Article
Infectious Diseases
Bingjie Wang, Qing Zhan, Yanghua Xiao, Yanlei Xu, Huilin Zhao, Lulin Rao, Xinyi Wang, Jiao Zhang, Li Shen, Ying Zhou, Yinjuan Guo, Xiaocui Wu, Jingyi Yu, Fangyou Yu
Summary: Mupirocin stimulates the biofilm formation of Staphylococcus epidermidis by accelerating autolysis and eDNA release, depending on the specific gene atlE.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2023)
Article
Cell Biology
Kidon Sung, Miseon Park, Jungwhan Chon, Ohgew Kweon, Saeed A. Khan, Andrew Shen, Angel Paredes
Summary: This study investigates the effect of subinhibitory concentrations of tigecycline on biofilms formed by Staphylococcus epidermidis strain RP62A. The results show that different concentrations of tigecycline can cause changes in biofilm production and significantly affect protein expression. The study suggests that analyzing the global protein expression profile of biofilm cells under antibiotic pressure can improve our understanding of the mechanisms of antibiotic resistance.
Article
Biochemical Research Methods
Chisato Takahashi, Mari Sato, Chikara Sato
Summary: Staphylococcus epidermidis, a gram-positive bacterium, plays an important role in biofilm formation and microvesicle secretion. This study successfully imaged the microvesicles secreted by Staphylococcus epidermidis and their integration into biofilms using atmospheric scanning electron microscopy (ASEM). The information obtained is expected to help elucidate the biological mechanism of biofilm formation and develop medicines against biofilms and associated infections.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2021)
Article
Infectious Diseases
Carlos F. Amabile-Cuevas
Summary: Biofilm formation by macrolide-resistant Staphylococcus aureus isolates can be induced by macrolides, especially in the early stages, suggesting that the empirical use of macrolides against infections caused by resistant S. aureus strains could lead to clinical failure or even enhance biofilm formation, making further treatment difficult.
Article
Biochemistry & Molecular Biology
Itzia S. Gomez-Alonso, Sergio Martinez-Garcia, Gabriel Betanzos-Cabrera, Esmeralda Juarez, Maria C. Sarabia-Leon, Maria Teresa Herrera, Fernando Gomez-Chavez, Luvia Sanchez-Torres, Sandra Rodriguez-Martinez, Mario E. Cancino-Diaz, Jorge Cancino, Juan C. Cancino-Diaz
Summary: Protease-3 released by neutrophils in the presence of commensal non-biofilm-forming S. epidermidis plays a key role in promoting biofilm formation by facilitating cell aggregation through the release of bacterial DNA.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Jiaxue Wang, Lulin Rao, Zhuoan Huang, Lili Ma, Tian Yang, Zhongqi Yu, Aihua Sun, Yumei Ge
Summary: The current study investigates the impact of the nitric oxide synthase (NOS) gene on biofilm formation in Staphylococcus epidermidis (S. epidermidis). The results show that deletion of the NOS gene enhances biofilm formation, slightly retards bacterial growth, decreases autolysis rate, and weakens bacterial biofilm dispersal. Gene expression analysis suggests that the NOS gene negatively regulates biofilm formation by affecting biofilm aggregation and dispersal.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Microbiology
Yongqi Mu, Hong Zeng, Wei Chen
Summary: Quercetin exhibits anti-biofilm activity against Staphylococcus epidermidis by reducing cell surface hydrophobicity and inhibiting polysaccharide intercellular adhesin production, indicating its potential as an anti-biofilm agent for biofilm infections caused by S. epidermidis and potentially other bacteria.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Microbiology
Ranjith Konduri, Chinthala Reddy Saiabhilash, Sisinthy Shivaji
Summary: The study revealed that Staphylococcus aureus and Staphylococcus epidermidis isolated from patients with Endophthalmitis have the potential to form biofilms, with faster formation on corneas and dispersal phase occurring within 48 hours. Biofilm formation renders the bacteria several-fold more resistant to antibiotics compared to planktonic cells.
