Article
Polymer Science
Kentaro Hata, Hiroshi Ikeda, Yuki Nagamatsu, Chihiro Masaki, Ryuji Hosokawa, Hiroshi Shimizu
Summary: A novel PMMA-based resin for SLA 3D-printing was developed in this study by mixing MMA, EGDMA, and PMMA powder, with optimal composition determined as 30% PMMA, 56% EGDMA, 14% MMA. The resin showed comparable or higher mechanical properties to commercial resins and acceptable physicochemical properties and cytotoxicity for oral environment use, making it a potential candidate material for dental applications.
Article
Polymer Science
Hamza Mahmoud Aboelanin, Stepan Podzimek, Vladimir Spacek
Summary: This study focuses on the detailed characterization of the molecular structure and dilute solution properties of highly dense star-like polymers of poly(methyl methacrylate) and poly(n-butyl methacrylate). The comparison of refractive index increment with corresponding linear homopolymers was conducted. The prepared polymers were characterized using size exclusion chromatography, multi-angle light scattering detector, and online viscometer. The obtained data allowed for the determination of arm distribution, average number of arms per molecule, and molar mass dependency of the draining factor. The relation between the number of arms per molecule and molar mass was estimated and compared with true values.
EUROPEAN POLYMER JOURNAL
(2023)
Article
Polymer Science
Chujuan Huang, Toyoko Suzuki, Hideto Minami
Summary: In this study, micrometer-sized block copolymer particles were successfully synthesized using iodine transfer polymerization as a first attempt. Methyl methacrylate (MMA) and vinyl acetate (VAc) were used as the hydrophilic monomers in a microsuspension system. The resulting poly(methyl methacrylate)-block-poly(vinyl acetate) (PMMA-b-PVAc) particles exhibited the desired molecular weight and relatively narrow molecular weight distribution, despite the low degree of polymerization of the PVAc block. The hydrolysis of these particles resulted in three different morphologies, and the formation mechanism of each morphology was proposed, attributing it to the interaction between the iodic ions generated from the degradation of iodine end groups and the elongated poly(vinyl alcohol) (PVA) segments derived from PVAc.
Article
Polymer Science
Dimitrios Selianitis, Stergios Pispas
Summary: This work introduces a series of novel multi-responsive hyperbranched copolymers which self-organize in aqueous media. The copolymers, prepared by RAFT polymerization, exhibit responsiveness to changes in solution temperature and pH, and are able to encapsulate hydrophobic drugs like curcumin. These hyperbranched copolymers show potential as candidates for drug delivery and bio-imaging applications, as they demonstrate stability in the presence of serum proteins.
Article
Polymer Science
Robert Mundil, Alexander Zhigunov, Mariusz Uchman
Summary: In this study, we synthesized and self-assembled mPEG-block-PDL-block-PMMA triblock terpolymers using a metal-free catalytic system, which showed better polymerization control compared to sequential copolymerization. The blocks were found to be incompatible, leading to their self-assembly into multicompartment micelles in water.
EUROPEAN POLYMER JOURNAL
(2022)
Review
Polymer Science
Ming Yuan, Dayun Huang, Yixuan Zhao
Summary: This article reviews the application and the relationship between the physical properties and molecular weight of PMMA, as well as different methods and mechanisms for preparing high molecular weight PMMA.
Article
Polymer Science
Jun Zhong, Xinyue Zhang, Xiaofeng Yu, Xuanyu Shi, Shihao Sun, Li Yang, Min Zuo, Yihu Song, Qiang Zheng
Summary: The selective distribution of silica nanoparticles grafted with crosslinked PMMA in PMMA/SAN blend was studied. Highly crosslinked PMMA chains mainly located in the PMMA-rich domains, while linear PMMA chains mainly located at the blend matrix interface. NPs grafted with slightly crosslinked chains were partially located at the interface and partially in the PMMA-rich domains. The deviation between theoretical prediction and actual location of modified NPs may be related to the heterogeneity of miniemulsion polymerization. The different locations of modified NPs induced by different grafted chain structures can result in various compatibilization effects on PMMA/SAN blend.
