Journal
JOURNAL OF NANOPARTICLE RESEARCH
Volume 18, Issue 1, Pages -Publisher
SPRINGER
DOI: 10.1007/s11051-015-3318-5
Keywords
Magnetic nanoparticles; Salicylic acid; CAM assay; Magnetic targeting; Nanoblocking; Nanomedicine
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Funding
- Project Excellence program for multidisciplinary doctoral and postdoctoral research in chronic diseases [POSDRU/159/1.5/S/133377]
- Sectoral Operational Programme Human Resources Development - European Social Fund
- Sectoral Operational Programme Human Resources Development of the Ministry of European Founds [POSDRU/159/1.5/S/132397]
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An aqueous dispersion of Fe3O4/salicylic acid magnetic nanoparticles (SaMNPs) was synthesized by a modified Massart method, characterized by Inductively Coupled Plasma-Optic Emission Spectrometry (ICP-OES), High-Resolution Transmission Electron Microscopy (HRTEM) and Dynamic Light Scattering (DLS) methods, and tested on the chick chorioallantoic membrane (CAM) model to evaluate biocompatibility, biodistribution, intravascular time persistence, and ability to be magnetically target driven in order to block the blood supply into a tumor xenograft. ICP-OES, DLS, and HRTEM SaMNPs sample analyses showed a 0.356 mg/mL Fe concentration, a good stability in water (average Zeta potential of 39.3 mV), a hydrodynamic diameter around 52 nm and a core diameter in the 7-15 nm range for the Fe3O4 nanoparticles. In vivo CAM assay showed that SaMNPs were biocompatible with the chick embryo, were fixed almost completely by the liver, had no embolic potential, and a threshold-dosedependent intravascular magnetic targeting time. Study on the CAM tumor model showed that SaMNPs could be used for long-term magnetically mediated nanoblocking of the capillary networks and 70-lm smaller arterioles.
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