Article
Orthopedics
Zhuan Deng, Zhi-Sheng Long, Fei-Peng Gong, Gang Chen
Summary: This study preliminarily assesses the therapeutic potentials and efficacy of platelet-rich plasma (PRP) in refractory wounds with exposed tendons. The results show that PRP can promote wound healing, reduce inflammation, and improve granulation tissue and angiogenesis, thereby demonstrating its effectiveness and safety.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2022)
Article
Critical Care Medicine
Hening Sun, Charles Godbout, Gareth Ryan, Graeme Hoit, James Higgins, Emil H. Schemitsch, Aaron Nauth
Summary: The study compared two bone grafting procedures in rat models of induced membrane technique (IMT), revealing significantly improved healing outcomes in the second group. This suggests that the revised bone grafting method plays a key role in enhancing healing outcomes and establishing a reliable rat model for IMT.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2022)
Article
Dermatology
C. L. Ebens, J. A. McGrath, J. A. Riedl, A. R. Keith, G. Lilja, S. Rusch, D. R. Keene, S. F. Tufa, M. J. Riddle, R. Shanley, A. E. Van Heest, J. Tolar
Summary: This study evaluated the effects of allogeneic epidermal skin grafts on wound healing and durability in patients with RDEB. The results showed significant reductions in wound area, successful fusion of epidermal grafts, and improvement in RDEB pseudosyndactyly.
BRITISH JOURNAL OF DERMATOLOGY
(2021)
Article
Pharmacology & Pharmacy
Anna Domaszewska-Szostek, Magdalena Gewartowska, Marek Stanczyk, Beata Narowska, Maria Moscicka-Wesolowska, Waldemar Lech Olszewski
Summary: Research shows that skin preserved in anhydrous sodium chloride can serve as a source for keratinocyte transplantation for treating extensive skin wounds. Transplanted keratinocytes maintained their morphology and functionality.
Article
Chemistry, Multidisciplinary
Yazan Al Thaher, Raida Khalil, Sharif Abdelghany, Mutaz S. Salem
Summary: This study investigated the release of gentamicin from carbon nanotubes incorporated in polymethyl methacrylate bone cement to prevent prosthetic joint infections. The results showed prolonged release of gentamicin from CNT-loaded bone cements over several weeks without affecting their mechanical and antimicrobial properties.
Article
Orthopedics
Jian Wei, Siqi Zhou, Hanwen Gu, Kai Tong
Summary: This study suggests that low-dose antibiotic-loaded acrylic cement commonly used in patients with periprosthetic joint infections does not adversely affect compressive strength and effectively kills gram-negative bacteria, with meropenem-loaded cement showing the best results. In the animal study, meropenem-loaded cement improves body weight, temperature, and inflammatory markers.
CLINICAL ORTHOPAEDICS AND RELATED RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Zhen Chang Liang, Chuan Yang, Xin Ding, James L. Hedrick, Wilson Wang, Yi Yan Yang
Summary: This study developed a series of bone cement formulations with enhanced antibacterial performance by adding carboxylic acid-functionalized polycarbonate block copolymers, prolonging antimicrobial release time, and increasing porosity of the cement. These formulations enhance the antibacterial performance of bone cement while maintaining mechanical strength, working characteristics, and osteoblastic biocompatibility.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Chemistry, Physical
John Jackson, Joey Lo, Eric Hsu, Helen M. Burt, Ali Shademani, Dirk Lange
Summary: The combination of gentamicin and silver nitrate in bone cement has shown a strong synergistic effect against both Gram-positive and Gram-negative bacteria, offering an economical and more effective method for anti-infective orthopedic treatments in the clinic.
Article
Dermatology
Leyi Cai, Zipu Hong, Yingying Zhang, Guangheng Xiang, Peng Luo, Weiyang Gao, Zhijie Li, Feiya Zhou
Summary: This study proposed a novel two-stage strategy for the treatment of traumatic wounds, which involved the use of PMMA cement and autologous split-thickness skin graft to cover the induced membrane. The results showed that this strategy was effective in managing non-healing wounds in the lower extremities, especially when bony structures were exposed in elderly patients, with a low morbidity rate.