Article
Polymer Science
Christopher B. Keller, Susan E. Walley, Curtis W. Jarand, Jibao He, Muhammad Ejaz, Daniel A. Savin, Scott M. Grayson
Summary: By grafting linear-bottlebrush amphiphilic copolymers onto the surface of silica nanoparticles, nanoparticle micelles with the ability to encapsulate and stabilize non-polar structures in aqueous media were successfully formed. These nanoparticles not only enhance oil encapsulation, but also provide an alternative dispersant system to address oil pollution in the environment.
Article
Materials Science, Multidisciplinary
Alireza Farazin, Alireza Shakeri, Hossein Mahdavi
Summary: In this study, an amphiphilic block copolymer suitable for modification of forward osmosis (FO) membrane support layers was synthesized using the ATRP method. The addition of this copolymer significantly improved the performance of the support layer, and the best performing membrane exhibited satisfactory FO performance.
ACS APPLIED POLYMER MATERIALS
(2023)
Article
Chemistry, Physical
Jonas Blahnik, Sebastian Krickl, Klaus Schmid, Eva Mueller, John Lupton, Werner Kunz
Summary: This article presents a free-radical polymerization method in a mesostructured system without surfactants or other auxiliary agents. The aim is to study the impact of surfactant-free mesostructuring on polymerization kinetics and derived polymers.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Engineering, Chemical
Wenli Liu, Qizhi Yang, Yili Yang, Feiyue Xing, Pu Xiao
Summary: In this study, narrowly distributed PMMAs with AIE properties were successfully prepared using a novel AIE-based initiator under mild conditions. The use of air-stable copper(II) bromide/TPMA photocatalyst led to high efficiency of initiation and low dispersity of the obtained PMMAs. The fluorescent intensity of TPE-PMMAs was found to increase with molecular weights, and they could also be employed to detect changes in solution viscosity, demonstrating potential for synthesizing functional sensors.
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
(2021)
Article
Chemistry, Physical
Maria del Prado Garrido, Ana Maria Borreguero, Francisco Javier Redondo, David Padilla, Manuel Carmona, Maria Jesus Ramos, Juan Francisco Rodriguez
Summary: In this study, St-MMA particles with PEGMA and/or GMA brushes were synthesized and found to effectively remove bilirubin by improving the BSA immobilization capacity and reducing processing time. Attachment of BSA to the particles reduced bilirubin concentration in plasma from levels that threaten patient survival to levels close to those of healthy individuals.
Review
Chemistry, Multidisciplinary
Muhammad Naziff Ahamad Said, Nurul Anis Hasbullah, Muhammad Ridhwan Hafiz Rosdi, Muhamad Sharan Musa, Arjulizan Rusli, Azlan Ariffin, Mohamad Danial Shafiq
Summary: This review discusses the synthesis of graphene oxide (GO)-incorporated poly(methyl methacrylate) (PMMA) nanocomposites (PMMA-GO) and their applications as multifunctional structural materials. It focuses on radical polymerization techniques, such as bulk and emulsion polymerization, and the effect of solvent polarity and types of surfactants and initiators on the polymerization process. Concentration and dispersity of GO are critical for the functionality and performance of PMMA-GO nanocomposites.
Article
Multidisciplinary Sciences
Gomathi Mahadevan, Suresh Valiyaveettil
Summary: Studies have shown that PVC and PMMA nanoparticles can affect cell viability, decrease ATP levels, and increase ROS concentrations. These plastic nanoparticles are internalized into cells through endocytosis, potentially disrupting cellular physiology in a negative manner.
SCIENTIFIC REPORTS
(2021)
Article
Polymer Science
Mahmut Muhammettursun, Tayfun Bel, Elif Kocacinar, Ecem Erman, Fuat Berke Gul, Andy Augousti, Nilgun Baydogan
Summary: The technique for synthesizing poly (methyl methacrylate) (PMMA) using graphene nanoplatelets (GNPs) has been improved to enhance the elastic properties of the polymer. The addition of GNPs at 2 wt% by mass increased compressive strength by 42.7% and Rockwell hardness by 19.9%. The structural changes due to the addition of GNPs were found to be uniquely linked to improvements in elastic parameters of the PMMA/GNPs nanocomposite.
