Review
Biotechnology & Applied Microbiology
Di Chang, Yuanyuan Ma, Xiaoxuan Xu, Jinbing Xie, Shenghong Ju
Summary: Polymeric nanoparticles are widely used as carriers in medicine, especially in cancer therapy, due to their biocompatibility and ability to respond to stimuli conditions. Stimuli-responsive polymeric nanoplatforms have the potential to significantly improve the effectiveness of cancer treatment by changing physicochemical properties in target tissues.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Nanoscience & Nanotechnology
Liming He, Xianyan Qin, Donghao Fan, Chenglan Feng, Qin Wang, Jiyu Fang
Summary: This study presents a novel dual stimuli-responsive polymeric micelle for delivering dexamethasone to arthritic joints and controlling release in response to inflammatory stimuli, showing potential for effective treatment of rheumatoid arthritis.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Review
Chemistry, Multidisciplinary
Chendi Ding, Chunbo Chen, Xiaowei Zeng, Hongzhong Chen, Yanli Zhao
Summary: Prodrugs are inactive drug molecules that are converted to active drugs after administration. They play a crucial role in drug treatment, especially in cancer therapy. Current research focuses on stimuli-responsive activation mechanisms, regulation of stimuli intensity in vivo, and the design of nanoscale prodrug formulations.
Article
Biochemistry & Molecular Biology
Yanggui Wu, Senbin Chen, Jintao Zhu
Summary: The article introduces the construction of supramolecular polymer micelles using H-bond technology, loaded with chemotherapeutic drugs and photothermal agents for synergistic chemo-/photothermal therapies. These nanomedicines have enhanced drug loading capacity, transport performance, and stimuli-responsive drug release.
Review
Polymer Science
Sina Shahi, Hossein Roghani-Mamaqani, Saeid Talebi, Hanieh Mardani
Summary: Covalently crosslinked stimuli-destructible hydrogels with irreversible stimuli-controlled bond dissociation have versatile applications in biomedical field and micro/nanotechnologies. These hydrogels, due to their easy preparation and biocompatibility, hold great potential in drug delivery, medical dressings, cell detection, and other areas.
Review
Chemistry, Multidisciplinary
Liuzhou Mao, Panqin Ma, Xi Luo, Hongwei Cheng, Zhanxiang Wang, Enyi Ye, Xian Jun Loh, Yun-Long Wu, Zibiao Li
Summary: The development of nanovaccines that use polymeric delivery carriers has gained significant attention for therapeutic treatment of cancer and infectious diseases. Stimuli-responsive polymeric nanocarriers have shown promise for targeted delivery of antigens and adjuvants, improving immune responses and immunotherapy. This review presents the recent advancements in stimulus-responsive polymer-based nanovaccines for immunotherapeutic applications and discusses strategies for future designs of multifunctional polymeric nanovaccines.
Review
Chemistry, Multidisciplinary
Alexander B. Cook, Paolo Decuzzi
Summary: Materials that respond to endogenous stimuli play a crucial role in enhancing spatiotemporal control in biomedical applications. These materials can be designed to undergo morphological or chemical changes in response to specific biological cues, offering promising opportunities for improving therapeutic efficacy and developing personalized healthcare systems. They can be engineered across different length scales to respond to endogenous signals such as enzymes, pH, glucose, and hold great potential for a wide range of applications.
Article
Biochemistry & Molecular Biology
Lan Wang, Zhen Du, Mengmeng Xu, Qiuju Dai, Qing-Yun Guo, Baoer Fan, Wen Tang
Summary: In this study, a drug delivery platform based on POSS-polymer conjugates was developed. By functionalizing the POSS and establishing coordination with boronic acids, the nanoparticles exhibited responsive behavior to multiple stimuli. The platform holds promise for the development of intelligent drug delivery systems, enhancing drug efficacy while minimizing systemic toxicity.