INTERNATIONAL WOUND JOURNAL
(2023)
Review
Endocrinology & Metabolism
Tingting Dong, Qi Huang, Zengmei Sun
Summary: This article provides a meta-analysis of the effectiveness of antibiotic bone cement in treating infected diabetic foot wounds, demonstrating that it reduces the time to wound healing, length of hospital stay, time to bacterial conversion of the wound, and the number of procedures compared to traditional treatment.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Engineering, Biomedical
Junio Augusto Rodrigues Pasqual, Lucas C. Freisleben, Julio Cesar Colpo, Jose Ramon Jurado Egea, Luis Alberto Loureiro dos Santos, Vania Caldas de Sousa
Summary: The use of drug delivery systems is a good technique to deliver the right quantity of medicine directly to the affected region in a suitable dose. This paper explores the possibility of using electrochemical impedance spectroscopy (EIS) as an instant technique to quantify drug delivery, compared to UV-Vis technique.
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
(2021)
Article
Orthopedics
Zhe Gao, Yang Xu, Yuchen Kan, Hailong Li, Rui Guo, Luyang Han, Wenhan Bu, Jianjun Chu
Summary: Non-leaching antibacterial bone cement can provide long-term antibacterial activity, but it cannot treat serious infections that have already occurred like antibiotic-loaded bone cement. The antibacterial activity and biocompatibility of non-leaching cement when loaded with antibiotics have not been determined yet.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2023)
Article
Critical Care Medicine
Nezih Ziroglu, Alican Koluman, Belisa Kaleci, Bulent Tanriverdi, Gamze Tanriverdi, Alev Kural, Mustafa Gokhan Bilgili
Summary: This study evaluated the effects of three antibiotics (fusidic acid, teicoplanin, and gentamicin) added to polymethylmethacrylate (PMMA) on osteogenesis and induced membrane (IM) progression. The results showed that the addition of these antibiotics enhanced bone regeneration and IM progression, improving the treatment of critical-size bone defects.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2023)
Article
Materials Science, Ceramics
N. Ribeiro, M. Reis, L. Figueiredo, A. Pimenta, L. F. Santos, A. C. Branco, A. P. Alves de Matos, M. Salema-Oom, A. Almeida, M. F. C. Pereira, R. Colaco, A. P. Serro
Summary: The study aimed to enhance the properties of commercial CPC for injectability and as a sustained antibiotic delivery system. The optimal formulation contained 42%LP + HPMC + 1.87% GS, displaying excellent properties and injectability, with sustained release of antibiotic for at least 14 days.
CERAMICS INTERNATIONAL
(2022)
Article
Cell Biology
Nicolas Soehling, Myriam Heilani, Charlotte Fremdling, Alexander Schaible, Katrin Schroeder, Jan C. Brune, Volker Eras, Christoph Nau, Ingo Marzi, Dirk Henrich, Rene D. Verboket
Summary: The classic two-stage masquelet technique is effective for treating large bone defects. Using decellularized dermis membrane (DCD) can save one surgery. It is also possible to use granular demineralized bone matrix (g-DBM) or fibrous demineralized bone matrix (f-DBM) instead of syngeneic cancellous bone (SCB) for defect filling.
Article
Chemistry, Multidisciplinary
Feifan Li, Xinyang Mu, Xueqing Tang, Ge Song, Hongzhao Sun, Xiuling Zha, Peiyan Sun, Jianhui Fang, Dongmei Hu, Shan Cong, Zhigang Zhao
Summary: Non-metallic materials have unique advantages over metal materials as active substrates for surface-enhanced Raman scattering (SERS). However, the Raman enhancement achieved with non-metallic materials is considerably lower due to their inefficient interaction with the incident wavelength. In this study, colourful semiconductor-based SERS substrates are proposed for the first time by utilizing a Fabry-Perot cavity, which allows for manipulating light. By finely adjusting the absorption frequency and intensity, resonant absorption can be achieved with various non-metal SERS substrates, leading to a sensitivity enhancement of approximately 100 times.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Energy & Fuels
Cun-Hai Wang, Hao Chen, Ze-Yi Jiang, Xin-Xin Zhang, Fu-Qiang Wang
Summary: In this paper, a passive thermoelectric system that produces continuous electric power during a full 24-hour day is proposed. The system utilizes radiative cooling and solar heating to maintain and amplify the thermoelectric output. The effects of various factors on system performance are studied, and the system's seasonal and locational performance in China is evaluated.
Article
Andrology
Jian-Wu Shi, Yi-Wen Zhou, Yu-Fei Chen, Mei Ye, Feng Qiao, Jia-Wei Tian, Meng-Ya Zhang, Hao-Cheng Lin, Gang-Cai Xie, Kin Lam Fok, Hui Jiang, Yang Liu, Hao Chen
Summary: This study characterized the cell atlas of the epididymis in a 46,XY disorders of sex development patient with a novel heterozygous mutation in the NR5A1 gene. The patient exhibited feminization of external genitalia and dysplastic testis. Single-cell RNA sequencing analysis revealed an increase in fibroblast cells and a decrease in main epididymal epithelial cells, suggesting an association with the epithelial-to-mesenchymal transition process. This study provides important insights into the pathophysiology of DSD.
