Article
Obstetrics & Gynecology
Emma C. Rossi, Edward Tanner
Summary: Sentinel lymph node biopsy is an accepted staging strategy for cervical and endometrial cancer surgeries; however, controversies remain in how it can be applied most safely and effectively. These issues ultimately need to be addressed through further clinical trials and observation of larger patient populations.
JOURNAL OF MINIMALLY INVASIVE GYNECOLOGY
(2021)
Editorial Material
Obstetrics & Gynecology
Antonino Ditto, Stefano Ferla, Fabio Martinelli, Giorgio Bogani, Umberto Leone Roberti Maggiore, Francesco Raspagliesi
Summary: This study aimed to share our experience of using real-time fluorescent ICG with 99m-technetium nanocolloid for bilateral sentinel lymph node biopsy in vulvar cancer surgery. Results showed that ICG mapping technique had a good detection rate and could help maintain surgical radicality and minimize complications in vulvar cancer patients.
JOURNAL OF MINIMALLY INVASIVE GYNECOLOGY
(2023)
Article
Agriculture, Dairy & Animal Science
Lavinia Elena Chiti, Elisa Maria Gariboldi, Damiano Stefanello, Donatella De Zani, Valeria Grieco, Mirja Christine Nolff
Summary: This study investigated the feasibility and detection rate of SLNB guided by NIRF-L or lymphoscintigraphy in cats with solid tumors. The results showed that SLNB guided by NIRF-L or lymphoscintigraphy is feasible and safe in cats with solid tumors, especially those with MCT.
Article
Oncology
Kelsey B. Montgomery, Tanya A. Correya, Kristy K. Broman
Summary: The adherence to nodal surveillance ultrasound (US) remains unknown in real-world practice for patients with sentinel lymph node-positive (SLN+) melanoma. This study found that adjuvant therapy appears to be associated with a decreased likelihood of US adherence.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Oncology
Andrea Ruzzenente, Simone Conci, Giulia Isa, Tommaso Campagnaro, Corrado Pedrazzani, Mario De Bellis, Ivan Marchitelli, Claudia Castelli, Sara Pecori, Alfredo Guglielmi
Summary: This study conducted an observational research to confirm the feasibility of ICG near-infrared imaging in liver and biliary cancer surgery. The results showed that ICG near-infrared imaging can accurately detect lymphatic outflow and sentinel lymph nodes, providing important guidance for surgery.
Article
Oncology
M. Poelcher, S. Matz, M. Braun, C. Brambs, M. Beer, M. Hamann
Summary: This study compared the detection rates of sentinel lymph nodes using indocyanine green (ICG) versus blue dye in patients with uterine or cervical cancer. The results showed a significantly higher rate of bilateral mapping with ICG, and a lower number of systematic lymph node dissection in the ICG cohort compared to the blue dye cohort, especially in endometrial cancer patients.
JOURNAL OF SURGICAL ONCOLOGY
(2021)
Article
Materials Science, Biomaterials
Ahmed A. Elbatrawy, Da Sol Lee, Sang Bong Lee, Hui-Jeon Jeon, Sijoon Lee, Kyung-ku Kang, Soo-Eun Sung, Ye Ri Han, Sung Jin Cho, Dong-Su Kim, Kil Soo Kim, Ghilsoo Nam, Yong Hyun Jeon
Summary: KSNP117, a novel quinoline-based fluorescent probe, shows great potential as a biocompatible and highly sensitive imaging agent for the accurate detection of sentinel lymph nodes, with no adverse effects on cell proliferation and excellent serum stability.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
Article
Otorhinolaryngology
Harleen K. Sethi, Elliott M. Sina, Leila J. Mady, Christopher E. Fundakowski
Summary: This study depicts an innovative surgical approach for sentinel lymph node biopsy in head and neck malignancies that utilizes near-infrared imaging with indocyanine green dye and hand-held gamma probe. The results suggest that SLNB with ICG and radionucleotide co-localization may enhance the identification of sentinel nodes without compromising outcomes in the hands of surgeons well-versed in the technique.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2023)
Article
Biochemistry & Molecular Biology
Georgia Karpathiou, Fabio Orlando, Jean Marc Dumollard, Mousa Mobarki, Celine Chauleur, Michel Peoc'h
Summary: This study aimed to evaluate the presence of premetastatic niche factors in lymph nodes draining gynecological cancers. The results showed higher levels of these factors in lymph nodes draining cervical cancer and lower levels in lymph nodes draining low-grade endometrial cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Health Care Sciences & Services
Vincenzo Cuccurullo, Marco Rapa, Barbara Catalfamo, Giuseppe Lucio Cascini
Summary: With the advancements in sentinel lymph node technology, histopathological staging can be done using lymphatic mapping and selective lymphadenectomy. Structural imaging techniques like US, CT, and MR allow precise measurement of lymph node volume, which is strongly linked to cancerous involvement. While hybrid imaging has shown higher accuracy than standard imaging in visualizing the sentinel lymph node, it hasn't impacted surgical detection. Non-radiological fields such as ophthalmology and dermatology are introducing alternatives like fluorescence or opto-acoustic imaging. This paper analyzes the advantages and limitations of innovative methods in sentinel lymph node detection, including the continued importance of lymphoscintigraphy techniques.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Review
Medicine, General & Internal
Ji-Hoon Kim, Minhee Ku, Jaemoon Yang, Hyung Kwon Byeon
Summary: Sentinel lymph node biopsy is used in oral cancer surgery to minimize the extent of neck dissection, with ICG imaging widely adopted in surgical oncology. Real-time ICG-guided SLN imaging is frequently used in minimally invasive surgeries for various cancers.
