Article
Pharmacology & Pharmacy
Xuelian Cheng, Jingjing Li, Limei Feng, Songwei Feng, Xiao Wu, Yongming Li
Summary: The study identifies HRGs as potential biomarkers for patients with refractory TACE and provides a novel immunological perspective for developing personalized therapies.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Genetics & Heredity
Yiming Zhang, Rong He, Xuan Lei, Lianghao Mao, Pan Jiang, Chenlie Ni, Zhengyu Yin, Xinyu Zhong, Chen Chen, Qiping Zheng, Dapeng Li
Summary: In this study, a prognostic model based on pyroptosis-related genes was constructed to predict the outcome of osteosarcoma patients. Key genes affecting the prognosis of osteosarcoma patients were identified, forming a signature that independently predicts survival and metastasis risk.
FRONTIERS IN GENETICS
(2021)
Article
Cell Biology
Wenshuo Zhang, Pang Lyu, Darja Andreev, Yewei Jia, Fulin Zhang, Aline Bozec
Summary: This study demonstrates the critical roles of hypoxia and the immune microenvironment in the development of osteosarcoma. By developing a gene signature based on hypoxia and immune status, the prognosis of osteosarcoma can be predicted. A nomogram was also constructed to optimize risk stratification and risk assessment for individual patients. These findings are highly important for the survival and personalized management of osteosarcoma patients.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
Yucheng Fu, Qiyuan Bao, Zhuochao Liu, Guoyu He, Junxiang Wen, Qi Liu, Yiqi Xu, Zhijian Jin, Weibin Zhang
Summary: This study identified hypoxia-associated genes related to osteosarcoma metastasis and constructed a gene signature to predict osteosarcoma prognosis. Two genes (DCN and P4HA1) were involved in the hypoxia-associated gene signature. Patients with high-risk scores showed lower survival rates, and the gene signature was identified as an independent prognostic factor.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Oncology
Zachary D. Prudowsky, Jason T. Yustein
Summary: Osteosarcoma is the most common bone malignancy of childhood. Standard chemotherapy regimens work well for many patients, but there are minimal options for patients with progressive or resistant disease. A better understanding of therapy resistance is necessary to improve current treatments and design new strategies for future treatment options.
Article
Veterinary Sciences
Hyo-Sung Kim, Han-Jun Kim, Hyun-Jeong Hwang, Jong-Hyun Ahn, Sun-Hee Do
Summary: This case study reports an extraskeletal osteosarcoma in a Maltese dog, which did not result in recurrence or metastasis after resection. Analysis revealed high expression of proliferation- and metastasis-related biomarkers in the tumor cells, along with the absence of angiogenesis-related biomarkers, suggesting a hypoxic tumor microenvironment preventing metastasis.
VETERINARY SCIENCES
(2021)
Article
Cell Biology
Ye Yuan, Lulu Tan, Liping Wang, Danyi Zou, Jia Liu, Xiaohuan Lu, Daan Fu, Guobin Wang, Lin Wang, Zheng Wang
Summary: This study identified hypoxia as the primary factor influencing CRC prognosis and constructed a gene signature that can accurately predict individual prognosis. Additionally, stromal and immune cells in the tumor microenvironment were found to be associated with hypoxia. The expression of drug resistance-related genes is crucial in CRC treatment decision-making.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Oncology
Huichao Fu, Yunjiao Wu, Jianbai Chen, Xing Hu, Xiaoyan Wang, Gongping Xu
Summary: Osteosarcoma (OS) is a primary malignant tumor characterized by tumor cells forming bone tissue. Exosomes have been found to play a significant role in the diagnosis, treatment, and chemotherapy resistance of OS. Furthermore, as natural nano-carriers with excellent targeted transport capacity and low toxicity, exosomes have great potential in the field of OS therapy.
FRONTIERS IN ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Min Jiang, Changyin Fang, Yongping Ma
Summary: This study aimed to determine the correlation between pyroptosis-related lncRNAs and gastric cancer prognoses. A predictive signature including six pyroptosis-related lncRNAs was established and confirmed to possess good predictive performance. High-risk gastric cancer patients were found to benefit from the combination of immunotherapy and chemotherapy. These findings highlight the potential of pyroptosis-related lncRNAs as novel biomarkers for the prognosis and treatment of gastric cancer.