ASIAN JOURNAL OF ANDROLOGY
(2023)
Article
Thermodynamics
Shujuan Bu, Xinle Yang, Weikang Li, Chang Su, Xin Wang, Xunan Liu, Ning Yu, Guanyu Wang, Jupeng Tang
Summary: Theoretical formulations for the shift-temperature of zeotropic mixtures (Tshift) were derived in different pinch point scenarios. Tshift was corrected and calculated using the impact factor analysis and Dragonfly algorithm. The optimal zeotropic mixture was matched based on Tg, in and Tshift. The results showed that Tshift is a property of every zeotropic mixture and is influenced by critical temperature and evaporation/condensation temperatures.
INTERNATIONAL COMMUNICATIONS IN HEAT AND MASS TRANSFER
(2023)
Article
Obstetrics & Gynecology
Jiaming Rao, Dazhi Fan, Demei Lu, Yan Liu, Zhaoxia Wu, Jieyun He, Xinjuan Liu, BingJie Peng, Xiaoling Guo, Zhengping Liu
Summary: This study aimed to investigate the association between walking or jogging during pregnancy and the success rate of vaginal birth after cesarean delivery (VBAC). The results showed that women who walked or jogged for >= 200 min/week during pregnancy had a higher likelihood of successful VBAC in women who underwent a trial of labor after cesarean delivery.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Pharmacology & Pharmacy
Ziyan Guo, Qiufang Jing, Zhongyu Xu, Dahe Zhang, Wenyun Zheng, Fuzheng Ren
Summary: Cholesterol (CHOL) is important for lipid nanoparticles (LNPs) used in gene delivery. This study developed corosolic acid (CA)-modified lipid nanoparticles (CLNPs) by replacing CHOL in LNPs to deliver pDNA. CLNPs with a higher CHOL/CA ratio showed similar characteristics to LNPs, but exhibited increased cellular uptake and enhanced transfection efficacy with low cytotoxicity. In vivo experiments on chickens showed that CLNPs with a N/P ratio of 3 could induce similar immune responses as LNPs with a higher N/P ratio, suggesting the potential use of CLNPs in DNA vaccines against avian influenza.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Endocrinology & Metabolism
Jiayang Lin, Linjie Yang, Junlin Huang, Yating Liu, Xuzhen Lei, Ruxin Chen, Bingyan Xu, Chensihan Huang, Weijuan Dou, Xueyun Wei, Deying Liu, Peizhen Zhang, Yan Huang, Zhimin Ma, Huijie Zhang
Summary: This study found that both low and high levels of circulating IGF-1 are associated with increased risk of cardiovascular disease in the general population. The results highlight the importance of monitoring IGF-1 status on cardiovascular health.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Chemistry, Analytical
Xiaohua Yang, Shuangqi Wang, Lina Qi, Shujing Chen, Kunze Du, Ye Shang, Jiading Guo, Shiming Fang, Jin Li, Han Zhang, Yanxu Chang
Summary: The quality evaluation of Qingjin Yiqi Granules (QJYQ), a Traditional Chinese Medicines (TCMs) prescription for postCOVID-19 condition, was conducted using deep-learning assisted mass defect filter (deep-learning MDF) for qualitative analysis and ultra-high performance liquid chromatography and scheduled multiple reaction monitoring method (UHPLC-sMRM) for precise quantitation. The study successfully classified and identified the phytochemical components of QJYQ and quantified 50 components. The comprehensive evaluation strategy established in this study provides an effective tool for accurately evaluating the quality of QJYQ as a whole.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2023)
Meeting Abstract
Immunology
Yanhong Li, Jiajia Chen, Yifei Sang, Yikong Lin, Lin Xu, Dajin Li, Meirong Du
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2023)
Article
Materials Science, Multidisciplinary
Yuxin Liu, Baomin Fan, Bin Xu, Biao Yang
Summary: In this study, it was found that decorating polyethyleneimine (PEI) on Ti3C2TX could solve its oxidation problem in aqueous solutions. The functionalized Ti3C2TX with PEI exhibited excellent corrosion inhibition for copper in 0.5 M NaOH solution. The Ti-N bond formed by Coulomb attraction was responsible for the grafting of PEI. The anchored polymer chain effectively capped the oxidation-sensitive defects on Ti3C2TX, leading to improved colloidal stability. When the mass ratio of PEI/Ti3C2TX reached 0.33 (M@0.33P), the aqueous dispersion showed robust shelf-life for 30 days at 25 degrees C. M@nP acted as a mixed-type inhibitor with dominant anodic effect for copper in NaOH solutions, and M@0.33P was the optimal prototype that further mitigated copper dissolution. The protective mechanism of M@nP for copper in alkaline electrolyte involved reduction of interfacial cupric/cuprous species by Ti3C2TX, electrostatic adsorption, and electrons sharing of PEI.
