Article
Endocrinology & Metabolism
Pierre-Yves Benhamou, Sandrine Lablanche, Anne Vambergue, Maeva Doron, Sylvia Franc, Guillaume Charpentier
Summary: The study compared the efficacy of the closed-loop Diabeloop system with the open-loop predictive low glucose suspend system in patients with highly unstable diabetes. The results showed that the closed-loop system was superior in improving metabolic control.
DIABETES OBESITY & METABOLISM
(2021)
Review
Endocrinology & Metabolism
Munachiso Nwokolo, Roman Hovorka
Summary: Diabetes technologies, such as CSII pumps and CGM, have significantly improved diabetes care by enhancing glycemic control and reducing diabetes distress. Closed-loop systems, including hybrid and fully closed-loop systems, have demonstrated safety and efficacy in research settings. However, the clinical adoption of closed-loop therapy is still in its early stages, with challenges in equitable access and regulatory navigation.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Review
Multidisciplinary Sciences
Bruce A. Perkins, Jennifer L. Sherr, Chantal Mathieu
Summary: Despite innovations in insulin therapy, most type 1 diabetes patients still struggle to achieve sufficient glycemic control. The future may lie in combining pharmacological solutions with automated insulin delivery methods, utilizing machine learning and other technologies to enhance effectiveness.
Review
Cardiac & Cardiovascular Systems
Keren Zhou, Diana Isaacs
Summary: This review discusses the development of closed-loop insulin pump systems and provides an overview of the currently approved systems and future technology. The findings show that these systems have demonstrated significant improvements in blood glucose control, hemoglobin A1c, and time spent in hypoglycemia. The newer systems also offer increased automation. However, there are notable differences in user experience between systems, and further research is required to achieve full automation without user input.
CURRENT CARDIOLOGY REPORTS
(2022)
Article
Endocrinology & Metabolism
Loic Olcomendy, Louis Cassany, Antoine Pirog, Roberto Franco, Emilie Puginier, Manon Jaffredo, David Gucik-Derigny, Hector Rios, Alejandra Ferreira de Loza, Julien Gaitan, Matthieu Raoux, Yannick Bornat, Bogdan Catargi, Jochen Lang, David Henry, Sylvie Renaud, Jerome Cieslak
Summary: This study focuses on diabetes treatment using continuous glucose monitoring and insulin delivery, and examines the limitations of glucose sensors and algorithms in blood glucose regulation. By using a computer model for simulation testing, the study evaluates the potential benefits of an islet-based biosensor and robust control theory in closed-loop insulin therapy.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Pilar Isabel Beato-Vibora, Ana Ambrojo-Lopez, Mercedes Fernandez-Bueso, Estela Gil-Poch, Francisco Javier Arroyo-Diez
Summary: This study prospectively evaluated the long-term benefit of using the advanced hybrid closed-loop system (AHCL) in different subpopulations. The results showed sustained improvement in blood glucose control and hypoglycemia risk with the AHCL system in all subgroups.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2022)
Article
Medicine, General & Internal
Richard M. Bergenstal, Revital Nimri, Roy W. Beck, Amy Criego, Lori Laffel, Desmond Schatz, Tadej Battelino, Thomas Danne, Stuart A. Weinzimer, Judy Sibayan, Mary L. Johnson, Ryan J. Bailey, Peter Calhoun, Anders Carlson, Elvira Isganaitis, Rachel Bello, Anastasia Albanese-O'Neill, Klemen Dovc, Torben Biester, Kate Weyman, Korey Hood, Moshe Phillip
Summary: In adolescents and young adults with type 1 diabetes, the use of an investigational advanced hybrid closed-loop system was found to reduce hyperglycemia without increasing the occurrence of hypoglycemia compared to a commercially available MiniMed 670G system. Further testing of this technology in underserved populations and in individuals with impaired awareness of hypoglycemia could advance its effective use.
Article
Chemistry, Analytical
Jesus Berian, Ignacio Bravo, Alfredo Gardel-Vicente, Jose-Luis Lazaro-Galilea, Mercedes Rigla
Summary: This paper presents a novel approach to dynamically determine the basal insulin needs of patients and incorporate this information into a closed-loop algorithm, improving the safety and performance of the system. Simulation results demonstrate that the proposed algorithm can adapt to various situations and achieve similar blood glucose control outcomes as in normal conditions.
