Journal
JOURNAL OF NATURAL PRODUCTS
Volume 79, Issue 4, Pages 760-766Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.5b00681
Keywords
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Funding
- National Natural Science Foundation of China [31170323, 81001368]
- Wuhan Youth Chenguang Program of Science and Technology [201271031389]
- Major New Drugs Innovation Project of China [2013ZX09103001-020]
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Sixteen new alkaloids belonging to the galanthamine (1-6), plicamine (7-14), and secoplicamine (15 and 16) classes, together with eight known analogues (17-24), were isolated from Zephyranthes candida. The structures of 1-16 were determined by extensive spectroscopic analyses, and the absolute configurations of 1, 2, 7, 8, and 17 were confirmed by single crystal X-ray diffraction analysis. The orientation of 3-OCH3 in N-methyl-5,6-dihydroplicane (22) was revised. Alkaloids 3, 12-14, and 18-21 exhibited anti-acetylcholinesterase activities with IC50 values ranging from 0.48 to 168.7 mu M. Compounds 10-12, 14, and 16 showed in vitro anti-inflammatory activities with IC50 values ranging from 7.50 to 23.55 mu M.
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