Journal
JOURNAL OF NEPHROLOGY
Volume 29, Issue 4, Pages 479-486Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s40620-016-0269-6
Keywords
IgM nephropathy; Minimal change disease; Focal segmental glomerulosclerosis; Nephrotic syndrome; Controversy
Categories
Ask authors/readers for more resources
Immunoglobulin (Ig)M nephropathy (IgMN), known since 1978, is a very controversial clinicopathological entity characterized by IgM diffuse deposits in the mesangium at immunofluorescence whereas light microscop identifies minimal glomerular lesion, hypercellularity and expansion of the mesangium or sclerotic focal, segmental lesion. Clinically, it is a nephrotic syndrome, especially in pediatric patients, or asymptomatic proteinuria and/or isolated hematuria. These characteristics narrowly define IgMN between minimal change disease and focal segmental glomerulosclerosis, so it is not often recognized as a separate pathology. Homogeneous epidemiologic, pathogenetic, clinical or histological data are not available. Recent research on the pathogenetic role of mesangial IgM has, however, renewed interest in IgMN and naturally the controversies.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available