Article
Polymer Science
Krisada Auepattana-Aumrung, Treethip Phakkeeree, Daniel Crespy
Summary: Corrosion is a significant issue for metals and alloys, but can be reduced by adding corrosion inhibitors to coatings, leading to the development of polymer-corrosion inhibitor conjugates. Different fields of applications require different levels and types of metal protection, where beta-thiopropionate and ester linkages play a role in providing suitable protection for varying corrosion levels.
JOURNAL OF APPLIED POLYMER SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Tovi Shapira-Furman, Abraham J. Domb
Summary: This report introduces a novel approach of nano formulation using stereo-interaction mechanism with poly(D-lactide)-polyethylene glycol (D-PLA-PEG) to address the challenges of controlled drug delivery for peptide and protein therapeutics. The study demonstrates that nano particles formed by the interaction between water-soluble D-PLA-PEG and insulin can achieve sustained release of insulin, showing potential application in diabetes treatment.
MACROMOLECULAR BIOSCIENCE
(2023)
Article
Chemistry, Physical
Gayathri R. Ediriweera, Yixin Chang, Qiaoyun Wang, Yutong Gong, Dewan T. Akhter, Huiwen Pang, Felicity Y. Han, Chunying Chen, Andrew K. Whittaker, Changkui Fu
Summary: A new polymer, poly(2-(methylsulfinyl)ethyl acrylate) (PMSEA), was developed for conjugation with transferrin (Tf) protein to overcome PEG-related immunogenicity and improve the in vivo pharmacokinetic profile of proteins. By using a cleavable thioketal linker, successful protein release was achieved, avoiding the loss of protein activity upon chemical modification. The Tf-PMSEA conjugate significantly improved the in vivo pharmacokinetics and tumor accumulation compared to the PEGylated counterpart, demonstrating the potential of PMSEA as a promising alternative to PEG for therapeutic delivery applications.
CHEMISTRY OF MATERIALS
(2023)
Review
Chemistry, Multidisciplinary
Asmita Banstola, Kishwor Poudel, Jong Oh Kim, Jee-Heon Jeong, Simmyung Yook
Summary: It has been found that low immunogenicity and immunosuppressive tumor microenvironments are significant obstacles to the application of cancer immunotherapy. Researchers are exploring the use of stimuli-responsive nanoparticles to improve cancer immunotherapy in order to overcome these challenges.
JOURNAL OF CONTROLLED RELEASE
(2021)
Review
Pharmacology & Pharmacy
Yijun Zhao, Xumei Ouyang, Yongjun Peng, Shaojun Peng
Summary: Gas therapy, particularly NO-based nanomedicines, holds promise in cancer treatment by enhancing therapeutic efficacy and reducing side effects. Numerous studies have focused on the design and development of NO-based nanomedicines triggered by various stimuli for synergistic cancer therapy. Challenges and future perspectives in this field are also discussed for further development.
Article
Pharmacology & Pharmacy
Abdurrahim Can Egil, Alessio Carmignani, Matteo Battaglini, Bengu Sueda Sengul, Egemen Acar, Gianni Ciofani, Gozde Ozaydin Ince
Summary: The study reported the synthesis of dual-responsive nanocarriers that can tune drug release rates by controlling pH and temperature, showing potential therapeutic effects on human colorectal adenocarcinoma cells.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Materials Science, Multidisciplinary
Pooyan Makvandi, Rezvan Jamaledin, Guojun Chen, Zahra Baghbantaraghdari, Ehsan Nazarzadeh Zare, Concetta Di Natale, Valentina Onesto, Raffaele Vecchione, Jesse Lee, Franklin R. Tay, Paolo Netti, Virgilio Mattoli, Ana Jaklenec, Zhen Gu, Robert Langer
Summary: Microneedle (MN) patches, made up of miniature needles, have emerged as a promising tool for minimally invasive translocation of biomolecules into the dermis. Stimuli-responsive MN patches are a new drug delivery system that can release cargos in response to internal or external triggers, with various mechanisms of action for different indications. Future opportunities and challenges in clinical translation are also discussed.
