Journal
JOURNAL OF NATURAL PRODUCTS
Volume 79, Issue 4, Pages 899-906Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.5b00952
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Funding
- National Natural Science Foundation of the People's Republic of China [21532007, 81273398]
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Nine new cedrelone-type limonoid derivatives, walsunoids A-I (1-9), and 11 known compounds were isolated from the leaves of Walsura robusta. Walsunoid A (1) is a new degradation product of cedrelone-type limonoids, and walsunoid I (9) is a rare cedrelone-type limonoid amide. Their structures and absolute configurations were determined by spectroscopic data, single-crystal X-ray diffraction, and ECD data analyses. Five compounds showed moderate inhibitory activities against human and/or mouse 11 beta-hydroxysteroid dehydrogenase type 1 (11 beta-HSD1) with IC50 values ranging from 0.69 to 9.9 mu M.
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