Article
Biochemistry & Molecular Biology
Jiaqi Sun, Fuyin Zhao, Zhenlei Wang, Weina Zhang, Xiudong Yang, Hongli Zhou, Peng Wan
Summary: This study aims to optimize the processing of Myristica fragrans Houtt. by talcum powder simmering, and the results show that the new process can reduce the content of toxic components and enhance the antioxidant and antibacterial activity of the essential oils.
Article
Biochemistry & Molecular Biology
Qi Dong, Na Hu, Huilan Yue, Honglun Wang
Summary: This study demonstrated that hypericin could potentially be a novel alpha-glucosidase inhibitor by using enzyme kinetics analysis, real-time interaction analysis, and molecular docking simulation. The results showed strong and fast binding affinities between hypericin and alpha-glucosidase, leading to a decrease in enzyme activity and suggesting potential for development of anti-diabetic drugs.
Article
Biochemistry & Molecular Biology
Shangming Liu, Jiahui Gao, Linhao He, Zhenwang Zhao, Gang Wang, Jin Zou, Li Zhou, Xiangjun Wan, Shilin Tang, Chaoke Tang
Summary: Myristica fragrans has been shown to promote cholesterol efflux from macrophages, reduce intracellular cholesterol accumulation, and modulate lipid metabolism and inflammation through the GATA3, LXR alpha, and ABCA1 pathways, indicating its potential therapeutic efficacy in atherosclerotic cardiovascular disease.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2021)
Article
Biochemistry & Molecular Biology
Jia Zhang, Ya-Nan Li, Lin-Bo Guo, Jun He, Peng-Hui Liu, Hai-Yan Tian, Wei-Ku Zhang, Jie-Kun Xu
Summary: A phytochemical investigation of the roots of Euphorbia fischeriana Steud. led to the isolation of eleven undescribed gallotannins, fishertannins A-K, together with four known analogues. Fishertannin A, possessing an unusual skeleton, showed the strongest inhibitory activity against alpha-glucosidase. These findings indicate the potential antidiabetic activity of the compounds from E. fischeriana.
Article
Biochemistry & Molecular Biology
Beiyun Shen, Xinchen Shangguan, Zhongping Yin, Shaofu Wu, Qingfeng Zhang, Wenwen Peng, Jingen Li, Lu Zhang, Jiguang Chen
Summary: Fisetin, extracted from Cotinus coggygria Scop., demonstrates promising potential as a therapeutic agent for treating type 2 diabetes mellitus by inhibiting alpha-glucosidase with strong activity and non-competitive inhibition mechanism.
Article
Chemistry, Applied
Ahmed Elbermawi, Ahmed F. Halim, El-Sayed S. Mansour, Kadria F. Ahmad, Ahmed Ashour, Yhiya Amen, Kuniyoshi Shimizu
Summary: A new glucoside, 3-methoxy-4-O-beta-D-glucopyranosyl-methyl benzoate, was isolated from Lycium schweinfurthii alongside five known compounds. These compounds were tested for their inhibitory effect on alpha-glucosidase enzyme, with four of them showing potent inhibitory activity that could potentially be used as a therapeutic approach to reduce postprandial hyperglycemia in diabetic patients.
NATURAL PRODUCT RESEARCH
(2021)
Article
Chemistry, Medicinal
Wencong Yang, Qi Tan, Yihao Yin, Yan Chen, Yi Zhang, Jianying Wu, Leyao Gao, Bo Wang, Zhigang She
Summary: Eight new compounds were isolated from the endophytic fungus Talaromyces sp. CY-3, including sambutoxin derivatives, highly oxygenated cyclopentenones, and highly oxygenated cyclohexenones. Some of these compounds exhibited better alpha-glucosidase inhibitory activity compared to the positive control.
Article
Biochemistry & Molecular Biology
Minghai Fu, Wenxiang Shen, Wenzhe Gao, Laxi Namujia, Xi Yang, Junwei Cao, Lijun Sun
Summary: The study found that myricetin is the most potent flavonoid in inhibiting alpha-glucosidase, with its inhibition effects influenced by its conformation, and 3-OH and 5'-OH groups can promote its binding to the enzyme active site. Additionally, the binding affinity of flavonoids with alpha-glucosidase correlates with inhibitory activity, indicating that the interactions between them are the reason for inhibition.