Article
Biochemistry & Molecular Biology
Romina Bashllari, Maria Sofia Molonia, Claudia Muscara, Antonio Speciale, Peter J. Wilde, Antonella Saija, Francesco Cimino
Summary: This study investigated the intracellular mechanisms involved in FFAs modulation of intestinal epithelial lipotoxicity and the protective effects of cyanidin-3-O-glucoside (C3G) in Caco-2 cells using a novel experimental model.
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
(2023)
Review
Chemistry, Physical
Carmelo Corsaro, Giulia Neri, Antonio Santoro, Enza Fazio
Summary: This article introduces the advantages and challenges of acrylate and methacrylate polymers, focusing on their applications in medical, electronic, food packaging, and environmental remediation fields. It also discusses the issue of their recyclability and describes the most influential strategies for recyclable composites based on acrylic polymers.
Review
Biochemistry & Molecular Biology
Antonio Speciale, Claudia Muscara, Maria Sofia Molonia, Mariateresa Cristani, Francesco Cimino, Antonella Saija
Summary: Liver cancer is a common cause of cancer mortality worldwide. Chemotherapy and radiotherapy are conventional therapies, but their toxicity limits their efficacy. Using glycyrrhetinic acid as a ligand to target liver cells can improve drug delivery systems and enhance treatment efficacy.
Article
Chemistry, Physical
Marcello Condorelli, Antonio Speciale, Francesco Cimino, Claudia Muscara, Enza Fazio, Luisa D'Urso, Carmelo Corsaro, Giulia Neri, Angela Maria Mezzasalma, Giuseppe Compagnini, Fortunato Neri, Antonina Saija
Summary: Gold nanoparticles (Au NPs) are highly regarded for their biocompatible nature and extensive biomedical applications. In our research, we investigated the bioproperties of functionalized Au NPs using LCCs for the first time. Results showed that the Au@LCC samples significantly reduced TNF gene expression and induced higher levels of heme oxygenase-1 gene expression compared to the 1:1 dispersion.
Article
Biochemistry & Molecular Biology
Antonio Speciale, Romina Bashllari, Claudia Muscara, Maria Sofia Molonia, Antonella Saija, Shikha Saha, Peter J. Wilde, Francesco Cimino
Summary: This study investigated the stability of anthocyanins in the digestive tract and their potential protective effects against inflammatory bowel diseases. The results showed that anthocyanins were unstable in the small intestine, but the digested extracts still exhibited anti-inflammatory and antioxidant activities. This suggests that dietary or supplement intake of anthocyanins may be beneficial for the prevention of inflammatory bowel diseases.
Article
Biochemistry & Molecular Biology
Edoardo Napoli, Giuseppe Ruberto, Alessandra Carrubba, Mauro Sarno, Claudia Muscara, Antonio Speciale, Mariateresa Cristani, Francesco Cimino, Antonella Saija
Summary: This study evaluated the phytochemical composition of wastewaters from hydrodistillation of five aromatic plants belonging to the Lamiaceae family and assessed their antioxidant and anti-inflammatory activities. The results showed that the wastewaters contained various phenolic compounds with good biological activities. This research contributes to the understanding of the polyphenolic composition of these wastewaters and their potential applications in the pharmaceutical and nutraceutical fields.
Correction
Chemistry, Physical
Marcello Condorelli, Antonio Speciale, Francesco Cimino, Claudia Muscara, Enza Fazio, Luisa D'Urso, Carmelo Corsaro, Giulia Neri, Angela Maria Mezzasalma, Giuseppe Compagnini, Fortunato Neri, Antonina Saija
Article
Biochemistry & Molecular Biology
Valeriy V. Ginzburg, Enza Fazio, Carmelo Corsaro
Summary: In this study, a new dynamic mean-field model combined with the Sanchez-Lacombe thermodynamic theory was used to describe the equation of state and diffusivity of liquid water. The model predictions were consistent with experimental data.
