Journal
JOURNAL OF NATURAL PRODUCTS
Volume 79, Issue 4, Pages 1005-1011Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.5b01073
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Funding
- University of Rennes 1 through project Defi emergent LICHENMASS
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Four new quinonoid naphthopyranones, ophioparmin (1), 4-methoxyhaemoventosins (2a and 2b), and 4-hydroxyhaemoventosin (3), together with anhydrofusarubin lactone (4) and haemoventosin (5) were isolated from the fruiting bodies of Ophioparma ventosa, a crustose lichen. Their structures were determined by spectroscopic analyses, and the absolute configurations of 1 and 2 were elucidated through experimental and calculated electronic circular dichroism analyses. Compounds 1, 2, and 5 exhibited moderate to strong antioxidant activities. The main pigment haemoventosin exhibited significant cytotoxicity toward a panel of nine cell lines.
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