Article
Oncology
Duygu Altin, Salih Taskin, Nedim Tokgozoglu, Dogan Vatansever, Adbul H. Guler, Mete Gungor, Tolga Tasci, Hasan Turan, Ilker Kahramanoglu, Ibrahim Yalcin, Cetin Celik, Faruk Kose, Firat Ortac, Macit Arvas, Ali Ayhan, Cagatay Taskiran
Summary: The study aimed to identify risk factors for non-sentinel lymph node metastasis in endometrial cancer patients with sentinel lymph node positivity, finding that the risk of non-sentinel lymph node metastasis increased with the size of sentinel lymph node metastasis. Non-sentinel lymph node metastasis was more common in higher-risk groups, particularly in cases where sentinel lymph nodes were macrometastatic.
JOURNAL OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Enora Laas, Virginie Fourchotte, Thomas Gaillard, Lea Pauly, Fabien Reyal, Jean-Guillaume Feron, Fabrice Lecuru
Summary: New parameters such as cytology and molecular biology have changed the management strategy of uterine cancer, making our algorithms more complex. This article discusses the integration of sentinel lymph node biopsy technique in the global management strategy of uterine cancer.
Article
Oncology
Yanglong Guo, Lu Sun, Xi Chen, Qiang Wen, Zhuyan Shao, Xuedong Tang, XiaoJun Shi, Jinyu Wang, Yingli Zhang, Tao Zhu
Summary: This study aims to compare the effectiveness of sentinel lymph node biopsy and lymphadenectomy for patients with early endometrial cancer and evaluate their impact on patients' quality of life.
Article
Materials Science, Biomaterials
Ye Ri Han, Da-Sol Lee, Sang Bong Lee, Hui-Jeon Jeon, Sijoon Lee, Soo-Eun Sung, Chang-Hee Lee, Sung Jin Cho, Kil Soo Kim, Dong-Su Kim, Yong Hyun Jeon
Summary: Novel phenaleno isoquinolinium-based fluorescent agents have been developed for sensitive detection of sentinel lymph nodes, showing potential for clinical applications.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
Article
Medicine, General & Internal
Lara Paracchini, Chiara Pesenti, Martina Delle Marchette, Luca Beltrame, Tommaso Bianchi, Tommaso Grassi, Alessandro Buda, Fabio Landoni, Lorenzo Ceppi, Cristina Bosetti, Mariachiara Paderno, Marco Adorni, Debora Vicini, Patrizia Perego, Biagio Eugenio Leone, Maurizio D'Incalci, Sergio Marchini, Robert Fruscio
Article
Obstetrics & Gynecology
Ignacio Zapardiel, Myriam Gracia, Javier Diez, Alessandro Buda, Maria C. Noya, Pierandrea De Iaco, Pedro Vieira-Baptista, Sara Iacoponi
Summary: The study concluded that postoperative radiotherapy appears to be the only independent factor associated with recurrence and overall survival in rare types of vulvar cancer.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2021)
Article
Oncology
Lorenzo Ceppi, Tommaso Grassi, Francesca Galli, Alessandro Buda, Giovanni Aletti, Andrea Alberto Lissoni, Marco Adorni, Annalisa Garbi, Nicoletta Colombo, Cristina Bonazzi, Fabio Landoni, Robert Fruscio
Summary: The study found that early-stage clear cell ovarian cancer has a longer relapse-free interval and similar cancer-specific survival compared to serous ovarian cancer, but a shorter post-relapse cancer-specific survival. Histological subtype of ovarian tumors affects patients' prognosis, and early use of adjuvant chemotherapy can improve the relapse-free interval.