JOURNAL OF APPLIED POLYMER SCIENCE
(2021)
Article
Agricultural Engineering
Francisco P. Machado, Diogo Folly, Jairo J. Salas Enriquez, Cicero B. Mello, Ricardo Esteves, Raquel S. Araujo, Pedro F. S. Toledo, Javier G. Mantilla-Afanador, Marcelo G. Santos, Eugenio E. Oliveira, Eduardo Ricci-Junior, Leandro Rocha
Summary: The widespread use of insecticides can lead to resistance in Aedes aegypti mosquitoes and harmful effects on non-target organisms. To address this issue, researchers developed and optimized a nanoemulsion with essential oil from Ocotea indecora leaves, which showed larvicidal properties against Ae. aegypti larvae. The nanoemulsion was also found to be safe for non-target organisms, such as Apis mellifera.
INDUSTRIAL CROPS AND PRODUCTS
(2023)
Article
Pharmacology & Pharmacy
Elisabete Regina Fernandes Ramos Ribeiro, Luana Barbosa Correa, Eduardo Ricci-Junior, Pedro Filho Noronha Souza, Clenilton Costa dos Santos, Alan Silva de Menezes, Elaine Cruz Rosas, Prapanna Bhattarai, Mohamed F. Attia, Lin Zhu, Luciana Magalhaes Rebelo Alencar, Ralph Santos-Oliveira
Summary: In this study, films made of chitosan and graphene quantum dots were developed for application in infected wounds. These films demonstrated biocompatibility, mechanical strength, and promoted wound healing. The results suggest that the use of chitosan-graphene films could be a promising approach for treating infected wounds.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Environmental Sciences
Geovana Dagostim Savi, Elton Torres Zanoni, Rahisa Scussel, Emily da Silva Corneo, Bianca Guimaraes Furtado, Domingos Lusitaneo Pier Macuvele, Janaina Nones, Paulo Emilio Feuser, Ricardo Andrez Machado-de-Avila, Elidio Angioletto
Summary: The study investigated the adsorption capacity of mesoporous silica nanoparticles (MSNs) on aflatoxin B-1 (AFB(1)), as well as the toxicity of MSNs with AFB(1) using NIH3T3 cells and hemolysis test. The results showed that MSNs had a high adsorption capacity for AFB(1), with an increase in adsorption when the MSN concentration increased. MSNs also demonstrated the ability to reduce cell toxicity produced by AFB(1) and showed no hemolysis in combination with AFB(1).
JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART B-PESTICIDES FOOD CONTAMINANTS AND AGRICULTURAL WASTES
(2023)
Review
Chemistry, Multidisciplinary
Natalia Silva de Santana, Luciana Betzler de Oliveira de Siqueira, Tatielle do Nascimento, Ralph Santos-Oliveira, Ana Paula dos Santos Matos, Eduardo Ricci-Junior
Summary: This study aims to systematically review the use of nanoparticles for the treatment of visceral leishmaniasis, with in vivo tests to evaluate the antileishmanial effect. The results show that nanoparticles can reduce parasite burden and toxicity, increasing the efficacy and safety of the treatment, providing a promising option for visceral leishmaniasis treatment.
