The 2022 monkeypox outbreak in nonendemic countries: a review for the emergency department clinician

Since May 2022, monkeypox (MPX) cases have been reported from several European countries, and this outbreak rapidly spread globally. Although MPX is not a new disease, most clinicians in nonendemic countries are unfamiliar with it. In addition, this current outbreak, unlike previous outbreaks in Africa, shows unique features in terms of epidemiology, transmission routes, and clinical manifestation. Most cases were men who have sex with men, had no travel history to an MPX endemic area, and presented with anogenital lesions, suggesting human-to-human trans-mission via close contact during sexual activity. In the emergency department setting, rapid identification of suspected cases and implementation of effective infection control and preven-tive measures are critical for preventing further transmission to healthcare workers and other patients. Emergency department clinicians should be aware of the clinical presentations of MPX and be alert to patients presenting with fever and vesicular rash or sexually transmitted disease -associated rash, especially among those with travel history to countries reporting an MPX out-break. This brief review provides current information of MPX to help emergency department cli-nicians understand the epidemiology, transmission, clinical manifestation, diagnosis, treatment, and infection prevention and control of MPX.

Automated summary

Monkeypox (MPX) cases have been reported in European countries since May 2022, and this outbreak differs from previous outbreaks in Africa in terms of transmission routes and clinical manifestation. The current outbreak is mainly transmitted through sexual contact, and emergency department clinicians should be vigilant and implement effective infection control measures.