Journal
NATURE CATALYSIS
Volume 5, Issue 9, Pages 788-797Publisher
NATURE PORTFOLIO
DOI: 10.1038/s41929-022-00831-1
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Funding
- National Natural Science Foundation of China [91956201, 21820102003, 21772053, 21822103, 21772052]
- Natural Science Foundation of Hubei Province [2017AHB047]
- International Joint Research Center for Intelligent Biosensing Technology and Health
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This article introduces a sustainable and economic alternative to palladium in asymmetric radical couplings using 3D metals. By combining asymmetric cobalt catalysis with organic photoredox catalysis and identifying an efficient chiral polydentate ligand, the authors successfully achieved visible-light-induced asymmetric radical couplings for the construction of axial chirality.
The 3d metals have been identified as economic and sustainable alternatives to palladium, the frequently used metal in transition-metal-catalysed cross-couplings. However, cobalt has long stood behind its neighbouring elements, nickel and copper, in asymmetric radical couplings owing to its high catalytic activity in the absence of ligands resulting in unfavourable un-asymmetric background reactions. Here we disclose an asymmetric metallaphotoredox catalysis (AMPC) strategy for the dynamic kinetic asymmetric transformation of racemic heterobiaryls, which represents a visible-light-induced, asymmetric radical coupling for the construction of axial chirality. This success can also be extended to the reductive cross-coupling variant featuring the use of more easily available organic halide feedstocks. The keys to these achievements are the rational design of a sustainable AMPC system that merges asymmetric cobalt catalysis with organic photoredox catalysis in combination with the identification of an efficient chiral polydentate ligand.
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