Article
Pediatrics
Jesus Dominguez-Riscart, Nuria Buero-Fernandez, Ana Garcia-Zarzuela, Fernando A. Marmolejo-Franco, Ana C. Perez-Guerrero, Alfonso M. Lechuga-Sancho
Summary: The goal of therapy for type 1 diabetes is to maintain optimal glycemic control, with the most advanced devices being hybrid closed-loop systems. The latest international guidelines for diabetes management during surgery include specific adjustments to insulin therapy and continuous monitoring.
FRONTIERS IN PEDIATRICS
(2021)
Article
Medicine, General & Internal
Mercedes J. Burnside, Dana M. Lewis, Hamish R. Crocket, Renee A. Meier, Jonathan A. Williman, Olivia J. Sanders, Craig A. Jefferies, Ann M. Faherty, Ryan G. Paul, Claire S. Lever, Sarah K. J. Price, Carla M. Frewen, Shirley D. Jones, Tim C. Gunn, Christina Lampey, Benjamin J. Wheeler, Martin de Bock
Summary: In patients with type 1 diabetes, the use of an open-source AID system resulted in a significantly higher percentage of time in the target glucose range compared to a sensor-augmented insulin pump.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Endocrinology & Metabolism
Pierre-Yves Benhamou, Alice Adenis, Hocine Lebbad, Yousra Tourki, Maria-Belen Heredia, Bernhard Gehr, Sylvia Franc, Guillaume Charpentier
Summary: This study reports the glycemic outcomes of the first 3706 users of the DBLG1 system, showing that the system has achieved good treatment results in adult patients with type 1 diabetes.
DIABETES OBESITY & METABOLISM
(2023)
Article
Obstetrics & Gynecology
Kaat Beunen, Nancy Van Wilder, Dominique Ballaux, Gerd Vanhaverbeke, Youri Taes, Xavier-Philippe Aers, Frank Nobels, Joke Marlier, Dahae Lee, Joke Cuypers, Vanessa Preumont, Sarah E. Siegelaar, Rebecca C. Painter, Annouschka Laenen, Pieter Gillard, Chantal Mathieu, Katrien Benhalima
Summary: This study aims to evaluate the efficacy, safety and cost-effectiveness of the MiniMed (TM) 780G HCL system in pregnant women with T1D. It is an international, open-label, randomized controlled trial that will compare the MiniMed (TM) 780G HCL system to standard of care. The primary outcome is the time spent within the pregnancy glucose target range.
BMC PREGNANCY AND CHILDBIRTH
(2023)
Review
Pediatrics
Julia Fuchs, Roman Hovorka
Summary: Recent advances in diabetes technology have led to the development of closed-loop insulin delivery systems for the management of type 1 diabetes. While all available systems have shown improvements in glycemic control and quality of life, challenges in using closed-loop systems vary among different pediatric age-groups. Understanding the capabilities and differences of current systems can be challenging for healthcare professionals, caregivers, and young people with type 1 diabetes.
FRONTIERS IN PEDIATRICS
(2021)
Article
Endocrinology & Metabolism
Helga Blauw, A. Joannet Onvlee, Michel Klaassen, Arianne C. van Bon, J. Hans DeVries
Summary: The study demonstrated that the bihormonal artificial pancreas provided superior glucose control in adults with type 1 diabetes compared to insulin pump therapy, without the need for meal or exercise announcements.
Article
Endocrinology & Metabolism
Emilie Bundgaard Lindkvist, Christian Laugesen, Asbjorn Thode Reenberg, Tobias Kasper Skov Ritschel, Jannet Svensson, John Bagterp Jorgensen, Kirsten Norgaard, Ajenthen G. G. Ranjan
Summary: This study compared the efficacy and safety of a dual-hormone closed-loop system (insulin and glucagon) with a single-hormone closed-loop system (insulin only) in adolescents with type 1 diabetes. The results showed that overall, both systems performed similarly in controlling blood glucose levels during a 26-hour monitoring period. However, the single-hormone system outperformed the dual-hormone system during the night and during exercise.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Ecology
Andres Valenzuela-Sanchez, Claudio Azat, Andrew A. Cunningham, Soledad Delgado, Leonardo D. Bacigalupe, Jaime Beltrand, Jose M. Serrano, Hugo Sentenac, Natashja Haddow, Veronica Toledo, Benedikt R. Schmidt, Hugo Cayuela
Summary: The study indicates that compensatory recruitment in response to Bd infection is crucial for maintaining population survival. Populations with high Bd prevalence exhibited higher adult recruitment and male reproductive effort, while populations with low Bd prevalence showed lower recruitment and survival rates.
