Article
Chemistry, Inorganic & Nuclear
Giriraj Kalaiarasi, Pathinathan Senthilrajkapoor, Ramasamy Indumathy
Summary: Four new bivalent ruthenium(II) organometallic complexes were synthesized and characterized. The complexes showed significant antimicrobial activity and anticancer potential, exceeding that of their parent ligands and the standard drug cisplatin.
INORGANIC CHEMISTRY COMMUNICATIONS
(2022)
Review
Chemistry, Physical
Dariusz Osypiuk, Agata Bartyzel, Beata Cristovao
Summary: The aim of this study was to synthesize and characterize new Zn-II complexes with different Schiff bases. The synthesized complexes showed stable polycrystalline structures and their coordination modes with zinc ions were determined by FTIR spectroscopy. The thermal analysis revealed that the decomposition of these complexes occurred in multiple stages, depending on the Schiff base ligands and the atmosphere. Additionally, the antioxidant activities of the complexes were evaluated, showing enhanced or comparable activity compared to the free Schiff bases when complexed with zinc ions. Rating: 7.5/10
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Chemistry, Inorganic & Nuclear
R. Tamizhselvi, Ayyakannu Arumugam Napoleon
Summary: A simple and easily synthesizable chromogenic small molecules probe L4 and L5 were successfully synthesized and characterized. L4 and L5 showed colorimetric naked eye detection of Cr3+ and Pb2+ ions, with good binding properties and low detection limits. The designed probes were applied for rapid detection of Cr3+ and Pb2+ in environmental samples, indicating their potential use.
INORGANIC CHEMISTRY COMMUNICATIONS
(2022)
Article
Chemistry, Applied
Serpil Kaya, Sultan Erkan, Duran Karakas
Summary: In this study, four-coordinated hypothetical platinum-II complexes were designed and characterized computationally. The complexes were found to have a distorted square planar geometry and the presence of an electron-donating group in the Schiff bases increased their anticancer and antibacterial activities.
APPLIED ORGANOMETALLIC CHEMISTRY
(2022)
Article
Chemistry, Applied
Kalaiarasi Giriraj, Mohamed Subarkhan Mohamed Kasim, Keerthana Balasubramaniam, Sathiya Kamatchi Thangavel, Janani Venkatesan, Sharmila Suresh, Pritha Shanmugam, Chiranjeevi Karri
Summary: Four Co (III) complexes containing substituted acetyl coumarin Schiff bases were synthesized and structurally characterized, showing two of the complexes with similar coordination behavior and the other two with different coordination modes. These complexes demonstrated higher anticancer activity than the standard drug and ligands, specifically targeting cancer cells and inducing cell death through apoptosis.
APPLIED ORGANOMETALLIC CHEMISTRY
(2022)
Review
Chemistry, Inorganic & Nuclear
Maryam Bashir, Maryam Saifullah, Mubeshar Riaz, Muhammad Arshad, Ahmad Irfan, Sadia Iqbal, Zahoor H. Farooqi, Robina Begum
Summary: This mini review summarizes the potential applications of phloroglucinol derivatives in various fields. Different groups of scientists have explored various derivatives of phloroglucinol for a wide range of applications. The review focuses on the synthesis, structural, medicinal, catalytic, and enzyme inhibitory importance of phloroglucinol Schiff bases and their metal complexes.
INORGANIC CHEMISTRY COMMUNICATIONS
(2023)
Article
Chemistry, Inorganic & Nuclear
Martin Schoeller, Karin Preinerova, Vladimir Jorik, Milan Mazur, Jan Moncol'
Summary: A new mononuclear manganese(II) complex with a chlorido-substituted hexadentate Schiff base ligand was synthesized and its crystal structure was determined by single-crystal X-ray diffraction. The complex exhibited a triclinic crystal system with a P1 space group. The manganese(II) central atom was coordinated by two oxygen atoms and four nitrogen atoms of the Schiff base. The supramolecular structure and intermolecular interactions of the complex were analyzed using Hirshfeld surface analysis. Characterization of the complex was done using UV-vis and infrared spectra, and the presence of a high-spin Mn(II) state (S = 5/2) was confirmed by solid-state EPR spectroscopy.