Article
Immunology
P. Kasparova, E. Vankova, L. Brazdova, K. Lokocova, O. Matatkova, J. Masak
Summary: Pterostilbene (PTE) is a natural compound with antioxidant and antimicrobial properties, which can enhance the effectiveness of erythromycin and tetracycline in inhibiting the growth and biofilm formation of Staphylococcus epidermidis. PTE was found to effectively inhibit S. epidermidis, reduce metabolic activity of biofilm cells, and enhance the action of antibiotics in overcoming biofilm cell tolerance.
MICROBIAL PATHOGENESIS
(2021)
Article
Microbiology
Shihua Lan, Xiaofeng Chen, Chuanping Yin, Shengjun Xie, Shuaishuai Wang, Rongrong Deng, Zhibin Shen
Summary: Research found that Disaspidin BB obtained from plant extracts and purifications has inhibitory effect on drug-resistant Staphylococcus epidermidis biofilms, and its mechanism of anti-biofilm activity was preliminarily investigated.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Biology
Chloe Catovic, Imen Abbes, Magalie Barreau, Catherine Sauvage, Jacques Follet, Cecile Duclairoir-Poc, Anne Groboillot, Sandra Leblanc, Pascal Svinareff, Sylvie Chevalier, Marc G. J. Feuilloley
Summary: This study investigated the effects of cotton and flax obtained through different agricultural methods on cutaneous bacteria. It was found that flax exhibited inhibitory effects on S. epidermidis bacteria, while cotton had no effect. Extracts of textile fibers were tested on bacteria and keratinocytes, and it was observed that all extracts affected biofilm formation by bacteria, but had no impact on resistance to antibiotics and biosurfactant production. Additionally, the extracts, especially those from organic flax, showed strong inhibitory effects on bacteria cytotoxicity. Analysis of flax extracts revealed the presence of benzyl alcohol, which could partly explain these effects.
Article
Microbiology
Davide Carcione, Gabriella Leccese, Gianmarco Conte, Elio Rossi, Jari Intra, Alice Bonomi, Simona Sabella, Massimo Moreo, Paolo Landini, Matteo Brilli, Moira Paroni
Summary: Staphylococcus epidermidis is an opportunistic pathogen that can cause nosocomial infections. A study conducted in an Italian hospital found that only a minority of S. epidermidis isolates displayed biofilm formation, regardless of their source. However, among the biofilm-producing isolates, those from catheters were the most efficient in biofilm formation. Interestingly, the production levels of PIA, the main extracellular polysaccharide of S. epidermidis, were similar in most isolates, including strong biofilm producers, compared to reference strains classified as non-biofilm formers. This suggests that high levels of PIA production may not confer a particular advantage for clinical isolates. The study also found that the correlation between biofilm production and decreased antibiotic sensitivity differed among the clinical isolates.
Article
Microbiology
Iwona Skiba-Kurek, Pawel Nowak, Joanna Empel, Magdalena Tomczak, Joanna Klepacka, Iwona Sowa-Sierant, Iwona Zak, Bartosz Pomierny, Elzbieta Karczewska
Summary: Staphylococcus epidermidis strains isolated from hospitalized newborns exhibited high resistance to methicillin, erythromycin, and clindamycin, and were capable of forming biofilms. The majority of strains demonstrated multidrug resistance and biofilm-forming ability, which could lead to antimicrobial therapy failure.
