Article
Genetics & Heredity
Yun-Qiang Zhang, Kai Li, Qiang Guo, Dan Li
Summary: This study explores the roles and mechanisms of quercetin target genes in the progression of lung adenocarcinoma (LUAD). The differentially expressed quercetin target genes were found to be involved in biological processes and prognosis of LUAD. The risk model based on these quercetin target genes can be used to assess the prognosis of LUAD patients.
FRONTIERS IN GENETICS
(2022)
Article
Medicine, General & Internal
Jia Liu, Guilin Li
Summary: A risk signature was constructed using ECM-related genes to predict the prognosis of glioma patients. Immune infiltration was assessed in different risk groups, and the molecular mechanisms of the genes employed in the risk score were explored through GSEA. The established risk signature considered 17 ECM-related genes and showed promising results in predicting glioma prognosis.
Article
Medicine, General & Internal
Yaqiu Wu, Ling Liu, Da Huang, Zhili Li, Ruxiang Xu, Meixiong Cheng, Longyi Chen, Qi Wang, Chao You
Summary: In this study, a risk score model related to DNA damage and repair (DDR) was established. The validity of the model was verified through various analyses, and its adaptability was confirmed in different glioma datasets and subgroups. Additionally, the knockdown of NUDT1 was found to reduce tumorigenesis and significantly decrease the expression level of HIF-1 alpha in glioma.
ANNALS OF MEDICINE
(2023)
Article
Genetics & Heredity
Zhiqiang Liu, Yong Qi, Haibo Wang, Qikun Zhang, Zhengsheng Wu, Wenyong Wu
Summary: This study revealed three new molecular subgroups based on cuproptosis-linked genes and established a prognostic risk model related to cuproptosis. It can assist in predicting prognosis and determining treatment options.
FRONTIERS IN GENETICS
(2022)
Article
Clinical Neurology
Guorong Yang, Shu Tang, Jie Zhang, Ling Qin
Summary: TRAF3IP3 is highly expressed in gliomas and associated with worse prognosis, suggesting it may serve as a potential biomarker for glioma prognosis.
WORLD NEUROSURGERY
(2021)
Article
Genetics & Heredity
Chong Zhang, Zhehao He, Ling Cheng, Jinlin Cao
Summary: The study focused on exploring potential prognostic markers of LUAD and successfully built a five-gene prognostic model, which effectively divided samples into high- and low-risk groups with favorable survival outcomes in the training set. Further analysis using GSEA, TMB, and immune infiltration revealed differences in gene expression, mutation frequency, and immune activity between the two risk groups.
FRONTIERS IN GENETICS
(2021)
Article
Neurosciences
Rong-Jun Wan, Wang Peng, Qin-Xuan Xia, Hong-Hao Zhou, Xiao-Yuan Mao
Summary: A majority of ferroptosis-related genes (FRGs) showed differential expression among GBM, LGG, and NON-TUMOR groups (96.6%). Glioma patients with low-risk score had a more favorable clinical outcome, regardless of their tumor grade. Functional analysis revealed a positive correlation between high-risk score group and immune checkpoint blockade-related positive signatures, highlighting the critical role of glioma immunotherapy based on the risk score.
CNS NEUROSCIENCE & THERAPEUTICS
(2021)
Article
Clinical Neurology
Qianrong Huang, Jianwen Li, Ligen Mo, Yinnong Zhao
Summary: This study investigated the expression and prognostic role of pyroptosis-related genes in glioma, constructing a risk signature based on 7 genes that effectively predicts clinical outcomes. Functional enrichment analysis suggested a potential association with invasion ability and immune function.
WORLD NEUROSURGERY
(2022)
Article
Immunology
Zijun Zhao, Zairan Wang, Zihan Song, Yue Wu, Qianxu Jin, Zongmao Zhao
Summary: This study systematically analyzed the role of the STEAP family in glioma and established risk models based on STEAP gene expression to independently predict the prognosis and treatment response of glioma patients.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Oncology
Ning Zhou, Min Zhou, Ning Ding, Qinglin Li, Guangming Ren
Summary: This study aimed to construct a risk model for predicting the prognosis of lung adenocarcinoma patients using miRNA-regulated target genes. By analyzing miRNA and gene data, five prognosis-related miRNAs and 11 key genes were identified to establish an accurate prognostic model for patient survival.