INORGANIC CHEMISTRY COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Marek Pajak, Magdalena Wozniczka, Marta E. Lichawska, Bartlomiej Czerwinski, Jakub Wlodarczyk, Jakub Fichna
Summary: This study investigates the complexation properties of oxime-containing Schiff bases with Co(II) ions and their potential application as synthetic oxygen transporters. The obtained data can contribute to the development of oxygen bioinorganic complexes and catalytic activity research.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Chemistry, Multidisciplinary
Domenico Iacopetta, Jessica Ceramella, Alessia Catalano, Carmela Saturnino, Maria Grazia Bonomo, Carlo Franchini, Maria Stefania Sinicropi
Summary: Schiff bases, named after Hugo Schiff, are highly reactive organic compounds widely used in various applications such as pigments, dyes, catalysts, intermediates in organic synthesis, and polymer stabilizers. They are known for their diverse biological activities, including antitumor properties, as well as their ability to form complexes with metals. The complexes of Schiff bases with metals have shown interesting antitumor activities.
APPLIED SCIENCES-BASEL
(2021)
Article
Biochemistry & Molecular Biology
Saira Manzoor, Rana Adnan Tahir, Muhammad Adnan Younis, Wen-Li Cao, Qamar-un-nisa Tariq, Amjad Ali, Naushad Ahmad, Chuntian Qiu, Bingbing Tian, Jian-Guo Zhang
Summary: In this study, a series of pyrimidine-derived Schiff bases were synthesized and evaluated for their antibacterial, antioxidant, antifungal, and anticancer activities. The computational docking analysis showed that these compounds exhibited better binding affinities compared to standard drugs.
BIOORGANIC CHEMISTRY
(2023)
Review
Engineering, Environmental
Sikandar Khan, Xiaojing Chen, Albandary Almahri, Esam S. Allehyani, Fahad A. Alhumaydhi, Munjed M. Ibrahim, Shujat Ali
Summary: Schiff bases are compounds synthesized through the condensation reaction of primary amines with carbonyl compounds, showing potential applications in medicine and chemical sensing. They coordinate with various metal ions to form stable complexes and are utilized as chemical sensors for detecting different metal ions.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2021)
Review
Chemistry, Inorganic & Nuclear
Muhammad Pervaiz, Anfal Munir, Aqsa Riaz, Zohaib Saeed, Umer Younas, Muhammad Imran, Sami Ullah, Rashida Bashir, Ayoub Rashid, Ahmad Adnan
Summary: Schiff base ligands and their metal complexes have gained significant attention due to their wide range of applications and unique structural features. They have been extensively used in various fields, including material science and biology, because of their broad-spectrum biological activities.
INORGANIC CHEMISTRY COMMUNICATIONS
(2022)
Review
Engineering, Electrical & Electronic
Sneha Kagatikar, Dhanya Sunil
Summary: Optoelectronics is a field of active research focusing on developing semiconducting materials with a wide emission window for energy conservation and improved device lifetime. Efficient material design for OLEDs has been a key area of research, along with the exploration of metal-organic compounds for OLED applications.
JOURNAL OF ELECTRONIC MATERIALS
(2021)
Article
Biochemistry & Molecular Biology
Hanan B. Howsaui, Amal S. Basaleh, Magda H. Abdellattif, Walid M. Hassan, Mostafa A. Hussien
Summary: Three novel 2-aminopyrazine Schiff bases and their uranyl complexes were synthesized and characterized, with studies on DNA binding and anticancer activities showing promising results. Molecular docking analysis provided insights into interactions with cancer proteins.
Review
Chemistry, Inorganic & Nuclear
Aemin Ali, Muhammad Pervaiz, Zohaib Saeed, Umer Younas, Rashida Bashir, Sami Ullah, Syed Majid Bukhari, Faisal Ali, Seemal Jelani, Ayoub Rashid, Ahmad Adnan
Summary: Schiff bases are versatile and valuable compounds in the field of medicine and pharmaceuticals. This article discusses the formation and characterization of metal complexes of Schiff base derived from 4-dimethylaminobenzaldehyde, highlighting their importance and applications. The complexes show strong biological activities and have potential therapeutic applications. Their catalytic activity is enhanced by metal coordination.