Article
Cell Biology
Xiao-Wei Fu, Chun-Qing Song
Summary: The study revealed that the pyroptosis-related gene signature comprised of GSDME, GPX4, and SCAF11 can serve as an independent prognostic factor for HCC patients, providing further evidence for more clinical and functional studies.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Genetics & Heredity
Yufu Zheng, Didi Yuan, Fei Zhang, Renkuan Tang
Summary: This study comprehensively analyzed the contribution of the gasdermin (GSDM) family in a pan-cancer setting. The results showed that GSDM genes were highly upregulated in most tested cancers, and their expression levels were associated with prognosis, clinical characteristics, tumor microenvironment, and stemness scores. The study also found a higher expression of GSDMB, GSDMC, and GSDMD in kidney carcinomas, particularly kidney renal clear cell carcinoma, which negatively impacted patient outcomes. Additionally, the expressions of GSDM genes were correlated with the sensitivity of tumor cells to certain chemotherapy drugs.
FRONTIERS IN GENETICS
(2022)
Article
Multidisciplinary Sciences
Jin-Zhou Xu, Qi-Dong Xia, Jian-Xuan Sun, Chen-Qian Liu, Jun-Lin Lu, Meng-Yao Xu, Ye An, Yang Xun, Zheng Liu, Jia Hu, Cong Li, Shao-Gang Wang
Summary: This study established a quantitative indicator to evaluate the transcription levels of genes related to pyroptosis and systematically explored the role of pyroptosis in various cancers. Pyroptosis was found to be closely related to immune regulation, tumorigenesis, and other forms of cell death. Furthermore, the pyroptosis status could serve as a biomarker for chemotherapy efficacy.
SCIENTIFIC REPORTS
(2023)
Article
Oncology
Zhengjun Lin, Xubin Xie, Shiyao Lu, Tang Liu
Summary: Osteosarcoma is the most frequent bone malignancy in children and adolescents, with the development of multi-drug resistance posing a major obstacle in improving chemotherapy efficacy. Research has shown that noncoding RNAs play significant roles in osteosarcoma progression and chemosensitivity, highlighting their potential as biomarkers and therapeutic targets for improving patient prognosis.
Review
Chemistry, Multidisciplinary
Xudong Zhu, Shenglong Li
Summary: In recent years, there has been an increase in the occurrence of gastrointestinal cancers, especially among young people. Effective treatment is crucial for improving patients' chances of survival. Programmed cell death, regulated by various genes, plays a vital role in the growth and development of organisms and is involved in maintaining tissue and organ homeostasis and various pathological processes. Aside from apoptosis, other forms of programmed cell death such as ferroptosis, necroptosis, and pyroptosis can cause severe inflammatory responses and contribute to the development of gastrointestinal cancers. This review provides a comprehensive summary of the biological roles and molecular mechanisms of these cell death processes, as well as their regulators, in gastrointestinal cancers, aiming to explore new avenues for targeted therapy in the future.
Article
Cell Biology
Bo Wu, Wenzhuo Yang, Zhaoyu Fu, Haoqun Xie, Zhen Guo, Daqun Liu, Junliang Ge, Sheng Zhong, Luwei Liu, Jingyi Liu, Dong Zhu
Summary: Novel prognostic and therapeutic targets for osteosarcoma patients were identified through gene expression analysis, with CDK1 and topoisomerase II alpha mRNA levels found to correlate with patient prognosis. Computational techniques were used to screen for potential CDK1 inhibitor PHA-793887, which was shown to be effective in reducing viability and clonogenicity of osteosarcoma cells in vitro.
