between CRF and dopamine in the core of the nucleus accumbens, which in turn affects performance in a reward-based decision-making task. Dopamine and CRF have different effects on different behavioral aspects.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Oncology
Matthias Schneider, Lea Vollmer, Anna-Laura Potthoff, Vidhya M. Ravi, Bernd O. Evert, Mohummad A. Rahman, Shahin Sarowar, Jan Kueckelhaus, Paulina Will, David Zurhorst, Kevin Joseph, Julian P. Maier, Nicolas Neidert, Paolo D'Errico, Melanie Meyer-Luehmann, Ulrich G. Hofmann, Andreas Dolf, Paolo Salomoni, Erdem Guresir, Per O. Enger, Martha Chekenya, Torsten Pietsch, Patrick Schuss, Oliver Schnell, Mike-Andrew Westhoff, Jurgen Beck, Hartmut Vatter, Andreas Waha, Ulrich Herrlinger, Dieter H. Heiland
Summary: This study explored the relationship between network architecture and transcriptional profile in glioblastoma cells, finding that meclofenamate (MFA) can effectively disrupt syncytial network structures. MFA treatment led to reduced intercellular cytosolic traffic and breakdown of long membrane protrusions, ultimately affecting the communication networks and response to chemotherapy in glioblastoma cells. These findings suggest a potential therapeutic approach targeting tumor microtubes (TMs) with MFA in clinical settings.
Article
Cell Biology
Julian P. Maier, Vidhya M. Ravi, Jan Kueckelhaus, Simon P. Behringer, Niklas Garrelfs, Paulina Will, Na Sun, Jasmin von Ehr, Jonathan M. Goeldner, Dietmar Pfeifer, Marie Follo, Luciana Hannibal, Axel Karl Walch, Ulrich G. Hofmann, Jurgen Beck, Dieter Henrik Heiland, Oliver Schnell, Kevin Joseph
Summary: Glioblastoma demonstrates dynamic responses to its microenvironment and resistance to treatment. Glutamate signaling, particularly through the metabotropic receptor 3 (GRM3), plays a crucial role in modulating chemoresistance and transcriptional profile of GBM cells. Inhibition of GRM3 receptor enhances sensitivity of GBM to chemotherapy, providing potential therapeutic strategies for GBM treatment.
CELL DEATH & DISEASE
(2021)
Article
Engineering, Biomedical
Kevin Joseph, Matthias Kirsch, Midori Johnston, Christian Munkel, Thomas Stieglitz, Carola A. Haas, Ulrich G. Hofmann
Summary: Long-term implantation of (micro-)probes into neural tissue leads to unique responses in glial cells. While animals implanted for 18 weeks show signs of recovery, upregulation of certain genes suggests that structural and functional remodeling is not complete at this time point.
Article
Neurosciences
Paolo d'Errico, Stephanie Ziegler-Waldkirch, Vanessa Aires, Philippe Hoffmann, Charlotte Mezoe, Daniel Erny, Laura Sebastian Monasor, Sabine Liebscher, Vidhya M. Ravi, Kevin Joseph, Oliver Schnell, Katrin Kierdorf, Ori Staszewski, Sabina Tahirovic, Marco Prinz, Melanie Meyer-Luehmann
Summary: This study demonstrates that Aβ can enter and deposit within wild-type grafts via microglia, identifying microglia as carriers of Aβ deposition into previously unaffected brain tissue, thus supporting a previously unexplored mechanism of Aβ propagation.
NATURE NEUROSCIENCE
(2022)
Article
Multidisciplinary Sciences
Vidhya M. Ravi, Nicolas Neidert, Paulina Will, Kevin Joseph, Julian P. Maier, Jan Kueckelhaus, Lea Vollmer, Jonathan M. Goeldner, Simon P. Behringer, Florian Scherer, Melanie Boerries, Marie Follo, Tobias Weiss, Daniel Delev, Julius Kernbach, Pamela Franco, Nils Schallner, Christine Dierks, Maria Stella Carro, Ulrich G. Hofmann, Christian Fung, Roman Sankowski, Marco Prinz, Juergen Beck, Henrike Salie, Bertram Bengsch, Oliver Schnell, Dieter Henrik Heiland
Summary: The study demonstrates that a subset of myeloid cells in Glioblastomas induce dysfunctional T cells through Interleukin-10 signaling, and inhibiting downstream JAK/STAT pathway could restore the responsiveness of immune therapy. The findings are validated using in vitro and in vivo models, providing further evidence of Interleukin-10 release being a driving force of tumor immune escape. Integrative modeling of single cell and spatial transcriptomics data proves to be a valuable tool for studying the tumor immune microenvironment and may contribute to the development of successful immunotherapies.