INORGANIC CHEMISTRY COMMUNICATIONS
(2022)
Article
Medicine, Research & Experimental
Yousra Abdel-Mottaleb, Howaida S. Ali, Mohamed K. El-Kherbetawy, Amany Y. Elkazzaz, Mohamed H. ElSayed, Amr Elshormilisy, Amira H. Eltrawy, Sally Y. Abed, Asma M. Alshahrani, Abdullah A. Hashish, Eman Saad Alamri, Sawsan A. Zaitone
Summary: This study examines the potential therapeutic effect of a saponin-rich extract of Tribulus terrestris (TTS) on dietary obesity in female rats. The results show that TTS can control inflammatory burden, improve insulin resistance and body weight gain, and ameliorate reproductive system pathologies.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Chemistry, Multidisciplinary
Reem Alshaman, Abdullah Alattar, Rehab M. El-Sayed, Ahmed R. Gardouh, Rabie E. Elshaer, Amany Y. Elkazaz, Mohamed Ahmed Eladl, Mohamed El-Sherbiny, Noha E. Farag, Ahmed Mohsen Hamdan, Sawsan A. Zaitone
Summary: The study formulated doxycycline-loaded polymeric nanoparticles and tested their characteristics and drug release rate. In animal experiments, the doxycycline-loaded nanoparticles showed enhanced antitumor activity and reduced angiogenesis indicators.
Article
Cardiac & Cardiovascular Systems
Umar Abdolah Alharbe, Hanad Hassan Alatawi, Palanisamy Amirthalingam, Sultan Mohammed Daghriri, Alanoud Abduallah Alhwiti, Tahani Saud Alenazi, Abdulelah Turki S. Al Ahmare, Sawsan A. Zaitone, Ahmed Aljabri, Ahmed Mohsen Hamdan
Summary: This study compared the risk factors of acute myocardial infarction among Saudi nationals and expatriates and found significant differences, suggesting a potential genetic contribution to the risk factors.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Chemistry, Analytical
Eman A. Abdel Hameed, Zaitona A. Abd El-Naby, Alaa El Gindy, Roshdy E. Saraya, Aisha Nawaf Al Balawi, Sawsan A. Zaitone, Gasser M. Khairy
Summary: Novel green HPLC and HPTLC chromatographic methods were developed for the concurrent determination of moxifloxacin, levofloxacin, and gemifloxacin. Both methods were optimized, validated, and assessed using the Green analytical procedure index (GAPI). The results showed that these methods are suitable for pharmaceutical analysis and detection of cross-contamination during manufacturing processes.
Article
Medicine, Research & Experimental
Hala M. F. Mohammad, Sahar Galal Gouda, Mohamed Ahmed Eladl, Amany Y. Elkazaz, Khaled S. Elbayoumi, Noha E. Farag, Amr Elshormilisy, Buthainah B. Al-Ammash, Ann Hegazy, Sozan M. Abdelkhalig, Abir S. Mohamed, Mohamed El-Dosoky, Sawsan A. Zaitone
Summary: This study investigates the molecular mechanisms leading to DN and the role of LRG1, ALK1, and TGF beta 1 in DN pathologic alterations. It also explores the protective action of metformin against DN and its influence on LRG1 and ALK1/TGF beta 1 induced renal angiogenesis. The results show that metformin has renoprotective effects in a diabetic model, partly mediated by downregulation of LRG1 and TGF beta 1/ALK1-induced renal angiogenesis.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Correction
Immunology
Nehal M. Elsherbiny, Eman Ahmed, Ghada Abdel Kader, Yousra Abdel-mottaleb, Mohamed H. ElSayed, Amal M. Youssef, Sawsan A. Zaitone
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Medicine, Research & Experimental
Hebatallah Husseini Atteia, Eman Saad Alamri, Nizar Sirag, Nahla Salah Zidan, Raghad Humod Aljohani, Sharifa Alzahrani, Manar Hamed Arafa, Nanies Sameeh Mohammad, Mervat Elsayed Asker, Sawsan A. Zaitone, Amr Tawfik Sakr
Summary: This study investigated the potential of isoliquiritigenin, a bioflavonoid extracted from licorice roots, as a natural activator for soluble Guanylate Cyclase (sGC) in a chronic kidney disease (CKD) rat model. The results showed that isoliquiritigenin dose-dependently improved CKD-related renal and endothelial dysfunction, reduced fibrosis, apoptosis, and calcification, and attenuated inflammation and oxidative stress. These protective effects were associated with the activation of sGC, increased cGMP and its downstream PKG. However, co-treatment with a selective sGC inhibitor antagonized the therapeutic impact of isoliquiritigenin.
