The intracellular cation channel TMEM176B as a dual immunoregulator

Pharmacogenomics of Anti-TNF Treatment Response Marks a New Era of Tailored Rheumatoid Arthritis Therapy

(2022) Tomasz Wysocki et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Protective immune trajectories in early viral containment of non-pneumonic SARS-CoV-2 infection

(2022) Kami Pekayvaz et al.   Nature Communications

TH17 cells promote CNS inflammation by sensing danger signals via Mincle

(2022) Quanri Zhang et al.   Nature Communications

A Potential Diagnostic and Prognostic Biomarker TMEM176B and Its Relationship With Immune Infiltration in Skin Cutaneous Melanoma

(2022) Linlan Jiang et al.   Frontiers in Cell and Developmental Biology

The Ala134Thr variant in TMEM176B exerts a beneficial role in colorectal cancer prognosis by increasing NLRP3 inflammasome activation

(2022) Raylane Adrielle Gonçalves Cambui et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

PD-1/PD-L1 blockade abrogates a dysfunctional innate-adaptive immune axis in critical β-coronavirus disease

(2022) Maite Duhalde Vega et al.   Science Advances

Targeting tumor-derived NLRP3 reduces melanoma progression by limiting MDSCs expansion

(2021) Isak W. Tengesdal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dendritic Cells Require TMEM176A/B Ion Channels for Optimal MHC Class II Antigen Presentation to Naive CD4+ T Cells

(2021) Melanie Lancien et al.   JOURNAL OF IMMUNOLOGY

The tetraspan MS4A family in homeostasis, immunity, and disease

(2021) Irene Mattiola et al.   TRENDS IN IMMUNOLOGY

CD11b+ lung dendritic cells at different stages of maturation induce Th17 or Th2 differentiation

(2021) Gentaro Izumi et al.   Nature Communications

Role of inflammasome activation in tumor immunity triggered by immune checkpoint blockers

(2020) M. Segovia et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Transcriptional and Functional Analysis of CD1c+ Human Dendritic Cells Identifies a CD163+ Subset Priming CD8+CD103+ T Cells

(2020) Pierre Bourdely et al.   IMMUNITY

The Paradoxical Roles of Inflammation during PD-1 Blockade in Cancer

(2020) Marcelo Hill et al.   TRENDS IN IMMUNOLOGY

CD8 T Cell Exhaustion During Chronic Viral Infection and Cancer

(2019) Laura M. McLane et al.   Annual Review of Immunology

Targeting TMEM176B Enhances Antitumor Immunity and Augments the Efficacy of Immune Checkpoint Blockers by Unleashing Inflammasome Activation

(2019) Mercedes Segovia et al.   CANCER CELL

Unleashing Type-2 Dendritic Cells to Drive Protective Antitumor CD4+ T Cell Immunity

(2019) Mikhail Binnewies et al.   CELL

Single-Cell Analysis of Human Mononuclear Phagocytes Reveals Subset-Defining Markers and Identifies Circulating Inflammatory Dendritic Cells

(2019) Charles-Antoine Dutertre et al.   IMMUNITY

Transcriptional Basis of Mouse and Human Dendritic Cell Heterogeneity

(2019) Chrysothemis C. Brown et al.   CELL

Effects of interleukin-2 in immunostimulation and immunosuppression

(2019) Jonathan G. Pol et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cancer immunotherapy using checkpoint blockade

(2018) Antoni Ribas et al.   SCIENCE

Orchestration of NLRP3 Inflammasome Activation by Ion Fluxes

(2018) Tao Gong et al.   TRENDS IN IMMUNOLOGY

The Dual Nature of Type I and Type II Interferons

(2018) Amanda J. Lee et al.   Frontiers in Immunology

Critical role for Sec22b-dependent antigen cross-presentation in antitumor immunity

(2017) Andrés Alloatti et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Single-cell RNA-seq reveals new types of human blood dendritic cells, monocytes, and progenitors

(2017) Alexandra-Chloé Villani et al.   SCIENCE

Pro-inflammatory Ca++-activated K+ channels are inhibited by hydroxychloroquine

(2017) María Eugenia Schroeder et al.   Scientific Reports

Inflammasome Complexes: Emerging Mechanisms and Effector Functions

(2016) Vijay A.K. Rathinam et al.   CELL

T cell–intrinsic ASC critically promotes TH17-mediated experimental autoimmune encephalomyelitis

(2016) Bradley N Martin et al.   NATURE IMMUNOLOGY

RORγt+ cells selectively express redundant cation channels linked to the Golgi apparatus

(2016) Lucile Drujont et al.   Scientific Reports

The MS4A family: counting past 1, 2 and 3

(2015) Li Eon Kuek et al.   IMMUNOLOGY AND CELL BIOLOGY

Autologous Dendritic Cells Prolong Allograft Survival ThroughTmem176b-Dependent Antigen Cross-Presentation

(2014) M. Segovia et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Classical Flt3L-dependent dendritic cells control immunity to protein vaccine

(2014) Niroshana Anandasabapathy et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Antigen Release Kinetics in the Phagosome Are Critical to Cross-Presentation Efficiency

(2014) S. W. Howland et al.   JOURNAL OF IMMUNOLOGY

Cellular Zinc Levels Are Modulated by TRPML1-TMEM163 Interaction

(2014) Math P. Cuajungco et al.   TRAFFIC

Blood RNA profiling in a large cohort of multiple sclerosis patients and healthy controls

(2013) Dorothee Nickles et al.   HUMAN MOLECULAR GENETICS

Control of T Helper 2 Responses by Transcription Factor IRF4-Dependent Dendritic Cells

(2013) Yan Gao et al.   IMMUNITY

Abnormal accumulation of human transmembrane (TMEM)-176A and 176B proteins is associated with cancer pathology

(2012) Math P. Cuajungco et al.   ACTA HISTOCHEMICA

A Validated Regulatory Network for Th17 Cell Specification

(2012) Maria Ciofani et al.   CELL

Cutting Edge: Expression of XCR1 Defines Mouse Lymphoid-Tissue Resident and Migratory Dendritic Cells of the CD8 + Type

(2011) K. Crozat et al.   JOURNAL OF IMMUNOLOGY

Tmem176B and Tmem176A are associated with the immature state of dendritic cells

(2010) Thomas Condamine et al.   JOURNAL OF LEUKOCYTE BIOLOGY