JOURNAL OF NANOPARTICLE RESEARCH
(2023)
Article
Biophysics
Sara Gemini-Piperni, Eduardo Ricci-Junior, Derya Ilem-Ozdemir, Beatriz da Silva Batista, Luciana Magalhaes Rabelo Alencar, Alexandre Malta Rossi, Ralph Santos-Oliveira
Summary: The use of targeted alpha therapy (TAT) for bone cancer is increasing, with radium [223Ra]Ra+2 being the first approved alpha radionuclide for bone cancer metastasis therapy. The development of [223Ra]Ra+2-based radiopharmaceutical is crucial to expand the range of TAT drugs. This study successfully developed, characterized, and evaluated [223Ra] Ra-nano-hydroxyapatite, demonstrating its potential as a radiopharmaceutical with a dose-response relationship for osteosarcoma cells and safety for human fibroblast cells.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Review
Chemistry, Medicinal
Martha Sahyli Ortega Pijeira, Tais Monteiro Magne, Natalia Cristina Gomes da Silva, Elisabete Regina Fernandes Ramos Ribeiro, Yuri Jose Albuquerque Silva, Eduardo Ricci-Junior, Luciana Magalhaes Rebelo Alencar, Ralph Santos-Oliveira
Summary: Ionizing radiation is a useful tool in promoting controlled chemical reactions for developing new materials. It can also be applied to reduce or eliminate harmful compounds from solutions. This review discusses the chemistry behind material irradiation and the attractive use of ionizing radiation in scientific and industrial development. It emphasizes the efficiency and green strategies of graft polymerization, crosslinking, and chain scission reactions induced by ionizing radiation.
CURRENT TOPICS IN MEDICINAL CHEMISTRY
(2023)
Article
Polymer Science
Fernando Elias Guckert, Karina Cesca, Claudia Sayer, Debora de Oliveira, Pedro H. Hermes de Araujo, Bruno Francisco Oechsler
Summary: This study investigated the enzymatic polycondensation of polybutylene succinate (PBS) in solution for biomedical applications. The results showed that reactions containing 5% diphenyl ether as solvent at 80°C and 90°C had the most advantageous synthesis results, with average molar masses between 2,500 and 3,350 g·mol-1. However, it was observed that diphenyl ether affected the stability of the immobilized biocatalyst, indicating the need for further research on using green solvents that maintain the stability of the catalyst.
EUROPEAN POLYMER JOURNAL
(2023)
Article
Polymer Science
Thayli Ramires Araujo, Daniela Bresolin, Debora de Oliveira, Claudia Sayer, Pedro Henrique Hermes de Araujo, Jose Vladimir de Oliveira
Summary: The valorization of lignin in polyurethane products enables the utilization of this biomass, which is the second most abundant natural polymer in the world. However, the complex and cross-linked molecular structure of lignin limits its use, making it necessary to develop methods to make lignin more reactive. Chemical modification and fragmentation are among the methods that have been developed, but research on the production of lignopolyols derived from enzymatic catalysis applicable to polyurethanes is lacking.
EUROPEAN POLYMER JOURNAL
(2023)
Article
Engineering, Chemical
Tamara Agner, Amadeo Zimermann, Fabricio Machado, Brenno A. D. Neto, Pedro H. H. de Araujo, Claudia Sayer
Summary: In this study, iron-containing imidazolium-based ionic liquids were used as catalysts for the homogeneous polymerization of n-butyl vinyl ether to investigate the conditions that lead to high molecular weights. The Lewis acidic IL proved to be highly efficient, even at low catalyst concentrations, suggesting its potential for industrial applications. In contrast, the neutral iron-containing IL showed no catalytic activity.
MACROMOLECULAR REACTION ENGINEERING
(2023)
Article
Biochemistry & Molecular Biology
Leonardo de Assuncao Pinto, Francisco Paiva Machado, Ricardo Esteves, Victor Moebus Farias, Felipe Braz Nielsen Koptcke, Eduardo Ricci-Junior, Leandro Rocha, Luiz Antonio Moura Keller
Summary: This study aimed to prepare and characterize nanoemulsion and essential oil from the leaves of Ocotea indecora, a native species from the Mata Atlantica forest in Brazil, and evaluate their activity against Aspergillus species. The results showed that the nanoemulsion significantly reduced the fungistatic concentration of the essential oil, but had no significant effect on aflatoxin production.