Article
Toxicology
Mohammed A. Attia, Nema Soliman, Mohamed Ahmed Eladl, Shymaa E. Bilasy, Taghrid B. El-Abaseri, Howaida S. Ali, Faten Abbas, Dalia Ibrahim, Noura M. S. Osman, Abdullah A. Hashish, Asma Alshahrani, Abir S. Mohamed, Sawsan A. Zaitone
Summary: The current study demonstrated that topiramate has a neuroprotective effect in mouse peripheral diabetic neuropathy and investigated the underlying mechanisms. Treatment with topiramate increased the hotplate latency time and von-Frey test pain threshold, alleviating pain in DN mice. Additionally, topiramate also attenuated axonal degeneration in sciatic nerves and suppressed the expression of GFAP and inflammatory cytokines while enhancing the plasticity of the spinal cord. This study reinforces the neuroprotective role of topiramate and provides insights into its mechanisms in alleviating neuropathy.
TOXICOLOGY MECHANISMS AND METHODS
(2023)
Article
Pharmacology & Pharmacy
Mohamed F. Zaky, Taha M. Hammady, Shadeed Gad, Abdullah Alattar, Reem Alshaman, Ann Hegazy, Sawsan A. Zaitone, Mamdouh Mostafa Ghorab, Mohamed A. Megahed
Summary: Nanostructured lipid carriers (NLCs) have been studied for their potential to enhance the bioavailability and efficacy of drugs, and the surface modification of NLCs with chitosan and PEGylation has been investigated in this study. The results showed that both chitosanization and PEGylation improved the stability, bioavailability, and pharmacodynamic activity of NLCs loaded with apixaban. Chitosan-modified NLCs displayed better stability and enhanced anticoagulant activity, while PEGylated NLCs showed higher absorption profile in rats.
Article
Infectious Diseases
Mohamed F. Ghaly, Marzough Aziz Albalawi, Mahmoud M. Bendary, Ahmed Shahin, Mohamed A. Shaheen, Abeer F. Abu Eleneen, Mohammed M. Ghoneim, Ayman Abo Elmaaty, Mohamed F. M. Elrefai, Sawsan A. Zaitone, Amira I. Abousaty
Summary: The worldwide crises of multi-drug-resistant bacterial infections have led to a search for alternative therapies. Our research group evaluated the antimicrobial activities of the ethanolic extract of Tamarindus indica, a traditional medicine. The extract showed promising antimicrobial activities against multi-drug-resistant pathogens, with confirmed mechanisms of action and antivirulence activities. We hope that pharmaceutical companies can utilize our findings to develop a new formulation of T. indica extract with other antibiotics.
Article
Chemistry, Medicinal
Samah M. M. Elaidy, Mohamed K. K. El-Kherbetawy, Sally Y. Y. Abed, Abdullah Alattar, Reem Alshaman, Mohamed Ahmed Eladl, Eman Saad Alamri, Aisha Nawaf Al Balawi, AbdelNaser Zaid, Amany Y. Y. Elkazzaz, Sozan M. M. Abdelkhalig, Ziad E. E. Hamed, Sawsan A. A. Zaitone
Summary: This study investigated the chemotherapeutic effect of alpha-hederin in combination with cisplatin on Ehrlich solid tumors in mice. The results showed that alpha-hederin significantly enhanced the chemotherapeutic efficacy of cisplatin against Ehrlich solid tumors by suppressing the signaling pathway of SDF1/CXCR4/p-AKT/NF kappa B.
Article
Chemistry, Medicinal
Eman J. Heikal, Rashad M. Kaoud, Shadeed Gad, Hatem I. Mokhtar, Afaf A. Aldahish, Wafa Ali Alzlaiq, Sawsan A. Zaitone, Yasser M. Moustafa, Taha M. Hammady
Summary: This study aimed to develop a pharmaceutical dosage form containing omeprazole and curcumin for treating experimental peptic ulcers. The complex of omeprazole and curcumin was loaded into alginate beads and coated with chitosan for sustained release. The formulated beads showed improved anti-ulcer effectiveness compared to free omeprazole or omeprazole-only-loaded beads. Evaluation: x/10
Article
Polymer Science
Eman J. Heikal, Rashad M. Kaoud, Shadeed Gad, Hatem I. Mokhtar, Abdullah Alattar, Reem Alshaman, Sawsan A. Zaitone, Yasser M. Moustafa, Taha M. Hammady
Summary: This research developed a drug delivery system by coating alginate/chitosan beads with Eudragit (R) S-100 to target the colon and effectively treat colitis. The coated beads showed controlled release of curcumin/mesalamine at different pH levels. The optimized formula demonstrated high entrapment efficiency, swelling, and bead size. It significantly reduced colitis, indicating its potential for treating ulcerative colitis.