GYNECOLOGIC ONCOLOGY
(2021)
Article
Oncology
Giorgio Bogani, Andrea Papadia, Alessandro Buda, Jvan Casarin, Violante Di Donato, Maria Luisa Gasparri, Francesco Plotti, Ciro Pinelli, Maria Chiara Paderno, Salvatore Lopez, Anna Myriam Perrone, Fabio Barra, Rocco Guerrisi, Claudia Brusadelli, Antonella Cromi, Debora Ferrari, Valentina Chiapp, Mauro Signorelli, Umberto Leone Roberti Maggiore, Antonino Ditto, Innocenza Palaia, Simone Ferrero, Pierandrea De Iaco, Roberto Angioli, Pierluigi Benedetti Panici, Fabio Ghezzi, Fabio Landoni, Michael D. Mueller, Francesco Raspagliesi
Summary: This study evaluated the outcomes of high-risk EC patients undergoing SNM, with or without back-up lymphadenectomy, and found that the type of nodal assessment did not impact survival outcomes. Back-up lymphadenectomy may help remove positive nodes, but its therapeutic value remains controversial.
GYNECOLOGIC ONCOLOGY
(2021)
Biographical-Item
Oncology
Alessandro Buda, Pedro T. Ramirez, Giovanni Scambia
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2021)
Correction
Oncology
Alessandro Buda, Jvan Casarin, Michael Mueller, Francesco Fanfani, Ignacio Zapardiel, Liliana Mereu, Andrea Puppo, Elena De Ponti, Marco Adorni, Debora Ferrari, Maria Luisa Gasparri, Fabio Ghezzi, Giovanni Scambia, Andrea Papadia
Summary: The name of the second author in the original article is incorrect.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2021)
Article
Oncology
Francesco Fanfani, Luigi Pedone Anchora, Giampaolo Di Martino, Nicolo Bizzarri, Maria Letizia Di Meo, Vittoria Carbone, Mariachiara Paderno, Camilla Fedele, Cristiana Paniga, Anna Fagotti, Fabio Landoni, Giovanni Scambia, Alessandro Buda
Summary: Objective conization/simple trachelectomy is feasible for early-stage cervical cancer patients desiring fertility preservation. This study in two Italian centers provided oncologic and obstetric outcomes of patients with 2018 FIGO stage IB1 cervical cancer managed by conization, demonstrating favorable oncologic outcomes and successful pregnancies in this group of patients. Future prospective studies are needed for further insight.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2021)
Article
Oncology
Kristen Moloney, Monika Janda, Michael Frumovitz, Mario Leitao, Nadeem R. Abu-Rustum, Emma Rossi, James L. Nicklin, Marie Plante, Fabrice R. Lecuru, Alessandro Buda, Andrea Mariani, Yee Leung, Sarah Elizabeth Ferguson, Rene Pareja, Rainer Kimmig, Pearl Shuang Ye Tong, Orla McNally, Naven Chetty, Kaijiang Liu, Ken Jaaback, Julio Lau, Soon Yau Joseph Ng, Henrik Falconer, Jan Persson, Russell Land, Fabio Martinelli, Andrea Garrett, Alon Altman, Adam Pendlebury, David Cibula, Roberto Altamirano, Donal Brennan, Thomas Edward Ind, Cornelis De Kroon, Ka Yu Tse, George Hanna, Andreas Obermair
Summary: Specific mandatory and prohibited steps of sentinel lymph node dissection in endometrial cancer have been identified and validated based on consensus among a large number of international experts. A competency assessment tool is now available and can be used for surgeon selection in clinical trials and for ongoing, prospective quality assurance in routine clinical care. The tool demonstrated high internal consistency and was effective in differentiating between skill levels in surgical videos.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2021)
Article
Oncology
Chiara Comerio, Marta Jaconi, Benedetta Zambetti, Mariachiara Paderno, Maria Gabriella Valente, Alessandro Buda
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2021)
Article
Oncology
Khaled Ghoniem, Alyssa M. Larish, Giorgia Dinoi, Xun Clare Zhou, Mariam Alhilli, Sumer Wallace, Christoph Wohlmuth, Glauco Baiocchi, Nedim Tokgozoglu, Francesco Raspagliesi, Alessandro Buda, Vanna Zanagnolo, Ignacio Zapardiel, Nisha Jagasia, Robert Giuntoli, Ariel Glickman, Michele Peiretti, Maximillian Lanner, Enrique Chacon, Julian Di Guilmi, Augusto Pereira, Enora Laas, Ami Fishman, Caroline C. Nitschmann, Susan Parker, Amy Joehlin-Price, Brittany Lees, Allan Covens, Louise De Brot, Cagatay Taskiran, Giorgio Bogani, Cristiana Paniga, Francesco Multinu, Alicia Hernandez-Gutierrez, Amy L. Weaver, Michaela E. McGree, Andrea Mariani
Summary: The study evaluated oncologic outcomes in endometrial cancer patients with low-volume metastasis in the sentinel lymph nodes, finding that Non-endometrioid histology, lymphovascular space invasion, and uterine serosal invasion were independent risk factors for recurrence. Patients with any of these risk factors had poor prognosis even with adjuvant therapy. On the other hand, patients with isolated tumor cell and grade 1 endometrioid disease had favorable prognosis even without adjuvant therapy, suggesting a potential for withholding adjuvant therapy in this low-risk subgroup.