Article
Biochemistry & Molecular Biology
Denis Swolana, Malgorzata Kepa, Celina Kruszniewska-Rajs, Robert D. Wojtyczka
Summary: Nanosilver has an impact on biofilm formation, gene expression, and viability of Staphylococcus epidermidis. Low concentrations of nanosilver may increase biofilm production, while high concentrations do not have this effect.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Qiang Ren, Wanhe Luo, Haoming Chi, Lili Zhang, Wei Chen
Summary: This study investigated the inhibitory mechanisms of isookanin on biofilm formation in Staphylococcus epidermidis and found that it could decrease biofilm formation, reduce bacterial numbers, and regulate gene expression. The study also discovered that isookanin in combination with beta-lactam antibiotics had a synergistic effect, reducing antibiotic doses. This research provides guidance for the treatment of antibiotic resistance caused by biofilms.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Cell Biology
Jiang Zhu, Guangjie Duan, Lang Lang, Yao Liu, Junmin Zhu, Hu Wang, Yousheng Liu
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
(2015)
Article
Infectious Diseases
Fengjun Sun, Dongsheng Zhou, Qian Wang, Jiao Feng, Wei Feng, Wenbo Luo, Yao Liu, Xuewen Qiu, Zhe Yin, Peiyuan Xia
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2016)
Article
Biochemistry & Molecular Biology
Ya Yang, Di Li, Zhiqiang Tian, Jun Lv, Fengjun Sun, Qian Wang, Yao Liu, Peiyuan Xia
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2016)
Article
Oncology
Fengjun Sun, Qianyi Ou, Qian Wang, Wei Feng, Xuewen Qiu, Jianhong Chen, Yao Liu, Peiyuan Xia
JOURNAL OF CHEMOTHERAPY
(2016)
Article
Plant Sciences
Zhiqiang Tian, Yao Liu, Bo Yang, Ji Zhang, Haiyang He, Hui Ge, Yuzhang Wu, Zigang Shen
Article
Biochemistry & Molecular Biology
Jun Lv, Yahong Zhang, Zhiqiang Tian, Fang Liu, Ying Shi, Yao Liu, Peiyuan Xia
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2017)
Article
Medicine, Research & Experimental
Yixuan Sun, Fengjun Sun, Wei Feng, Xuewen Qiu, Yao Liu, Bo Yang, Yongchuan Chen, Peiyuan Xia
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2017)
Article
Oncology
Lin Song, Cui-Yao He, Nan-Ge Yin, Fang Liu, Yun-Tao Jia, Yao Liu
Article
Oncology
Yu Kang, Fang Liu, Yao Liu
Article
Oncology
Di Li, Ya Yang, Zhiqiang Tian, Jun Lv, Fengjun Sun, Qian Wang, Yao Liu, Peiyuan Xia
Article
Pharmacology & Pharmacy
Junhui Zhang, Lingfei Li, Qiong Zhang, Xu Yang, Can Zhang, Xingyue Zhang, Dongxia Zhang, Yanling Lv, Huapei Song, Bing Chen, Yao Liu, Jiongyu Hu, Yuesheng Huang
FRONTIERS IN PHARMACOLOGY
(2019)
Article
Cell Biology
Liwen Luo, Junfeng Gong, Hongyu Zhang, Jinghao Qin, Changqing Li, Junfeng Zhang, Yu Tang, Yang Zhang, Jian Chen, Yue Zhou, Zhiqiang Tian, Yao Liu, MingHan Liu
Summary: The study demonstrated that stem cells derived from cartilage endplate cells could transdifferentiate into nucleus pulposus cells via autocrine exosomes, activating the HIF-1 alpha/Wnt pathway to promote invasion, migration, and differentiation, thus inhibiting intervertebral disc degeneration. Additionally, GATA4 played a key role in promoting TGF-beta secretion and enhancing the transdifferentiation of stem cells, ultimately aiding in intervertebral disc repair.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Engineering, Biomedical
Liwen Luo, Junfeng Gong, Zhouguang Wang, Yao Liu, Jiaming Cao, Jinghao Qin, Rui Zuo, Hongyu Zhang, Shuai Wang, Ping Zhao, Di Yang, Mengjie Zhang, Yanqiu Wang, Junfeng Zhang, Yue Zhou, Changqing Li, Bing Ni, Zhiqiang Tian, MingHan Liu
Summary: This study presents a novel and efficient non-invasive combinational strategy for treating IVDD by injecting ECM-Gels loaded with CESCs that express sustained release of functional exosomes.
BIOACTIVE MATERIALS
(2022)
Article
Pediatrics
Lin Song, Yuntao Jia, Sujuan Ran, Bin Li, Jin Xu, Bennian Huo, Nange Yin, Maolin Ai, Yao Liu
Summary: The number of pediatric clinical trials in China has been increasing, but there are still challenges to be addressed, such as promoting pediatric clinical trials, facilitating the marketing application and administrative approval of appropriate drugs for children, conducting large-scale pediatric clinical trials, developing dosage forms suitable for children, particularly neonates and premature babies, and improving the uneven geographical distribution of sponsors and researchers.