Article
Medicine, Research & Experimental
Mohammed H. ElSayed, Khaled S. Elbayoumi, Mohamed Ahmed Eladl, Abeer A. K. Mohamed, Ann Hegazy, Nagla A. El-Sherbeeny, Mohammed A. Attia, Fatma Azzahraa Hisham, Mohamed A. K. Saleh, Abdelhakeem Elaskary, Khaled Morsi, Amna M. A. Mustsafa, Eman T. Enan, Sawsan A. Zaitone
Summary: Diabetic retinopathy (DRET) can lead to vision loss in adults, but there are limited therapeutic options available. This study investigated the neuroprotective effect of memantine, an anti-Alzheimer drug, in experimental DRET and its impact on ROS/TXNIP/NLRP3 signaling cascade. The results demonstrated that memantine attenuated retinal damage and reduced inflammation in DRET.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Pharmacology & Pharmacy
Reem Alshaman, Mona Qushawy, Hatem I. Mokhtar, Angie M. Ameen, Rehab M. El-Sayed, Eman Saad Alamri, Lamiaa M. Elabbasy, Ahmed M. N. Helaly, Walid F. Elkhatib, Eidah M. Alyahya, Sawsan A. Zaitone
Summary: This study demonstrated that treatment with M-Oil or M-NE improved motor performance in mice with experimental PD, enhanced anti-inflammatory and antioxidant actions, downregulated inflammatory markers and malondialdehyde levels, and improved physical characteristics by formulating M-Oil as M-NE.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Chemistry, Physical
Xinlei Chen, Shiyi Chen, Xuele Lin, Jingxuan Zhou, Xingjun Gao, Yaoqi Zhen, Xiaodan Ma, Shouwen Jin, Linfang Shi, Hui Liu, Daqi Wang
Summary: Nine mixed-ligand Cd2+ complexes with different geometric structures were synthesized and characterized. The complexes exhibit various coordination modes and form both intra- and intermolecular hydrogen bonds.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Rupali Mahajan, Abhishek Sharma, Bhagyashree Patra, Lijo Mani, Parul Grover, Sandeep Kumar, Santosh Kumar Guru, Gananadhamu Samanthula, Amol G. Dikundwar, Amit Asthana
Summary: This research article provides a comprehensive characterization and toxicological assessment of a photoisomeric impurity of the antianemic drug Roxadustat. The impurity has a distinct structure compared to the drug and its formation due to light exposure is a concern. Through various experiments, including single crystal XRD, physicochemical characterization, and in vitro cytotoxicity assays, the researchers confirmed the structure of the impurity, evaluated its conversion with Roxadustat, and assessed its toxicological activity. These findings contribute to the understanding of drug stability, safety, and formulation development.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Laila S. Alqarni, Azzah M. Alghamdi, Nuha Y. Elamin, A. Rajeh
Summary: The solution casting method was used to produce a new type of nanocomposites made of chitosan, gelatin, and co-doped ZnO nanoparticles. The addition of 3.5% co-doped ZnO nanoparticles improved the physicochemical characteristics and antimicrobial effects of the nanocomposites, indicating their significant potential in food packaging and energy storage.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Ruchi Gaur
Summary: The structure and intermolecular interactions of a newly synthesized bis-chalcone THXA were studied using experimental and computational methods. The importance of non-covalent interactions such as pi center dot center dot center dot pi, C-H center dot center dot center dot S, and C-H center dot center dot center dot pi was revealed.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Andrii Bazylevich, Leonid Patsenker, Sarit Aviel-Ronen, Gary Gellerman
Summary: Drug combination therapy is commonly used for treating various skin disorders, but its effectiveness is often limited. In this study, researchers synthesized conjugates of anti-pigmenting drugs and hyaluronic acid (HA) to improve treatment efficacy. These HA-drug conjugates exhibited measurable drug release profiles and demonstrated superior depigmentation effects compared to control groups in a swine model.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Xiaodan Ma, Xinlei Chen, Yaoqi Zhen, Xunjie Zheng, Chengzhe Shi, Shouwen Jin, Bin Liu, Bin Chen, Daqi Wang
Summary: Cocrystallization experiments between minoxidil and aryl acids coformers resulted in the successful formation of multi-component samples. The nature of these samples was determined using various techniques and their structural and supramolecular aspects were investigated. The outcomes revealed the importance of nonbonding contacts and different types of interactions in stabilizing and expanding the crystal structures.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Najla A. Alshaye, Magdy A. Ibrahim, Al-Shimaa Badran
