Pathogenic Mutations within the Disordered Palindromic Region of the Prion Protein Induce Structure Therein and Accelerate the Formation of Misfolded Oligomers

Title
Pathogenic Mutations within the Disordered Palindromic Region of the Prion Protein Induce Structure Therein and Accelerate the Formation of Misfolded Oligomers
Authors
Keywords
cellular prion protein, circular dichroism, hydrogen–deuterium exchange–mass spectrometry, size-exclusion chromatography, oligomerization
Journal
JOURNAL OF MOLECULAR BIOLOGY
Volume 428, Issue 20, Pages 3935-3947
Publisher
Elsevier BV
Online
2016-08-23
DOI
10.1016/j.jmb.2016.08.015

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