JOURNAL OF ANIMAL ECOLOGY
(2022)
Article
Endocrinology & Metabolism
Laura Gabriela Gonzalez Briceno, Dulanjalee Kariyawasam, Dinane Samara-Boustani, Elisa Giani, Jacques Beltrand, Stephanie Bolle, Brice Fresneau, Stephanie Puget, Christian Sainte-Rose, Claire Alapetite, Graziella Pinto, Marie-Liesse Piketty, Severine Brabant, Samuel Abbou, Isabelle Aerts, Kevin Beccaria, Marie Bourgeois, Thomas Roujeau, Thomas Blauwblomme, Federico Di Rocco, Caroline Thalassinos, Christian Pauwels, Charlotte Rigaud, Syril James, Kanetee Busiah, Albane Simon, Franck Bourdeaut, Lauriane Lemelle, Lea Guerrini-Rousseau, Daniel Orbach, Philippe Touraine, Francois Doz, Christelle Dufour, Jacques Grill, Michel Polak
Summary: This study described the endocrine follow-up of patients with primary brain tumors and found a high incidence of early-onset endocrine disorders. It is recommended to conduct endocrine consultation and nutritional evaluation for all brain tumor patients, especially those with suprasellar tumors or after hypothalamus/pituitary irradiation.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Marie Mouler, Yael Lebenthal, Liat de Vries, Michal Yackobovitch-Gavan, Noa Sheffer Averbuch, Anne Laure Fauret-Amsellem, Helene Cave, Jacques Beltrand, Michel Polak, Moshe Phillip, Revital Nimri
Summary: Neonatal diabetes mellitus (NDM) patients have specific genetic and treatment characteristics, with some developing chronic diabetes complications after long-term illness. Patients with transient neonatal diabetes have higher height and weight and catch-up growth rapidly to reach normal growth parameters.
PEDIATRIC DIABETES
(2022)
Article
Endocrinology & Metabolism
Sylvain Lachal, Yousra Tourki, Sylvia Franc, Erik Huneker, Guillaume Charpentier, Pierre Yves Benhamou
Summary: This study evaluated the efficiency and safety of ultrarapid lispro insulin in closed-loop regulation algorithms. The results showed that using ultrarapid lispro insulin improved the regulation performance and was safe.
JOURNAL OF DIABETES SCIENCE AND TECHNOLOGY
(2023)
Review
Endocrinology & Metabolism
Caroline de Gouveia Buff Passone, Elisa Giani, Laurence Vaivre-Douret, Dulanjalee Kariyawasam, Marianne Berdugo, Laure Garcin, Jacques Beltrand, Wanderley Marques Bernardo, Michel Polak
Summary: Based on a systematic review and meta-analysis of published literature, this study found that sulfonylureas, particularly glibenclamide, can significantly improve neurological abnormalities in patients with monogenic diabetes caused by KCNJ11 and ABCC8 mutations. The most responsive symptoms to treatment were hypotonia, epilepsy, and motor function.