Review
Nutrition & Dietetics
Raissa Mara Kao Yien, Ana Paula dos Santos Matos, Anne Caroline Candido Gomes, Denise de Abreu Garofalo, Ralph Santos-Oliveira, Naomi Kato Simas, Eduardo Ricci
Summary: Biodiversity is important in the Asteraceae family, and some species have pharmacological potential. The search for new substances from natural products has been ongoing for years, but developing a final product remains challenging. Nanotechnology has emerged as a tool to improve the pharmacokinetic parameters of active substances and formulations. This study reviewed the use of nanotechnology in developing formulations from Asteraceae species from 2010 to 2021, and found that nanoemulsions were the most commonly used formulation. Nanotechnology has shown to improve the pharmacokinetic parameters of active substances.
Article
Biochemistry & Molecular Biology
Francisco Paiva Machado, Diogo Folly, Ricardo Esteves, Bettina Monika Ruppelt, Victoria Marques da Silva, Ana Paula dos Santos Matos, Jose Augusto Albuquerque dos Santos, Leonardo da Silva Rangel, Marcelo Guerra Santos, Natalia Lidmar von Ranke, Carlos Rangel Rodrigues, Eduardo Ricci-Junior, Leandro Rocha, Robson Xavier Faria
Summary: Schistosomiasis, a tropical disease transmitted in water environments, affects 200 million people worldwide. This study evaluated a nanoemulsion containing Myrciaria floribunda leaf essential oil as a molluscicidal and cercaricidal agent against Biomphalaria glabrata mollusks and Schistosoma mansoni cercariae. The nanoemulsion showed promising results, with small droplet size and stability. The Myrciaria floribunda nanoemulsion exhibited significant efficacy in killing mollusks and cercariae, with low toxicity to human cells.
Review
Nutrition & Dietetics
Sandro Pinheiro da Costa, Raphaela Aparecida Schuenck-Rodrigues, Veronica da Silva Cardoso, Simone Sacramento Valverde, Alane Beatriz Vermelho, Eduardo Ricci-Junior
Summary: This review summarizes the latest advances and perspectives of the plant species Brugmansia suaveolens, including aspects of botany, traditional uses, phytochemistry, pharmacology, and toxicology. It describes 120 compounds present in B. suaveolens, including alkaloids, flavonoids, terpenoids, steroids, amino acids, aromatics, and aliphatics. The therapeutic potential of B. suaveolens is discussed in various aspects such as antitumor, anti-inflammatory, antioxidant, antimicrobial, antispasmodic, anticoagulant, and analgesic effects. The review also highlights the toxicity of this genus, particularly its potential for organ toxicity, providing a scientific basis for future studies on the value of B. suaveolens for the development of new natural products.
Article
Pharmacology & Pharmacy
Thais Menezes dos Santos, Danieli Silva Feijo de Sousa, Karina Chamma Di Piero, Adriane Regina Todeschini, Wagner Barbosa Dias, Catarina Amorim Oliveira, Elisabete Pereira dos Santos, Mariana Sato de Souza Bustamante Monteiro, Maria Katia Gomes, Cristiano dos Reis Moura, Pedro Antonio Castelo Teixeira, Eduardo Ricci-Junior, Zaida Maria Faria de Freitas
Summary: This study produced carboxypolymethylene hydrogels containing 2% and 10% concentrations of papain and 5% concentration of urea. The stability, proteolytic activity, and rheological aspects of the hydrogels were evaluated. Clinical evaluation in patients with lower limb ulcers showed that while there were no significant differences in healing time, the 10% papain hydrogel performed better for various tissue types in the wound bed.
BRAZILIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Eduardo Ricci Jr, Denise de Abreu Garofalo, Maria Amelia Geraldes Bordalo Mont'Alverne, Melanie Tavares, Marcia Maria Barros dos Passos, Zaida Maria Faria Freitas, Elisabete Pereira dos Santos, Mariana Sato de Souza de Bustamante Monteiro
Summary: The University Pharmacy Program from the Federal University of Rio de Janeiro offers curricular internships to undergraduate pharmacy students, providing care for about 200 patients per day. It serves as a reference for handling neglected drugs and provides access to medications for low-income users, playing a significant social role.
BRAZILIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