Summary: The chemical behavior of 3-substituted-6,8-dimethylchromones towards phenylhydrazine was examined. Different reaction conditions produced various products, and the molecular geometries and reactivity descriptors of the compounds were also investigated. The results suggest that these compounds are suitable for nonlinear optical applications.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Hayette Alliouche, Houria Bouria, Rafik Bensegueni, Mounia Guergouri, Abdelmalek Bouraiou, Ali Belfaitah
Summary: In this paper, a combined experimental and theoretical study was conducted to synthesize and characterize new 2-quinolone-piperidine and -morpholine hybrids. The results from experiments were validated using computational calculations, and the affinity between these compounds and Acetylcholinesterase/Butyrylcholinesterase was estimated through molecular docking.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Wei-Min Chen, Juan-Juan Shao, Yi Zhang, Zhen-Dong Xue, Peng-Lai Liu, Jian-Ling Ni, Li-Zhuang Chen, Qiang Gao, Fang-Ming Wang
Summary: This study synthesized and characterized a novel Mn-based LMOF, and achieved good results in detecting heavy metal Al3+ in water, showing good stability, high selectivity and sensitivity. This provides new insights into the potential applications of Mn-based MOFs in chemical sensing.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Jun-Xia Li, Yi-Jing Lu, Ke-Ying Quan, Li-Bing Wu, Xun Feng, Wei-Zhou Wang
Summary: This study synthesized two cobalt(II) complexes and analyzed their crystal structures using single-crystal X-ray diffraction. The results showed that the crystal structures of these complexes were different, and they exhibited different crystal packing and magnetic properties.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Yang Li, Yan Zhang, Hong Xu, Min Li, Zhen Li, Zi-yu Song, Ji-shi Chen, Yan-Jun Liu, Yong Sun, Zhao Yang
Summary: This study reports the synthesis and solid-state characterization of a new pharmaceutical cocrystal, PRO-BPE, which can enhance the solubility of the highly water-insoluble prodrug probenecid. The PRO-BPE cocrystals were found to have superior water solubility compared to pure PRO. This research provides valuable insights into improving the solubility of poorly soluble drugs.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Lucas G. B. Felicio, Bianca B. M. Vieira, Ivana S. Lula, Renata Diniz, Frank Alexis, Flavio B. Miguz, Frederico B. De Sousa
Summary: A novel spiropyran derivative was synthesized for heavy metals sensing in water. The results demonstrated that the new derivative can serve as a rapid, sensitive, and simple tool for detecting Hg2+ ions in water with high selectivity.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Junqing Meng, Jie Wang, Lijuan Wang, Chunhui Lyu, Haiyan Chen, Yingpei Lyu, Baisheng Nie
Summary: Material modification with low surface energy can achieve lower surface free energy on micro-and nano-rough structures, which is crucial for developing superhydrophobic surfaces. In this study, attapulgite (APT) was modified with alkylamine, alkylammonium salt, and stearic acid, and the interaction between low surface materials and attapulgite was explained. The results showed that the hydrophobicity of APT was significantly modified by the modifiers, and the surface free energy of the composites first decreased and then increased with increasing molecular number of low surface energy monomers.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Karan Goswami, Dipak Das, Parthasarathi Bera, Sounak Roy, Md. Motin Seikh, Prasanta Kumar Sinha, Arup Gayen
Summary: This work presents the development of a simple and highly active heterogeneous Pd catalyst for Suzuki-Miyaura carbon-carbon cross-coupling reaction. The NiPdFe-1 catalyst shows the best activity and stability among the prepared catalysts. It efficiently promotes the coupling reaction between aryl bromide and phenyl boronic acid under mild reaction conditions with high isolated yields.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Ekta Pardhi, Devendra Singh Tomar, Rahul Khemchandani, Gananadhamu Samanthula, Pankaj Kumar Singh, Neelesh Kumar Mehra
Summary: The main aim of this study was to prepare a drug-drug coamorphous system to improve the physiochemical properties, solubility and stability of Apremilast and Indomethacin. Various solid-state characterization techniques were used to characterize the prepared system. Molecular level interactions were studied using molecular modeling and ATR-FTIR and 1H NMR. Solubility and dissolution studies showed the benefits of the coamorphous system. The system was found to be stable for a period of five months. Permeation study also demonstrated improved flux for both drugs compared to their crystalline forms. The coamorphous system showed anti-psoriatic and anti-melanogenic activity based on molecular docking results. Overall, the developed CAM-based supersaturated system exhibited improved physicochemical properties and physical stability.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