GYNECOLOGIC ONCOLOGY
(2021)
Article
Obstetrics & Gynecology
Giorgio Bogani, Andrea Papadia, Alessandro Buda, Jvan Casarin, Violante Di Donato, Francesco Plotti, Maria Luisa Gasparri, Chiara Cimmino, Ciro Pinelli, Anna Myriam Perrone, Fabio Barra, Antonella Cromi, Giampaolo Di Martino, Innocenza Palaia, Simone Ferrero, Alice Indini, Pierandrea De Iaco, Roberto Angioli, Daniela Luvero, Ludovico Muzii, Fabio Ghezzi, Fabio Landoni, Michael D. Mueller, Pierluigi Benedetti Panici, Francesco Raspagliesi
Summary: The study identified body mass index and open abdominal surgery as independent factors predicting surgery-related morbidity in patients undergoing surgical staging for high-risk endometrial cancer. Laparoscopic surgery and sentinel node mapping were associated with a lower risk of surgery-related events in these patients.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2021)
Article
Oncology
Stefano Restaino, Alessandro Buda, Andrea Puppo, Vito Andrea Capozzi, Giulio Sozzi, Jvan Casarin, Vitalba Gallitelli, Ferdinando Murgia, Giuseppe Vizzielli, Alessandro Baroni, Giacomo Corrado, Tina Pasciuto, Debora Ferrari, Antonia Novelli, Roberto Berretta, Francesco Legge, Enrico Vizza, Vito Chiantera, Fabio Ghezzi, Fabio Landoni, Giovanni Scambia, Francesco Fanfani
Summary: This study aimed to evaluate the anatomical distribution of sentinel lymph nodes (SLNs) and the most frequent locations of nodal metastasis in endometrial cancer patients. The majority of SLNs and positive SLNs were found at the external iliac and obturator level. Older age, higher body mass index, and non-endometrioid histology negatively impacted SLN mapping.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2022)
Review
Oncology
Alessandro Buda, Martina Borghese, Andrea Puppo, Stefania Perotto, Antonia Novelli, Chiara Borghi, Elena Olearo, Elisa Tripodi, Alessandra Surace, Enrica Bar, Giovanni Scambia, Francesco Fanfani
Summary: This article aims to provide assistance to women affected by IB2 cervical cancer who wish to preserve fertility. Research indicates that neoadjuvant chemotherapy offers a conservative option for tumors larger than 2cm, and suboptimal response may have a negative impact on survival. An algorithm is proposed to aid in decision-making for this specific subgroup of patients.
Meeting Abstract
Radiology, Nuclear Medicine & Medical Imaging
Lavinia Monaco, Gregory Mathoux, Cinzia Crivellaro, Federica Elisei, Alessandro Buda, Robert Fruscio, Claudio Landoni, Luca Guerra, Cristina Messa, Elisabetta De Bernardi
JOURNAL OF NUCLEAR MEDICINE
(2021)
Article
Oncology
Alessandro Buda, Jvan Cesarin, Michael Mueller, Francesco Fanfani, Ignacio Zapardiel, Liliana Mereu, Andrea Puppo, Elena De Ponti, Marco Adorni, Debora Ferrari, Maria Luisa Gasparri, Fabio Ghezzi, Giovanni Scambia, Andrea Papadia
Summary: Ultrastaging analysis increased the detection rate of low-volume metastasis in women with early-stage cervical cancer, but the type of nodal staging did not impact patients' 3-year disease-free survival.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2021)