FRONTIERS IN ONCOLOGY
(2021)
Article
Cell Biology
Fei Yang, Yi Zhang
Summary: This study used gene expression data to identify optimal genes for predicting prognosis in osteosarcoma patients. A risk score signature based on six genes was constructed and found to be associated with overall survival. The risk score was also independent of age and gender, and was related to immune cell infiltration.
Article
Neurosciences
Yunbo Yuan, Mingrong Zuo, Shuxin Zhang, Siliang Chen, Wentao Feng, Zhihao Wang, Mina Chen, Yanhui Liu
Summary: The disturbed redox balance is closely associated with the development of high-grade glioma (HGG) cells and their microenvironment. The expression pattern of redox-related genes (ROGs) can divide HGG patients into subgroups with different prognosis. Functional analysis reveals differential activation of cell cycle regulation and immune-related pathways. Evaluation of immune landscapes and risk signature can predict the survival and response to immunotherapies in HGG patients.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Cell Biology
Lin Wang, Yunqian Li, Yubo Wang, Jia Li, Yajuan Sun, Jiajun Chen, Ziqian Wang
Summary: In this study, a risk model based on cuproptosis-related lncRNAs was constructed and shown to have excellent prognostic prediction ability for glioma patients. The model also indicated the immuno-microenvironment status of glioma.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2022)
Article
Genetics & Heredity
Minxin He, Mingrui Li, Yibing Guan, Ziyan Wan, Juanhua Tian, Fangshi Xu, Haibin Zhou, Mei Gao, Hang Bi, Tie Chong
Summary: In this study, autophagy related genes (ATGs) were analyzed in clear cell renal cell carcinoma (ccRCC) patients to find a new prognostic risk score. Through various statistical analyses and functional enrichment analysis, 7 genes (BIRC5, CAPS, CLDN7, CLVS1, GMIP, IFI16, and TCIRG1) were identified as components of the risk score. The risk score showed the ability to predict the prognosis of ccRCC patients and can be used as a tool to identify novel prognostic markers. Further experiments are needed to validate its practicality.
FRONTIERS IN GENETICS
(2022)
Article
Immunology
Song Wang, Zhiwei Zhang, Jianhui Liang, Kaihuang Li, Li Bo, Haibo Zhan, Xin Hong, Jiawei Hu, Lu Yang Qian, Xuqiang Liu, Bin Zhang
Summary: In this study, LOXL1 and PTTG1 were identified as highly expressed genes in osteoarthritis and inflammation, while REEP5 and CDC14B showed no change in expression levels. Inhibition of PTTG1 expression was found to suppress the expression of inflammatory factors and protect the extracellular matrix through the MAPK signaling pathway. These findings suggest that LOXL1 and PTTG1 may serve as potential targets for the treatment of osteoarthritis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Clinical Neurology
Xiangyu Gao, Kangyi Yue, Jidong Sun, Yuan Cao, Boyan Zhao, Haofuzi Zhang, Shuhui Dai, Lei Zhang, Peng Luo, Xiaofan Jiang
FRONTIERS IN NEUROLOGY
(2020)
Review
Clinical Neurology
Xiangyu Gao, Kangyi Yue, Jidong Sun, Yuan Cao, Boyan Zhao, Haofuzi Zhang, Shuhui Dai, Lei Zhang, Peng Luo, Xiaofan Jiang
Summary: Treating brainstem cavernous malformations with microsurgery or radiosurgery has shown to be effective in reducing the rehemorrhage rate. The neurosurgery cohort had lower incidence of symptomatic intracranial hemorrhage, while the radiosurgery cohort had lower incidence of persistent focal neurological deficit.
FRONTIERS IN NEUROLOGY
(2021)
Article
Cell Biology
Yutao Huang, Xiangyu Gao, Erwan Yang, Kangyi Yue, Yuan Cao, Boyan Zhao, Haofuzi Zhang, Shuhui Dai, Lei Zhang, Peng Luo, Xiaofan Jiang
Summary: With the shift from the histology epoch to the molecular era in malignant glioma research, there is a growing need to investigate diagnostic/prognostic/therapeutic biomarkers and their regulatory mechanisms. This study identified differentially expressed genes and ceRNA networks in malignant glioma and constructed predictive models. The results revealed correlations between these genes and circadian rhythm, tumor immune microenvironment, and cellular senescence pathways. These findings provide new insights for precise diagnosis and personalized treatment of malignant glioma.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Yutao Huang, Haofuzi Zhang, Erwan Yang, Kangyi Yue, Xiangyu Gao, Shuhui Dai, Jialiang Wei, Yuefan Yang, Peng Luo, Xin Li, Xiaofan Jiang
Summary: In this study, differentially expressed proteins (DEPs) and differentially expressed phosphoproteins (DEPPs) in the early and late stages of TBI were identified using TMT labeling, Phos affinity enrichment, and high-resolution LC-MS/MS analysis. Integrative analyses revealed the different and similar pathophysiologic mechanisms between the early and late stages, providing insights into useful biomarkers and underlying mechanisms in TBI and its sequelae.