BIOORGANIC CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Arezoo Rastegari, Azadeh Manayi, Mahdi Rezakazemi, Mahdieh Eftekhari, Mahnaz Khanavi, Tahmineh Akbarzadeh, Mina Saeedi
Summary: This study found that the ethyl acetate fraction of Myristica fragrans has inhibitory activity against BChE and neuroprotective effects against H2O2-induced cell death. Compound 2 from Myristica fragrans showed the best inhibitory activity against both AChE and BChE.
Article
Chemistry, Physical
Suresh Sagadevan, J. Anita Lett, Selvaraj Vennila, P. Varun Prasath, Gobi Saravanan Kaliaraj, Is Fatimah, Estelle Leonard, Faruq Mohammad, Hamad A. Al-Lohedan, Solhe F. Alshahateet, C. T. Lee
Summary: In this study, titanium dioxide (TiO2) nanoparticles were successfully synthesized via green synthesis routes, and their photocatalytic activity was evaluated. The TiO2 nanoparticles demonstrated excellent photocatalytic degradation of methylene blue and congo red, indicating superior photocatalytic performance.
CHEMICAL PHYSICS LETTERS
(2021)
Article
Nutrition & Dietetics
Yunita Eka Puspitasari, Emmy Tuenter, Kenn Foubert, Herawati Herawati, Anik Martinah Hariati, Aulanni'am Aulanni'am, Luc Pieters, Tess De Bruyne, Nina Hermans
Summary: This study investigated the saponin profile in the body wall of Holothuria atra and evaluated its alpha-glucosidase inhibitory activity. UPLC-HRMS analysis identified 11 compounds, 7 of which were previously unreported. Two triterpene glycosides, desholothurin B (1) and a novel epimer, 12-epi-desholothurin B (2), were isolated and characterized. The Me90 fraction of the H. atra body wall exhibited the strongest alpha-glucosidase inhibitory activity (IC50 value 0.158 ± 0.002 mg/mL), surpassing acarbose (IC50 value 2.340 ± 0.044 mg/mL).
Article
Chemistry, Medicinal
Bin Zhang, Zhang-xin Yu, Xue-ming Zhou, Xu-hua Nong, Xiao-bao Li, Hao Wang, Hui Wang, Guang-ying Chen
Summary: Four new alkaloids, nonialkaloids A-D (1-4), and six known analogues (5-10) were isolated from noni juice. Among the new compounds, 1 and 2 are indole alkaloids with a seven-membered fused N-heterocyclic ring, while 3 and 4 are quaternary ammonium derivatives. Compounds 1 and 3 showed potent inhibitory activity against alpha-glucosidase with IC50 values of 413.7 and 364.4 μM, respectively.
Article
Biochemistry & Molecular Biology
Yasukiyo Yoshioka, Ryunoshin Kono, Masaki Kuse, Yoko Yamashita, Hitoshi Ashida
Summary: This study investigated the active compounds in Myristica fragrans and their mechanism in promoting glucose uptake. The researchers found that myristicin, licarin B, ADDP, and ADTP were the active compounds that promoted GLUT4 translocation. Oral administration of Myristica fragrans extract suppressed post-prandial hyperglycemia in mice. Therefore, Myristica fragrans shows promise as a functional food for preventing post-prandial hyperglycemia and type 2 diabetes mellitus.
Article
Food Science & Technology
Yu Zhang, Yu Chen, Xinyang Liu, Wei Wang, Junhong Wang, Xue Li, Suling Sun
Summary: This study aimed to obtain peptides with alpha-glucosidase inhibition activity from shiitake mushroom protein hydrolysate. The optimal conditions of enzymatic hydrolysis were determined by response surface test. Four peptides were identified and synthesized, showing potential inhibitory activity against alpha-glucosidase.
Article
Biochemistry & Molecular Biology
Shouye Han, Yu Liu, Wan Liu, Fan Yang, Jia Zhang, Ruifeng Liu, Fenqin Zhao, Wei Xu, Zhongbin Cheng
Summary: The fungal strain YPGA3 isolated from the sediments of the Yap Trench was identified as Penicillium thomii, and from it, eight new chromone derivatives were isolated. Two of the isolated derivatives have unique structures and showed remarkable inhibition against alpha-glucosidase.