Article
Biochemistry & Molecular Biology
Maryem Bouabidi, Federica Lina Salamone, Chemseddoha Gadhi, Hafida Bouamama, Antonio Speciale, Giovanna Ginestra, Luana Pulvirenti, Laura Siracusa, Antonia Nostro, Mariateresa Cristani
Summary: This study investigates the bioactivity of extracts from two Moroccan Cistus species as potential coadjuvants in the treatment of mild acne vulgaris. The extracts contain various polyphenols and exhibit good antibacterial activity, particularly against Staphylococcus aureus, S. epidermidis, and Propionibacterium acnes, which are the main acne-causing bacteria.
Article
Chemistry, Physical
Carmelo Corsaro, Marcello Condorelli, Antonio Speciale, Francesco Cimino, Giuseppe Forte, Francesco Barreca, Salvatore Spadaro, Claudia Muscara, Manuela D'Arrigo, Giovanni Toscano, Luisa D'Urso, Giuseppe Compagnini, Fortunato Neri, Antonina Saija, Enza Fazio
Summary: The synthesis of contaminant-free silver@linear carbon chains (Ag@LCCs) nanohybrid systems, at different Ag/LCCs ratios, by pulsed laser ablation was investigated. The ablation products were characterized using UV-Vis optical absorption, micro-Raman spectroscopy, and transmission mode scanning electron microscopy. The experimental results were supported by theoretical simulations. Moreover, the bioproperties of the Ag@LCCs nanosystems were studied for wound-healing activity, and it was found that Ag@LCC nanohybrids exhibited good antibacterial properties and had enhanced interaction with mammalian cells, suggesting their potential application in wound healing.
Article
Chemistry, Physical
Ettore Maggiore, Carmelo Corsaro, Enza Fazio, Inam Mirza, Francesco Ripamonti, Matteo Tommasini, Paolo M. M. Ossi
Summary: This study aimed to replace the soft Ultra High Molecular Weight Polyethylene (UHMWPE) used for skiing bases with a hard metallic material. By using ultra-short laser pulses, the surface of square plates made of AISI 301H stainless steel was modified to reduce the friction coefficient. The treated bases performed worse than UHMWPE in laboratory tests, but waxing improved their performance.
Review
Polymer Science
Martina Vacalebre, Renato Frison, Carmelo Corsaro, Fortunato Neri, Antonio Santoro, Sabrina Conoci, Elena Anastasi, Maria Cristina Curatolo, Enza Fazio
Summary: Intraocular lenses (IOLs) are implanted after cataract surgery and various materials like collamer, hydrophobic acrylic, hydrophilic acrylic, PHEMA copolymer, PMMA, and silicone are used for IOL manufacturing. The evolution of polymeric materials for IOL design and their unique properties are discussed, including the need for biocompatibility and tunable refractive index to prevent posterior capsular opacification.
Article
Food Science & Technology
Maria Sofia Molonia, Claudia Muscara, Antonio Speciale, Federica Lina Salamone, Gregorio Costa, Grazia Vento, Antonella Saija, Francesco Cimino
Summary: This study reveals that low concentrations of antimony exposure during preadipocyte differentiation have obesogenic effects, leading to metabolic dysfunction, activation of inflammatory response, and disturbance of endoplasmic reticulum homeostasis.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Engineering, Electrical & Electronic
Rayhane Zribi, Angelo Ferlazzo, Enza Fazio, Marcello Condorelli, Luisa D'Urso, Giulia Neri, Carmelo Corsaro, Fortunato Neri, Giuseppe Compagnini, Giovanni Neri
Summary: This study fabricated and characterized a sensor based on silver nanoplates colloidal solutions deposited onto screen-printed carbon electrodes. The sensor showed wavelength-dependent and size-tunable electrochemical sensing response towards hydrogen peroxide (H2O2). The study also demonstrated the potential of using Ag nanoparticles with specific nanoplates morphology for electrochemical redox probes.
IEEE TRANSACTIONS ON INSTRUMENTATION AND MEASUREMENT
(2023)