PEDIATRIC DIABETES
(2022)
Article
Endocrinology & Metabolism
Caroline de Gouveia Buff Passone, Gaelle Vermillac, Willem Staels, Alix Besancon, Dulanjalee Kariyawasam, Cecile Godot, Cecile Lambe, Cecile Talbotec, Muriel Girard, Christophe Chardot, Laureline Berteloot, Taymme Hachem, Alexandre Lapillonne, Amelie Poidvin, Caroline Storey, Mathieu Neve, Cosmina Stan, Emmanuelle Dugelay, Anne-Laure Fauret-Amsellem, Yline Capri, Helene Cave, Marina Ybarra, Vikash Chandra, Raphael Scharfmann, Elise Bismuth, Michel Polak, Jean Claude Carel, Benedicte Pigneur, Jacques Beltrand
Summary: This study presents the clinical management and analysis of four new cases of Mitchell-Riley syndrome (MRS), a rare genetic disorder caused by mutations in the RFX6 transcription factor gene. The study highlights the impact of these mutations on RFX6 function and discusses the multidisciplinary approach to treatment that has improved the prognosis for these patients. The findings suggest that further understanding of RFX6 function could lead to new therapeutic interventions for MRS.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Felix Reschke, Stefanie Lanzinger, Vivien Herczeg, Priya Prahalad, Riccardo Schiaffini, Dick Mul, Helen Clapin, Bedowra Zabeen, Julie Pelicand, Moshe Phillip, Catarina Limbert, Thomas Danne
Summary: This study analyzed data from large pediatric diabetes centers globally and found that the COVID-19 pandemic did not increase the number of new-onset type 1 diabetes cases in children, but it did impact the seasonality of disease onset.
Article
Endocrinology & Metabolism
Andreanne Jodoin, Maud Marchand, Jacques Beltrand
Summary: Wolfram syndrome (WFS) is a rare neurodegenerative disease characterized by nonautoimmune insulin-dependent diabetes, bilateral optic atrophy, and deafness. This case report highlights the importance of gonadal function assessment and follow-up.
JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM
(2022)
Article
Clinical Neurology
Pierre Gauthier, Chesner Desir, Maud Plombas, Eloise Joffray, Pierre-Yves Benhamou, Anne-Laure Borel
Summary: This study aimed to investigate the association between sleep habits, eating schedule, physical activity, and glycaemic control in patients with type 2 diabetes. The results showed that the total daily dose of meal boluses of insulin and sleep duration were inversely associated with glycaemic variability. Physical activity did not show a significant association with overall glycaemic control, but days with higher physical activity levels had lower glycaemic variability.
JOURNAL OF SLEEP RESEARCH
(2023)
Article
Endocrinology & Metabolism
Pierre-Yves Benhamou, Alice Adenis, Hocine Lebbad, Yousra Tourki, Maria-Belen Heredia, Bernhard Gehr, Sylvia Franc, Guillaume Charpentier
Summary: This study reports the glycemic outcomes of the first 3706 users of the DBLG1 system, showing that the system has achieved good treatment results in adult patients with type 1 diabetes.
DIABETES OBESITY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Pierre-Yves Benhamou, Alice Adenis, Sandrine Lablanche, Sylvia Franc, Coralie Amadou, Alfred Penfornis, Dulanjalee Kariyawasam, Jacques Beltrand, Guillaume Charpentier
Summary: DBLG1 is an efficient and safe closed-loop system for patients with type 1 diabetes. The system has shown significant improvement in time in range (TIR) and a remarkably low level of time below range (TBR), making it an effective treatment option.
JOURNAL OF DIABETES SCIENCE AND TECHNOLOGY
(2023)
Article
Endocrinology & Metabolism
Alfonso Galderisi, Dulanjalee Kariyawasam, Athanasia Stoupa, Adrien Nguyen Quoc, Graziella Pinto, Magali Viaud, Severine Brabant, Jacques Beltrand, Michel Polak, Dinane Samara-Boustani
Summary: This study observed the daytime glucose profile of 11 children with classical CAH, finding a higher risk of nighttime hypoglycemia and a disruption in daily glucose patterns paralleled by lower cortisol levels. The duration of hypoglycemia was associated with lower cortisol levels in the early morning and late evening.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2023)
Article
Medical Informatics
Dulanjalee Kariyawasam, Carole Morin, Kristina Casteels, Claire Le Tallec, Annie Sfez, Cecile Godot, Erik Huneker, Nathalie Garrec, Pierre-Yves Benhamou, Michel Polak, Guillaume Charpentier, Sylvia Franc, Jacques Beltrand
Summary: The study evaluated the safety and efficiency of the Diabeloop DBL4K hybrid closed-loop system in prepubescent children with type 1 diabetes. The closed-loop system reduced the occurrence of hypoglycaemic episodes and provided good metabolic control.
LANCET DIGITAL HEALTH
(2022)