Reconsidering the need for gain-of-function research on enhanced potential pandemic pathogens in the post-COVID-19 era

Risky ‘gain-of-function’ studies need stricter guidance, say US researchers

(2022) Max Kozlov   NATURE

SARS-CoV-2 D614G spike mutation increases entry efficiency with enhanced ACE2-binding affinity

(2021) Seiya Ozono et al.   Nature Communications

SARS-CoV-2 spike L452R variant evades cellular immunity and increases infectivity

(2021) Chihiro Motozono et al.   Cell Host & Microbe

Acquisition of the L452R mutation in the ACE2-binding interface of Spike protein triggers recent massive expansion of SARS-CoV-2 variants

(2021) Veronika Tchesnokova et al.   JOURNAL OF CLINICAL MICROBIOLOGY

The shifting sands of ‘gain-of-function’ research

(2021) Amber Dance   NATURE

BNT162b2 Vaccine Booster and Mortality Due to Covid-19

(2021) Ronen Arbel et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Impact of Mutations in SARS-CoV-2 Spike on Viral Infectivity and Antigenicity

(2020) Qianqian Li et al.   CELL

The impact of the COVID-19 pandemic on suicide rates

(2020) Leo Sher   QJM-AN INTERNATIONAL JOURNAL OF MEDICINE

COVID-19 vaccine BNT162b1 elicits human antibody and TH1 T cell responses

(2020) Ugur Sahin et al.   NATURE

Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine

(2020) Fernando P. Polack et al.   NEW ENGLAND JOURNAL OF MEDICINE

Safety and immunogenicity of a recombinant adenovirus type-5 vector-based Ebola vaccine in healthy adults in Sierra Leone: a single-centre, randomised, double-blind, placebo-controlled, phase 2 trial

(2017) Feng-Cai Zhu et al.   LANCET

The next SARS?

(2016) Cláudio Nunes-Alves   NATURE REVIEWS MICROBIOLOGY

Gain-of-Function Research: Ethical Analysis

(2016) Michael J. Selgelid   SCIENCE AND ENGINEERING ETHICS

A SARS-like cluster of circulating bat coronaviruses shows potential for human emergence

(2015) Vineet D Menachery et al.   NATURE MEDICINE

US suspends risky disease research

(2014) Sara Reardon   NATURE

Gain-of-function experiments: time for a real debate

(2014) W. Paul Duprex et al.   NATURE REVIEWS MICROBIOLOGY

Vagueness and Costs of the Pause on Gain-of-Function (GOF) Experiments on Pathogens with Pandemic Potential, Including Influenza Virus

(2014) Michael J. Imperiale et al.   mBio

Influenza Gain-of-Function Experiments: Their Role in Vaccine Virus Recommendation and Pandemic Preparedness

(2014) S. Schultz-Cherry et al.   mBio

mBio Addresses the Pause in Gain-of-Function (GOF) Experiments Involving Pathogens with Pandemic Potential (PPP)

(2014) Arturo Casadevall et al.   mBio

Moratorium on Research Intended To Create Novel Potential Pandemic Pathogens: FIG 1 

(2014) Marc Lipsitch et al.   mBio

Ethical Alternatives to Experiments with Novel Potential Pandemic Pathogens

(2014) Marc Lipsitch et al.   PLOS MEDICINE

Isolation and characterization of a bat SARS-like coronavirus that uses the ACE2 receptor

(2013) Xing-Yi Ge et al.   NATURE

Work resumes on lethal flu strains

(2013) Declan Butler   NATURE

H5N1 viral-engineering dangers will not go away

(2013) Simon Wain-Hobson   NATURE

H5N1 virus: Transmission studies resume for avian flu

(2013) Ron A. M. Fouchier et al.   NATURE

A Framework for Decisions About Research with HPAI H5N1 Viruses

(2013) A. P. Patterson et al.   SCIENCE

Transmission Studies Resume For Avian Flu

(2013) R. A. M. Fouchier et al.   SCIENCE

Pause on avian flu transmission studies

(2012) Ron A. M. Fouchier et al.   NATURE

Flu transmission work is urgent

(2012) Yoshihiro Kawaoka   NATURE