JOURNAL OF MOLECULAR NEUROSCIENCE
(2022)
Review
Pharmacology & Pharmacy
Haofuzi Zhang, Xin Li, Dan Liao, Peng Luo, Xiaofan Jiang
Summary: ABHD6 is a transmembrane serine hydrolase that plays important roles in neurotransmission, inflammation, and other biological processes. It has potential therapeutic implications for neurological diseases.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cell Biology
Haofuzi Zhang, Yuefan Yang, Erwan Yang, Zhicheng Tian, Yutao Huang, Zhuoyuan Zhang, Mingdong Bao, Dan Liao, Junmiao Ge, Chao Wang, Xin Li, Peng Luo
Summary: Pulsed electromagnetic fields (PEMFs) reduce neuroinflammation following brain ischemia by modulating astrocytic receptors and signaling pathways.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2023)
Review
Pediatrics
Xiangyu Gao, Kangyi Yue, Jidong Sun, Zheng Fang, Yuan Cao, Boyan Zhao, Haofuzi Zhang, Shuhui Dai, Lei Zhang, Peng Luo, Xiaofan Jiang
Summary: The study found through meta-analysis that surgery is an effective and safe treatment for pediatric patients with CCM-related epilepsy. The seizure control rate was 88%, and there was a low risk of postoperative complications and death after surgical excision of CCMs.
FRONTIERS IN PEDIATRICS
(2022)
Article
Cell Biology
Zhicheng Tian, Zixuan Cao, Erwan Yang, Juan Li, Dan Liao, Fei Wang, Taozhi Wang, Zhuoyuan Zhang, Haofuzi Zhang, Xiaofan Jiang, Xin Li, Peng Luo
Summary: Repetitive mild traumatic brain injury can lead to neurodegeneration and cognitive impairment, mainly due to damage to the hippocampus. This study found that mice exhibited cognitive impairment, increased p-tau expression, and decreased neuronal dendritic spines density in the hippocampus after repetitive mild traumatic brain injury. Proteomic and phosphoproteomic analyses revealed that inflammation, immunity, and coagulation were involved in the pathological changes in the hippocampus, while pathways related to neuronal function and structure were more consistent with neurodegeneration. N-methyl-D-aspartate receptor 1 was identified as a key molecule in the response to repetitive mild traumatic brain injury and its inhibition improved cognitive impairment. This suggests that N-methyl-D-aspartate receptor 1 signaling in the hippocampus plays a role in cognitive impairment in the chronic stage after repetitive mild traumatic brain injury and may serve as a potential target for intervention and treatment.
NEURAL REGENERATION RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Haofuzi Zhang, Shuhui Dai, Yuefan Yang, Jialiang Wei, Xin Li, Peng Luo, Xiaofan Jiang
Summary: Sirt3, an NAD(+)-dependent deacetylase, plays an important role in the metabolic processes of mitochondria, including energy generation, the tricarboxylic acid cycle, and oxidative stress. Activation of Sirt3 has a strong neuroprotective impact by slowing down or preventing mitochondrial dysfunction in neurodegenerative disorders. The regulatory factors of Sirt3 in neurodegenerative diseases include antiapoptosis, oxidative stress, and the maintenance of metabolic homeostasis.
Review
Neurosciences
Haofuzi Zhang, Kangyi Yue, Zijian Jiang, Xiuquan Wu, Xin Li, Peng Luo, Xiaofan Jiang
Summary: The aim of this study was to evaluate the incidence of stress-induced hyperglycemia (SIH) in acute ischemic stroke (AIS). A total of 13 studies involving 4552 patients were included in the meta-analysis. The results showed that the incidence of SIH in AIS was 24%, with higher rates observed in North America compared to Europe and Asia. The study also found that the incidence of SIH decreased in studies published after 2010. These findings highlight the importance of prevention and control of SIH in AIS.
Biographical-Item
Clinical Neurology
Haofuzi Zhang, Xiaofan Jiang