Article
Biochemistry & Molecular Biology
Dongjie Chen, Jixing Liu, Longjun Zang, Tijun Xiao, Xianlin Zhang, Zheng Li, Hongwei Zhu, Wenzhe Gao, Xiao Yu
Summary: This study proposes a novel classification system for hepatocellular carcinoma (HCC) based on cancer stem cells (CSCs) that can predict patients' response to immunotherapy. Using RNA-seq datasets and machine learning algorithms, the study computes a stemness index (mRNAsi) and performs clustering analysis to categorize HCC patients into different stemness subtypes. This stemness-based classification system can facilitate prognostic prediction and guide clinical strategies for immunotherapy and targeted therapy in HCC.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Immunology
Dongjie Chen, Hui Huang, Longjun Zang, Wenzhe Gao, Hongwei Zhu, Xiao Yu
Summary: By analyzing gene expression data of PDAC patients, we constructed a risk score model with seven signature genes that can effectively predict patient prognosis, stratifying patients into high-risk and low-risk groups. Patients in the low-risk group showed significantly better overall survival compared to those in the high-risk group.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Dongjie Chen, Wenzhe Gao, Longjun Zang, Xianlin Zhang, Zheng Li, Hongwei Zhu, Xiao Yu
Summary: This study identified ferroptosis-related lncRNAs with prognostic significance in pancreatic cancer patients and established a ferroptosis-related lncRNA prognostic marker (Fe-LPM). Fe-LPM can be used to predict the overall survival of pancreatic cancer patients and guide clinical strategies.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Geriatrics & Gerontology
Yanyao Deng, Yanjin Feng, Zhicheng Lv, Jinli He, Xun Chen, Chen Wang, Mingyang Yuan, Ting Xu, Wenzhe Gao, Dongjie Chen, Hongwei Zhu, Deren Hou
Summary: This study found that ferroptosis might be involved in the pathogenesis of Alzheimer's disease. By screening ferroptosis-related genes, a diagnostic model for AD was established, providing directions for further study of disease pathogenesis and therapy targets.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Immunology
Wenzhe Gao, Dongjie Chen, Jixing Liu, Longjun Zang, Tijun Xiao, Xianlin Zhang, Zheng Li, Hongwei Zhu, Xiao Yu
Summary: This study reveals the interplay network of four RNA modifications in pancreatic cancer. The WM_Score model demonstrates powerful predictive capacity in epigenetic, immunological, and biological landscape, providing a theoretical basis for future clinical judgments in pancreatic cancer.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
Dongjie Chen, Yizhi Cao, Haoyu Tang, Longjun Zang, Na Yao, Youwei Zhu, Yongsheng Jiang, Shuyu Zhai, Yihao Liu, Minmin Shi, Shulin Zhao, Weishen Wang, Chenlei Wen, Chenghong Peng, Hao Chen, Xiaxing Deng, Lingxi Jiang, Baiyong Shen
Summary: Evidence has shown that reprogramming super-enhancers (SEs) can promote metastasis in pancreatic cancer (PC). By analyzing primary pancreatic tumors (PTs) and hepatic metastases (HMs), a novel SEMet classifier was established based on prognostic HM-SE genes. The classifier showed strong predictive performance and a correlation with metastatic phenotypes in PC. Additionally, the study identified E2F7 as a potential driver of PC metastasis and identified flumethasone as a potential enhancer of gemcitabine chemotherapy in metastatic PC.
Article
Oncology
Xinling He, Mingfang Yu, Jiasong Zhao, Aiyang Wang, Ji Yin, Haoyu Wang, Jiao Qiu, Xueyi He, Xiao Wu
Summary: This study investigated the therapeutic mechanism of moxibustion in rheumatoid arthritis (RA) and whether it can adjust the circadian rhythm disrupted by RA. The results showed that moxibustion can treat RA by modulating the core clock genes CLOCK and BMAL1 to restore the circadian rhythm. However, there was no significant difference between moxibustion treatment in the morning and in the afternoon.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2022)
Article
Oncology
Xin Wu, Shiqin Li, Dongjie Chen, Guiping Zheng, Zhaohua Zhang, Zian Li, Xiaoying Sun, Qiangqiang Zhao, Jingjuan Xu
Summary: A potential inflammatory response-related signature consisting of 11 differentially expressed genes was identified in this study, which was associated with prognosis and immune status in AML patients. Moreover, the expression levels of this signature were also found to be associated with susceptibility to chemotherapy in AML patients.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2022)
Article
Immunology
Zhongguang Wu, Xiaobo Zhang, Dongjie Chen, Zian Li, Xin Wu, Jianlong Wang, Youwen Deng
Summary: N6-adenosine methylation plays an important role in tumors, especially in osteosarcoma. This study found that the expression of m(6)A-related lncRNAs is closely associated with the clinical outcomes of OS patients. Additionally, the levels of m(6)A-related lncRNAs and infiltrating immune cells are also related to the prognosis of OS.
FRONTIERS IN IMMUNOLOGY
(2022)