Journal
JOURNAL OF MICROENCAPSULATION
Volume 33, Issue 3, Pages 199-208Publisher
TAYLOR & FRANCIS LTD
DOI: 10.3109/02652048.2016.1144818
Keywords
Biodegradable particles; drug encapsulation; drug release; risperidone
Funding
- Russian Scientific Foundation [14-50-00069]
- Russian Science Foundation [14-50-00069] Funding Source: Russian Science Foundation
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The paper is devoted to the investigation of the effect of polyester hydrophobicity and ability for crystallisation on lipophilic drug loading and release from microparticles fabricated on the base of these polymers. Poly(l-lactic acid), poly(d, l-lactic acid) and poly (lactic acid-co-glycolic acid) were synthesised by ring-opening polymerisation using stannous octoate as catalyst, while poly(caprolactone) (PCL) and poly(-pentadecalactone) (PPDL) formation was catalysed by lipase. The particles were formed via single emulsion evaporation/diffusion method. The particles obtained were studied using SEM, XRD and DSC methods. The degradation of particles based on different polyesters, entrapment and release of a model hydrophobic drug (risperidone (R)) were thoroughly studied. The effect of particles hydrophobicity and crystallinity on these parameters was of most interest. The drug entrapment is greater for the hydrophobic polymers. Drug release was more rapid from crystalline particles (PLLA, PCL, PPDL), than from amorphous PDLLA and PLGA ones.
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