NATURE COMMUNICATIONS
(2022)
Article
Oncology
Vidhya M. Ravi, Paulina Will, Jan Kueckelhaus, Na Sun, Kevin Joseph, Henrike Salie, Lea Vollmer, Ugne Kuliesiute, Jasmin von Ehr, Jasim K. Benotmane, Nicolas Neidert, Marie Follo, Florian Scherer, Jonathan M. Goeldner, Simon P. Behringer, Pamela Franco, Mohammed Khiat, Junyi Zhang, Ulrich G. Hofmann, Christian Fung, Franz L. Ricklefs, Katrin Lamszus, Melanie Boerries, Manching Ku, Jurgen Beck, Roman Sankowski, Marius Schwabenland, Marco Prinz, Ulrich Schueller, Saskia Killmer, Bertram Bengsch, Axel K. Walch, Daniel Delev, Oliver Schnell, Dieter Henrik Heiland
Summary: This study utilizes spatially resolved transcriptomics, metabolomics, and proteomics to characterize glioblastomas and uncover their spatial organization and adaptive mechanisms to inflammatory and metabolic stimuli. The integration of metabolic imaging and imaging mass cytometry reveals the interdependence between tumor and host in a locoregional manner, leading to spatially exclusive adaptive transcriptional programs. The findings confirm the importance of environmental stress in shaping glioblastoma subclones and their transcriptional programs.
Article
Medicine, Research & Experimental
Joris Guyon, Ignacio Fernandez-Moncada, Claire M. Larrieu, Cyrielle L. Bouchez, Antonio C. Pagano Zottola, Johanna Galvis, Tiffanie Chouleur, Audrey Burban, Kevin Joseph, Vidhya M. Ravi, Heidi Espedal, Gro Vatne Rosland, Boutaina Daher, Aurelien Barre, Benjamin Dartigues, Slim Karkar, Justine Rudewicz, Irati Romero-Garmendia, Barbara Klink, Konrad Gruetzmann, Marie-Alix Derieppe, Thibaut Molinie, Nina Obad, Celine Leon, Giorgio Seano, Hrvoje Miletic, Dieter Henrik Heiland, Giovanni Marsicano, Macha Nikolski, Rolf Bjerkvig, Andreas Bikfalvi, Thomas Daubon
Summary: Lactate plays a crucial role in the metabolism of glioblastoma, and the inhibition of both LDHA and LDHB sensitizes the tumor to therapy, improving survival rates in mice.
EMBO MOLECULAR MEDICINE
(2022)
Meeting Abstract
Oncology
Kevin Joseph, Lea Vollmer, Vidyha Ravi, Juergen Beck, Ulrich Hofmann, Oliver Schnell, Dieter Henrik Heiland
Meeting Abstract
Oncology
Kevin Joseph, Julian Maier, Vidyha Ravi, Jurgen Beck, Ulrich Hofmann, Dieter Henrik Heiland, Oliver Schnell
Meeting Abstract
Oncology
Jan Kueckelhaus, Paulina Will, Franz Ricklefs, Jasim Kada Benotmane, Kevin Joseph, Juegen Beck, Oliver Schnell, Vidyha Ravi, Dieter Henrik Heiland
Meeting Abstract
Oncology
Vidyha Ravi, Nicolas Neidert, Paulina Will, Kevin Joseph, Ulrich Hofmann, Jurgen Beck, Oliver Schnell, Dieter Henrik Heiland
Meeting Abstract
Oncology
Vidyha Ravi, Kevin Joseph, Jurgen Beck, Oliver Schnell, Ulrich Hofmann, Dieter Henrik Heiland
Meeting Abstract
Oncology
Paulina Will, Jan Kuckelhaus, Jasim Kada Benotmane, Kevin Joseph, Jurgen Beck, Oliver Schnell, Vidyha Ravi, Dieter Henrik Heiland
Meeting Abstract
Oncology
Jasim Kada Benotmane, Jan Kueckelhaus, Kevin Joseph, Juergen Beck, Oliver Schnell, Vidyha Ravi, Dieter Henrik Heiland
Article
Cell Biology
Margarida Ferreira, Stephany Francisco, Ana R. Soares, Ana Nobre, Miguel Pinheiro, Andreia Reis, Sonya Neto, Ana Joao Rodrigues, Nuno Sousa, Gabriela Moura, Manuel A. S. Santos
Summary: The study identified tissue-specific effects of aging in the brain, heart, liver, skeletal muscle, and pancreas of C57BL/6 mice, showing alterations in immune, inflammation responses, amino acid and fatty acid metabolism, and tissue regeneration. Additionally, it revealed significant gender differences in gene expression, particularly in proteostasis-related pathways, across the lifespan, highlighting the common biological processes triggered by aging in distinct tissues.