Article
Chemistry, Multidisciplinary
Suet Yen Chong, Xiaoyuan Wang, Louis van Bloois, Chenyuan Huang, Nilofer Sayed Syeda, Sitong Zhang, Hui Jun Ting, Vaarsha Nair, Yuanzhe Lin, Charles Kang Liang Lou, Ayca Altay Benetti, Xiaodong Yu, Nicole Jia Ying Lim, Michelle Siying Tan, Hwee Ying Lim, Sheau Yng Lim, Chung Hwee Thiam, Wen Donq Looi, Olga Zharkovaa, Nicholas W. S. Chew, Cheng Han Ngg, Glenn Kunnath Bonney, Mark Muthiah, Xiaoyuan Chen, Giorgia Pastorin, A. Mark Richards, Veronique Angeli, Gert Storm, Jiong-Wei Wang
Summary: Atherosclerosis is a chronic vascular disease characterized by plaque formation in artery walls, and docosahexaenoic acid (DHA) has been suggested as a therapeutic option due to its anti-inflammatory and antioxidant properties. However, inconsistent results in clinical trials may be due to variations in DHA formulation and bioavailability. In this study, an injectable liposomal DHA formulation was developed, which protected DHA against degradation and increased its concentration within plaques. This formulation showed promising results in attenuating atherosclerosis progression and stabilizing plaques in experimental models.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Materials Science, Multidisciplinary
Chun-Yan Wu, Yu-Xuan Le, Li-Yan Liang, Jing-Yue Li, Feng-Xia Liang, Shi-Rong Chen, Xiao-Ping Yang, Yu-Xue Zhou, Lin-Bao Luo
Summary: In this study, a sensitive deep ultraviolet (DUV) photodetector was fabricated using CsPbBr3 nanosheets synthesized through confined-space growth at room temperature. The photodetector exhibited a blueshift in peak photoresponse with decreasing thickness, and a 68 nm CsPbBr3 nanosheet based device displayed a peak response to 265 nm illumination. Theoretical simulation revealed that the blueshift was related to the wavelength-dependent absorption coefficient of CsPbBr3 nanosheets.
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
(2023)
Article
Chemistry, Organic
Yanting Li, Xiao-Yong Duan, Chengxian Yang, Yamei Wei, Jiahan Li, Xiaojie Ren, Jing Qi
Summary: This article describes a N-heterocyclic carbene-catalyzed atroposelective [3+3] annulation of enals with 2-aminomaleate derivatives. A series of substituted dihydropyridones with both C-N axis and point chirality were synthesized with good diastereo- and enantioselectivity under mild conditions. This efficient strategy introduces an additional point chiral element to an axial backbone, and the resulting structurally interesting atropisomers may have potential applications in drug discovery.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Materials Science, Ceramics
Hui Yang, Yucheng Chang, Yumei Wang, Lijuan Wang, Xi Zhang, Jinsheng Liang
Summary: By using mathematical deconvolution analysis, the kinetic mechanisms of sintering shrinkage at different temperatures were separated into the formation of Al-Si-spinel, nucleation of mullite, and growth of mullite. The anisotropy of sintering shrinkage is primarily attributed to the parallel arrangement of clay plates, and the dominant role of mullite growth during densification.
JOURNAL OF THE EUROPEAN CERAMIC SOCIETY
(2023)
Article
Chemistry, Analytical
Jiaodi Li, Linzi Huang, Minghui Huang, Yaqi Yang, Zhifang Liu, Chenxi Wang, Yixi Xie, Pengcheng Zhao, Junjie Fei
Summary: In this study, a three-dimensional CdS/rGO@Au heterojunction was successfully synthesized and used for selective photoelectrochemical detection of Cu2+. The CdS/rGO@Au heterojunction showed a photocurrent 7 times higher than that of CdS, indicating a good photoresponse intensity. The developed photoelectrochemical sensor was able to detect Cu2+ concentration in the range of 5 nM to 4 mu M with a low limit of detection of 2.88 nM.
MICROCHEMICAL JOURNAL
(2023)